GO:0008116

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Name prostaglandin-I synthase activity
Categary Function
Go Slim No
Go Link GO:0008116
Unique Molecular Interactions 36
Total Molecular Interactions 39
Total Single Events 400
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-I synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin-I synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
2 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
3 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 0.17 0.58 0.44
4 INT187603 Binding of Ptgis and Ppara 1 0.00 0.26 0.31
5 INT66243 KNG1 Positive_regulation of Ptgis 1 0.01 0 0.3
6 INT142450 B4GALNT1 Regulation of Gene_expression of PTGIS 1 0.02 0.24 0.27
7 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
8 INT19839 Positive_regulation of Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.26
9 INT19840 Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.25
10 INT142446 Regulation of CPOX Regulation of Gene_expression of PTGIS 1 0.10 0.26 0.22
11 INT142448 TNF Positive_regulation of Localization of PTGIS 1 0.35 0.28 0.21
12 INT303003 Gene_expression of Ptgis Positive_regulation of Pah 1 0.36 1.67 0.13
13 INT303007 Binding of Pah and Ptgis 1 0.26 0.99 0.12
14 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08
15 INT303026 Gene_expression of MCPH1 Positive_regulation of Gene_expression of Ptgis 1 0.02 0.78 0.04
16 INT303008 Gene_expression of Pah Positive_regulation of Gene_expression of Ptgis 1 0.31 0.78 0.04
17 INT331157 Ptgis Positive_regulation of Ptgs2 1 0.04 0.77 0.03
18 INT177672 Vmn1r51 Positive_regulation of Localization of Ptgis 1 0.00 0.24 0.03
19 INT303010 Ptgis Positive_regulation of Rock2 1 0.05 1.23 0.03
20 INT281907 VEGFA Positive_regulation of Gene_expression of PTGIS 1 0.03 0.14 0
21 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-I synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin-I synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1
2 INT19934 Negative_regulation of Ptgis 18 0.32 6.18 5.03
3 INT66242 Gene_expression of Ptgis 15 0.64 6.73 3.84
4 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8
5 INT66237 Positive_regulation of Ptgis 5 0.33 1.49 1.96
6 INT66240 Localization of Ptgis 9 0.58 1.36 1.95
7 INT103024 Positive_regulation of Gene_expression of Ptgis 5 0.48 4.02 1.83
8 INT19831 Binding of Ptgis 3 0.08 3.33 1.77
9 INT15916 Positive_regulation of Ptgis 11 0.39 6.6 1.74
10 INT37441 Localization of Ptgis 7 0.10 5.02 1.43
11 INT169363 Negative_regulation of PTGIS 4 0.20 3.35 1.22
12 INT5115 Negative_regulation of Gene_expression of Ptgis 9 0.33 3.33 1.2
13 INT10033 Localization of PTGIS 10 0.69 6.8 1.07
14 INT15917 Positive_regulation of Gene_expression of Ptgis 5 0.35 3.69 0.95
15 INT66236 Positive_regulation of Localization of Ptgis 4 0.33 0.13 0.84
16 INT103023 Positive_regulation of Positive_regulation of Ptgis 1 0.18 0.7 0.8
17 INT66239 Negative_regulation of Gene_expression of Ptgis 3 0.28 0.23 0.59
18 INT66238 Regulation of Gene_expression of Ptgis 3 0.23 0.13 0.54
19 INT142452 Regulation of Gene_expression of PTGIS 3 0.23 0.72 0.53
20 INT296837 Negative_regulation of Gene_expression of PTGIS 2 0.17 1.11 0.52
21 INT19830 Positive_regulation of Binding of Ptgis 1 0.00 0.15 0.46
22 INT19832 Negative_regulation of Binding of Ptgis 1 0.00 0.16 0.4
23 INT66241 Regulation of Ptgis 1 0.34 0 0.37
24 INT60362 Regulation of Gene_expression of Ptgis 2 0.04 0.22 0.36
25 INT44325 Positive_regulation of Localization of Ptgis 3 0.03 2.47 0.3
26 INT66235 Negative_regulation of Localization of Ptgis 1 0.21 0 0.3
27 INT6955 Positive_regulation of Gene_expression of PTGIS 3 0.36 0.6 0.29
28 INT10034 Positive_regulation of Localization of PTGIS 1 0.31 1.38 0.26
29 INT142451 Negative_regulation of Localization of PTGIS 2 0.50 2 0.22
30 INT141874 Binding of PTGIS 1 0.36 1.06 0.22
31 INT10031 Positive_regulation of PTGIS 2 0.31 0.67 0.12
32 INT303021 Binding of Ptgis 1 0.31 0.98 0.12
33 INT39152 Regulation of Ptgis 1 0.02 0.12 0.12
34 INT172663 Regulation of PTGIS 1 0.00 0.27 0.05
35 INT281929 Transcription of PTGIS 1 0.07 0.34 0.03
36 INT39151 Positive_regulation of Negative_regulation of Ptgis 2 0.06 0 0
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