GO:0008140

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Name cAMP response element binding protein binding
Categary Function
Go Slim No
Go Link GO:0008140
Unique Molecular Interactions 47
Total Molecular Interactions 59
Total Single Events 218
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cAMP response element binding protein binding. They are ordered first by their pain relevance and then by number of times they were reported for cAMP response element binding protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
2 INT141373 Ier3 Positive_regulation of CREM 1 0.00 0 0.95
3 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
4 INT103184 Prkaca Positive_regulation of Phosphorylation of CRTC1 1 0.01 0.57 0.55
5 INT141371 Positive_regulation of CREM Negative_regulation of Crem 1 0.00 0 0.54
6 INT141372 CREM Negative_regulation of Crem 1 0.00 0 0.53
7 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
8 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
9 INT151551 Regulation of Camk4 Positive_regulation of Atf2 1 0.34 0.36 0.37
10 INT151547 Camk4 Positive_regulation of Atf2 1 0.38 0.36 0.37
11 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
12 INT110459 Binding of Atf2 and Jun 1 0.32 0 0.31
13 INT111813 CREM Regulation of Regulation of CRH 1 0.12 0 0.3
14 INT169048 Positive_regulation of Binding of Atf2 and Sult4a1 1 0.38 0.11 0.24
15 INT169054 Binding of Atf2 and Sult4a1 1 0.37 0.11 0.24
16 INT255942 Elk1 Regulation of Binding of ATF2 1 0.07 0.12 0.22
17 INT255842 CREB1 Regulation of Binding of ATF2 1 0.03 0.12 0.22
18 INT255837 ATF2 Regulation of Binding of CREB1 1 0.03 0.12 0.22
19 INT255941 ATF2 Regulation of Transcription of Elk1 1 0.07 0.12 0.22
20 INT255835 ATF2 Regulation of Transcription of CREB1 1 0.03 0.12 0.22
21 INT255839 CREB1 Regulation of Transcription of ATF2 1 0.03 0.12 0.22
22 INT255937 ATF2 Regulation of Binding of Elk1 1 0.07 0.12 0.22
23 INT156162 Binding of HCFC1 and CREB3 1 0.13 0.35 0.22
24 INT255939 Elk1 Regulation of Transcription of ATF2 1 0.07 0.12 0.22
25 INT114043 Binding of CREM and FOS 1 0.04 0.17 0.19
26 INT114045 Binding of CREM and JUN 1 0.03 0.17 0.19
27 INT114044 Positive_regulation of Binding of CREM and JUN 1 0.04 0.17 0.19
28 INT85916 CAMP Positive_regulation of CREM 1 0.22 0 0.18
29 INT117913 CREM Positive_regulation of Negative_regulation of BIRC2 1 0.15 0.81 0.14
30 INT57500 CREM Positive_regulation of Regulation of CRH 1 0.39 0 0.14
31 INT342459 CXCR3 Positive_regulation of CRTC1 1 0.00 0.59 0.11
32 INT147675 Positive_regulation of Atf2 Positive_regulation of GRP 1 0.04 0 0.07
33 INT238207 Binding of Bmx and Sik1 1 0.01 0.43 0.07
34 INT179232 Binding of CREM and GSR 1 0.00 0 0.06
35 INT238208 Sik1 Positive_regulation of Positive_regulation of Bmx 1 0.01 0 0.05
36 INT238211 Binding of STAT3 and Sik1 1 0.04 0.25 0.04
37 INT335213 RDH5 Positive_regulation of CREM 1 0.00 0.96 0.04
38 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
39 INT351099 EPAS1 Regulation of Gene_expression of CRTC1 1 0.00 0.8 0
40 INT225606 Ncoa6 Regulation of Atf2 1 0.05 0.21 0
41 INT225887 HGF Positive_regulation of ATF2 1 0.01 0 0
42 INT169052 Atf2 Regulation of Sult4a1 1 0.21 0.17 0
43 INT286026 Mapk8 Positive_regulation of Phosphorylation of Atf2 1 0.03 0.34 0
44 INT182925 Binding of CREM and PITPNM1 1 0.02 0 0
45 INT245217 Binding of CREM and TFAM 1 0.00 1.44 0
46 INT286029 Binding of Tp53 and Atf2 1 0.03 0.33 0
47 INT169055 Atf2 Regulation of SULT1A2 1 0.00 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cAMP response element binding protein binding. They are ordered first by their pain relevance and then by number of times they were reported in cAMP response element binding protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53
2 INT88286 Phosphorylation of Atf2 11 0.66 1.93 5.69
3 INT88282 Positive_regulation of Phosphorylation of Atf2 8 0.44 1.77 4.85
4 INT141366 Positive_regulation of Positive_regulation of CREM 1 0.31 0 3.84
5 INT77251 Positive_regulation of Atf2 8 0.70 2.45 3.62
6 INT88285 Transcription of Atf2 4 0.36 1.56 2.62
7 INT52326 Negative_regulation of Atf2 7 0.45 0.94 2.5
8 INT57501 Binding of CREM 11 0.27 3.67 2.15
9 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13
10 INT102694 Localization of CREM 4 0.27 1.6 1.8
11 INT110444 Positive_regulation of Atf2 7 0.50 2 1.48
12 INT130207 Phosphorylation of ATF2 5 0.60 1.34 1.25
13 INT83154 Transcription of CREM 2 0.02 0.62 1.05
14 INT130209 Positive_regulation of Phosphorylation of ATF2 3 0.36 1.15 1.03
15 INT288676 Negative_regulation of CREM 3 0.18 1.34 0.96
16 INT83983 Phosphorylation of Atf2 6 0.63 2 0.95
17 INT83984 Positive_regulation of Positive_regulation of Atf2 1 0.44 0.48 0.89
18 INT69913 Binding of ATF2 6 0.13 0.83 0.84
19 INT69922 Positive_regulation of ATF2 3 0.05 1.28 0.74
20 INT103888 Gene_expression of Atf2 7 0.58 1.69 0.59
21 INT88290 Positive_regulation of Transcription of Atf2 1 0.31 0.09 0.56
22 INT141368 Positive_regulation of Gene_expression of CREM 1 0.38 0 0.56
23 INT88291 Regulation of Transcription of Atf2 1 0.18 0.1 0.55
24 INT103181 Phosphorylation of CRTC1 1 0.02 0.56 0.55
25 INT103182 Positive_regulation of Phosphorylation of CRTC1 1 0.01 0.57 0.55
26 INT93214 Positive_regulation of Phosphorylation of Atf2 2 0.38 0.99 0.44
27 INT147482 Regulation of Phosphorylation of Atf2 1 0.22 0.56 0.43
28 INT69915 Regulation of ATF2 2 0.34 0.81 0.42
29 INT83985 Negative_regulation of Positive_regulation of Atf2 1 0.43 0.26 0.42
30 INT255920 Gene_expression of ATF2 3 0.75 1.52 0.33
31 INT83986 Localization of Atf2 1 0.81 0.27 0.28
32 INT155351 Negative_regulation of Positive_regulation of CREM 1 0.00 1.3 0.27
33 INT93217 Negative_regulation of Phosphorylation of Atf2 1 0.12 0.08 0.26
34 INT83153 Positive_regulation of Transcription of CREM 1 0.00 0.56 0.25
35 INT255901 Transcription of ATF2 1 0.25 0.12 0.22
36 INT88734 Regulation of CREM 10 0.27 2.01 0.21
37 INT311546 Phosphorylation of CREB3 1 0.55 0.6 0.21
38 INT311543 Positive_regulation of Phosphorylation of CREB3 1 0.34 0.6 0.21
39 INT311544 Positive_regulation of CREB3 1 0.34 0.6 0.2
40 INT169047 Positive_regulation of Gene_expression of Atf2 1 0.36 0.31 0.19
41 INT156168 Negative_regulation of CREB3 1 0.18 0.34 0.16
42 INT69920 Negative_regulation of Binding of ATF2 1 0.06 0 0.1
43 INT69918 Negative_regulation of ATF2 1 0.06 0 0.1
44 INT85922 Phosphorylation of CREM 1 0.79 0 0.09
45 INT147663 Positive_regulation of Positive_regulation of Atf2 1 0.33 0.99 0.07
46 INT238167 Localization of Sik1 1 0.06 0.16 0.07
47 INT238165 Gene_expression of Sik1 1 0.05 0.2 0.07
48 INT342463 Positive_regulation of CRTC1 1 0.01 0.57 0.06
49 INT238158 Phosphorylation of Sik1 1 0.06 0.69 0.03
50 INT238181 Binding of Sik1 1 0.04 0.18 0.03
51 INT225443 Binding of Atf2 1 0.07 0.27 0.03
52 INT238182 Positive_regulation of Localization of Sik1 1 0.04 0 0.03
53 INT238161 Positive_regulation of Phosphorylation of Sik1 1 0.04 0 0.03
54 INT208931 Localization of Atf2 1 0.01 0 0
55 INT351118 Gene_expression of CRTC1 1 0.02 0.79 0
56 INT308517 Negative_regulation of Gene_expression of ATF2 1 0.07 0.13 0
57 INT238166 Positive_regulation of Sik1 1 0.03 0.13 0
58 INT308516 Positive_regulation of Gene_expression of ATF2 1 0.08 0.13 0
59 INT286034 Gene_expression of Atf2 1 0.27 0.17 0
60 INT238157 Positive_regulation of Gene_expression of Sik1 1 0.03 0 0
61 INT341510 Negative_regulation of Gene_expression of CREM 1 0.41 0.39 0
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