GO:0008104

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Name protein localization
Categary Process
Go Slim No
Go Link GO:0008104
Unique Molecular Interactions 781
Total Molecular Interactions 1099
Total Single Events 7589
Pain Genes Associated 54

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein localization. They are ordered first by their pain relevance and then by number of times they were reported for protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
3 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
4 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
5 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
6 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
7 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
8 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
9 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
10 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
11 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
12 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
13 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
14 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
15 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
16 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
17 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
18 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
19 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
20 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
21 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
22 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
23 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
24 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
25 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
26 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
27 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
28 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
29 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92
30 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91
31 INT255377 Nrcam Regulation of Positive_regulation of AIS 1 0.00 0 0.9
32 INT108647 Binding of Grin2a and Camk1d 1 0.33 0.78 0.9
33 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
34 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
35 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
36 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
37 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
38 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
39 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
40 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
41 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
42 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
43 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
44 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
45 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
46 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
47 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
48 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
49 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
50 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
51 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72
52 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
53 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72
54 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
55 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
56 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
57 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
58 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
59 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
60 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63
61 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
62 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
63 INT166387 Binding of Gnb2l1 and Mdk 1 0.30 0.24 0.61
64 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
65 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
66 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
67 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57
68 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
69 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
70 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56
71 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
72 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
73 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
74 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
75 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
76 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54
77 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
78 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
79 INT223934 HSPG2 Negative_regulation of Gene_expression of Cux1 1 0.03 0 0.53
80 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
81 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
82 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
83 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
84 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
85 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
86 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
87 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
88 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
89 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
90 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
91 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
92 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
93 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
94 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
95 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
96 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
97 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
98 INT208122 Grin2a Positive_regulation of Positive_regulation of Ltp 1 0.16 0.21 0.49
99 INT88889 Binding of HSPG2 and CALCRL 1 0.00 0 0.48
100 INT250081 Grin2a Positive_regulation of Ltp 1 0.20 0.14 0.48
101 INT208120 Binding of Grin2a and Hpcal1 1 0.10 0.07 0.48
102 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
103 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
104 INT223936 HSPG2 Positive_regulation of Gene_expression of Cux1 1 0.03 0 0.46
105 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
106 INT223935 HSPG2 Positive_regulation of Cux1 1 0.03 0 0.45
107 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
108 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
109 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45
110 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
111 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
112 INT343642 Adp Positive_regulation of Localization of Hspg2 1 0.01 0 0.44
113 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
114 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
115 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
116 INT343643 Adp Positive_regulation of Positive_regulation of Hspg2 1 0.01 0 0.43
117 INT96615 Binding of F11 and Nrcam 1 0.12 0.52 0.43
118 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
119 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
120 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
121 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
122 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
123 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
124 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
125 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
126 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
127 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4
128 INT28237 BBS2 Positive_regulation of Localization of Cck 1 0.04 0.33 0.39
129 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
130 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38
131 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
132 INT183647 Dss1 Positive_regulation of Macf1 1 0.01 1.23 0.38
133 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38
134 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
135 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
136 INT250076 Grin2a Regulation of Positive_regulation of Ltp 1 0.10 0.06 0.35
137 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
138 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
139 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
140 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
141 INT251148 Negative_regulation of Binding of Grin2a and Dlg2 1 0.37 0.45 0.32
142 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32
143 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
144 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
145 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
146 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
147 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
148 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
149 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
150 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
151 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
152 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
153 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
154 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
155 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
156 INT212289 Vsnl1 Negative_regulation of Grin2a 1 0.04 0.38 0.28
157 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
158 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
159 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
160 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
161 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
162 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
163 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
164 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
165 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
166 INT274934 Binding of Pick1 and Grip1 1 0.05 0 0.27
167 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
168 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
169 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
170 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
171 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27
172 INT263732 Binding of Grin2a and Neto1 1 0.41 0 0.27
173 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
174 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
175 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
176 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
177 INT317510 Binding of Grin2a and Gnptab 1 0.00 0 0.26
178 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
179 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
180 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
181 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
182 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
183 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
184 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
185 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
186 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
187 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
188 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
189 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
190 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
191 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
192 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
193 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
194 INT250075 Binding of Hpcal4 and Negative_regulation of Gene_expression of Grin2a 1 0.03 0 0.24
195 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
196 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
197 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
198 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
199 INT308084 Binding of HSPG2 and OXT 1 0.04 0.25 0.23
200 INT62090 CXCR1 Positive_regulation of HSPG2 1 0.54 0.18 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein localization. They are ordered first by their pain relevance and then by number of times they were reported in protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
2 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
3 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
4 INT13501 Binding of Drd2 65 0.48 23.76 35.6
5 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
6 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
7 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
8 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
9 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
10 INT12484 Binding of Drd2 45 0.48 15.17 24.72
11 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
12 INT49774 Binding of DRD2 48 0.48 17.42 20.73
13 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
14 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
15 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
16 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65
17 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
18 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
19 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8
20 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
21 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
22 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32
23 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2
24 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
25 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
26 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
27 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
28 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
29 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31
30 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
31 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49
32 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
33 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
34 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
35 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
36 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
37 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06
38 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
39 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
40 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
41 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
42 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
43 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
44 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
45 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
46 INT197493 Localization of Apoe 61 0.79 27.48 7.06
47 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03
48 INT166383 Positive_regulation of Gene_expression of Gnb2l1 1 0.69 2.19 7.02
49 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
50 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
51 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
52 INT24460 Localization of Drd2 12 0.73 2.96 6.46
53 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41
54 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
55 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
56 INT86772 Localization of Drd2 14 0.80 1.93 6.17
57 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
58 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
59 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
60 INT63042 Binding of Apoe 59 0.48 31.23 5.88
61 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
62 INT67693 Binding of Grin2a 9 0.38 1.74 5.68
63 INT159115 Negative_regulation of Gene_expression of Gnb2l1 3 0.42 1.33 5.59
64 INT208108 Localization of Grin2a 19 0.70 1.5 5.22
65 INT60585 Regulation of TP53 59 0.59 54.55 5.21
66 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
67 INT19549 Binding of Grin2a 12 0.45 1.24 5.09
68 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
69 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95
70 INT135474 Negative_regulation of Gene_expression of Grin2a 7 0.39 6.94 4.89
71 INT17312 Binding of HSPG2 30 0.41 33.01 4.88
72 INT111947 Positive_regulation of Gene_expression of Grin2a 7 0.68 1.75 4.84
73 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
74 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
75 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
76 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
77 INT159122 Positive_regulation of Gnb2l1 8 0.69 2.2 4.61
78 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56
79 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53
80 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
81 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
82 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
83 INT107771 Localization of HSPG2 10 0.78 8.47 4.3
84 INT9349 Gene_expression of BBS2 15 0.49 12.77 4.22
85 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
86 INT103999 Positive_regulation of Phosphorylation of Grin2a 5 0.38 3.12 3.94
87 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
88 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
89 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
90 INT121986 Phosphorylation of Grin2a 5 0.76 0.83 3.71
91 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
92 INT47678 Positive_regulation of Positive_regulation of HSPG2 7 0.49 3.94 3.56
93 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
94 INT255367 Phosphorylation of Nrcam 1 0.07 0 3.48
95 INT209221 Regulation of Gene_expression of Grin2a 5 0.24 2.81 3.45
96 INT72141 Binding of Apoe 11 0.37 10.91 3.27
97 INT97710 Localization of Apoe 1 0.79 7.18 3.2
98 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
99 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
100 INT90611 Positive_regulation of Positive_regulation of Grin2a 4 0.63 1.89 3
101 INT8103 Binding of TP53 46 0.44 40.2 2.96
102 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
103 INT166381 Negative_regulation of Gnb2l1 1 0.43 0.73 2.68
104 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
105 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
106 INT105730 Localization of Grin2a 7 0.67 0.64 2.56
107 INT199798 Positive_regulation of BBS2 2 0.50 5.85 2.55
108 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
109 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
110 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47
111 INT141075 Transcription of Grin2a 5 0.49 1.89 2.46
112 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43
113 INT55952 Transcription of TP53 16 0.61 12.14 2.36
114 INT159117 Regulation of Gene_expression of Gnb2l1 3 0.56 0.5 2.36
115 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
116 INT121910 Binding of Nrcam 4 0.03 1.51 2.26
117 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
118 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
119 INT168959 Gene_expression of CAV3 5 0.65 0.7 2.2
120 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
121 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
122 INT138095 Gene_expression of Grin2c 3 0.63 0.36 2.03
123 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
124 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
125 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
126 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
127 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
128 INT120407 Positive_regulation of Localization of HSPG2 2 0.49 2.11 1.92
129 INT74595 Regulation of Transcription of Grin2a 2 0.42 0.66 1.92
130 INT103624 Negative_regulation of Gene_expression of Grin2a 5 0.56 1.58 1.9
131 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
132 INT65855 Localization of TP53 18 0.76 17.08 1.89
133 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88
134 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86
135 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
136 INT151174 Negative_regulation of Transcription of Grin2a 3 0.40 0 1.8
137 INT159120 Protein_catabolism of Gnb2l1 1 0.26 0.37 1.79
138 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
139 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
140 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75
141 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
142 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
143 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
144 INT168964 Negative_regulation of Gene_expression of CAV3 1 0.47 0 1.68
145 INT248253 Positive_regulation of Gene_expression of HSPG2 3 0.44 4.61 1.65
146 INT156484 Binding of Apoa1 4 0.47 6.78 1.63
147 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
148 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
149 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
150 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
151 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
152 INT181881 Positive_regulation of Gene_expression of Apoa1 13 0.48 14.31 1.45
153 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
154 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
155 INT172953 Binding of Trp53 33 0.37 20.76 1.41
156 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
157 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
158 INT262545 Positive_regulation of Positive_regulation of Hspg2 4 0.49 1.39 1.41
159 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
160 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
161 INT145221 Binding of Tp53 10 0.37 8.59 1.37
162 INT181882 Localization of Apoa1 8 0.71 7.94 1.37
163 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
164 INT159378 Localization of Hspg2 6 0.80 0.9 1.35
165 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
166 INT250445 Transcription of Grin2c 3 0.30 0.11 1.3
167 INT105729 Negative_regulation of Localization of Grin2a 3 0.38 0.08 1.29
168 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
169 INT141862 Binding of Cav1 11 0.36 1.32 1.25
170 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
171 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
172 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
173 INT314186 Gene_expression of Npm1 1 0.01 1.78 1.22
174 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
175 INT168095 Positive_regulation of Transcription of Cav3 1 0.47 0.91 1.2
176 INT77216 Localization of DRD2 3 0.75 0 1.19
177 INT174156 Localization of Trp53 16 0.72 13.52 1.18
178 INT59029 Positive_regulation of DHCR24 2 0.22 0.51 1.18
179 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
180 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
181 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
182 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11
183 INT139647 Positive_regulation of Positive_regulation of Grin2a 2 0.44 0.38 1.11
184 INT177481 Negative_regulation of BBS2 6 0.31 5.34 1.06
185 INT168957 Positive_regulation of CAV3 1 0.40 0 1.06
186 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
187 INT168960 Binding of CAV3 1 0.30 0 1.05
188 INT120395 Regulation of HSPG2 4 0.26 5.96 1.03
189 INT91830 Gene_expression of CD81 4 0.31 2.24 1.03
190 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
191 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
192 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
193 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
194 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
195 INT19550 Positive_regulation of Binding of Grin2a 1 0.04 0 0.94
196 INT149903 Localization of Cav3 3 0.80 1.1 0.93
197 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
198 INT141076 Negative_regulation of Transcription of Grin2a 2 0.40 0.82 0.92
199 INT235828 Binding of Hspg2 4 0.25 2.24 0.89
200 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
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