GO:0008180

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Name signalosome
Categary Component
Go Slim No
Go Link GO:0008180
Unique Molecular Interactions 27
Total Molecular Interactions 34
Total Single Events 299
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for signalosome. They are ordered first by their pain relevance and then by number of times they were reported for signalosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
2 INT65254 LOC100360318 Regulation of Gene_expression of Basp1 1 0.00 0.05 1.11
3 INT65256 Pebp1 Regulation of Gene_expression of Basp1 1 0.00 0.05 0.64
4 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
5 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
6 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
7 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52
8 INT65255 Gpm6a Regulation of Gene_expression of Basp1 1 0.01 0 0.47
9 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
10 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24
11 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
12 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
13 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
14 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
15 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
16 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
17 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
18 INT76862 Dynll1 Positive_regulation of Rb1 1 0.37 0.1 0.06
19 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
20 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0
21 INT206943 Hspa5 Positive_regulation of Atf4 1 0.47 0.62 0
22 INT86996 NGF Regulation of Regulation of DYNLL1 1 0.26 0 0
23 INT207255 INS Negative_regulation of Gene_expression of NCKIPSD 1 0.02 0.94 0
24 INT207261 ZNF236 Positive_regulation of Gene_expression of NCKIPSD 1 0.00 0.93 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for signalosome. They are ordered first by their pain relevance and then by number of times they were reported in signalosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57176 Positive_regulation of Dynll1 9 0.49 4.76 7.71
2 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
3 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25
4 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06
5 INT74393 Gene_expression of Dynll1 8 0.65 2.64 4.39
6 INT169344 Positive_regulation of Gene_expression of Dynll1 3 0.49 2.34 3.48
7 INT103910 Binding of NOD2 19 0.47 12.24 2.93
8 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81
9 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78
10 INT130702 Positive_regulation of Gene_expression of HSPA5 7 0.59 7.53 2.68
11 INT22739 Positive_regulation of DYNLL1 5 0.67 1.69 2.67
12 INT86999 Regulation of DYNLL1 5 0.44 2.85 2.18
13 INT65251 Gene_expression of Basp1 4 0.04 0.42 2.17
14 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06
15 INT79198 Positive_regulation of Positive_regulation of Dynll1 2 0.42 0.99 1.99
16 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
17 INT81924 Positive_regulation of HSPA1B 1 0.03 1.47 1.82
18 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
19 INT167288 Regulation of Dynll1 3 0.45 1.22 1.56
20 INT159186 Positive_regulation of Gene_expression of DYNLL1 1 0.49 1.25 1.4
21 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
22 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
23 INT75251 Negative_regulation of Positive_regulation of DYNLL1 1 0.41 0.18 0.99
24 INT81925 Positive_regulation of Positive_regulation of HSPA1B 1 0.02 0.74 0.91
25 INT159015 Positive_regulation of Localization of HSPA5 1 0.36 0.33 0.88
26 INT159013 Localization of HSPA5 2 0.42 0.32 0.87
27 INT99156 Binding of HSPA5 3 0.38 0.57 0.84
28 INT165847 Positive_regulation of HSP90AB1 1 0.60 0.31 0.6
29 INT165849 Protein_catabolism of HSP90AB1 1 0.56 0.28 0.56
30 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
31 INT130698 Negative_regulation of Positive_regulation of HSPA5 2 0.36 1.58 0.42
32 INT109486 Positive_regulation of Negative_regulation of Dynll1 1 0.48 0 0.41
33 INT171764 Localization of NOD2 2 0.74 0.86 0.37
34 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36
35 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
36 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
37 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
38 INT333957 Regulation of HSPA5 3 0.52 0.61 0.27
39 INT129812 Gene_expression of HSP90AB1 1 0.75 0.72 0.27
40 INT193545 Binding of Dynll1 2 0.36 0.39 0.25
41 INT124643 Binding of DYNLL1 3 0.36 0.9 0.23
42 INT142482 Positive_regulation of Positive_regulation of HSPA5 1 0.28 1.17 0.22
43 INT61713 Gene_expression of NCKIPSD 5 0.72 2.43 0.19
44 INT144676 Gene_expression of Hspa5 1 0.06 1.12 0.19
45 INT222274 Regulation of Regulation of NOD2 1 0.27 0.45 0.13
46 INT144677 Positive_regulation of Gene_expression of Hspa5 1 0.04 0.59 0.1
47 INT144668 Positive_regulation of Hspa5 1 0.03 0.53 0.09
48 INT102037 Localization of DYNLL1 2 0.78 0.32 0.08
49 INT333944 Regulation of Regulation of HSPA5 1 0.38 0.14 0.07
50 INT193543 Localization of Dynll1 1 0.68 0.17 0.07
51 INT222267 Regulation of Transcription of NOD2 1 0.45 0 0.05
52 INT337002 Positive_regulation of Binding of HSPA5 1 0.14 0.05 0.05
53 INT130701 Negative_regulation of Gene_expression of HSPA5 1 0.50 0.5 0.05
54 INT223372 Gene_expression of HSPA1B 2 0.58 1.03 0.03
55 INT147003 Binding of HSPA1B 1 0.35 0.14 0
56 INT74062 Regulation of NCKIPSD 1 0.18 0.11 0
57 INT102038 Negative_regulation of Localization of DYNLL1 1 0.42 0.24 0
58 INT293680 Positive_regulation of Localization of HSP90AB1 1 0.45 0 0
59 INT293675 Localization of HSP90AB1 1 0.68 0 0
60 INT222273 Positive_regulation of Regulation of NOD2 1 0.46 0.09 0
61 INT174710 Regulation of Hspa5 1 0.01 0.14 0
62 INT337007 Negative_regulation of Binding of HSPA5 1 0.14 0 0
63 INT259915 Positive_regulation of Cops5 1 0.15 0.12 0
64 INT174711 Transcription of Hspa5 1 0.02 0.7 0
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