GO:0008203

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Name cholesterol metabolic process
Categary Process
Go Slim No
Go Link GO:0008203
Unique Molecular Interactions 1390
Total Molecular Interactions 1873
Total Single Events 13392
Pain Genes Associated 89

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cholesterol metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cholesterol metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
4 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
5 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
6 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 0.03 1.28 1.49
7 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
8 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
9 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 0.39 2.42 1.4
10 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
11 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
12 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
13 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2
14 INT142075 IL4 Negative_regulation of Binding of IDO1 1 0.02 2.07 1.19
15 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
16 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
17 INT100678 IL4 Positive_regulation of STAT6 1 0.49 2.63 1.08
18 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
19 INT174468 IL7 Positive_regulation of Gene_expression of IL4 1 0.40 1.88 1.02
20 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
21 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
22 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
23 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
24 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
25 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
26 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
27 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
28 INT129214 RYBP Positive_regulation of Gene_expression of Il4 1 0.01 1.04 0.94
29 INT133073 IL4 Positive_regulation of Phosphorylation of STAT6 1 0.39 0 0.9
30 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
31 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
32 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
33 INT73492 PTGER2 Positive_regulation of Gene_expression of IL4 1 0.08 1.11 0.87
34 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79
35 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
36 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78
37 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
38 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
39 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
40 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77
41 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
42 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74
43 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
44 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
45 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
46 INT209037 Il4 Positive_regulation of Csf2 1 0.03 0.38 0.73
47 INT209038 Il4 Positive_regulation of Ccr1 1 0.01 0.38 0.73
48 INT209058 Il4 Positive_regulation of Elf1 1 0.08 0.38 0.73
49 INT209034 Il4 Positive_regulation of Il17a 1 0.04 0.38 0.73
50 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73
51 INT209064 Il4 Positive_regulation of Cxcl1 1 0.05 0.38 0.73
52 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72
53 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
54 INT116020 Positive_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
55 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
56 INT116021 Binding of Il4 and Mavs 1 0.02 0.08 0.7
57 INT116019 Negative_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
58 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7
59 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
60 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
61 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
62 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
63 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
64 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
65 INT209859 IL4 Positive_regulation of PPARA 1 0.22 1.66 0.69
66 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
67 INT190177 Gene_expression of IL13 Regulation of Gene_expression of IL4 1 0.04 0.05 0.68
68 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68
69 INT190171 Gene_expression of IL4 Regulation of Gene_expression of IL13 1 0.04 0.05 0.68
70 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68
71 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67
72 INT230336 IL4 Regulation of IL5 2 0.04 0.82 0.67
73 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
74 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
75 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
76 INT178334 Binding of Pon1 and Chdh 1 0.11 11.45 0.66
77 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
78 INT209854 IL4 Positive_regulation of Gene_expression of CD36 1 0.51 1.2 0.65
79 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
80 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
81 INT153797 NUBPL Negative_regulation of PPARD 1 0.02 0.69 0.64
82 INT142076 IL4 Negative_regulation of Gene_expression of IFNG 1 0.01 1.58 0.64
83 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
84 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 0.28 0.26 0.62
85 INT190170 IL4 Regulation of Gene_expression of IL13 1 0.04 0 0.62
86 INT190175 IL13 Regulation of Gene_expression of IL4 1 0.04 0 0.62
87 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
88 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
89 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
90 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
91 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
92 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6
93 INT151460 Olr1745 Positive_regulation of Il4 1 0.04 0.83 0.59
94 INT62034 POMC Regulation of Positive_regulation of IL4 1 0.44 0 0.58
95 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
96 INT207440 Binding of HDLBP and PLA2G7 1 0.06 1.25 0.58
97 INT172133 IL4 Negative_regulation of Gene_expression of HMOX2 1 0.00 0.81 0.58
98 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
99 INT228497 Il4 Regulation of Ncoa5 1 0.01 1.24 0.57
100 INT222183 Binding of HDLBP and PLA2G15 1 0.01 0.7 0.57
101 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
102 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
103 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
104 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
105 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
106 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
107 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
108 INT278688 MTX1 Negative_regulation of Positive_regulation of SOAT1 1 0.04 0.69 0.54
109 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54
110 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
111 INT351332 Positive_regulation of Il4 Positive_regulation of Gene_expression of Il10 1 0.09 1.78 0.53
112 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
113 INT125699 CR1 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0.64 0.53
114 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
115 INT328058 IL4 Positive_regulation of FAAH 1 0.29 4.29 0.53
116 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
117 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
118 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51
119 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
120 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
121 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51
122 INT131364 Bcar3 Positive_regulation of Il4 1 0.00 0.37 0.51
123 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
124 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51
125 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
126 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5
127 INT349636 IL17A Positive_regulation of Gene_expression of IL4 1 0.06 1.28 0.5
128 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
129 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
130 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
131 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
132 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49
133 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48
134 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
135 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48
136 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
137 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48
138 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48
139 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48
140 INT185067 Bpifa2 Positive_regulation of Il4 1 0.20 0.84 0.48
141 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47
142 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
143 INT323905 Positive_regulation of CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
144 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
145 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
146 INT323904 CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
147 INT72087 IL4 Positive_regulation of POMC 1 0.16 0 0.46
148 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
149 INT323907 ACCS Positive_regulation of IL4 1 0.04 0.9 0.45
150 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
151 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
152 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
153 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
154 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44
155 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
156 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43
157 INT270043 Binding of Ldlr and Hdl1 1 0.01 2.3 0.43
158 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43
159 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
160 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
161 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
162 INT292627 IL21 Positive_regulation of IL4 1 0.10 0.41 0.42
163 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
164 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
165 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
166 INT299789 IL4 Negative_regulation of Gene_expression of RAE1 1 0.00 0.84 0.41
167 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
168 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
169 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
170 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
171 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
172 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
173 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4
174 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
175 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4
176 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39
177 INT292887 IL4 Regulation of IL12A 1 0.01 0.25 0.39
178 INT292892 IL4 Regulation of IL8 1 0.01 0.25 0.39
179 INT228739 Il4 Positive_regulation of Gene_expression of Ccl17 1 0.14 0.66 0.39
180 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
181 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
182 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
183 INT297423 Gene_expression of Il4 Regulation of Ppara 1 0.07 1.19 0.38
184 INT254278 Binding of Il13 and Il4 1 0.02 0.74 0.38
185 INT297425 Il4 Regulation of Ppara 1 0.07 1.17 0.38
186 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
187 INT144047 IL4 Positive_regulation of PTGES 1 0.29 0.43 0.37
188 INT299790 IL4 Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37
189 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
190 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
191 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
192 INT292622 IL6 Positive_regulation of IL4 1 0.02 0.36 0.36
193 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36
194 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
195 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
196 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
197 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
198 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
199 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35
200 INT181438 Il4 Regulation of Gene_expression of Ccl2 1 0.38 0.74 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for cholesterol metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cholesterol metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12
2 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42
3 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92
4 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
5 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4
6 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75
7 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
8 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
9 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34
10 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
11 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
12 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
13 INT20379 Localization of Il4 85 0.73 51.22 20.55
14 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39
15 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
16 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65
17 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
18 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
19 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
20 INT75908 Regulation of LEP 77 0.60 60.16 15.19
21 INT69303 Positive_regulation of Gene_expression of Il4 27 0.68 20.01 14.8
22 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15
23 INT73641 Regulation of Lep 45 0.62 26.2 12.59
24 INT69158 Localization of IL4 48 0.71 31.3 11.98
25 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42
26 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
27 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
28 INT36453 Binding of ABCA1 48 0.45 19.9 10.84
29 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
30 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
31 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
32 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
33 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
34 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
35 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
36 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27
37 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
38 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9
39 INT79693 Regulation of Il4 30 0.51 21.96 8.6
40 INT82082 Localization of Lep 63 0.81 26.41 8.56
41 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54
42 INT75907 Binding of LEP 53 0.46 46.65 8.44
43 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28
44 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18
45 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87
46 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
47 INT50040 Localization of Il4 15 0.67 8.26 7.69
48 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39
49 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
50 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
51 INT197493 Localization of Apoe 61 0.79 27.48 7.06
52 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05
53 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
54 INT19146 Negative_regulation of Apoa2 19 0.36 5.34 6.73
55 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
56 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21
57 INT58484 Regulation of Il4 12 0.45 8.67 6.09
58 INT67397 Transcription of Il4 15 0.54 11.36 6.06
59 INT63042 Binding of Apoe 59 0.48 31.23 5.88
60 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
61 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
62 INT56299 Transcription of IL4 15 0.64 10.2 5.44
63 INT65356 Localization of LEP 46 0.79 41.17 5.43
64 INT91338 Binding of Lep 31 0.48 26.86 5.39
65 INT77146 Binding of IL4 23 0.36 13.69 5.39
66 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
67 INT38366 Regulation of Cat 45 0.62 23.45 5.34
68 INT186063 Phosphorylation of SOAT1 29 0.28 11.77 5.34
69 INT171562 Regulation of IL4 19 0.36 12.12 5.33
70 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28
71 INT102935 Regulation of Lep 31 0.60 18.47 5.24
72 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2
73 INT67228 Regulation of Gene_expression of Il4 11 0.50 6.67 5.2
74 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
75 INT2848 Localization of ABCA1 23 0.70 10.64 4.73
76 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
77 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58
78 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57
79 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56
80 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49
81 INT97391 Binding of Lep 18 0.48 8.97 4.47
82 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15
83 INT163581 Localization of Lep 27 0.79 18.99 4.08
84 INT2453 Positive_regulation of Apoa2 20 0.54 3.49 4.08
85 INT64473 Regulation of Gene_expression of IL4 17 0.58 6.61 3.96
86 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95
87 INT62497 Binding of Il4 7 0.26 4.19 3.88
88 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
89 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
90 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
91 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
92 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
93 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7
94 INT92200 Negative_regulation of Localization of Il4 10 0.51 5.66 3.65
95 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64
96 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61
97 INT70919 Binding of Il4 19 0.36 6.58 3.59
98 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56
99 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56
100 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
101 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
102 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49
103 INT57728 Regulation of LDLR 25 0.41 13.18 3.46
104 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44
105 INT97438 Transcription of Il4 17 0.67 9.17 3.4
106 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39
107 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38
108 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32
109 INT5166 Binding of Ldlr 14 0.48 11.95 3.32
110 INT72141 Binding of Apoe 11 0.37 10.91 3.27
111 INT28130 Positive_regulation of ABCA1 18 0.61 7.08 3.22
112 INT97710 Localization of Apoe 1 0.79 7.18 3.2
113 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13
114 INT12948 Positive_regulation of Gene_expression of Cat 17 0.67 6.46 3.12
115 INT84890 Negative_regulation of PPARD 7 0.59 3.27 3.1
116 INT10057 Gene_expression of Ldlr 35 0.67 23.99 3.05
117 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04
118 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
119 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01
120 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87
121 INT79722 Regulation of Cat 14 0.62 5.88 2.86
122 INT10556 Regulation of Apoa2 5 0.44 0.51 2.8
123 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78
124 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73
125 INT49759 Negative_regulation of CETP 43 0.58 52 2.68
126 INT50080 Binding of APOE 38 0.45 29.61 2.67
127 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67
128 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
129 INT113892 Binding of Cat 6 0.48 3.95 2.65
130 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64
131 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63
132 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
133 INT16672 Negative_regulation of MBTPS1 6 0.26 1.45 2.46
134 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45
135 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
136 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43
137 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
138 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37
139 INT231557 Positive_regulation of Phosphorylation of SOAT1 7 0.22 5.22 2.33
140 INT157049 Regulation of Localization of Il4 2 0.25 1.46 2.33
141 INT2452 Localization of Apoa2 9 0.55 0 2.3
142 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
143 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
144 INT92119 Negative_regulation of Positive_regulation of Il4 3 0.14 1.88 2.2
145 INT101516 Positive_regulation of PPARD 8 0.49 4.75 2.19
146 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18
147 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
148 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15
149 INT3723 Binding of PON1 9 0.46 5.83 2.13
150 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
151 INT15765 Localization of PON1 8 0.75 3.61 2.08
152 INT48803 Gene_expression of CELA3B 9 0.22 7.24 2.06
153 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
154 INT83392 Transcription of Lep 6 0.54 5.07 2.04
155 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
156 INT190883 Gene_expression of Apoc3 16 0.38 14.18 1.93
157 INT78960 Binding of SOAT1 9 0.36 2.56 1.92
158 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
159 INT217691 Gene_expression of LIPE 24 0.70 29.84 1.87
160 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86
161 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86
162 INT123873 Positive_regulation of Negative_regulation of Cat 7 0.50 2.86 1.86
163 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85
164 INT39458 Negative_regulation of SOAT1 8 0.57 10.56 1.83
165 INT21813 Gene_expression of Apoa2 10 0.61 3.68 1.81
166 INT207370 Negative_regulation of Gene_expression of ABCA1 1 0.54 2.75 1.78
167 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
168 INT76417 Positive_regulation of Positive_regulation of Il4 3 0.09 0.34 1.7
169 INT112339 Localization of Cyp11a1 2 0.71 0.94 1.68
170 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67
171 INT97434 Positive_regulation of Positive_regulation of Il4 8 0.40 3.51 1.66
172 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
173 INT174478 Negative_regulation of Localization of IL4 6 0.34 3.56 1.65
174 INT156484 Binding of Apoa1 4 0.47 6.78 1.63
175 INT239016 Binding of Sqle 1 0.01 5.43 1.63
176 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
177 INT45030 Negative_regulation of CELA3B 5 0.34 2.17 1.6
178 INT262117 Negative_regulation of Gene_expression of Cyp7a1 3 0.25 0.91 1.6
179 INT100694 Negative_regulation of Positive_regulation of IL4 5 0.34 3.27 1.58
180 INT184241 Regulation of Localization of Il4 4 0.15 3.89 1.58
181 INT163666 Localization of Cat 8 0.80 5.84 1.57
182 INT9466 Binding of APOB 27 0.41 19.36 1.56
183 INT163861 Positive_regulation of Gene_expression of Cyp11a1 2 0.38 0.64 1.53
184 INT118400 Positive_regulation of Transcription of Il4 2 0.35 1.78 1.53
185 INT163858 Regulation of Gene_expression of Cyp11a1 1 0.46 0.55 1.53
186 INT39459 Gene_expression of SOAT1 10 0.75 7.62 1.52
187 INT93350 Binding of Lepr 17 0.05 27.21 1.5
188 INT84889 Positive_regulation of Gene_expression of PPARD 4 0.70 2.94 1.49
189 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
190 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
191 INT181881 Positive_regulation of Gene_expression of Apoa1 13 0.48 14.31 1.45
192 INT84888 Binding of PPARD 5 0.48 2.82 1.45
193 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
194 INT270631 Gene_expression of Insig1 15 0.32 5.19 1.43
195 INT180581 Negative_regulation of Protein_catabolism of CYP27A1 2 0.29 3.19 1.43
196 INT100540 Localization of SOAT1 9 0.78 2.67 1.42
197 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
198 INT10570 Positive_regulation of Cyp11a1 9 0.47 2.67 1.4
199 INT155845 Transcription of SOAT1 6 0.67 2.89 1.4
200 INT113960 Positive_regulation of Gene_expression of APOB 8 0.49 5.88 1.39
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