GO:0008202

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Name steroid metabolic process
Categary Process
Go Slim No
Go Link GO:0008202
Unique Molecular Interactions 902
Total Molecular Interactions 1245
Total Single Events 11588
Pain Genes Associated 94

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for steroid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for steroid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
2 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
5 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
6 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
7 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
8 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
9 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
10 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
11 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
12 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
13 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
14 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
15 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
16 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
17 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
18 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
19 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
20 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
21 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
22 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
23 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
24 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
25 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
26 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
27 INT209087 Crh Positive_regulation of Ceacam3 1 0.24 1.45 1.54
28 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
29 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
30 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
31 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
32 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
33 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
34 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
35 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
36 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
37 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
38 INT29714 Crh Regulation of Localization of LH 2 0.26 0 1.19
39 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
40 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
41 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
42 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
43 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
44 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
45 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
46 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
47 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
48 INT88971 Binding of Sult4a1 and Atrn 1 0.02 0.54 1.03
49 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
50 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
51 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
52 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
53 INT209151 OXT Positive_regulation of PNLIP 1 0.08 0.73 0.99
54 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
55 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
56 INT36002 Negative_regulation of Crh Negative_regulation of LH 2 0.29 0.66 0.96
57 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
58 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
59 INT47342 Penk Regulation of Fabp6 1 0.01 0.39 0.95
60 INT62449 Gnrh1 Regulation of Crh 1 0.40 0.34 0.91
61 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
62 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
63 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
64 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
65 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
66 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
67 INT64629 Binding of Gal and Crh 1 0.18 0.1 0.83
68 INT64627 Binding of Oxt and Crh 1 0.07 0.1 0.83
69 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
70 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
71 INT36003 Crh Positive_regulation of Localization of LH 2 0.45 0 0.79
72 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
73 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
74 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76
75 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
76 INT28620 Penk Regulation of Crh 2 0.40 0.25 0.75
77 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
78 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
79 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
80 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
81 INT30838 Crh Negative_regulation of D230030E09Rik 1 0.17 0.1 0.73
82 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
83 INT210144 Binding of Slc6a3 and Slc37a4 1 0.11 0.23 0.72
84 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
85 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71
86 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
87 INT12022 Crh Positive_regulation of Localization of Prl 1 0.02 0.14 0.7
88 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7
89 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
90 INT55205 Prl Positive_regulation of Localization of Crh 1 0.47 0 0.69
91 INT55209 Prl Positive_regulation of Crh 1 0.51 0 0.69
92 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69
93 INT135119 Binding of Pomc and Crh 1 0.35 0 0.67
94 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
95 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
96 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
97 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
98 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
99 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
100 INT34212 PSG2 Regulation of Localization of Crh 1 0.02 0.09 0.63
101 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
102 INT34211 DNM2 Regulation of Localization of Crh 1 0.01 0.09 0.63
103 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
104 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
105 INT23576 Binding of Penk and Crh 2 0.18 0 0.62
106 INT20162 Crh Regulation of GNRH1 2 0.02 0.07 0.62
107 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
108 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
109 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
110 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61
111 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
112 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
113 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
114 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6
115 INT108018 Binding of Slc37a4 and Clec4d 1 0.00 1.18 0.6
116 INT104050 Binding of Crh and Nts 1 0.40 0 0.6
117 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
118 INT321285 Ins1 Negative_regulation of G6pc 1 0.07 0.52 0.59
119 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58
120 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
121 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
122 INT207440 Binding of HDLBP and PLA2G7 1 0.06 1.25 0.58
123 INT91393 Crh Positive_regulation of SST 1 0.01 0.73 0.58
124 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
125 INT62445 Pomc Negative_regulation of Localization of Crh 1 0.12 0.07 0.58
126 INT30268 Binding of Gnrh1 and Crh 1 0.45 0.65 0.57
127 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 0.05 0.76 0.57
128 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
129 INT222183 Binding of HDLBP and PLA2G15 1 0.01 0.7 0.57
130 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
131 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
132 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
133 INT544 Binding of ALB and GC 1 0.13 0 0.55
134 INT141020 Crh Positive_regulation of Gene_expression of Pomc 1 0.05 0.17 0.55
135 INT278688 MTX1 Negative_regulation of Positive_regulation of SOAT1 1 0.04 0.69 0.54
136 INT209152 Regulation of OXT Positive_regulation of PNLIP 1 0.05 0.42 0.54
137 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
138 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 0.66 2.42 0.54
139 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
140 INT125699 CR1 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0.64 0.53
141 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
142 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52
143 INT55208 Prl Negative_regulation of Localization of Crh 1 0.43 0 0.51
144 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
145 INT127337 Crh Regulation of LOC308670 1 0.01 0 0.51
146 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51
147 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51
148 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
149 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
150 INT27066 Crh Positive_regulation of Localization of Oxt 1 0.40 0 0.48
151 INT59546 Avp Positive_regulation of Localization of Crh 1 0.05 0.08 0.47
152 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47
153 INT59548 Negative_regulation of Avp Positive_regulation of Crh 1 0.04 0.08 0.47
154 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
155 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
156 INT28619 Negative_regulation of Penk Regulation of Crh 1 0.41 0 0.46
157 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
158 INT237452 Binding of STAR and CHTF8 1 0.00 0.48 0.45
159 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
160 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
161 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
162 INT62447 Gnrh1 Regulation of Localization of Crh 1 0.40 0.17 0.45
163 INT57983 Il1b Regulation of Crh 1 0.37 0.09 0.44
164 INT57981 Regulation of Il1b Positive_regulation of Crh 1 0.22 0.1 0.44
165 INT30083 Binding of Crh and Lvp1 1 0.00 0.35 0.44
166 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44
167 INT80679 Abat Regulation of Localization of Sult1b1 1 0.01 0 0.44
168 INT270043 Binding of Ldlr and Hdl1 1 0.01 2.3 0.43
169 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
170 INT237453 Binding of STAR and MESP1 1 0.00 0.47 0.42
171 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
172 INT139486 Oprm1 Positive_regulation of Crh 1 0.27 0.1 0.42
173 INT327562 Binding of MCS and AKR1B10 1 0.00 0.5 0.41
174 INT55202 Crh Positive_regulation of Negative_regulation of Prl 1 0.51 0 0.41
175 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
176 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
177 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
178 INT237454 Binding of STAR and GREM1 1 0.00 0.44 0.4
179 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
180 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
181 INT273893 ARSA Positive_regulation of HSD11B1 1 0.00 0.61 0.4
182 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39
183 INT321301 Fig4 Negative_regulation of G6pc 1 0.07 0.33 0.39
184 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
185 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
186 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38
187 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
188 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
189 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
190 INT41460 Crh Regulation of Pomc 1 0.10 0.1 0.36
191 INT157147 LSS Positive_regulation of PTGIR 1 0.09 0.96 0.36
192 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
193 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
194 INT26197 Qrfp Regulation of Localization of Crh 1 0.02 0 0.36
195 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
196 INT41461 Crh Regulation of Localization of Pomc 1 0.10 0.1 0.36
197 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
198 INT66368 Pomc Regulation of Positive_regulation of Crh 1 0.36 0 0.35
199 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
200 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for steroid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in steroid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1562 Localization of Crh 499 0.81 126.74 236.68
2 INT438 Gene_expression of Crh 376 0.78 159.11 169.17
3 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14
4 INT1898 Regulation of Crh 220 0.62 61.33 102.64
5 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
6 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
7 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92
8 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
9 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
10 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23
11 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
12 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
13 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
14 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
15 INT2499 Positive_regulation of Sult1b1 51 0.43 2.83 32.38
16 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
17 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26
18 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29
19 INT16879 Binding of Crh 72 0.48 21.65 28.43
20 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
21 INT21379 Transcription of Crh 65 0.72 15.64 27.92
22 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
23 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
24 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
25 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
26 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
27 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34
28 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73
29 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
30 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
31 INT2660 Negative_regulation of Fabp6 58 0.49 33.74 18.27
32 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
33 INT7258 Localization of Sult1b1 42 0.68 0.17 17.85
34 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
35 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
36 INT10056 Positive_regulation of Fabp6 77 0.59 36.99 16.8
37 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
38 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
39 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
40 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
41 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
42 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35
43 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5
44 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
45 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
46 INT2496 Gene_expression of Sult1b1 32 0.66 3 10.97
47 INT36453 Binding of ABCA1 48 0.45 19.9 10.84
48 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52
49 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
50 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
51 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
52 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
53 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
54 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
55 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27
56 INT3954 Regulation of Fabp6 33 0.52 15.64 9.27
57 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
58 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
59 INT1224 Gene_expression of Fabp6 34 0.64 23.69 9.08
60 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
61 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
62 INT82709 Negative_regulation of Slc37a4 17 0.34 3.41 8.6
63 INT2500 Negative_regulation of Positive_regulation of Sult1b1 13 0.18 0.6 8.6
64 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
65 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
66 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28
67 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
68 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97
69 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87
70 INT6335 Binding of TSPO 39 0.44 10.88 7.66
71 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
72 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
73 INT2501 Positive_regulation of Positive_regulation of Sult1b1 19 0.19 2.38 7.16
74 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13
75 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05
76 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
77 INT22336 Positive_regulation of Transcription of Crh 18 0.68 4.61 6.91
78 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
79 INT83745 Gene_expression of SULT2A1 34 0.59 15.96 6.66
80 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
81 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
82 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21
83 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16
84 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04
85 INT6229 Positive_regulation of Gene_expression of Sult1b1 18 0.22 2.21 6.04
86 INT23210 Localization of Fabp6 11 0.58 6.14 5.81
87 INT102836 Binding of LRP2 12 0.38 11.27 5.58
88 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
89 INT22485 Negative_regulation of Positive_regulation of Crh 13 0.59 4.49 5.46
90 INT18244 Regulation of Positive_regulation of Crh 11 0.45 3.87 5.41
91 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
92 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
93 INT186063 Phosphorylation of SOAT1 29 0.28 11.77 5.34
94 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
95 INT22338 Negative_regulation of Transcription of Crh 11 0.43 2.09 5.24
96 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
97 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
98 INT2497 Regulation of Positive_regulation of Sult1b1 7 0.23 0.49 5.11
99 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
100 INT2848 Localization of ABCA1 23 0.70 10.64 4.73
101 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
102 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7
103 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
104 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
105 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
106 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
107 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
108 INT23440 Negative_regulation of Sult1b1 12 0.45 1.77 4.33
109 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
110 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
111 INT89925 Gene_expression of NR1I2 22 0.75 9.63 4.21
112 INT24360 Binding of Fabp6 5 0.32 4.62 4.11
113 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
114 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
115 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
116 INT108086 Negative_regulation of AKR1C3 17 0.58 7.7 3.99
117 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95
118 INT7257 Positive_regulation of Localization of Sult1b1 8 0.59 0 3.91
119 INT63441 Regulation of Transcription of Crh 9 0.60 4.51 3.9
120 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
121 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
122 INT99889 Transcription of SRD5A1 5 0.71 1.45 3.74
123 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
124 INT170182 Negative_regulation of SULT2A1 14 0.34 11.47 3.63
125 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
126 INT545 Binding of GC 15 0.45 10.74 3.47
127 INT57728 Regulation of LDLR 25 0.41 13.18 3.46
128 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39
129 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38
130 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32
131 INT5166 Binding of Ldlr 14 0.48 11.95 3.32
132 INT28130 Positive_regulation of ABCA1 18 0.61 7.08 3.22
133 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13
134 INT107011 Positive_regulation of NR1I2 14 0.49 8.85 3.11
135 INT28715 Negative_regulation of Regulation of Crh 7 0.43 0.97 3.06
136 INT10057 Gene_expression of Ldlr 35 0.67 23.99 3.05
137 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04
138 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
139 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
140 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
141 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
142 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96
143 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
144 INT169046 Gene_expression of Sult4a1 12 0.71 1.49 2.83
145 INT7256 Negative_regulation of Localization of Sult1b1 5 0.37 0 2.81
146 INT2502 Regulation of Gene_expression of Sult1b1 5 0.11 0.92 2.8
147 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
148 INT78146 Gene_expression of AKR1C3 24 0.77 5.71 2.77
149 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77
150 INT61231 Gene_expression of SULT1A1 14 0.75 3.01 2.76
151 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
152 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73
153 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
154 INT19685 Localization of Sult2a1 12 0.70 0.83 2.7
155 INT49759 Negative_regulation of CETP 43 0.58 52 2.68
156 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64
157 INT5510 Negative_regulation of Negative_regulation of Crh 8 0.43 1.05 2.61
158 INT22339 Positive_regulation of Negative_regulation of Crh 5 0.67 1.36 2.59
159 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
160 INT169553 Positive_regulation of Slc37a4 9 0.13 2.94 2.49
161 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47
162 INT16672 Negative_regulation of MBTPS1 6 0.26 1.45 2.46
163 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
164 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
165 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
166 INT82381 Negative_regulation of Sult4a1 4 0.59 1.97 2.39
167 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
168 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
169 INT80391 Negative_regulation of Cyp2b2 4 0.54 0.12 2.36
170 INT231557 Positive_regulation of Phosphorylation of SOAT1 7 0.22 5.22 2.33
171 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
172 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24
173 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
174 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
175 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
176 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
177 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
178 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
179 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
180 INT86460 Binding of Slc37a4 5 0.04 1.8 2.08
181 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
182 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
183 INT83744 Gene_expression of SULT1E1 9 0.75 3.12 2.07
184 INT342815 Positive_regulation of Transcription of SRD5A1 1 0.49 0.33 2.04
185 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
186 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
187 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
188 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02
189 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
190 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
191 INT170185 Localization of SULT2A1 4 0.47 4.65 2
192 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
193 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97
194 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97
195 INT101410 Negative_regulation of Positive_regulation of CYP2C9 5 0.42 0.23 1.96
196 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
197 INT78960 Binding of SOAT1 9 0.36 2.56 1.92
198 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
199 INT124322 Negative_regulation of PNLIP 11 0.31 6.53 1.88
200 INT217691 Gene_expression of LIPE 24 0.70 29.84 1.87
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