GO:0008207

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Name C21-steroid hormone metabolic process
Categary Process
Go Slim No
Go Link GO:0008207
Unique Molecular Interactions 77
Total Molecular Interactions 92
Total Single Events 651
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for C21-steroid hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for C21-steroid hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
2 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58
3 INT7791 Akr1d1 Regulation of Nts 1 0.03 0 1.58
4 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
5 INT7797 Akr1d1 Regulation of Sst 1 0.02 0 1.54
6 INT81097 Akr1d1 Regulation of Localization of Abat 1 0.00 0 1.2
7 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
8 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
9 INT97721 Akr1d1 Regulation of Gene_expression of Penk 1 0.00 0 0.98
10 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
11 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
12 INT80601 Akr1d1 Regulation of Positive_regulation of Fos 1 0.06 0 0.94
13 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
14 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
15 INT7799 Akr1d1 Regulation of Positive_regulation of Ptgdr 1 0.01 0 0.86
16 INT261461 Positive_regulation of Akr1d1 Regulation of Sftpd 1 0.01 0 0.86
17 INT261458 Akr1d1 Regulation of Sftpd 1 0.01 0 0.82
18 INT261447 Sftpd Positive_regulation of Akr1d1 1 0.01 0 0.77
19 INT82039 Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.74
20 INT7792 Akr1d1 Regulation of Gene_expression of Npy 1 0.02 0 0.65
21 INT261453 Binding of Akr1d1 and Ptgdr 1 0.00 0.56 0.65
22 INT82038 Positive_regulation of Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.64
23 INT63161 Akr1d1 Regulation of Gene_expression of Pdyn 1 0.01 0 0.59
24 INT54485 Positive_regulation of Akr1d1 Positive_regulation of Gene_expression of Rabep2 1 0.00 0 0.53
25 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
26 INT7291 Akr1d1 Regulation of Regulation of Penk 1 0.01 0 0.48
27 INT195192 Akr1d1 Regulation of Msn 1 0.01 0.34 0.47
28 INT261462 Akr1d1 Positive_regulation of Hrasls 1 0.00 0.3 0.33
29 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
30 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
31 INT51858 Akr1d1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0 0.27
32 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
33 INT64290 Akr1d1 Regulation of Penk 1 0.00 0 0.26
34 INT64291 Akr1d1 Regulation of Slc3a1 1 0.01 0 0.23
35 INT64289 Slc3a1 Regulation of Akr1d1 1 0.01 0 0.23
36 INT261460 Binding of Sftpd and Akr1d1 1 0.01 0.43 0.16
37 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
38 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
39 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
40 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
41 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0
42 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0
43 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
44 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for C21-steroid hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in C21-steroid hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7787 Positive_regulation of Akr1d1 52 0.66 3.55 31.71
2 INT20575 Gene_expression of Akr1d1 48 0.57 6.2 22.5
3 INT7920 Binding of Akr1d1 26 0.27 3.64 19.73
4 INT34569 Regulation of Akr1d1 26 0.24 3.06 18.37
5 INT11034 Negative_regulation of Akr1d1 23 0.18 3.43 14.84
6 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
7 INT20579 Transcription of Akr1d1 9 0.04 2.91 8.37
8 INT50572 Localization of Akr1d1 14 0.59 0.51 5.87
9 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
10 INT26754 Positive_regulation of Positive_regulation of Akr1d1 8 0.05 0.28 4.75
11 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
12 INT122511 Negative_regulation of Binding of Akr1d1 1 0.04 0.14 3.29
13 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
14 INT50571 Regulation of Gene_expression of Akr1d1 3 0.33 0.33 2.4
15 INT20578 Positive_regulation of Gene_expression of Akr1d1 5 0.22 0.26 2.1
16 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
17 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
18 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
19 INT35937 Negative_regulation of Positive_regulation of Akr1d1 2 0.40 0 1.72
20 INT73616 Positive_regulation of Localization of Akr1d1 2 0.07 0 1.68
21 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
22 INT61553 Positive_regulation of Regulation of Akr1d1 1 0.05 0 1.46
23 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
24 INT20576 Negative_regulation of Gene_expression of Akr1d1 2 0.03 0.23 1.13
25 INT168395 Transcription of Cyp19a1 2 0.51 2.5 1.06
26 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06
27 INT122347 Transcription of Hsd3b1 1 0.52 0 0.99
28 INT168398 Localization of Cyp19a1 1 0.08 0.89 0.97
29 INT82533 Regulation of Positive_regulation of Akr1d1 1 0.08 0 0.94
30 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
31 INT54353 Regulation of Transcription of Akr1d1 1 0.03 0.08 0.74
32 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
33 INT20577 Negative_regulation of Transcription of Akr1d1 1 0.02 0.23 0.66
34 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
35 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
36 INT61552 Regulation of Binding of Akr1d1 1 0.06 0 0.49
37 INT137556 Negative_regulation of Cyp19a1 3 0.35 1.53 0.48
38 INT122348 Regulation of Hsd3b1 1 0.60 0 0.46
39 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
40 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
41 INT34570 Regulation of Regulation of Akr1d1 1 0.01 0 0.35
42 INT51857 Positive_regulation of Phosphorylation of Akr1d1 1 0.01 0 0.27
43 INT51854 Phosphorylation of Akr1d1 1 0.02 0 0.27
44 INT282487 Regulation of Negative_regulation of Cyp19a1 1 0.22 0.6 0.27
45 INT220399 Positive_regulation of Cyp19a1 4 0.43 2.2 0.07
46 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06
47 INT220400 Positive_regulation of Transcription of Cyp19a1 1 0.49 0.84 0
48 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
49 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
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