GO:0008138

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Name protein tyrosine/serine/threonine phosphatase activity
Categary Function
Go Slim No
Go Link GO:0008138
Unique Molecular Interactions 67
Total Molecular Interactions 77
Total Single Events 618
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine/serine/threonine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein tyrosine/serine/threonine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
2 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
3 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
4 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
5 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
6 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
7 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
8 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
9 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
10 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46
11 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
12 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
13 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
14 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
15 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
16 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32
17 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
18 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
19 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
20 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
21 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19
22 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
23 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
24 INT212808 Rngtt Negative_regulation of Gene_expression of Ptger2 1 0.00 0.31 0.12
25 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
26 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
27 INT212814 Rngtt Negative_regulation of Gene_expression of Tlr4 1 0.00 0.08 0.1
28 INT212807 Rngtt Negative_regulation of Nos2 1 0.03 0.08 0.1
29 INT212811 Rngtt Negative_regulation of Tlr4 1 0.00 0.08 0.1
30 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
31 INT341812 Binding of SBF1 and Aia1 1 0.01 0.56 0.07
32 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07
33 INT244130 Binding of CASP1 and RNGTT 1 0.07 0.24 0.07
34 INT244131 Binding of RNGTT and NLRP1 1 0.11 0.24 0.07
35 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
36 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
37 INT265451 CSPG4 Positive_regulation of RNGTT 1 0.03 0.24 0.04
38 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04
39 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04
40 INT274830 Tlr4 Positive_regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
41 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
42 INT250226 Binding of Camp and Rngtt 1 0.14 0.85 0.03
43 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
44 INT274829 Tlr4 Regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
45 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
46 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
47 INT265458 RNGTT Positive_regulation of Gene_expression of ROS1 1 0.08 0.88 0
48 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
49 INT163585 Lep Positive_regulation of Gene_expression of Epm2a 1 0.03 0.14 0
50 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
51 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0
52 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
53 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
54 INT351682 Fut1 Positive_regulation of PTEN 1 0.01 1.81 0
55 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
56 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
57 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
58 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
59 INT163584 Lep Positive_regulation of Epm2a 1 0.03 0.13 0
60 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0
61 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0
62 INT221467 Binding of Creb1 and Dusp1 1 0.10 0 0
63 INT293804 PTEN Regulation of AKT1 1 0.04 0.07 0
64 INT274831 Dusp6 Positive_regulation of Tlr4 1 0.00 0 0
65 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine/serine/threonine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein tyrosine/serine/threonine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
2 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
3 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21
4 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
5 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
6 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
7 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18
8 INT192676 Binding of PTEN 14 0.46 10.58 3.06
9 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
10 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
11 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
12 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45
13 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
14 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
15 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
16 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94
17 INT244169 Localization of RNGTT 8 0.23 1.92 1.81
18 INT15556 Positive_regulation of Epm2a 3 0.44 1.53 1.69
19 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
20 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
21 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
22 INT207092 Localization of Dusp1 6 0.70 4.7 1.51
23 INT228249 Binding of Pten 7 0.48 3.26 1.45
24 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
25 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
26 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
27 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
28 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
29 INT190014 Regulation of Pten 8 0.62 6.03 1.2
30 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
31 INT178674 Positive_regulation of RNGTT 6 0.15 1.05 1.09
32 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
33 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
34 INT147183 Gene_expression of RNGTT 16 0.37 2.43 0.82
35 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
36 INT226221 Binding of Dusp1 1 0.04 0.92 0.68
37 INT276199 Binding of Pten 2 0.30 0.4 0.67
38 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
39 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
40 INT276179 Regulation of Pten 1 0.46 0.81 0.63
41 INT244157 Negative_regulation of RNGTT 2 0.12 0.17 0.61
42 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
43 INT161322 Localization of PTEN 9 0.73 5.65 0.57
44 INT191677 Positive_regulation of Gene_expression of Dusp1 2 0.20 4.93 0.55
45 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
46 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
47 INT163579 Gene_expression of Epm2a 2 0.06 1.15 0.49
48 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
49 INT58201 Binding of SBF1 2 0.30 0.58 0.45
50 INT244163 Positive_regulation of Localization of RNGTT 1 0.15 0.08 0.43
51 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
52 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
53 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
54 INT203816 Localization of Pten 4 0.75 1.37 0.4
55 INT212803 Gene_expression of Rngtt 6 0.37 0.47 0.37
56 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
57 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
58 INT111097 Negative_regulation of Dusp1 3 0.58 1.41 0.32
59 INT281469 Transcription of Pten 2 0.72 1.12 0.32
60 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
61 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
62 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31
63 INT231658 Regulation of Epm2a 1 0.03 0.5 0.31
64 INT274883 Positive_regulation of Gene_expression of Dusp6 1 0.07 0.39 0.27
65 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
66 INT244149 Regulation of Gene_expression of RNGTT 1 0.13 0.99 0.26
67 INT274876 Positive_regulation of Positive_regulation of Dusp6 1 0.04 0.49 0.25
68 INT250224 Regulation of Rngtt 1 0.25 0.77 0.18
69 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
70 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
71 INT244142 Transcription of RNGTT 1 0.21 0.13 0.16
72 INT221451 Negative_regulation of Positive_regulation of Dusp1 2 0.35 1.17 0.14
73 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
74 INT250223 Negative_regulation of Rngtt 1 0.24 0.53 0.1
75 INT266511 Binding of Epm2a 1 0.11 0.17 0.08
76 INT250225 Positive_regulation of Rngtt 2 0.28 0.78 0.07
77 INT212802 Negative_regulation of Gene_expression of Rngtt 1 0.05 0 0.05
78 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
79 INT176144 Positive_regulation of Phosphorylation of PTEN 1 0.36 0.29 0.04
80 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
81 INT244172 Regulation of Transcription of RNGTT 1 0.13 0.06 0.04
82 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0
83 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
84 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
85 INT89797 Negative_regulation of Epm2a 1 0.37 0 0
86 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0
87 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0
88 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0
89 INT176158 Regulation of Positive_regulation of PTEN 1 0.32 0.23 0
90 INT310134 Positive_regulation of SBF1 1 0.01 0 0
91 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
92 INT163583 Negative_regulation of Gene_expression of Epm2a 1 0.02 0.14 0
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