GO:0007610

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Name behavior
Categary Process
Go Slim No
Go Link GO:0007610
Unique Molecular Interactions 3020
Total Molecular Interactions 4610
Total Single Events 49019
Pain Genes Associated 58

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for behavior. They are ordered first by their pain relevance and then by number of times they were reported for behavior. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
4 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
5 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
6 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
7 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
8 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
9 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
10 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
11 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
12 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
13 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
14 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
15 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
16 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
17 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
18 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
19 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
20 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
21 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
22 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
23 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
24 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
25 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
26 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
27 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
28 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
29 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
30 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
31 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
32 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
33 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
34 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
35 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
36 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
37 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
38 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
39 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
40 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
41 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
42 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
43 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
44 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
45 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
46 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
47 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
48 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
49 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1
50 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
51 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
52 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
53 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
54 INT152699 Bdnf Positive_regulation of Ltp 5 0.05 1.22 2.95
55 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
56 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
57 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
58 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
59 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
60 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
61 INT30133 Binding of Cck and Penk 1 0.27 2.49 2.71
62 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
63 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
64 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
65 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
66 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
67 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
68 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
69 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
70 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
71 INT340117 Binding of Bdnf and Pain1 1 0.01 2.48 2.55
72 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
73 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
74 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
75 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
76 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
77 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
78 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
79 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
80 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
81 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
82 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
83 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
84 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
85 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
86 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
87 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
88 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
89 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
90 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
91 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
92 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
93 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
94 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
95 INT18355 Penk Positive_regulation of Localization of Sst 1 0.31 0 2.04
96 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
97 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
98 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
99 INT58678 Binding of Penk and Abat 2 0.40 1.39 1.97
100 INT2653 Slc3a1 Regulation of Penk 3 0.04 0.37 1.96
101 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
102 INT349585 Aap Positive_regulation of Etf1 1 0.00 1.68 1.94
103 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
104 INT37882 Penk Positive_regulation of LOC100366054 1 0.08 0.35 1.93
105 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
106 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
107 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
108 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
109 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
110 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
111 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
112 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
113 INT75069 Penk Regulation of Gene_expression of Pkhd1l1 1 0.09 0 1.85
114 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85
115 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
116 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
117 INT40238 Penk Regulation of Oxt 1 0.04 0 1.83
118 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
119 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
120 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
121 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
122 INT122964 FSCN1 Positive_regulation of Bdnf 1 0.01 1.14 1.79
123 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
124 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
125 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
126 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
127 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
128 INT14576 Tac4 Regulation of Penk 1 0.07 0 1.77
129 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
130 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
131 INT140892 Penk Negative_regulation of Mnp 1 0.13 0.55 1.75
132 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74
133 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
134 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
135 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71
136 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
137 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
138 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
139 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
140 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
141 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
142 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
143 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
144 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
145 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
146 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
147 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
148 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
149 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
150 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
151 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
152 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
153 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
154 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
155 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
156 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
157 INT42928 Penk Negative_regulation of Localization of Oxt 2 0.03 0 1.57
158 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
159 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
160 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
161 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
162 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
163 INT54844 Negative_regulation of Penk Positive_regulation of Vip 1 0.26 0 1.54
164 INT33815 Vta1 Negative_regulation of Penk 1 0.25 0 1.54
165 INT40887 Penk Regulation of Th 1 0.04 0 1.53
166 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
167 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53
168 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 0.10 0.23 1.51
169 INT62481 Penk Negative_regulation of Slc6a7 2 0.60 0 1.5
170 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5
171 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
172 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
173 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
174 INT48101 RT1-DMb Positive_regulation of Penk 1 0.10 0 1.5
175 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
176 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
177 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
178 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
179 INT116094 Binding of TACR1 and TFF2 1 0.06 0 1.47
180 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
181 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
182 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
183 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
184 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
185 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
186 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
187 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
188 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
189 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
190 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
191 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
192 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
193 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
194 INT136346 Binding of Aap and Ads1 1 0.09 2.95 1.44
195 INT158282 Binding of Penk and Csf2 1 0.33 0.87 1.44
196 INT180768 Bdnf Regulation of Localization of Trpv1 1 0.13 1.21 1.43
197 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
198 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
199 INT158283 Binding of Penk and Accn4 1 0.07 0.87 1.43
200 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43

Single Events

The table below shows the top 100 pain related interactions that have been reported for behavior. They are ordered first by their pain relevance and then by number of times they were reported in behavior. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 812 0.62 111.13 542.24
5 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
6 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81
7 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1
8 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
9 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
10 INT1396 Binding of Penk 355 0.48 22.79 269.65
11 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
12 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
13 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
14 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82
15 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07
16 INT4803 Transcription of Penk 435 0.72 59.09 182.4
17 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
18 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
19 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
20 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
21 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
22 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88
23 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
24 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
25 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73
26 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68
27 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01
28 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
29 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
30 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45
31 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
32 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
33 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
34 INT67682 Localization of Bdnf 204 0.81 72.36 88.92
35 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
36 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
37 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49
38 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13
39 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
40 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
41 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66
42 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
43 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5
44 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
45 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
46 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36
47 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
48 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
49 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68
50 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
51 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32
52 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
53 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95
54 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
55 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24
56 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
57 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81
58 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
59 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
60 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
61 INT19488 Localization of ABAT 56 0.69 21.51 50.56
62 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37
63 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
64 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
65 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
66 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
67 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
68 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
69 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
70 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55
71 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64
72 INT4862 Localization of PENK 62 0.81 11.57 40.28
73 INT16194 Binding of CNR1 82 0.48 20.75 39.59
74 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
75 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81
76 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
77 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
78 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
79 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
80 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
81 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
82 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24
83 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
84 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
85 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45
86 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4
87 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
88 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54
89 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42
90 INT610 Regulation of PENK 47 0.62 14.17 31.55
91 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
92 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
93 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77
94 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
95 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29
96 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
97 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
98 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
99 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78
100 INT10684 Negative_regulation of Protein_catabolism of Penk 41 0.59 2.33 28.63
101 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5
102 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
103 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28
104 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03
105 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83
106 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
107 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57
108 INT5851 Positive_regulation of Gene_expression of Penk 52 0.70 14.57 25.05
109 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92
110 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77
111 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
112 INT96557 Binding of Bdnf 46 0.47 21.74 24.26
113 INT5592 Regulation of Regulation of Penk 36 0.62 4.37 24.02
114 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
115 INT21344 Negative_regulation of Penk 34 0.57 8.83 23.32
116 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
117 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
118 INT113925 Localization of Bdnf 59 0.79 24.03 22.76
119 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
120 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
121 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
122 INT102203 Transcription of Bdnf 35 0.71 18.26 20.59
123 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2
124 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
125 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
126 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
127 INT11243 Localization of NPY 33 0.78 11.18 19.24
128 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12
129 INT79955 Localization of Cnr1 26 0.81 8.44 19.06
130 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91
131 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
132 INT66004 Binding of Cnr2 35 0.48 12.82 18.63
133 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21
134 INT18621 Binding of ABAT 28 0.36 9.88 18.04
135 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
136 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91
137 INT8056 Regulation of Positive_regulation of Penk 34 0.59 4.71 17.66
138 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
139 INT106556 Negative_regulation of Gene_expression of Bdnf 42 0.59 34.71 17.64
140 INT13790 Binding of HTR1A 52 0.47 18.83 17.59
141 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
142 INT102903 Regulation of Gene_expression of Bdnf 35 0.62 20.1 17.42
143 INT9780 Regulation of Penk 30 0.60 6.78 17.19
144 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
145 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
146 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
147 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
148 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57
149 INT7290 Negative_regulation of Transcription of Penk 33 0.59 7.28 16.5
150 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
151 INT87932 Positive_regulation of Gene_expression of Cnr1 28 0.69 8.86 16.38
152 INT8530 Transcription of Penk 48 0.70 11.67 16.34
153 INT62629 Localization of CNR1 35 0.76 11.86 16.3
154 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09
155 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
156 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
157 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
158 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
159 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
160 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
161 INT163479 Binding of Bdnf 36 0.48 25.77 14.83
162 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74
163 INT8223 Transcription of PENK 53 0.69 6.84 14.7
164 INT18526 Positive_regulation of Aap 19 0.56 12.28 14.57
165 INT18527 Localization of Aap 31 0.72 5.6 14.42
166 INT34952 Regulation of ABAT 28 0.61 6.05 14.39
167 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27
168 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
169 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66
170 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
171 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
172 INT20881 Negative_regulation of OPRK1 20 0.43 3.73 13.37
173 INT20495 Regulation of Protein_catabolism of Penk 17 0.62 0.96 13.3
174 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
175 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14
176 INT1590 Binding of PENK 27 0.47 2.99 12.81
177 INT1827 Gene_expression of Aap 11 0.67 9.37 12.66
178 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
179 INT57580 Positive_regulation of TACR1 18 0.69 9.35 12.47
180 INT69763 Positive_regulation of Positive_regulation of Cnr1 12 0.50 9.05 12.46
181 INT83601 Binding of CNR2 30 0.47 7.79 12.37
182 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92
183 INT2415 Binding of MAOA 26 0.47 13.26 11.86
184 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83
185 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
186 INT64225 Positive_regulation of Localization of ABAT 15 0.60 4.46 11.28
187 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26
188 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
189 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
190 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
191 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91
192 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68
193 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
194 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
195 INT1459 Positive_regulation of Binding of Penk 15 0.67 0.08 10.45
196 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
197 INT2294 Protein_catabolism of PENK 19 1.00 0.64 10.22
198 INT5854 Regulation of Gene_expression of Penk 22 0.61 6.91 10.03
199 INT2777 Positive_regulation of Regulation of Penk 21 0.67 0.63 9.96
200 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93
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