GO:0008179

From wiki-pain
Jump to: navigation, search
Name adenylate cyclase binding
Categary Function
Go Slim No
Go Link GO:0008179
Unique Molecular Interactions 121
Total Molecular Interactions 161
Total Single Events 1509
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adenylate cyclase binding. They are ordered first by their pain relevance and then by number of times they were reported for adenylate cyclase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
2 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
3 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
4 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
5 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
6 INT281089 Binding of Gria1 and Ltp 1 0.25 0.6 0.9
7 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
8 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
9 INT127545 Gria1 Positive_regulation of Gene_expression of Gnptab 1 0.00 0.7 0.83
10 INT214876 Ap3d1 Negative_regulation of Gria1 1 0.00 0.4 0.78
11 INT232621 Binding of Gria1 and Psd 1 0.10 0.29 0.77
12 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
13 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
14 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
15 INT311525 Binding of Gria1 and Ltp 1 0.00 0.1 0.73
16 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
17 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
18 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
19 INT51433 Gria1 Positive_regulation of Eif3g 1 0.03 0 0.7
20 INT162224 Grin1 Positive_regulation of Gene_expression of Gria1 1 0.27 0.07 0.66
21 INT281083 Binding of Gria1 and Gipc1 1 0.01 0 0.65
22 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59
23 INT296456 Gria1 Negative_regulation of Rbm39 1 0.00 0.45 0.57
24 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
25 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
26 INT134530 Grin1 Regulation of Gria1 1 0.12 0 0.56
27 INT281087 Binding of Gria1 and Hmmr 1 0.04 0 0.55
28 INT312751 Phosphorylation of Gria1 Positive_regulation of GRIA1 1 0.18 0.22 0.55
29 INT259184 Binding of Gria2 and Gria1 2 0.26 0.28 0.54
30 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54
31 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54
32 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
33 INT232618 Gene_expression of Grid2ip Regulation of Localization of Gria1 1 0.28 0.86 0.52
34 INT349130 Phosphorylation of Gria1 Positive_regulation of Shisa9 1 0.00 0.49 0.52
35 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
36 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
37 INT259180 Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
38 INT296457 Camk2a Positive_regulation of Phosphorylation of Gria1 1 0.19 0.28 0.49
39 INT259181 Phosphorylation of Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
40 INT259183 Gria1 Positive_regulation of Phosphorylation of Gria2 1 0.30 0.39 0.49
41 INT155958 Binding of Kcnk2 and Akap5 1 0.15 0.64 0.48
42 INT232619 Binding of Gria1 and Grid2ip 1 0.23 0.51 0.48
43 INT273110 Bdnf Regulation of Positive_regulation of Gria1 1 0.43 0 0.47
44 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
45 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
46 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
47 INT86069 Positive_regulation of Gria1 Positive_regulation of Gene_expression of Fos 1 0.11 0.3 0.42
48 INT127543 Gria1 Positive_regulation of Gene_expression of Cryge 1 0.00 0.35 0.42
49 INT74713 Binding of Gria1 and Olr1868 1 0.00 0 0.42
50 INT127546 Gria1 Positive_regulation of Gene_expression of Kcnab3 1 0.02 0.35 0.42
51 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
52 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39
53 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
54 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
55 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35
56 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
57 INT46788 Chrna7 Positive_regulation of G6pd 1 0.50 0 0.33
58 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
59 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
60 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
61 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
62 INT296453 Binding of Gria1 and Mpdz 1 0.02 0.23 0.31
63 INT59682 Hps6 Positive_regulation of Binding of Chrna7 1 0.02 0 0.29
64 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
65 INT103482 RARB Positive_regulation of Gene_expression of Gria1 1 0.00 0 0.27
66 INT103483 BDNF Positive_regulation of Gene_expression of Gria1 1 0.03 0 0.26
67 INT59683 Binding of Chrna7 and Evi2a 1 0.03 0 0.25
68 INT51432 Gria1 Positive_regulation of Trib3 1 0.04 0 0.25
69 INT143972 Chrna7 Negative_regulation of Gene_expression of Trpv1 1 0.01 0.18 0.24
70 INT273109 Bdnf Positive_regulation of Gene_expression of Gria1 1 0.66 0.07 0.24
71 INT296467 Binding of Cacng2 and Gria1 1 0.12 0.25 0.23
72 INT218832 Ppp1r9a Regulation of Phosphorylation of Gria1 1 0.15 0.66 0.23
73 INT296449 Binding of Gria1 and Tinagl1 1 0.08 0.25 0.23
74 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
75 INT311527 Binding of Grin2a and Gria1 1 0.01 0 0.21
76 INT143974 Chrna7 Positive_regulation of Vti1b 1 0.17 0.16 0.2
77 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19
78 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
79 INT170366 Gria1 Regulation of Phosphorylation of Camk2a 1 0.23 0.07 0.18
80 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
81 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
82 INT243772 Safb Negative_regulation of Gria1 1 0.23 0.84 0.17
83 INT101725 Binding of ITGA4 and Chrna7 1 0.00 0 0.16
84 INT273097 Binding of Bdnf and Gria1 1 0.39 0.17 0.16
85 INT349850 Gfra1 Negative_regulation of Adcyap1r1 1 0.15 0.36 0.15
86 INT349851 Gfra3 Negative_regulation of Adcyap1r1 1 0.28 0.31 0.15
87 INT349849 Gfra2 Negative_regulation of Adcyap1r1 1 0.33 0.31 0.15
88 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15
89 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
90 INT311526 Gria1 Regulation of Gene_expression of Grin2a 1 0.01 0.32 0.15
91 INT204497 Fmr1 Regulation of Positive_regulation of Gria1 1 0.04 1.75 0.14
92 INT315388 Binding of Adcyap1r1 and Adcyap1 1 0.02 0.5 0.12
93 INT263752 Binding of Gria1 and Igh-Lev 1 0.00 0 0.11
94 INT273108 Gria1 Regulation of Positive_regulation of Gria2 1 0.04 0.09 0.1
95 INT273104 Mtor Negative_regulation of Gene_expression of Gria1 1 0.46 0.15 0.08
96 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
97 INT273115 Bdnf Negative_regulation of Gene_expression of Gria1 1 0.47 0.15 0.08
98 INT218834 Ppp1cc Regulation of Phosphorylation of Gria1 1 0.19 0.66 0.07
99 INT218829 Ppp1cc Regulation of Phosphorylation of Gria1 1 0.20 0.63 0.07
100 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
101 INT218830 Camk2a Regulation of Phosphorylation of Gria1 1 0.36 0.63 0.06
102 INT190750 Adcyap1 Regulation of Positive_regulation of Adcyap1r1 1 0.11 0 0.06
103 INT352062 Binding of SV2A and Chrna7 1 0.00 0.7 0.04
104 INT273102 Bdnf Regulation of Gria1 1 0.30 0.08 0.03
105 INT273095 Rbm14 Regulation of Gria1 1 0.00 0.07 0.03
106 INT273105 Mtor Regulation of Gria1 1 0.29 0.07 0.03
107 INT233526 Tlr4 Regulation of Adrb2 1 0.03 0.07 0
108 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
109 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0
110 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adenylate cyclase binding. They are ordered first by their pain relevance and then by number of times they were reported in adenylate cyclase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
2 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
3 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
4 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
5 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
6 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
7 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
8 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
9 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
10 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
11 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
12 INT49538 Binding of Gria1 22 0.47 2.66 13.35
13 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03
14 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
15 INT8072 Localization of Gria1 17 0.75 2.62 10.04
16 INT96298 Negative_regulation of Gria1 25 0.57 10.61 9.7
17 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
18 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
19 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
20 INT57023 Negative_regulation of Gene_expression of Gria1 20 0.58 6.92 7.17
21 INT139149 Binding of Gria1 22 0.37 5.71 6.88
22 INT120298 Negative_regulation of Phosphorylation of Gria1 6 0.57 8.99 6.68
23 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
24 INT94927 Transcription of Gria1 12 0.69 3.14 5.94
25 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
26 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
27 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
28 INT63651 Gene_expression of Adcyap1r1 17 0.77 2.57 4.58
29 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
30 INT92902 Negative_regulation of Positive_regulation of Gria1 6 0.57 1.06 4.1
31 INT88156 Regulation of Gria1 12 0.54 2.5 4.06
32 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
33 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
34 INT129990 Positive_regulation of Phosphorylation of Gria1 11 0.61 3.44 3.87
35 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
36 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
37 INT84564 Regulation of Positive_regulation of Gria1 2 0.33 1.86 3.3
38 INT51427 Positive_regulation of Positive_regulation of Gria1 11 0.45 1.33 3.28
39 INT170343 Positive_regulation of Gene_expression of Gria1 10 0.61 2.77 3.09
40 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
41 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
42 INT131973 Positive_regulation of Transcription of Gria1 3 0.49 0.35 2.62
43 INT139148 Negative_regulation of Gene_expression of Gria1 6 0.51 0.89 2.56
44 INT170350 Localization of Gria1 7 0.65 2.36 2.51
45 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
46 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
47 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
48 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
49 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
50 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
51 INT218827 Negative_regulation of Phosphorylation of Gria1 6 0.36 3.61 1.67
52 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63
53 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57
54 INT312743 Regulation of Phosphorylation of Gria1 2 0.51 2.01 1.5
55 INT123880 Positive_regulation of Positive_regulation of Gria1 3 0.15 0.7 1.48
56 INT65179 Regulation of Regulation of Gria1 2 0.07 0.37 1.39
57 INT232603 Positive_regulation of Binding of Gria1 2 0.50 0.23 1.34
58 INT129988 Regulation of Phosphorylation of Gria1 3 0.28 1.94 1.25
59 INT170347 Positive_regulation of Localization of Gria1 3 0.44 0.33 1.22
60 INT129989 Negative_regulation of Positive_regulation of Gria1 2 0.35 0.82 1.21
61 INT24197 Regulation of Binding of Chrna7 2 0.11 0 1.14
62 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
63 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
64 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
65 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
66 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
67 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
68 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
69 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
70 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
71 INT71970 Positive_regulation of Adcyap1r1 6 0.14 0.49 0.84
72 INT170355 Regulation of Gene_expression of Gria1 4 0.54 0.98 0.82
73 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
74 INT52373 Positive_regulation of Adcyap1r1 1 0.00 0.3 0.78
75 INT100833 Transcription of Akap12 1 0.64 0.28 0.78
76 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
77 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
78 INT296440 Regulation of Binding of Gria1 1 0.16 1.14 0.66
79 INT257798 Transcription of Gria1 1 0.18 0.4 0.61
80 INT190734 Transcription of Adcyap1r1 1 0.19 0.1 0.6
81 INT200893 Negative_regulation of Transcription of Gria1 2 0.08 0.6 0.58
82 INT259171 Protein_catabolism of Gria1 1 0.76 0.48 0.58
83 INT124786 Localization of Adrb2 1 0.04 0.07 0.44
84 INT13884 Positive_regulation of Positive_regulation of Adrb2 1 0.34 0 0.42
85 INT2018 Regulation of Adcyap1r1 2 0.44 0.3 0.4
86 INT100832 Regulation of Akap12 1 0.25 0.08 0.4
87 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
88 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
89 INT513 Transcription of Adrb2 2 0.06 0.55 0.37
90 INT169388 Transcription of Chrna7 2 0.69 0.27 0.36
91 INT169386 Regulation of Transcription of Chrna7 1 0.45 0.05 0.36
92 INT190725 Regulation of Gene_expression of Adcyap1r1 1 0.13 0 0.32
93 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
94 INT63649 Positive_regulation of Gene_expression of Adcyap1r1 1 0.03 0.1 0.26
95 INT2017 Negative_regulation of Regulation of Adcyap1r1 1 0.41 0 0.25
96 INT316938 Negative_regulation of Regulation of Gria1 1 0.32 0.23 0.24
97 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23
98 INT200897 Negative_regulation of Localization of Gria1 1 0.07 0 0.22
99 INT115874 Negative_regulation of Positive_regulation of Adrb2 1 0.20 0 0.21
100 INT538 Protein_catabolism of Chrna7 2 0.57 1.01 0.19
101 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17
102 INT257804 Regulation of Localization of Gria1 1 0.15 0.7 0.16
103 INT323165 Regulation of Akap5 1 0.10 0.08 0.14
104 INT313103 Positive_regulation of Regulation of Gria1 1 0.02 0.29 0.13
105 INT1796 Phosphorylation of Chrna7 1 0.82 0 0.12
106 INT81943 Regulation of Regulation of Adrb2 1 0.29 0 0.12
107 INT81944 Regulation of Positive_regulation of Adrb2 1 0.18 0 0.12
108 INT43207 Regulation of Positive_regulation of Chrna7 1 0.01 0 0.11
109 INT323163 Negative_regulation of Akap5 1 0.16 0.1 0.07
110 INT323162 Transcription of Akap5 1 0.19 0.1 0.07
111 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
112 INT209148 Transcription of ADRB2 1 0.53 0 0.06
113 INT354954 Negative_regulation of Regulation of Gria1 1 0.27 0.16 0.06
114 INT202858 Regulation of Adcyap1r1 1 0.05 0.06 0.04
115 INT349847 Negative_regulation of Adcyap1r1 1 0.42 0.32 0.04
116 INT354956 Negative_regulation of Localization of Gria1 1 0.26 0 0
117 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
118 INT230388 Localization of Adrb2 1 0.51 0.71 0
119 INT310175 Binding of Adcyap1r1 1 0.02 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox