GO:0008158

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Name hedgehog receptor activity
Categary Function
Go Slim No
Go Link GO:0008158
Unique Molecular Interactions 38
Total Molecular Interactions 51
Total Single Events 241
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hedgehog receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for hedgehog receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
2 INT18115 Binding of NPC1 and Oprd1 1 0.11 0 0.54
3 INT28006 NPC1 Negative_regulation of Positive_regulation of Rps6ka1 1 0.01 0.37 0.33
4 INT28005 NPC1 Negative_regulation of Rps6ka1 1 0.01 0.45 0.32
5 INT234724 Binding of NPC1 and Cxcl1 1 0.00 0.33 0.21
6 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
7 INT86216 Hpd Regulation of NPC1 1 0.02 0.93 0.15
8 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
9 INT201543 Binding of NPC1 and RNASE1 1 0.07 1.33 0.08
10 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05
11 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
12 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
13 INT201539 Binding of NPC1 and THY1 1 0.36 1.28 0
14 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
15 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
16 INT201541 Binding of NPC1 and BRD7 1 0.35 1.59 0
17 INT201537 Binding of NPC1 and HHATL 1 0.16 1.43 0
18 INT201532 RASSF1 Regulation of NPC1 1 0.44 1.41 0
19 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
20 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
21 INT201540 GADD45G Negative_regulation of NPC1 1 0.32 1.7 0
22 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
23 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
24 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
25 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
26 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
27 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
28 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
29 INT201538 Binding of BCL2 and NPC1 1 0.17 1.41 0
30 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
31 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
32 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
33 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
34 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
35 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
36 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
37 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
38 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hedgehog receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in hedgehog receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT76227 Binding of NPC1 30 0.41 32.31 4.05
2 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79
3 INT169862 Regulation of NPC1 13 0.53 13.61 1.84
4 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44
5 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
6 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
7 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94
8 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
9 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
10 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
11 INT156997 Localization of NPC1 19 0.64 30 0.42
12 INT201565 Positive_regulation of Gene_expression of NPC1 5 0.43 5.94 0.26
13 INT309880 Positive_regulation of Localization of NPC1 1 0.04 1.06 0.25
14 INT222898 Protein_catabolism of NPC1 2 0.76 2.62 0.09
15 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
16 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
17 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
18 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
19 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
20 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
21 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
22 INT222902 Negative_regulation of Gene_expression of NPC1 2 0.36 1.6 0.04
23 INT325061 Regulation of Regulation of NPC1 1 0.01 0.76 0.03
24 INT201564 Regulation of Gene_expression of NPC1 2 0.39 3.26 0
25 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
26 INT222907 Negative_regulation of Localization of NPC1 1 0.36 1.46 0
27 INT342196 Transcription of NPC1 1 0.17 1.09 0
28 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
29 INT222901 Negative_regulation of Phosphorylation of NPC1 1 0.36 0.83 0
30 INT222904 Phosphorylation of NPC1 1 0.69 0.83 0
31 INT222896 Negative_regulation of Binding of NPC1 1 0.37 1.65 0
32 INT222894 Positive_regulation of Binding of NPC1 1 0.43 0.8 0
33 INT222895 Regulation of Binding of NPC1 1 0.39 0.77 0
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