GO:0008160

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Name protein tyrosine phosphatase activator activity
Categary Function
Go Slim No
Go Link GO:0008160
Unique Molecular Interactions 50
Total Molecular Interactions 87
Total Single Events 540
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine phosphatase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for protein tyrosine phosphatase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
2 INT133002 Mmp9 Regulation of Negative_regulation of Igfbp3 1 0.26 0.39 0.42
3 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
4 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
5 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
6 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11
7 INT258147 IGFBP3 Negative_regulation of Hcrt 1 0.28 1.87 0.11
8 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
9 INT78446 Binding of GH1 and IGFBP3 1 0.11 0.48 0.1
10 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09
11 INT124732 Gh Regulation of Positive_regulation of IGFBP3 1 0.00 0.24 0.08
12 INT49372 Gh Positive_regulation of Gene_expression of IGFBP3 1 0.00 0.51 0.08
13 INT354113 Binding of IGFBP3 and MIR524 1 0.01 0.69 0.07
14 INT354125 Binding of IGFBP3 and MIR15B 1 0.00 0.7 0.07
15 INT354111 Binding of IGFBP3 and MIR125A 1 0.11 0.7 0.07
16 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05
17 INT275758 Binding of xn and Igfbp3 1 0.03 5.39 0.04
18 INT252801 PPP2R4 Regulation of Positive_regulation of CREB1 1 0.01 2.71 0.04
19 INT258148 Gene_expression of IGFBP3 Negative_regulation of Hcrt 1 0.28 0.86 0.04
20 INT252780 Positive_regulation of CREB1 Positive_regulation of PPP2R4 1 0.01 2.71 0.04
21 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
22 INT275754 Regulation of Binding of xn and Igfbp3 1 0.02 0.79 0.04
23 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
24 INT258144 IGFBP3 Regulation of Gene_expression of Hcrt 1 0.30 2.23 0.03
25 INT275760 Binding of Igfbp3 and xn 1 0.00 1.32 0
26 INT234622 IGFBP3 Positive_regulation of TNFSF10 1 0.56 1.08 0
27 INT258150 IGFBP3 Regulation of Gene_expression of Gopc 1 0.05 1.22 0
28 INT258146 Binding of IGFBP3 and Hcrt 1 0.23 2.04 0
29 INT275733 Igfbp3 Regulation of Ins1 1 0.03 0.16 0
30 INT278498 IGFBP3 Regulation of GH1 1 0.06 0 0
31 INT234621 CDX2 Negative_regulation of IGFBP3 1 0.38 0.8 0
32 INT258086 Binding of CSF2 and IGFBP3 1 0.05 1.18 0
33 INT258145 IGFBP3 Regulation of Hcrt 1 0.16 0.56 0
34 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0
35 INT215209 Binding of Igf1 and Igfbp3 1 0.11 0 0
36 INT258152 IGFBP3 Regulation of Transcription of Hcrt 1 0.40 0.42 0
37 INT215205 Binding of Igf2 and Igfbp3 1 0.04 0 0
38 INT258087 Negative_regulation of ANTXR2 Negative_regulation of Gene_expression of IGFBP3 1 0.04 0.29 0
39 INT141959 Binding of IGFBP3 and Igf2 1 0.01 0.09 0
40 INT234623 Binding of CDX2 and IGFBP3 1 0.32 1.71 0
41 INT258151 IGFBP3 Negative_regulation of Binding of Hcrt 1 0.28 0.49 0
42 INT132069 Binding of Igf1 and Igfbp3 1 0.38 0.08 0
43 INT180858 TGFB1 Regulation of Transcription of IGFBP3 1 0.24 0.77 0
44 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0
45 INT258149 IGFBP3 Negative_regulation of Gene_expression of Hcrt 1 0.38 1.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine phosphatase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in protein tyrosine phosphatase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19
2 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78
3 INT51279 Regulation of IGFBP3 17 0.49 15.89 2.45
4 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9
5 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73
6 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41
7 INT114822 Negative_regulation of PPP2R4 2 0.57 1.89 1.28
8 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21
9 INT142777 Phosphorylation of PPP2R4 2 0.61 1.03 1.07
10 INT142776 Positive_regulation of Phosphorylation of PPP2R4 1 0.45 1.04 1.07
11 INT215202 Localization of Igfbp3 3 0.62 2.5 0.91
12 INT132068 Gene_expression of Igfbp3 10 0.64 3.73 0.83
13 INT117849 Negative_regulation of Gene_expression of IGFBP3 8 0.39 8.75 0.75
14 INT277652 Negative_regulation of Localization of Igfbp3 1 0.11 0.74 0.72
15 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71
16 INT277647 Negative_regulation of Igfbp3 1 0.15 0.94 0.62
17 INT335991 Positive_regulation of Localization of Igfbp3 1 0.42 1.57 0.61
18 INT67341 Transcription of IGFBP3 27 0.72 30.46 0.57
19 INT277649 Localization of Igfbp3 1 0.20 0.69 0.55
20 INT63364 Positive_regulation of Igfbp3 9 0.64 1.92 0.53
21 INT132996 Positive_regulation of Gene_expression of Igfbp3 4 0.49 3.2 0.5
22 INT61067 Positive_regulation of Igfbp3 3 0.41 1.21 0.5
23 INT124719 Regulation of Regulation of IGFBP3 3 0.36 2.02 0.38
24 INT294079 Protein_catabolism of IGFBP3 3 0.27 1.89 0.38
25 INT132995 Negative_regulation of Igfbp3 1 0.44 0.36 0.38
26 INT277650 Negative_regulation of Transcription of Igfbp3 1 0.11 0.24 0.3
27 INT277654 Transcription of Igfbp3 1 0.18 0.24 0.3
28 INT145860 Negative_regulation of Gene_expression of Igfbp3 2 0.35 1.52 0.27
29 INT124720 Regulation of Gene_expression of IGFBP3 2 0.39 3.1 0.26
30 INT132992 Negative_regulation of Gene_expression of Igfbp3 1 0.37 0.84 0.26
31 INT258095 Binding of Igfbp3 4 0.29 2.86 0.23
32 INT132067 Binding of Igfbp3 7 0.33 2.51 0.19
33 INT215200 Regulation of Igfbp3 3 0.35 0.71 0.18
34 INT275741 Positive_regulation of Gene_expression of Igfbp3 2 0.25 1.3 0.17
35 INT294084 Regulation of Negative_regulation of IGFBP3 1 0.08 0.81 0.14
36 INT78375 Localization of PPP2R4 1 0.73 0.43 0.14
37 INT285629 Regulation of Binding of Igfbp3 1 0.35 0.56 0.13
38 INT75111 Negative_regulation of Positive_regulation of IGFBP3 2 0.40 3.44 0.09
39 INT124721 Regulation of Localization of IGFBP3 1 0.10 0.23 0.07
40 INT234630 Negative_regulation of Transcription of IGFBP3 1 0.43 2.1 0.06
41 INT132066 Regulation of Igfbp3 1 0.56 0.09 0.06
42 INT234629 Regulation of Transcription of IGFBP3 3 0.40 3.29 0.05
43 INT275737 Positive_regulation of Binding of Igfbp3 1 0.18 0 0.05
44 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04
45 INT278502 Positive_regulation of Positive_regulation of IGFBP3 1 0.26 0.4 0.03
46 INT180890 Positive_regulation of Transcription of IGFBP3 2 0.47 2.18 0
47 INT307056 Positive_regulation of Localization of IGFBP3 1 0.39 0.99 0
48 INT293342 Regulation of PPP2R4 1 0.03 0 0
49 INT275743 Negative_regulation of Binding of Igfbp3 1 0.16 0.2 0
50 INT307062 Negative_regulation of Localization of IGFBP3 1 0.24 0.05 0
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