GO:0008064

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Name regulation of actin polymerization or depolymerization
Categary Process
Go Slim No
Go Link GO:0008064
Unique Molecular Interactions 46
Total Molecular Interactions 79
Total Single Events 357
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of actin polymerization or depolymerization. They are ordered first by their pain relevance and then by number of times they were reported for regulation of actin polymerization or depolymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
2 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
3 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
4 INT182198 Binding of CXCR5 and CXCL12 1 0.33 1.25 0.94
5 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93
6 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66
7 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
8 INT76379 Negative_regulation of Binding of Cit and Flvcr2 1 0.11 0.08 0.58
9 INT76377 Regulation of Binding of Cit and Flvcr2 1 0.07 0.09 0.57
10 INT190290 Binding of CXCL12 and VIPR1 1 0.06 0 0.33
11 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
12 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
13 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
14 INT181765 WISP3 Regulation of Gene_expression of RHOC 1 0.49 1.46 0.21
15 INT291354 CXCL12 Positive_regulation of EPHB2 1 0.42 2.02 0.16
16 INT117191 Binding of CXCR4 and Coro1a 1 0.39 0.28 0.16
17 INT291358 Binding of CXCL12 and CXCR7 1 0.20 0.11 0.09
18 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
19 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06
20 INT183863 RHOC Positive_regulation of Gene_expression of MAPK1 1 0.25 0.26 0.05
21 INT183851 RHOC Positive_regulation of MAPK1 1 0.34 0.26 0.05
22 INT345307 CXCL12 Positive_regulation of Gene_expression of MMP15 1 0.00 2.5 0.05
23 INT183859 RHOC Positive_regulation of IFI44 1 0.18 0.26 0.05
24 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05
25 INT183850 RHOC Positive_regulation of Gene_expression of IFI44 1 0.13 0.26 0.05
26 INT348818 Coro1a Positive_regulation of Gene_expression of TFDP3 1 0.19 0.42 0.04
27 INT348816 Coro1a Positive_regulation of Positive_regulation of Cd4 1 0.16 0.42 0.04
28 INT183858 Negative_regulation of RHOC Positive_regulation of MAPK1 1 0.26 0.17 0.03
29 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03
30 INT272609 Binding of Cit and Dlg4 1 0.11 0 0.03
31 INT121650 Negative_regulation of Binding of CXCL12 and CXCR4 2 0.47 1.61 0
32 INT245071 Binding of CXCL12 and KDELR1 1 0.04 1.49 0
33 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
34 INT121649 Binding of CD4 and CXCL12 1 0.29 0.2 0
35 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0
36 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
37 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
38 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
39 INT183897 Binding of RHOC and Racgap1 1 0.01 0.2 0
40 INT183860 Binding of RHOC and CAV1 1 0.34 0.4 0
41 INT183856 Negative_regulation of RHOC Positive_regulation of Gene_expression of CAV1 1 0.42 0.09 0
42 INT183866 CAV1 Regulation of RHOC 1 0.25 0.2 0
43 INT183867 Binding of CAV1 and Positive_regulation of Positive_regulation of RHOC 1 0.46 0.1 0
44 INT183852 CAV1 Regulation of Positive_regulation of RHOC 1 0.41 0.63 0
45 INT183855 Binding of RHOC and ARHGEF3 1 0.02 1.8 0
46 INT183854 Regulation of CAV1 Positive_regulation of RHOC 1 0.41 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of actin polymerization or depolymerization. They are ordered first by their pain relevance and then by number of times they were reported in regulation of actin polymerization or depolymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79
2 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
3 INT121661 Binding of CXCL12 25 0.37 11.27 3.82
4 INT130646 Regulation of CXCL12 14 0.47 7.67 3.48
5 INT76375 Binding of Cit 6 0.12 0.39 2.77
6 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
7 INT121659 Positive_regulation of CXCL12 8 0.53 9.17 2.36
8 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36
9 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
10 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
11 INT76376 Negative_regulation of Binding of Cit 1 0.15 0.22 1.64
12 INT113110 Negative_regulation of CXCL12 8 0.43 6.01 1.63
13 INT130647 Regulation of Gene_expression of CXCL12 6 0.39 5.01 1.38
14 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
15 INT245089 Localization of CXCL12 8 0.65 10.17 1.28
16 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
17 INT57370 Gene_expression of Coro1a 4 0.58 1.36 0.91
18 INT291371 Positive_regulation of Localization of CXCL12 2 0.35 2.8 0.65
19 INT279647 Regulation of Cit 1 0.27 0 0.64
20 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
21 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
22 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
23 INT272569 Gene_expression of Cit 2 0.40 0 0.5
24 INT291367 Negative_regulation of Gene_expression of CXCL12 3 0.32 4.15 0.47
25 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
26 INT279645 Binding of Cit 1 0.29 0.46 0.45
27 INT131851 Positive_regulation of RHOC 3 0.57 9.44 0.41
28 INT131849 Negative_regulation of RHOC 4 0.54 6.46 0.34
29 INT18505 Negative_regulation of Coro1a 4 0.57 0.9 0.26
30 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
31 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
32 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
33 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
34 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
35 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
36 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
37 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
38 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
39 INT245087 Transcription of CXCL12 2 0.46 2.04 0.2
40 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
41 INT312713 Protein_catabolism of CXCL12 1 0.37 0.45 0.17
42 INT131847 Negative_regulation of Gene_expression of RHOC 2 0.39 1.38 0.12
43 INT131852 Positive_regulation of Negative_regulation of RHOC 1 0.46 1.12 0.12
44 INT172526 Regulation of RHOC 2 0.51 4.7 0.1
45 INT279642 Negative_regulation of Cit 1 0.25 0 0.1
46 INT109862 Negative_regulation of Localization of Rhoa 1 0.33 0.37 0.08
47 INT279640 Regulation of Gene_expression of Cit 1 0.27 0 0.07
48 INT149758 Binding of Coro1a 2 0.36 0.61 0.05
49 INT148812 Localization of RHOC 2 0.62 1.75 0.05
50 INT126629 Negative_regulation of Transcription of Rhoa 1 0.33 0 0.05
51 INT348794 Positive_regulation of Coro1a 1 0.17 0.64 0.04
52 INT126630 Transcription of Rhoa 1 0.54 0 0.04
53 INT291363 Positive_regulation of Binding of CXCL12 1 0.38 0.36 0.03
54 INT183874 Negative_regulation of Positive_regulation of RHOC 1 0.35 0.18 0
55 INT245083 Regulation of Positive_regulation of CXCL12 1 0.39 1.6 0
56 INT183884 Positive_regulation of Binding of RHOC 1 0.41 0.27 0
57 INT183891 Regulation of Positive_regulation of RHOC 1 0.22 0.37 0
58 INT183887 Binding of RHOC 1 0.40 3.01 0
59 INT269884 Negative_regulation of Gene_expression of Coro1a 1 0.35 0.24 0
60 INT104239 Negative_regulation of Cit 1 0.06 0 0
61 INT183875 Positive_regulation of Positive_regulation of RHOC 1 0.38 0.73 0
62 INT183872 Regulation of Gene_expression of RHOC 1 0.32 0.34 0
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