GO:0008206

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Name bile acid metabolic process
Categary Process
Go Slim No
Go Link GO:0008206
Unique Molecular Interactions 476
Total Molecular Interactions 675
Total Single Events 5527
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bile acid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for bile acid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
4 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
5 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
6 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
7 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
8 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
9 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
10 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
11 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
12 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
13 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
14 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92
15 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
16 INT218037 Binding of ALB and Penk 1 0.13 0 0.81
17 INT110726 Binding of ALB and LTF 1 0.01 0 0.81
18 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
19 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
20 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
21 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
22 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
23 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
24 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
25 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
26 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
27 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
28 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
29 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
30 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
31 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
32 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
33 INT92045 Binding of ALB and SERPINA1 1 0.30 1.37 0.64
34 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
35 INT177269 Binding of CXADR and NR1H4 1 0.04 0 0.58
36 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
37 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
38 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
39 INT544 Binding of ALB and GC 1 0.13 0 0.55
40 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
41 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
42 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
43 INT351581 Binding of ALB and GOPC 1 0.11 0 0.55
44 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
45 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
46 INT18115 Binding of NPC1 and Oprd1 1 0.11 0 0.54
47 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
48 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
49 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5
50 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
51 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
52 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
53 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
54 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
55 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
56 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
57 INT46225 Binding of ALB and POMC 1 0.36 0 0.4
58 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
59 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
60 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
61 INT43956 GCG Regulation of ALB 1 0.16 0.15 0.38
62 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
63 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37
64 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
65 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
66 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
67 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
68 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
69 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
70 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
71 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
72 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
73 INT28006 NPC1 Negative_regulation of Positive_regulation of Rps6ka1 1 0.01 0.37 0.33
74 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
75 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
76 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
77 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
78 INT28005 NPC1 Negative_regulation of Rps6ka1 1 0.01 0.45 0.32
79 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
80 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
81 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
82 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
83 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
84 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
85 INT207355 ZNF398 Regulation of CYP27A1 1 0.00 0 0.31
86 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
87 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
88 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
89 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
90 INT35963 Binding of ALB and MPG 1 0.40 0 0.3
91 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
92 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
93 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
94 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
95 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
96 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
97 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
98 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
99 INT126006 Binding of ALB and IL8 1 0.41 0.28 0.28
100 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
101 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
102 INT335049 PPARA Negative_regulation of Gene_expression of CYP7B1 1 0.27 0 0.26
103 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
104 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
105 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
106 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25
107 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25
108 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
109 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
110 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
111 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23
112 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
113 INT344714 Nr1h4 Negative_regulation of Gene_expression of Lipg 1 0.02 0.77 0.23
114 INT354926 IL6 Regulation of Gene_expression of ALB 1 0.14 1.3 0.23
115 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
116 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
117 INT354924 IL6 Positive_regulation of Gene_expression of ALB 1 0.26 1.3 0.23
118 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
119 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
120 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
121 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
122 INT234724 Binding of NPC1 and Cxcl1 1 0.00 0.33 0.21
123 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
124 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
125 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
126 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
127 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
128 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
129 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
130 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
131 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
132 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
133 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2
134 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
135 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
136 INT327112 HCCS Positive_regulation of Gene_expression of SLCO1B3 1 0.03 0.65 0.19
137 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
138 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
139 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
140 INT57612 Binding of ALB and HGF 1 0.20 0.52 0.18
141 INT126007 Negative_regulation of Binding of ALB and IL8 1 0.37 0.18 0.18
142 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
143 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
144 INT321290 Positive_regulation of Nr1h4 Positive_regulation of Nr0b2 1 0.20 0.2 0.18
145 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
146 INT207339 TBXA2R Negative_regulation of Negative_regulation of CYP27A1 1 0.01 0 0.17
147 INT161148 ALB Regulation of Gene_expression of COMMD3 1 0.08 0 0.17
148 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
149 INT146552 Kcnab3 Positive_regulation of Nr5a2 1 0.07 0 0.17
150 INT207354 TBXA2R Regulation of Gene_expression of CYP27A1 1 0.01 0 0.17
151 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
152 INT207351 ZNF398 Negative_regulation of CYP27A1 1 0.00 0 0.17
153 INT161143 MPG Regulation of ALB 1 0.16 0 0.17
154 INT161145 ORM2 Regulation of ALB 1 0.06 0 0.17
155 INT207340 PTGER2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0.17
156 INT161149 ALB Regulation of OXA1L 1 0.15 0 0.17
157 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
158 INT207357 TBXA2R Positive_regulation of CYP27A1 1 0.01 0 0.16
159 INT207349 TBXA2R Regulation of CYP27A1 1 0.01 0 0.16
160 INT229289 FGF19 Negative_regulation of CYP7A1 1 0.26 0.32 0.16
161 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
162 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
163 INT86216 Hpd Regulation of NPC1 1 0.02 0.93 0.15
164 INT60364 GRP Positive_regulation of Localization of ALB 1 0.02 0.15 0.15
165 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
166 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
167 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
168 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
169 INT207346 PTGER2 Negative_regulation of Negative_regulation of CYP27A1 1 0.00 0 0.14
170 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
171 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
172 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
173 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13
174 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12
175 INT264403 NR1H4 Negative_regulation of IL1R2 1 0.04 0.09 0.12
176 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
177 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
178 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
179 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12
180 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12
181 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
182 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
183 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
184 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
185 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
186 INT133361 FABP6 Negative_regulation of PTGS2 1 0.01 0.07 0.11
187 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
188 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
189 INT133362 FABP6 Negative_regulation of LOX 1 0.01 0.08 0.11
190 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
191 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
192 INT156056 AKR1C1 Negative_regulation of UMOD 1 0.03 0.41 0.1
193 INT210363 Binding of ALB and M6PR 1 0.00 1.19 0.1
194 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1
195 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
196 INT186242 Binding of ALB and SCN5A 1 0.04 0.36 0.1
197 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
198 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
199 INT273892 LPA Positive_regulation of ALB 1 0.01 0.95 0.1
200 INT186244 Binding of AGRP and ALB 1 0.03 0.53 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported for bile acid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in bile acid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT546 Binding of ALB 311 0.48 85.98 60.14
2 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
3 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
4 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
5 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
6 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
7 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
8 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
9 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
10 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
11 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
12 INT75908 Regulation of LEP 77 0.60 60.16 15.19
13 INT18773 Localization of ALB 117 0.80 69.18 13.8
14 INT73641 Regulation of Lep 45 0.62 26.2 12.59
15 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
16 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
17 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
18 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
19 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
20 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
21 INT860 Regulation of ALB 48 0.60 25.11 8.95
22 INT82082 Localization of Lep 63 0.81 26.41 8.56
23 INT75907 Binding of LEP 53 0.46 46.65 8.44
24 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
25 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
26 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85
27 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
28 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
29 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
30 INT65356 Localization of LEP 46 0.79 41.17 5.43
31 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43
32 INT91338 Binding of Lep 31 0.48 26.86 5.39
33 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
34 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28
35 INT102935 Regulation of Lep 31 0.60 18.47 5.24
36 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04
37 INT97391 Binding of Lep 18 0.48 8.97 4.47
38 INT163581 Localization of Lep 27 0.79 18.99 4.08
39 INT76227 Binding of NPC1 30 0.41 32.31 4.05
40 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
41 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
42 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
43 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56
44 INT91929 Gene_expression of Nr5a2 5 0.31 2.15 3.52
45 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
46 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44
47 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
48 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
49 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
50 INT132575 Binding of NR1H4 57 0.20 22.06 2.82
51 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79
52 INT321310 Positive_regulation of Nr1h4 1 0.49 1.75 2.75
53 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67
54 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
55 INT169073 Positive_regulation of Nr1h4 8 0.47 2.44 2.45
56 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
57 INT31134 Regulation of Binding of ALB 13 0.62 2.51 2.37
58 INT19537 Negative_regulation of Binding of ALB 6 0.43 3.32 2.26
59 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
60 INT142626 Negative_regulation of Localization of ALB 9 0.55 6.63 2.24
61 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18
62 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18
63 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15
64 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
65 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
66 INT58108 Positive_regulation of Positive_regulation of ALB 4 0.70 1.02 2.11
67 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
68 INT36616 Positive_regulation of Binding of ALB 8 0.67 3 2.07
69 INT83392 Transcription of Lep 6 0.54 5.07 2.04
70 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02
71 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
72 INT169862 Regulation of NPC1 13 0.53 13.61 1.84
73 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
74 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
75 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51
76 INT96663 Binding of FABP6 1 0.47 3.17 1.45
77 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44
78 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
79 INT180581 Negative_regulation of Protein_catabolism of CYP27A1 2 0.29 3.19 1.43
80 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
81 INT135132 Positive_regulation of NR1H4 17 0.30 8.63 1.38
82 INT96694 Negative_regulation of Slc27a5 1 0.53 0.96 1.3
83 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23
84 INT122171 Negative_regulation of AKR1C1 5 0.59 1.92 1.22
85 INT133112 Regulation of Baat 2 0.61 11.99 1.2
86 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
87 INT213465 Transcription of Lep 4 0.68 2.11 1.15
88 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
89 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11
90 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
91 INT321329 Positive_regulation of Positive_regulation of Nr1h4 1 0.35 0.43 1.07
92 INT9075 Regulation of Positive_regulation of ALB 3 0.45 0.76 1.06
93 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05
94 INT123577 Negative_regulation of Positive_regulation of Baat 2 0.58 1.78 1.02
95 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94
96 INT57596 Regulation of Gene_expression of ALB 9 0.44 5.44 0.91
97 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
98 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
99 INT269764 Positive_regulation of Localization of CYP27A1 4 0.38 2.45 0.8
100 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
101 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
102 INT156533 Transcription of LEP 9 0.69 4.35 0.74
103 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
104 INT126646 Negative_regulation of Gene_expression of Nr5a2 1 0.20 0.1 0.71
105 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
106 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7
107 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7
108 INT262118 Negative_regulation of Binding of Nr5a2 1 0.07 0.36 0.7
109 INT262041 Binding of Nr5a2 1 0.06 0.35 0.7
110 INT46847 Phosphorylation of ALB 2 0.68 2.72 0.68
111 INT262091 Negative_regulation of Nr1h4 1 0.15 0.76 0.68
112 INT187079 Gene_expression of CYP7B1 2 0.32 1 0.66
113 INT115276 Gene_expression of AKR1C1 11 0.77 4.65 0.63
114 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
115 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
116 INT42098 Regulation of Akr1c1 1 0.37 0 0.6
117 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
118 INT44696 Gene_expression of Baat 5 0.64 3.1 0.59
119 INT176041 Transcription of FABP6 1 0.05 0.64 0.59
120 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
121 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58
122 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
123 INT95550 Negative_regulation of Positive_regulation of ALB 4 0.42 1.16 0.57
124 INT257885 Negative_regulation of Positive_regulation of CYP27A1 2 0.37 1.62 0.57
125 INT156077 Negative_regulation of Akr1c1 1 0.09 0.74 0.57
126 INT127291 Transcription of ALB 7 0.67 4.26 0.55
127 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
128 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
129 INT83217 Positive_regulation of Nr5a2 3 0.16 0 0.49
130 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
131 INT109162 Negative_regulation of Nr5a2 2 0.15 0.12 0.47
132 INT340845 Regulation of Baat 1 0.08 0 0.47
133 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
134 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46
135 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
136 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
137 INT262102 Binding of Nr1h4 1 0.13 0.34 0.43
138 INT229307 Positive_regulation of Negative_regulation of CYP7A1 1 0.31 0.1 0.43
139 INT156997 Localization of NPC1 19 0.64 30 0.42
140 INT104324 Negative_regulation of Baat 4 0.38 9.79 0.42
141 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
142 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
143 INT122170 Regulation of AKR1C1 1 0.12 0.22 0.42
144 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
145 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
146 INT91175 Regulation of Localization of ALB 4 0.28 0.1 0.41
147 INT188613 Gene_expression of CYP8B1 2 0.58 1.04 0.41
148 INT173810 Positive_regulation of Gene_expression of CYP27A1 5 0.49 1.35 0.4
149 INT187078 Positive_regulation of Gene_expression of CYP7B1 1 0.01 1 0.4
150 INT234463 Phosphorylation of NR1H4 23 0.34 14.56 0.39
151 INT85937 Protein_catabolism of ALB 6 0.86 4.31 0.38
152 INT104323 Regulation of Positive_regulation of Baat 2 0.39 1.61 0.38
153 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37
154 INT348975 Negative_regulation of Transcription of ALB 1 0.04 2.2 0.37
155 INT329889 Positive_regulation of CYP8B1 1 0.41 0.47 0.37
156 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
157 INT156401 Regulation of NR5A2 1 0.00 1.06 0.36
158 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
159 INT120525 Gene_expression of SLCO1B3 2 0.57 1.47 0.33
160 INT296900 Negative_regulation of Binding of CYP27A1 1 0.17 0.83 0.33
161 INT112287 Gene_expression of SLCO1B1 3 0.75 0.09 0.32
162 INT234456 Negative_regulation of Gene_expression of NR1H4 2 0.18 1.05 0.32
163 INT44695 Binding of Baat 1 0.26 0.67 0.32
164 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
165 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
166 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
167 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
168 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29
169 INT112288 Localization of SLCO1B1 1 0.73 0 0.29
170 INT168052 Gene_expression of Akr1c1 1 0.40 0 0.28
171 INT154494 Transcription of AKR1C1 4 0.72 0.99 0.27
172 INT78997 Negative_regulation of AKR1C4 2 0.57 0.23 0.27
173 INT156076 Negative_regulation of Localization of Akr1c1 1 0.09 0.43 0.27
174 INT156078 Localization of Akr1c1 1 0.15 0.43 0.27
175 INT201565 Positive_regulation of Gene_expression of NPC1 5 0.43 5.94 0.26
176 INT270115 Negative_regulation of Localization of CYP27A1 2 0.02 1.11 0.26
177 INT199408 Positive_regulation of FABP6 2 0.49 0.39 0.25
178 INT309880 Positive_regulation of Localization of NPC1 1 0.04 1.06 0.25
179 INT44697 Positive_regulation of Gene_expression of Baat 1 0.42 0.6 0.24
180 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
181 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23
182 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
183 INT133113 Positive_regulation of Positive_regulation of Baat 1 0.46 0.57 0.22
184 INT262108 Negative_regulation of Positive_regulation of Nr1h4 1 0.15 0.14 0.22
185 INT181826 Transcription of Baat 4 0.35 4.43 0.2
186 INT90773 Binding of AKR1C4 2 0.36 0.52 0.2
187 INT255180 Gene_expression of FABP6 1 0.58 2.67 0.2
188 INT181819 Binding of Baat 2 0.24 0.96 0.19
189 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
190 INT78998 Regulation of AKR1C4 1 0.44 0.2 0.19
191 INT120526 Positive_regulation of Gene_expression of SLCO1B3 2 0.34 0.65 0.18
192 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18
193 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
194 INT155442 Negative_regulation of Slc27a5 1 0.42 0.22 0.17
195 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
196 INT321313 Regulation of Nr1h4 1 0.32 0.37 0.17
197 INT207368 Positive_regulation of Positive_regulation of CYP27A1 1 0.04 0.37 0.17
198 INT234469 Negative_regulation of Phosphorylation of NR1H4 2 0.14 1.25 0.16
199 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
200 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
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