GO:0008191

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Name metalloendopeptidase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0008191
Unique Molecular Interactions 304
Total Molecular Interactions 385
Total Single Events 2815
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for metalloendopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for metalloendopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
3 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
4 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
5 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
6 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
7 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01
8 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01
9 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
10 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85
11 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
12 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74
13 INT196526 Binding of TIMP1 and TIMP2 1 0.45 1.49 0.71
14 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
15 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
16 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
17 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 0.00 0.94 0.62
18 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
19 INT239489 Spna1 Negative_regulation of Timp1 1 0.00 0.89 0.57
20 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
21 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
22 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56
23 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56
24 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
25 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
26 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
27 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55
28 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55
29 INT285758 RETNLB Positive_regulation of Gene_expression of TIMP1 1 0.01 1.79 0.55
30 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54
31 INT196522 Binding of MMP1 and TIMP1 1 0.39 0.29 0.53
32 INT150795 ZNF398 Positive_regulation of Localization of TIMP2 1 0.06 0.51 0.53
33 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
34 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
35 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
36 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
37 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
38 INT93951 Nfkb1 Regulation of Gene_expression of Timp1 1 0.00 0.26 0.51
39 INT150799 ZNF398 Positive_regulation of TIMP2 1 0.09 0.49 0.51
40 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51
41 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
42 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
43 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
44 INT277064 CRP Positive_regulation of Gene_expression of TIMP1 1 0.15 1.47 0.45
45 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4
46 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39
47 INT303444 Timp1 Regulation of Fig4 1 0.15 0.43 0.39
48 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37
49 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36
50 INT198969 GAPDH Negative_regulation of TIMP1 1 0.47 0 0.35
51 INT179845 Il11 Positive_regulation of Negative_regulation of Timp1 1 0.14 0 0.35
52 INT97328 Ptger2 Regulation of Transcription of Timp1 1 0.00 0.48 0.34
53 INT224701 Timp3 Negative_regulation of TNF 1 0.01 0.65 0.34
54 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
55 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31
56 INT97327 Ptger2 Positive_regulation of Gene_expression of Timp1 1 0.00 0.46 0.31
57 INT97358 IL1A Regulation of Timp1 1 0.04 0.51 0.31
58 INT97326 Ptger2 Positive_regulation of Transcription of Timp1 1 0.00 0.49 0.31
59 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3
60 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3
61 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
62 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29
63 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29
64 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29
65 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29
66 INT319753 Mpo Positive_regulation of Timp1 1 0.14 2.13 0.29
67 INT55682 IL1B Positive_regulation of TIMP1 2 0.46 0.17 0.28
68 INT218709 Mmp1a Negative_regulation of TIMP1 1 0.00 1.84 0.28
69 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
70 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
71 INT55683 IL1B Positive_regulation of Gene_expression of TIMP1 1 0.64 0.17 0.28
72 INT55681 IL1B Regulation of Gene_expression of TIMP1 1 0.56 0.18 0.28
73 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
74 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
75 INT218660 Mmp1a Negative_regulation of Timp1 1 0.02 1.84 0.28
76 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
77 INT220870 Timp3 Negative_regulation of Adamts4 1 0.03 0.15 0.27
78 INT172140 CSF2 Positive_regulation of Gene_expression of TIMP1 1 0.07 0.72 0.27
79 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27
80 INT34231 PTGER2 Positive_regulation of Gene_expression of TIMP1 1 0.13 0.23 0.27
81 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
82 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
83 INT277066 MMP1 Positive_regulation of Gene_expression of TIMP1 1 0.16 0.76 0.24
84 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
85 INT210794 Timp4 Positive_regulation of Itgbl1 1 0.40 0 0.23
86 INT227905 IL10 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.48 0.22
87 INT218675 Olr811 Negative_regulation of Gene_expression of Timp1 1 0.00 0.22 0.22
88 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22
89 INT218664 Olr811 Regulation of Timp1 1 0.00 0.9 0.22
90 INT220192 PTGER2 Negative_regulation of Positive_regulation of TIMP1 1 0.04 0.99 0.22
91 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
92 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
93 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2
94 INT336379 TIMP1 Negative_regulation of FADS1 1 0.01 0.52 0.2
95 INT21576 NT5C3 Negative_regulation of Gene_expression of TIMP1 1 0.03 0.25 0.2
96 INT214590 TIMP1 Regulation of ICAM1 1 0.10 0.29 0.19
97 INT21577 IL4I1 Positive_regulation of Gene_expression of TIMP1 1 0.11 0.24 0.19
98 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19
99 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18
100 INT181928 RLN1 Positive_regulation of TIMP1 1 0.00 0.1 0.17
101 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
102 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16
103 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16
104 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
105 INT328793 Binding of Mmp7 and Timp2 1 0.00 0.72 0.15
106 INT328794 Binding of Timp2 and Mmp3 1 0.00 0.72 0.15
107 INT246018 Timp1 Negative_regulation of Localization of Il1 1 0.01 1.05 0.14
108 INT246019 Timp1 Negative_regulation of Localization of TNF 1 0.23 1.05 0.14
109 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14
110 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13
111 INT281267 Binding of CRP and TIMP1 1 0.06 0.82 0.13
112 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
113 INT170991 FGF2 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.72 0.13
114 INT337676 Binding of TIMP1 and Scrib 1 0.01 1.24 0.13
115 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13
116 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13
117 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13
118 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
119 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13
120 INT126882 Negative_regulation of TIMP1 Regulation of NA 1 0.28 0 0.12
121 INT213144 TIMP1 Negative_regulation of THBD 1 0.04 1.16 0.12
122 INT220197 PTGER2 Negative_regulation of TIMP1 1 0.03 0.23 0.12
123 INT181929 GOPC Regulation of Gene_expression of TIMP1 1 0.00 0 0.12
124 INT126883 TIMP1 Regulation of NA 1 0.17 0 0.12
125 INT245313 Negative_regulation of Binding of MMP2 and TIMP1 1 0.01 0.45 0.11
126 INT321863 Timp1 Negative_regulation of Gene_expression of Mcpt1 1 0.25 0.79 0.11
127 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
128 INT321861 Timp1 Negative_regulation of Mcpt1 1 0.25 0.79 0.11
129 INT321862 Timp1 Negative_regulation of Il6 1 0.12 0.79 0.11
130 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1
131 INT203628 Cxcl1 Negative_regulation of TIMP2 1 0.01 0 0.1
132 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1
133 INT187112 Binding of TIMP2 and Positive_regulation of TIMP1 1 0.32 0.26 0.1
134 INT218713 Mmp1a Negative_regulation of Gene_expression of TIMP1 1 0.00 0.18 0.1
135 INT203590 Negative_regulation of IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
136 INT203626 IL6 Negative_regulation of Timp1 1 0.12 0 0.1
137 INT203586 IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
138 INT203623 Cxcl1 Negative_regulation of Timp1 1 0.01 0 0.1
139 INT213145 DAK Positive_regulation of TIMP1 1 0.02 0.36 0.09
140 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 0.01 0.14 0.07
141 INT336383 TIMP1 Positive_regulation of Ppara 1 0.08 0.77 0.07
142 INT187104 Binding of IGHG3 and TIMP1 1 0.01 0.22 0.07
143 INT218671 Mmp1a Negative_regulation of Gene_expression of Timp1 1 0.02 0.6 0.06
144 INT266655 TIMP1 Regulation of Gene_expression of MMP9 1 0.18 0.11 0.06
145 INT266662 TIMP1 Regulation of Gene_expression of GOPC 1 0.06 0.11 0.06
146 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
147 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05
148 INT209155 MMP9 Negative_regulation of TIMP1 1 0.01 0.17 0.05
149 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
150 INT209156 MMP2 Negative_regulation of TIMP1 1 0.00 0.17 0.05
151 INT299954 Negative_regulation of LXN Negative_regulation of FTSJ3 1 0.00 0.75 0.05
152 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04
153 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04
154 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04
155 INT270330 Binding of HYAL1 and TIMP1 1 0.00 0.2 0.04
156 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
157 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04
158 INT335289 IRF6 Positive_regulation of Gene_expression of TIMP1 1 0.03 0.16 0.04
159 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04
160 INT289250 Il6 Positive_regulation of Gene_expression of Timp1 1 0.11 0.64 0.03
161 INT218712 Timp1 Regulation of MMP1 1 0.00 0.41 0.03
162 INT94426 CTS Positive_regulation of Gene_expression of TIMP2 1 0.04 0 0
163 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0
164 INT284095 HNF1A Positive_regulation of TIMP3 1 0.38 2.3 0
165 INT94424 IL1B Negative_regulation of Negative_regulation of TIMP2 1 0.06 0 0
166 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
167 INT335312 SLC15A4 Negative_regulation of TIMP1 1 0.01 0.07 0
168 INT94425 IL1B Negative_regulation of Transcription of TIMP2 1 0.06 0 0
169 INT213148 TIMP1 Regulation of DAK 1 0.01 0.73 0
170 INT156682 ASAP1 Negative_regulation of Gene_expression of TIMP1 1 0.17 0.07 0
171 INT281259 Binding of INS and TIMP1 1 0.04 0.27 0
172 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0
173 INT185817 SPP1 Positive_regulation of Gene_expression of TIMP1 1 0.64 0 0
174 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0
175 INT213146 TIMP1 Regulation of HSD11B1 1 0.02 0.7 0
176 INT213143 DAK Regulation of TIMP1 1 0.01 0.73 0
177 INT185801 SPP1 Regulation of Gene_expression of TIMP1 1 0.25 0 0
178 INT354096 Timp1 Negative_regulation of Positive_regulation of NFKB2 1 0.04 0.94 0
179 INT295575 Binding of Mstn and Wfikkn2 1 0.02 0.19 0
180 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
181 INT266657 TIMP1 Regulation of Localization of MMP9 1 0.18 0 0
182 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0
183 INT347153 Mirlet7a-1 Regulation of Timp3 1 0.14 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for metalloendopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in metalloendopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29
2 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54
3 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99
4 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16
5 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86
6 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98
7 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
8 INT55687 Localization of TIMP1 47 0.74 30.24 12.31
9 INT111397 Localization of Timp1 17 0.70 11.67 8.76
10 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
11 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17
12 INT36678 Binding of TIMP1 33 0.36 14.99 7.87
13 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14
14 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94
15 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05
16 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72
17 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51
18 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
19 INT106813 Positive_regulation of RECK 1 0.69 2.39 5.38
20 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78
21 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77
22 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
23 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14
24 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09
25 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91
26 INT106817 Gene_expression of RECK 8 0.77 2.78 3.62
27 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
28 INT93947 Regulation of Gene_expression of Timp1 5 0.25 5.04 3.42
29 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28
30 INT230060 Binding of Timp1 7 0.47 5.61 3.2
31 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
32 INT130603 Binding of Timp1 9 0.35 8.52 3.04
33 INT55739 Transcription of Timp1 7 0.67 4.72 3
34 INT104476 Protein_catabolism of Timp1 6 0.41 5.75 2.61
35 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58
36 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
37 INT158459 Negative_regulation of Gene_expression of Timp1 8 0.40 4.21 2.16
38 INT106814 Positive_regulation of Gene_expression of RECK 2 0.69 1.04 2.1
39 INT173509 Positive_regulation of Localization of Timp1 5 0.41 2.99 2.04
40 INT101912 Regulation of TIMP2 8 0.44 5.55 2
41 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96
42 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92
43 INT187128 Binding of TIMP2 11 0.41 6.43 1.9
44 INT102825 Regulation of Timp1 10 0.38 5.49 1.79
45 INT97333 Regulation of Gene_expression of Timp1 6 0.54 4.8 1.71
46 INT98469 Positive_regulation of Transcription of Timp1 4 0.45 3.2 1.68
47 INT215928 Binding of Timp2 1 0.23 0.79 1.66
48 INT77314 Gene_expression of Lxn 3 0.76 5.67 1.55
49 INT269828 Transcription of Timp1 3 0.38 5.2 1.53
50 INT53131 Transcription of TIMP1 8 0.68 3.89 1.5
51 INT150809 Localization of TIMP2 7 0.65 2.6 1.43
52 INT113268 Positive_regulation of Positive_regulation of Timp1 3 0.15 3.23 1.43
53 INT97332 Regulation of Timp1 4 0.44 3.6 1.38
54 INT345377 Positive_regulation of Positive_regulation of TIMP3 1 0.37 0.09 1.29
55 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
56 INT233286 Positive_regulation of Timp3 1 0.02 1.46 1.1
57 INT159775 Negative_regulation of Gene_expression of Timp1 9 0.37 4.36 1.08
58 INT106816 Negative_regulation of RECK 1 0.37 0.34 1.01
59 INT106812 Transcription of RECK 2 0.68 0.76 1
60 INT172176 Regulation of Regulation of TIMP1 1 0.20 2.33 0.97
61 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96
62 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
63 INT110739 Negative_regulation of Negative_regulation of TIMP1 4 0.41 3.29 0.95
64 INT101913 Regulation of Gene_expression of TIMP2 2 0.44 1.2 0.93
65 INT295679 Regulation of Localization of TIMP1 1 0.17 2.7 0.93
66 INT316726 Regulation of Localization of Timp1 1 0.15 0.81 0.92
67 INT129850 Binding of Lxn 1 0.37 0 0.89
68 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88
69 INT178987 Positive_regulation of Positive_regulation of TIMP1 5 0.20 2.81 0.83
70 INT93665 Negative_regulation of Gene_expression of TIMP2 4 0.37 2.47 0.82
71 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
72 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
73 INT104475 Regulation of Protein_catabolism of Timp1 1 0.00 0.61 0.79
74 INT34233 Regulation of Negative_regulation of TIMP1 3 0.27 0.48 0.77
75 INT134752 Negative_regulation of Gene_expression of TIMP3 5 0.37 2.25 0.73
76 INT51053 Negative_regulation of Positive_regulation of TIMP1 6 0.35 1.67 0.69
77 INT324890 Negative_regulation of Negative_regulation of Timp2 2 0.40 1.09 0.68
78 INT55689 Positive_regulation of Transcription of TIMP1 3 0.46 1.02 0.67
79 INT94429 Transcription of TIMP2 3 0.61 4.05 0.67
80 INT342612 Positive_regulation of Positive_regulation of Timp2 1 0.43 1.05 0.57
81 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
82 INT153940 Localization of Timp1 3 0.78 0.63 0.55
83 INT213154 Positive_regulation of Binding of TIMP1 2 0.41 1.33 0.55
84 INT139666 Binding of Timp2 3 0.13 0.55 0.5
85 INT303453 Negative_regulation of Binding of Timp1 1 0.41 1.44 0.49
86 INT303455 Regulation of Binding of Timp1 1 0.44 1.21 0.48
87 INT173583 Negative_regulation of Binding of TIMP1 1 0.13 0 0.48
88 INT180920 Positive_regulation of Positive_regulation of Timp1 2 0.38 1.59 0.46
89 INT110738 Positive_regulation of Negative_regulation of TIMP1 4 0.44 0.44 0.45
90 INT311099 Positive_regulation of Negative_regulation of TIMP3 2 0.22 0.78 0.45
91 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
92 INT210769 Gene_expression of Timp4 1 0.53 0 0.42
93 INT184444 Binding of Timp3 3 0.47 0.25 0.41
94 INT150095 Regulation of Positive_regulation of TIMP1 2 0.44 0.76 0.41
95 INT181987 Negative_regulation of Negative_regulation of Timp1 1 0.23 1.39 0.41
96 INT94430 Positive_regulation of Transcription of TIMP2 2 0.24 2.25 0.39
97 INT269822 Transcription of Timp2 1 0.36 1.43 0.36
98 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32
99 INT321592 Localization of Lxn 1 0.79 1.11 0.32
100 INT317974 Localization of Timp2 1 0.38 0.88 0.3
101 INT187136 Negative_regulation of Localization of TIMP2 1 0.37 0.69 0.3
102 INT187130 Positive_regulation of Negative_regulation of TIMP2 1 0.43 0.78 0.29
103 INT233398 Localization of TIMP3 2 0.45 1.31 0.26
104 INT24734 Positive_regulation of LXN 1 0.21 0.7 0.23
105 INT323894 Negative_regulation of Regulation of TIMP2 1 0.20 1.04 0.23
106 INT156686 Negative_regulation of Localization of TIMP1 2 0.35 1.29 0.22
107 INT341658 Negative_regulation of Regulation of TIMP1 1 0.33 0.91 0.21
108 INT321587 Positive_regulation of Lxn 1 0.68 0.9 0.21
109 INT324889 Positive_regulation of Gene_expression of Timp2 1 0.17 0.55 0.2
110 INT151968 Regulation of Gene_expression of RECK 1 0.52 0.3 0.2
111 INT189564 Binding of TIMP3 4 0.31 2.45 0.17
112 INT151969 Regulation of RECK 1 0.52 0.52 0.17
113 INT210765 Negative_regulation of Timp4 1 0.38 0 0.16
114 INT321593 Regulation of Lxn 1 0.23 0.93 0.15
115 INT310587 Positive_regulation of Negative_regulation of Timp1 1 0.44 0.81 0.14
116 INT187124 Positive_regulation of Positive_regulation of TIMP2 1 0.40 0.22 0.11
117 INT153941 Localization of Timp2 2 0.58 0.07 0.1
118 INT321857 Phosphorylation of Timp1 1 0.61 0.76 0.1
119 INT180707 Regulation of Localization of Timp2 1 0.35 0 0.1
120 INT321859 Negative_regulation of Phosphorylation of Timp1 1 0.32 0.76 0.1
121 INT351074 Negative_regulation of Binding of Timp1 1 0.04 1.14 0.09
122 INT323892 Regulation of Transcription of TIMP2 1 0.21 0.9 0.08
123 INT180695 Regulation of Timp2 2 0.21 0.67 0.05
124 INT299979 Negative_regulation of LXN 1 0.02 0.74 0.05
125 INT227010 Regulation of TIMP3 3 0.62 1.72 0.03
126 INT189570 Positive_regulation of Gene_expression of TIMP3 3 0.44 1.57 0
127 INT299138 Regulation of Positive_regulation of Timp2 1 0.12 0.26 0
128 INT321589 Negative_regulation of Lxn 1 0.37 0.32 0
129 INT299135 Regulation of Positive_regulation of Timp1 1 0.26 0.26 0
130 INT347143 Gene_expression of Timp3 1 0.73 0 0
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