GO:0008210

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Name estrogen metabolic process
Categary Process
Go Slim No
Go Link GO:0008210
Unique Molecular Interactions 63
Total Molecular Interactions 85
Total Single Events 850
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for estrogen metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for estrogen metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
2 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
3 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
4 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
5 INT168459 Sult1a1 Negative_regulation of Gene_expression of Arr3 1 0.05 2.98 1.23
6 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
7 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03
8 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
9 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
10 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
11 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84
12 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
13 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83
14 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82
15 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
16 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
17 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
18 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
19 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
20 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
21 INT327712 Binding of Comt and Rbm39 1 0.00 0.27 0.74
22 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
23 INT167455 Binding of MSD and Comt 1 0.15 0.28 0.5
24 INT168460 Sult1a1 Negative_regulation of Gene_expression of Ifih1 1 0.02 0.96 0.41
25 INT168463 Sult1a1 Negative_regulation of TNF 1 0.01 1 0.4
26 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
27 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
28 INT168454 Sult1a1 Negative_regulation of Ifih1 1 0.02 0.89 0.39
29 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37
30 INT107751 POMC Negative_regulation of HSD17B1 1 0.33 0.39 0.33
31 INT107747 CRH Negative_regulation of HSD17B1 1 0.40 0.41 0.3
32 INT327701 Comt Regulation of Npcd 1 0.01 0 0.29
33 INT327706 Comt Regulation of Gopc 1 0.10 0 0.29
34 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26
35 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
36 INT107749 IL1B Positive_regulation of HSD17B1 1 0.20 0.21 0.22
37 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21
38 INT266103 Binding of COMT and SNRNP70 1 0.04 0.78 0.21
39 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
40 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
41 INT107746 TNF Positive_regulation of HSD17B1 1 0.39 0.2 0.17
42 INT107750 CRH Regulation of Transcription of HSD17B1 1 0.19 0.21 0.17
43 INT107748 POMC Regulation of Transcription of HSD17B1 1 0.15 0.21 0.17
44 INT107745 POMC Regulation of Gene_expression of HSD17B1 1 0.25 0.21 0.17
45 INT327700 Binding of Comt and 4930579C15Rik 1 0.08 0 0.15
46 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
47 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12
48 INT335840 Binding of GAST and Sult1e1 1 0.03 1.15 0.12
49 INT327703 Cish Regulation of Transcription of Comt 1 0.13 0.77 0.12
50 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
51 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
52 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
53 INT285383 Cars Regulation of Regulation of Sult1a1 1 0.01 0 0.06
54 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
55 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
56 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0
57 INT122291 Binding of SULT1E1 and SULT1A3 1 0.33 0 0
58 INT154023 Binding of NOVA2 and Comt 1 0.03 0.08 0
59 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0
60 INT122295 Binding of SULT1E1 and SULT1A1 1 0.36 0 0
61 INT156700 Binding of Crp and UGT1A1 1 0.40 0 0
62 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for estrogen metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in estrogen metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
2 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
3 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
4 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
5 INT135629 Binding of COMT 33 0.48 16.68 19.37
6 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
7 INT101119 Negative_regulation of Comt 19 0.58 8.77 13.09
8 INT17619 Regulation of COMT 12 0.45 8.46 12.22
9 INT520 Binding of Comt 24 0.48 8.98 12.21
10 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
11 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
12 INT44537 Positive_regulation of Comt 7 0.69 2.62 7.78
13 INT101121 Regulation of Comt 19 0.53 10.66 7.22
14 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
15 INT150825 Binding of Comt 13 0.42 6.65 6.42
16 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23
17 INT2162 Regulation of Comt 13 0.60 2.9 5.18
18 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78
19 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
20 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06
21 INT172198 Protein_catabolism of Comt 7 0.88 2.78 3.6
22 INT206598 Regulation of Gene_expression of Comt 9 0.60 6 3.56
23 INT195964 Transcription of Comt 8 0.71 4.72 3.4
24 INT194289 Transcription of COMT 3 0.72 3.56 2.72
25 INT202257 Localization of COMT 7 0.75 2.13 2.65
26 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6
27 INT206593 Negative_regulation of Gene_expression of Comt 3 0.56 1.68 2.52
28 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
29 INT54969 Binding of Sult1a1 4 0.35 1.4 2.18
30 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
31 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
32 INT83744 Gene_expression of SULT1E1 9 0.75 3.12 2.07
33 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
34 INT447 Localization of Comt 4 0.75 0.76 1.8
35 INT89826 Transcription of HSD17B1 5 0.69 2.75 1.71
36 INT89824 Gene_expression of HSD17B1 5 0.75 2.69 1.66
37 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57
38 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
39 INT65165 Positive_regulation of Negative_regulation of Comt 1 0.03 0 1.15
40 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09
41 INT295326 Gene_expression of Sult1a1 2 0.65 1.29 1.06
42 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1
43 INT282479 Regulation of Protein_catabolism of Comt 2 0.45 1.17 0.85
44 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
45 INT265663 Positive_regulation of Gene_expression of COMT 2 0.50 0.26 0.79
46 INT96879 Positive_regulation of CYP1B1 14 0.70 5.73 0.78
47 INT195983 Localization of Comt 2 0.74 0.93 0.76
48 INT344931 Positive_regulation of Protein_catabolism of Comt 1 0.49 0 0.76
49 INT37113 Positive_regulation of Sult1a1 3 0.44 0.81 0.75
50 INT136963 Regulation of Protein_catabolism of COMT 1 0.24 0.49 0.72
51 INT10226 Negative_regulation of SULT1E1 10 0.58 0.57 0.6
52 INT51532 Negative_regulation of Sult1a1 2 0.50 1.72 0.55
53 INT265655 Regulation of Positive_regulation of COMT 1 0.39 0.38 0.49
54 INT37013 Negative_regulation of Sult1a1 3 0.57 0.35 0.48
55 INT327677 Regulation of Transcription of Comt 2 0.60 1.49 0.48
56 INT107755 Positive_regulation of HSD17B1 1 0.52 0.71 0.45
57 INT266128 Positive_regulation of Transcription of COMT 1 0.44 0.35 0.41
58 INT50711 Regulation of Gene_expression of Comt 2 0.01 0 0.39
59 INT56192 Regulation of Sult1a1 3 0.44 0.85 0.31
60 INT107754 Regulation of HSD17B1 1 0.46 0.68 0.31
61 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
62 INT266123 Negative_regulation of Transcription of COMT 1 0.59 0.65 0.3
63 INT287124 Negative_regulation of Protein_catabolism of Comt 1 0.38 0.22 0.29
64 INT301726 Negative_regulation of Positive_regulation of Sult1a1 1 0.04 0.35 0.27
65 INT295323 Positive_regulation of Localization of Sult1a1 1 0.49 1.3 0.27
66 INT295325 Localization of Sult1a1 1 0.73 1.29 0.27
67 INT266127 Regulation of Binding of COMT 1 0.39 0.54 0.27
68 INT107752 Negative_regulation of HSD17B1 1 0.32 0.74 0.26
69 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25
70 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25
71 INT96888 Negative_regulation of Gene_expression of CYP1B1 5 0.43 1.13 0.23
72 INT96885 Localization of CYP1B1 4 0.80 2.11 0.23
73 INT266124 Positive_regulation of Binding of COMT 1 0.44 0 0.23
74 INT96883 Positive_regulation of Gene_expression of CYP1B1 3 0.70 1.24 0.22
75 INT278672 Positive_regulation of Transcription of UGT1A1 1 0.27 0.07 0.22
76 INT278655 Negative_regulation of Gene_expression of SULT1E1 1 0.19 0 0.22
77 INT266122 Regulation of Localization of COMT 1 0.39 0 0.21
78 INT96887 Regulation of Gene_expression of CYP1B1 2 0.45 0.9 0.2
79 INT327698 Regulation of Binding of Comt 1 0.39 0 0.2
80 INT107753 Positive_regulation of Transcription of HSD17B1 1 0.35 0.25 0.19
81 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18
82 INT327691 Negative_regulation of Transcription of Comt 1 0.37 0.33 0.18
83 INT327679 Regulation of Positive_regulation of Comt 1 0.39 0.39 0.17
84 INT151741 Regulation of PDGFRA 2 0.44 0.78 0.16
85 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13
86 INT37114 Localization of Sult1a1 1 0.55 0 0.13
87 INT209806 Transcription of Comt 1 0.69 2.12 0.11
88 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08
89 INT266125 Regulation of Transcription of COMT 1 0.24 0.88 0.08
90 INT232713 Binding of PDGFRA 1 0.35 1.43 0.08
91 INT278678 Positive_regulation of Gene_expression of UGT1A1 1 0.37 0.09 0.06
92 INT285350 Regulation of Sult1a1 1 0.01 0 0.06
93 INT104466 Binding of Sult1a1 1 0.17 0.48 0.05
94 INT262005 Regulation of CYP1B1 4 0.62 4.52 0
95 INT262004 Negative_regulation of CYP1B1 4 0.59 3.24 0
96 INT262003 Binding of CYP1B1 3 0.48 3.34 0
97 INT352608 Binding of Pdgfra 1 0.27 0.7 0
98 INT320463 Transcription of CYP1B1 1 0.68 0.14 0
99 INT295427 Localization of PDGFRA 1 0.40 1.04 0
100 INT349463 Negative_regulation of Gene_expression of UGT1A1 1 0.22 1.05 0
101 INT352609 Positive_regulation of Gene_expression of Pdgfra 1 0.58 1.18 0
102 INT200836 Transcription of Pdgfra 1 0.30 0.26 0
103 INT292012 Positive_regulation of Localization of COMT 1 0.44 0.13 0
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