GO:0008047

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Name enzyme activator activity
Categary Function
Go Slim No
Go Link GO:0008047
Unique Molecular Interactions 186
Total Molecular Interactions 235
Total Single Events 1434
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enzyme activator activity. They are ordered first by their pain relevance and then by number of times they were reported for enzyme activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
3 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
4 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
5 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18
6 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
7 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
8 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
9 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
10 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95
11 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94
12 INT182199 Binding of CXCR5 and CXCL1 1 0.16 1.24 0.94
13 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
14 INT182189 Binding of CXCL1 and CXCL13 1 0.14 1.24 0.93
15 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 0.13 1.31 0.91
16 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 0.36 0.33 0.88
17 INT105249 Cyb5b Positive_regulation of Localization of Prl 1 0.04 0 0.79
18 INT105250 Cyb5b Regulation of Localization of Gh1 1 0.00 0 0.79
19 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
20 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
21 INT196526 Binding of TIMP1 and TIMP2 1 0.45 1.49 0.71
22 INT148454 Gene_expression of Inhbe Positive_regulation of Prkce 1 0.08 0.67 0.69
23 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
24 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
25 INT112513 Binding of Prkaca and Prkce 1 0.04 0.4 0.64
26 INT112516 Binding of Prkce and Trib3 1 0.01 0.4 0.64
27 INT164286 Alox5ap Positive_regulation of Cysltr2 1 0.19 1.11 0.61
28 INT164285 Ltc4s Positive_regulation of Cysltr2 1 0.20 1.11 0.61
29 INT164283 Ltb4r Positive_regulation of Ltc4s 1 0.37 1.1 0.6
30 INT164284 Ltb4r Positive_regulation of Alox5ap 1 0.34 1.1 0.6
31 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
32 INT335432 Ltc4s Regulation of Cysltr2 1 0.11 0.38 0.58
33 INT335436 Ltc4s Regulation of Gene_expression of Cysltr2 1 0.18 0.38 0.58
34 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
35 INT345302 MMP15 Positive_regulation of MMP2 1 0.06 1.17 0.57
36 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
37 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
38 INT150795 ZNF398 Positive_regulation of Localization of TIMP2 1 0.06 0.51 0.53
39 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
40 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
41 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
42 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
43 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
44 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
45 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
46 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
47 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
48 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
49 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
50 INT150799 ZNF398 Positive_regulation of TIMP2 1 0.09 0.49 0.51
51 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
52 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
53 INT65007 DAK Negative_regulation of CTSA 1 0.03 0.35 0.48
54 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44
55 INT7636 RFC1 Negative_regulation of Localization of Oxt 1 0.14 0 0.39
56 INT7634 RFC1 Negative_regulation of Localization of AVP 1 0.46 0 0.39
57 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38
58 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
59 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
60 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3
61 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3
62 INT44984 KNG1 Regulation of Ltc4s 1 0.01 0.17 0.3
63 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
64 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
65 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29
66 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
67 INT48161 RIMS3 Negative_regulation of Gene_expression of LTC4S 1 0.16 0.07 0.28
68 INT159201 Binding of Ppard and Ppara 1 0.01 0.68 0.28
69 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
70 INT283857 APOA5 Positive_regulation of Positive_regulation of MAPK1 1 0.00 0.6 0.22
71 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
72 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22
73 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
74 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
75 INT283860 APOA5 Negative_regulation of MAPK1 1 0.00 0.59 0.21
76 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
77 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
78 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
79 INT249893 Ltc4s Positive_regulation of Gpr17 1 0.04 0.92 0.2
80 INT49057 Positive_regulation of CEL Positive_regulation of Localization of LTC4S 1 0.41 0.28 0.18
81 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18
82 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
83 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18
84 INT33362 Binding of Ltc4s and Cysltr1 1 0.16 0.21 0.17
85 INT249895 Ltc4s Positive_regulation of P2ry4 1 0.00 0.71 0.17
86 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16
87 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16
88 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
89 INT329850 APOA5 Negative_regulation of Transcription of APOC3 1 0.24 0.85 0.15
90 INT328793 Binding of Mmp7 and Timp2 1 0.00 0.72 0.15
91 INT328794 Binding of Timp2 and Mmp3 1 0.00 0.72 0.15
92 INT56430 Ltc4s Regulation of NA 1 0.00 0 0.14
93 INT130921 HMHA1 Positive_regulation of CASP9 1 0.03 1.37 0.14
94 INT130919 HMHA1 Positive_regulation of Protein_catabolism of CASP9 1 0.03 1.37 0.14
95 INT134614 Prkce Regulation of Trpv1 1 0.30 0.15 0.13
96 INT17437 LTC4S Positive_regulation of CYSLTR1 1 0.03 0.2 0.13
97 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13
98 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13
99 INT270996 TBXA2R Regulation of LTC4S 1 0.24 0.83 0.13
100 INT110107 Acot1 Positive_regulation of Localization of Prkce 1 0.11 0 0.12
101 INT271002 Binding of LTC4S and Aia1 1 0.00 0.98 0.12
102 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
103 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
104 INT301307 Binding of GPR17 and LTC4S 1 0.00 0.42 0.11
105 INT203628 Cxcl1 Negative_regulation of TIMP2 1 0.01 0 0.1
106 INT312116 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 0.2 0.1
107 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1
108 INT294437 KLK4 Negative_regulation of CXCL1 1 0.00 0 0.1
109 INT187112 Binding of TIMP2 and Positive_regulation of TIMP1 1 0.32 0.26 0.1
110 INT213414 Binding of CXCL1 and SET 1 0.10 0.17 0.1
111 INT203590 Negative_regulation of IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
112 INT203586 IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
113 INT273354 Binding of ALOX5 and LTC4S 1 0.04 0.19 0.09
114 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08
115 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08
116 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08
117 INT102886 Binding of GBE1 and CTSA 1 0.00 0 0.07
118 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07
119 INT302175 BAX Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
120 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
121 INT308831 Binding of RFC1 and IGKV2D-29 1 0.02 0 0.06
122 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
123 INT345307 CXCL12 Positive_regulation of Gene_expression of MMP15 1 0.00 2.5 0.05
124 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05
125 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
126 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05
127 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04
128 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04
129 INT265462 CSPG4 Negative_regulation of Positive_regulation of CASP9 1 0.07 1.2 0.04
130 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04
131 INT265461 CSPG4 Negative_regulation of Gene_expression of CASP9 1 0.06 1.2 0.04
132 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04
133 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03
134 INT313551 Binding of ALOX5AP and Cor 1 0.02 1.01 0.03
135 INT201770 Binding of CASP9 and Apaf1 1 0.04 0.89 0.03
136 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03
137 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
138 INT327981 CASP9 Positive_regulation of CASP3 2 0.29 1.34 0
139 INT94426 CTS Positive_regulation of Gene_expression of TIMP2 1 0.04 0 0
140 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0
141 INT322559 TNFSF10 Positive_regulation of CASP9 1 0.03 1.79 0
142 INT94424 IL1B Negative_regulation of Negative_regulation of TIMP2 1 0.06 0 0
143 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
144 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
145 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
146 INT345168 Binding of Lpar1 and Ppard 1 0.03 0.21 0
147 INT94425 IL1B Negative_regulation of Transcription of TIMP2 1 0.06 0 0
148 INT327978 PNLIP Regulation of Regulation of CASP9 1 0.19 0.57 0
149 INT322561 Negative_regulation of TNFSF10 Positive_regulation of CASP9 1 0.03 1.15 0
150 INT255167 Binding of SAE1 and CERS1 1 0.08 0.72 0
151 INT348530 CASP10 Positive_regulation of CASP9 1 0.02 0.3 0
152 INT313499 Binding of ALOX5AP and CRP 1 0.07 0.45 0
153 INT164910 IL33 Positive_regulation of Gene_expression of CXCL1 1 0.12 0.05 0
154 INT283865 Binding of MAPK1 and APOA5 1 0.00 0.22 0
155 INT283866 Binding of SVIL and APOA5 1 0.00 0.22 0
156 INT169448 Binding of Prkce and Trpv4 1 0.04 0.08 0
157 INT302584 Binding of Lpl and Apoa5 1 0.20 0.63 0
158 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
159 INT336036 Positive_regulation of CASP9 Positive_regulation of CASP3 1 0.05 0.75 0
160 INT172893 Binding of Lta4h and Ltc4s 1 0.00 0.24 0
161 INT302594 Binding of CETP and Apoa5 1 0.26 0.63 0
162 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0
163 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
164 INT348536 Positive_regulation of TP63 Positive_regulation of Gene_expression of CASP9 1 0.02 0.55 0
165 INT201769 Akt1 Negative_regulation of Phosphorylation of CASP9 1 0.00 0.82 0
166 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0
167 INT327979 Positive_regulation of CASP9 Positive_regulation of Gene_expression of CASP3 1 0.07 0.78 0
168 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
169 INT297846 Nanos2 Regulation of Dnmt3l 1 0.34 0.6 0
170 INT318223 BAX Regulation of CASP9 1 0.09 0.18 0
171 INT302595 Binding of Apoa5 and HDLCQ1 1 0.02 0.16 0
172 INT302586 Binding of Lipc and Apoa5 1 0.26 0.63 0
173 INT200646 AKT1 Regulation of CASP9 1 0.10 1.09 0
174 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0
175 INT283899 Binding of Ephb2 and APOA5 1 0.00 0.67 0
176 INT351708 Binding of LMNA and SAE1 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enzyme activator activity. They are ordered first by their pain relevance and then by number of times they were reported in enzyme activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
2 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8
3 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
4 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
5 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62
6 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
7 INT4807 Localization of LTC4S 23 0.58 6.89 7.59
8 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14
9 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04
10 INT110104 Localization of Prkce 17 0.79 3.75 6.92
11 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62
12 INT101497 Phosphorylation of Prkce 9 0.81 2.55 5.59
13 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
14 INT91946 Regulation of Prkce 6 0.44 4.13 5.46
15 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
16 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05
17 INT109838 Phosphorylation of Prkce 6 0.67 5.26 4.95
18 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8
19 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78
20 INT60758 Gene_expression of Prkce 8 0.20 4.12 4.59
21 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
22 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86
23 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
24 INT109840 Localization of Prkce 5 0.74 3.01 3.45
25 INT16159 Regulation of Ltc4s 11 0.38 2.52 3.21
26 INT102034 Positive_regulation of Ppard 10 0.69 3.97 3.17
27 INT110100 Negative_regulation of Prkce 5 0.57 0.68 3.16
28 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13
29 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
30 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08
31 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92
32 INT112758 Binding of Ppard 7 0.37 3.6 2.87
33 INT195421 Positive_regulation of Gene_expression of ALOX5AP 12 0.49 5.17 2.82
34 INT163359 Gene_expression of RFC1 9 0.65 3.34 2.64
35 INT128184 Positive_regulation of Positive_regulation of Prkce 4 0.41 1.3 2.64
36 INT102033 Negative_regulation of Ppard 5 0.37 4.14 2.48
37 INT16089 Gene_expression of Ltc4s 11 0.77 3.37 2.29
38 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
39 INT128185 Gene_expression of Prkce 4 0.69 1.39 2.23
40 INT68277 Positive_regulation of CXCL1 6 0.56 6.98 2.14
41 INT136941 Positive_regulation of Localization of Prkce 3 0.43 1.42 2.06
42 INT151467 Localization of CASP9 9 0.73 7.62 2.04
43 INT124052 Binding of Prkce 2 0.06 2.52 2.03
44 INT101912 Regulation of TIMP2 8 0.44 5.55 2
45 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96
46 INT187128 Binding of TIMP2 11 0.41 6.43 1.9
47 INT134097 Binding of CXCL1 1 0.17 1.35 1.88
48 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
49 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
50 INT200779 Negative_regulation of Gene_expression of ALOX5AP 7 0.41 3.75 1.79
51 INT164275 Gene_expression of Alox5ap 3 0.55 3.79 1.72
52 INT127692 Positive_regulation of Gene_expression of CXCL1 8 0.56 6.26 1.71
53 INT200778 Positive_regulation of ALOX5AP 3 0.49 2.54 1.7
54 INT215928 Binding of Timp2 1 0.23 0.79 1.66
55 INT15996 Binding of Ltc4s 9 0.35 5.66 1.64
56 INT95056 Positive_regulation of Gene_expression of Ppard 5 0.52 3.84 1.6
57 INT122204 Positive_regulation of Alox5ap 1 0.26 0.23 1.53
58 INT104691 Positive_regulation of Localization of CXCL1 1 0.06 2.69 1.48
59 INT135611 Negative_regulation of Gene_expression of CXCL1 3 0.48 4.07 1.44
60 INT150809 Localization of TIMP2 7 0.65 2.6 1.43
61 INT164277 Transcription of Ltc4s 3 0.47 2.69 1.36
62 INT91947 Negative_regulation of Negative_regulation of Prkce 1 0.42 0.69 1.3
63 INT132495 Negative_regulation of Gene_expression of Ppard 4 0.44 2.64 1.28
64 INT110099 Positive_regulation of Localization of Prkce 4 0.68 1.3 1.25
65 INT91949 Regulation of Positive_regulation of Prkce 1 0.44 0.72 1.24
66 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
67 INT110106 Regulation of Prkce 4 0.44 0.4 1.2
68 INT110102 Negative_regulation of Localization of Prkce 3 0.49 0.17 1.13
69 INT122485 Negative_regulation of CASP9 18 0.46 15.78 1.12
70 INT131238 Negative_regulation of Positive_regulation of Prkce 1 0.41 0.44 1.12
71 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
72 INT12545 Negative_regulation of Ltc4s 8 0.42 2.53 1.07
73 INT28809 Regulation of CXCL1 3 0.53 3.21 1.07
74 INT112759 Negative_regulation of Binding of Ppard 2 0.39 2.08 0.99
75 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96
76 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
77 INT135111 Regulation of Gene_expression of Prkce 1 0.51 0.15 0.96
78 INT135115 Regulation of Localization of Prkce 1 0.38 0.15 0.96
79 INT101913 Regulation of Gene_expression of TIMP2 2 0.44 1.2 0.93
80 INT104696 Localization of CXCL1 2 0.09 1.68 0.92
81 INT24581 Negative_regulation of LTC4S 2 0.40 2.05 0.91
82 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88
83 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
84 INT16088 Negative_regulation of Gene_expression of Ltc4s 6 0.58 0.29 0.85
85 INT136944 Positive_regulation of Positive_regulation of Prkce 2 0.46 0.8 0.85
86 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
87 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84
88 INT252442 Binding of RFC1 3 0.05 0.3 0.84
89 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
90 INT93665 Negative_regulation of Gene_expression of TIMP2 4 0.37 2.47 0.82
91 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
92 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81
93 INT182077 Positive_regulation of RFC1 3 0.07 1.65 0.81
94 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
95 INT13541 Positive_regulation of Localization of LTC4S 3 0.51 1.01 0.75
96 INT48164 Negative_regulation of Gene_expression of LTC4S 3 0.55 0.22 0.74
97 INT40476 Negative_regulation of RFC1 5 0.18 2.85 0.72
98 INT109839 Positive_regulation of Phosphorylation of Prkce 1 0.18 1.27 0.71
99 INT34859 Positive_regulation of Localization of Ltc4s 2 0.34 1.26 0.7
100 INT154761 Positive_regulation of Gene_expression of Prkce 1 0.44 0.5 0.7
101 INT2384 Regulation of CTSA 4 0.44 2.22 0.69
102 INT154762 Negative_regulation of Phosphorylation of Prkce 1 0.38 0.48 0.69
103 INT324890 Negative_regulation of Negative_regulation of Timp2 2 0.40 1.09 0.68
104 INT94429 Transcription of TIMP2 3 0.61 4.05 0.67
105 INT57111 Negative_regulation of Localization of Ltc4s 1 0.27 1.02 0.62
106 INT65607 Regulation of Gene_expression of LTC4S 1 0.58 0.25 0.61
107 INT164276 Localization of Alox5ap 1 0.61 1.1 0.6
108 INT320096 Negative_regulation of SAE1 10 0.12 3.85 0.59
109 INT171767 Positive_regulation of Gene_expression of MMP15 4 0.38 4.48 0.59
110 INT221054 Transcription of CXCL1 1 0.21 0.61 0.59
111 INT152349 Regulation of Positive_regulation of CXCL1 1 0.44 1.17 0.59
112 INT49507 Negative_regulation of Ltc4s 1 0.16 0.61 0.59
113 INT252443 Regulation of RFC1 1 0.03 0.35 0.59
114 INT342612 Positive_regulation of Positive_regulation of Timp2 1 0.43 1.05 0.57
115 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
116 INT152068 Regulation of Gene_expression of Prkce 1 0.05 0.74 0.56
117 INT28417 Negative_regulation of Regulation of Ltc4s 1 0.03 0 0.56
118 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54
119 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51
120 INT151466 Binding of CASP9 3 0.36 2.44 0.5
121 INT139666 Binding of Timp2 3 0.13 0.55 0.5
122 INT43459 Positive_regulation of Positive_regulation of Ltc4s 2 0.11 2.47 0.5
123 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
124 INT136942 Negative_regulation of Positive_regulation of Prkce 1 0.39 0.66 0.48
125 INT213221 Negative_regulation of ASAP2 1 0.01 5.83 0.46
126 INT122205 Negative_regulation of Alox5ap 1 0.24 0 0.45
127 INT9910 Protein_catabolism of CXCL1 1 0.02 1.18 0.44
128 INT132946 Negative_regulation of Positive_regulation of Ppard 1 0.42 0.09 0.44
129 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
130 INT144204 Negative_regulation of HSPB2 2 0.41 1.08 0.43
131 INT15997 Negative_regulation of Binding of Ltc4s 2 0.43 0.33 0.42
132 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
133 INT135618 Negative_regulation of CXCL1 1 0.07 0.42 0.41
134 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4
135 INT182790 Positive_regulation of SAE1 3 0.49 3.18 0.39
136 INT94430 Positive_regulation of Transcription of TIMP2 2 0.24 2.25 0.39
137 INT13542 Negative_regulation of Localization of LTC4S 1 0.27 1.02 0.39
138 INT195416 Regulation of ALOX5AP 2 0.53 0.8 0.38
139 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37
140 INT38789 Regulation of LTC4S 3 0.51 1.1 0.37
141 INT132064 Regulation of Binding of Ltc4s 1 0.22 1.02 0.37
142 INT171765 Gene_expression of MMP15 3 0.59 7.64 0.36
143 INT269822 Transcription of Timp2 1 0.36 1.43 0.36
144 INT309930 Regulation of Gene_expression of Ltc4s 1 0.08 2.79 0.34
145 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
146 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
147 INT312038 Positive_regulation of Gene_expression of CTSA 1 0.04 0.72 0.32
148 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32
149 INT312033 Transcription of CTSA 1 0.05 0.72 0.32
150 INT213214 Positive_regulation of ASAP2 1 0.01 4.59 0.31
151 INT229244 Positive_regulation of Gene_expression of RFC1 1 0.09 0.07 0.3
152 INT144419 Regulation of Ppard 1 0.24 0.91 0.3
153 INT317974 Localization of Timp2 1 0.38 0.88 0.3
154 INT187136 Negative_regulation of Localization of TIMP2 1 0.37 0.69 0.3
155 INT191243 Binding of SAE1 4 0.35 2.88 0.29
156 INT20229 Negative_regulation of Positive_regulation of Ltc4s 2 0.23 0.87 0.29
157 INT187130 Positive_regulation of Negative_regulation of TIMP2 1 0.43 0.78 0.29
158 INT61115 Localization of Ppard 2 0.66 1.99 0.28
159 INT159198 Positive_regulation of Binding of Ppard 1 0.34 0.68 0.28
160 INT171007 Transcription of LTC4S 1 0.16 0.61 0.28
161 INT273358 Binding of LTC4S 4 0.17 0.88 0.27
162 INT323894 Negative_regulation of Regulation of TIMP2 1 0.20 1.04 0.23
163 INT247452 Gene_expression of APOA5 4 0.54 5.71 0.22
164 INT140351 Binding of Prkce 2 0.28 0.32 0.22
165 INT292751 Negative_regulation of Localization of CASP9 1 0.41 2.11 0.22
166 INT283891 Positive_regulation of Gene_expression of APOA5 1 0.01 1.36 0.22
167 INT40477 Negative_regulation of Negative_regulation of RFC1 1 0.18 0.4 0.22
168 INT169685 Regulation of Positive_regulation of Prkce 1 0.61 0.36 0.22
169 INT203173 Localization of ALOX5AP 3 0.48 0.78 0.21
170 INT259884 Negative_regulation of Binding of ALOX5AP 1 0.10 0.46 0.21
171 INT283877 Localization of APOA5 3 0.27 1.48 0.2
172 INT324889 Positive_regulation of Gene_expression of Timp2 1 0.17 0.55 0.2
173 INT312127 Positive_regulation of Positive_regulation of ALOX5AP 1 0.35 0.37 0.19
174 INT33357 Positive_regulation of Gene_expression of Ltc4s 1 0.45 0.22 0.18
175 INT312137 Transcription of ALOX5AP 1 0.50 0.37 0.18
176 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17
177 INT21351 Negative_regulation of Gene_expression of Ltc4s 3 0.19 1.14 0.17
178 INT46296 Regulation of Negative_regulation of CTSA 1 0.40 0.17 0.17
179 INT102892 Localization of CTSA 1 0.14 0 0.16
180 INT213220 Regulation of ASAP2 1 0.01 1.73 0.15
181 INT213212 Localization of ASAP2 1 0.01 0.78 0.13
182 INT312135 Negative_regulation of Regulation of ALOX5AP 1 0.30 0.19 0.13
183 INT209698 Gene_expression of PRKCD 1 0.33 1.78 0.12
184 INT144198 Positive_regulation of HSPB2 7 0.48 5.66 0.11
185 INT187124 Positive_regulation of Positive_regulation of TIMP2 1 0.40 0.22 0.11
186 INT153941 Localization of Timp2 2 0.58 0.07 0.1
187 INT180707 Regulation of Localization of Timp2 1 0.35 0 0.1
188 INT166890 Regulation of Binding of ALOX5AP 1 0.44 0.1 0.1
189 INT316114 Gene_expression of SAE1 6 0.14 2.95 0.09
190 INT97861 Negative_regulation of Gene_expression of CTSA 3 0.13 1.11 0.09
191 INT191244 Localization of SAE1 1 0.12 2.81 0.09
192 INT194789 Phosphorylation of HSPB2 2 0.30 2.61 0.08
193 INT238808 Binding of HSPB2 1 0.30 2.21 0.08
194 INT60010 Regulation of Positive_regulation of Ltc4s 1 0.06 0 0.08
195 INT182074 Negative_regulation of Gene_expression of RFC1 1 0.03 0.76 0.08
196 INT209688 Negative_regulation of Positive_regulation of PRKCD 1 0.18 1.1 0.08
197 INT323892 Regulation of Transcription of TIMP2 1 0.21 0.9 0.08
198 INT76914 Regulation of Localization of LTC4S 1 0.15 0.31 0.08
199 INT327731 Positive_regulation of Ltc4s 2 0.24 0.91 0.07
200 INT125103 Positive_regulation of Gene_expression of CASP9 5 0.31 2.52 0.06
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