GO:0008211

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Name glucocorticoid metabolic process
Categary Process
Go Slim No
Go Link GO:0008211
Unique Molecular Interactions 105
Total Molecular Interactions 146
Total Single Events 1232
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for glucocorticoid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for glucocorticoid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
2 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
3 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
4 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
5 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
6 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
7 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
8 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
9 INT52820 Oprd1 Regulation of NR3C1 1 0.02 0.17 0.61
10 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54
11 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
12 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
13 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
14 INT132242 NR3C1 Regulation of Gene_expression of Slc1a1 1 0.09 0.62 0.49
15 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
16 INT352031 Binding of NR3C1 and JUND 1 0.10 2.87 0.48
17 INT141729 NR3C1 Regulation of Positive_regulation of Cnr1 1 0.06 0.7 0.47
18 INT237452 Binding of STAR and CHTF8 1 0.00 0.48 0.45
19 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
20 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
21 INT237453 Binding of STAR and MESP1 1 0.00 0.47 0.42
22 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
23 INT237454 Binding of STAR and GREM1 1 0.00 0.44 0.4
24 INT227566 NR3C1 Positive_regulation of RS1 1 0.01 0 0.4
25 INT227568 NR3C1 Positive_regulation of HTR1A 1 0.00 0 0.4
26 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38
27 INT304340 FKBP5 Regulation of NR3C1 1 0.05 0.71 0.37
28 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
29 INT235884 Htr3a Regulation of Nr3c1 1 0.00 0.63 0.32
30 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27
31 INT210803 Igh-Dex Regulation of Nr3c1 1 0.05 0 0.24
32 INT305798 Binding of APOA1 and OxP-11D 1 0.02 0.45 0.23
33 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
34 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
35 INT189321 Binding of Apoa1 and Hdlcl1 1 0.00 0.68 0.2
36 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
37 INT52306 Nr3c1 Negative_regulation of Transcription of Penk 1 0.26 0 0.18
38 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18
39 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
40 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
41 INT75036 Slc6a14 Negative_regulation of Cyp11b1 1 0.00 0.17 0.17
42 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
43 INT129868 Regulation of SERPINA6 Regulation of AVP 1 0.25 0.59 0.14
44 INT276813 NR3C1 Regulation of Gene_expression of Hgs 1 0.03 1.09 0.13
45 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
46 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
47 INT276767 NR3C1 Regulation of Gene_expression of UTS2R 1 0.00 1.09 0.13
48 INT179234 Binding of SERPINA6 and ELANE 1 0.01 0.22 0.12
49 INT68493 Pomc Positive_regulation of NR3C1 1 0.02 0 0.12
50 INT128551 Binding of Cebpb and Nr3c1 1 0.06 0.15 0.11
51 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
52 INT352030 Binding of NR3C1 and IL2 1 0.15 0.5 0.11
53 INT305780 Binding of APOA1 and LRCH2 1 0.00 0.19 0.1
54 INT346074 Binding of Alb and Serpina6 1 0.00 0 0.09
55 INT75033 Slc6a14 Negative_regulation of Gene_expression of Cyp11b1 1 0.00 0.08 0.08
56 INT245642 Nr3c1 Regulation of Gene_expression of Hpse 1 0.05 1.33 0.08
57 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08
58 INT227565 NR3C1 Positive_regulation of UFM1 1 0.00 0.07 0.08
59 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
60 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
61 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
62 INT279652 PPARA Positive_regulation of Gene_expression of Apoa1 1 0.00 0.75 0.07
63 INT278613 NR3C1 Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07
64 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
65 INT335047 PPARA Positive_regulation of Gene_expression of APOA1 1 0.20 0.42 0.05
66 INT239348 Binding of Apoa1 and Hdl1 1 0.03 3.34 0.05
67 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05
68 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05
69 INT236722 Ppara Positive_regulation of Binding of Apoa1 1 0.10 0.18 0.04
70 INT288908 Apoa1 Positive_regulation of Gene_expression of HSD11B1 1 0.03 0.53 0.04
71 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03
72 INT239345 Apoa1 Positive_regulation of RCT 1 0.02 1.15 0.03
73 INT186248 NR5A1 Positive_regulation of Transcription of STAR 1 0.01 0.21 0
74 INT239332 Hdl1 Positive_regulation of Gene_expression of Apoa1 1 0.04 0.84 0
75 INT247444 Binding of APOA1 and APOC3 1 0.28 0.39 0
76 INT299438 Foxl2 Negative_regulation of Star 1 0.37 0.16 0
77 INT213017 Apoa1 Negative_regulation of Positive_regulation of Gtf3a 1 0.00 1.16 0
78 INT247436 Binding of APOA1 and SACM1L 1 0.27 0.39 0
79 INT290193 Binding of APOA1 and Hdl1 1 0.01 1 0
80 INT239353 CETP Regulation of Apoa1 1 0.16 0.65 0
81 INT239342 Lcat Regulation of Apoa1 1 0.16 0.65 0
82 INT326060 Binding of ABCA1 and APOA1 1 0.39 1.5 0
83 INT326058 Negative_regulation of PRKCA Negative_regulation of APOA1 1 0.15 0.32 0
84 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
85 INT326064 APOA1 Positive_regulation of HMGCR 1 0.16 0.19 0
86 INT182818 EEF1A2 Negative_regulation of STAR 1 0.01 1.48 0
87 INT213043 Regulation of Binding of Apoa1 and Scarb1 1 0.05 1.12 0
88 INT193343 Binding of STAR and WASF1 1 0.04 0 0
89 INT259452 Binding of STAR and Cyp11a1 1 0.25 0.06 0
90 INT239321 Binding of Abca1 and Apoa1 1 0.11 1.61 0
91 INT239319 Pltp Regulation of Apoa1 1 0.22 0.65 0
92 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
93 INT292155 Binding of STAR and SFTPA1 1 0.00 0.42 0
94 INT300197 Binding of APOA1 and C1S 1 0.39 3.56 0
95 INT239350 Eef1a2 Positive_regulation of Apoa1 1 0.22 0.86 0
96 INT247440 Binding of APOA1 and APOB 1 0.28 1.02 0
97 INT304270 Binding of Apoa1 and Scarb1 1 0.00 0.39 0
98 INT326066 APOA1 Positive_regulation of Positive_regulation of HMGCR 1 0.17 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for glucocorticoid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in glucocorticoid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83
2 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7
3 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
4 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65
5 INT10065 Positive_regulation of Serpina6 12 0.70 1.48 8.22
6 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02
7 INT66318 Gene_expression of NR3C1 26 0.76 20 7.55
8 INT49749 Negative_regulation of Nr3c1 13 0.43 6.25 7.36
9 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
10 INT7564 Positive_regulation of Nr3c1 16 0.68 4.98 6.25
11 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
12 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
13 INT38686 Binding of NR3C1 20 0.48 9.25 5.99
14 INT52819 Negative_regulation of NR3C1 14 0.50 7.22 5.84
15 INT52814 Negative_regulation of Nr3c1 9 0.57 5.69 5.41
16 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38
17 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
18 INT52818 Localization of NR3C1 13 0.69 7.65 4.57
19 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56
20 INT125282 Negative_regulation of Positive_regulation of NR3C1 3 0.57 0.54 4.31
21 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06
22 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82
23 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
24 INT76399 Binding of Serpina6 4 0.34 3.81 3.46
25 INT131165 Positive_regulation of Gene_expression of Nr3c1 8 0.70 7.18 3.44
26 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
27 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3
28 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64
29 INT77250 Positive_regulation of Gene_expression of Nr3c1 4 0.44 3.32 2.64
30 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43
31 INT8484 Localization of Nr3c1 8 0.53 3.12 2.32
32 INT71490 Positive_regulation of Positive_regulation of Serpina6 3 0.70 0.16 2.27
33 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24
34 INT125281 Positive_regulation of Positive_regulation of NR3C1 1 0.49 0 2.11
35 INT51316 Regulation of NR3C1 7 0.51 4.23 2.09
36 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08
37 INT99039 Negative_regulation of Gene_expression of Nr3c1 2 0.37 1.96 2.08
38 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
39 INT135313 Regulation of Gene_expression of Nr3c1 3 0.39 3.44 1.94
40 INT52305 Binding of Nr3c1 7 0.15 3.95 1.9
41 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
42 INT167456 Regulation of Gene_expression of Nr3c1 2 0.14 0.76 1.87
43 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86
44 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
45 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
46 INT26750 Positive_regulation of Nr3c1 6 0.46 5.46 1.75
47 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
48 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67
49 INT156484 Binding of Apoa1 4 0.47 6.78 1.63
50 INT49448 Positive_regulation of Positive_regulation of Nr3c1 1 0.38 0 1.55
51 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
52 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
53 INT7578 Transcription of Nr3c1 5 0.32 0.43 1.47
54 INT181881 Positive_regulation of Gene_expression of Apoa1 13 0.48 14.31 1.45
55 INT181882 Localization of Apoa1 8 0.71 7.94 1.37
56 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
57 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24
58 INT177629 Negative_regulation of SERPINA6 5 0.57 2.1 1.22
59 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
60 INT45674 Regulation of Gene_expression of Serpina6 3 0.14 0.86 1.14
61 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11
62 INT179262 Localization of SERPINA6 4 0.16 1.29 1.1
63 INT71491 Negative_regulation of Positive_regulation of Serpina6 2 0.59 0.3 1.04
64 INT91776 Negative_regulation of Gene_expression of Nr3c1 4 0.42 2.26 1.03
65 INT96327 Transcription of Serpina6 1 0.29 0 1.03
66 INT76398 Regulation of Binding of Serpina6 1 0.18 0.24 1.02
67 INT27587 Positive_regulation of STAR 7 0.46 6.37 0.99
68 INT166449 Positive_regulation of Gene_expression of NR3C1 4 0.68 3.73 0.99
69 INT76757 Positive_regulation of SERPINA6 3 0.59 1.19 0.97
70 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89
71 INT248304 Positive_regulation of Localization of Nr3c1 2 0.10 1.39 0.87
72 INT306786 Binding of STAR 3 0.47 1.71 0.86
73 INT181885 Binding of Apoa1 7 0.35 5.66 0.84
74 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
75 INT328725 Localization of Serpina6 1 0.50 1.51 0.71
76 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
77 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
78 INT68486 Transcription of NR3C1 4 0.20 0.19 0.69
79 INT280463 Binding of Mecp2 3 0.37 4 0.63
80 INT96321 Negative_regulation of Gene_expression of Serpina6 1 0.23 0 0.62
81 INT96325 Negative_regulation of Transcription of Serpina6 1 0.24 0 0.62
82 INT7576 Positive_regulation of Transcription of Nr3c1 1 0.19 0.3 0.62
83 INT181888 Regulation of Apoa1 5 0.26 5.07 0.6
84 INT213118 Negative_regulation of Gene_expression of Apoa1 2 0.42 2.86 0.6
85 INT96323 Regulation of Transcription of Nr3c1 1 0.20 0 0.59
86 INT170768 Regulation of Gene_expression of NR3C1 3 0.42 2.61 0.58
87 INT83353 Negative_regulation of Binding of NR3C1 3 0.24 1.09 0.57
88 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
89 INT20239 Regulation of APOA1 10 0.60 10.98 0.51
90 INT299420 Negative_regulation of Gene_expression of Star 1 0.33 6.66 0.5
91 INT129748 Transcription of Nr3c1 1 0.58 0.53 0.48
92 INT129747 Regulation of Transcription of Nr3c1 1 0.22 0.53 0.48
93 INT290850 Regulation of Positive_regulation of Nr3c1 1 0.12 0.75 0.47
94 INT96326 Positive_regulation of Gene_expression of Serpina6 2 0.27 0.5 0.46
95 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
96 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
97 INT103896 Negative_regulation of Gene_expression of NR3C1 1 0.09 0.83 0.45
98 INT190882 Regulation of Gene_expression of Apoa1 4 0.23 3.67 0.43
99 INT52815 Regulation of Negative_regulation of Nr3c1 1 0.08 0.05 0.43
100 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
101 INT177628 Protein_catabolism of SERPINA6 2 0.96 1.2 0.42
102 INT175024 Positive_regulation of Localization of NR3C1 1 0.10 0.5 0.41
103 INT96322 Positive_regulation of Transcription of Serpina6 1 0.26 0 0.41
104 INT38685 Regulation of Binding of NR3C1 2 0.61 0.59 0.4
105 INT190691 Negative_regulation of APOA1 12 0.42 15.9 0.39
106 INT181883 Negative_regulation of Negative_regulation of Apoa1 1 0.40 1.24 0.39
107 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
108 INT72673 Transcription of APOA1 2 0.52 1.2 0.36
109 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
110 INT128546 Binding of Nr3c1 4 0.34 1.4 0.35
111 INT261209 Localization of Apoa1 4 0.73 2.61 0.33
112 INT307779 Positive_regulation of Localization of Apoa1 1 0.49 0.88 0.31
113 INT189968 Binding of APOA1 12 0.47 10.1 0.3
114 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
115 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
116 INT57359 Positive_regulation of Gene_expression of STAR 8 0.49 2.71 0.24
117 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
118 INT89580 Negative_regulation of STAR 16 0.35 14.88 0.2
119 INT190874 Negative_regulation of Gene_expression of Apoa1 1 0.15 0.9 0.2
120 INT151659 Regulation of Positive_regulation of Nr3c1 1 0.03 0.1 0.2
121 INT11846 Regulation of Cyp11b1 3 0.15 0 0.19
122 INT79657 Positive_regulation of Transcription of NR3C1 1 0.17 0.09 0.19
123 INT79655 Positive_regulation of Phosphorylation of NR3C1 1 0.17 0.09 0.19
124 INT79662 Phosphorylation of NR3C1 1 0.30 0.09 0.19
125 INT239275 Regulation of Localization of Apoa1 1 0.19 1.62 0.18
126 INT317595 Negative_regulation of Transcription of Nr3c1 1 0.05 0.14 0.18
127 INT177627 Negative_regulation of Protein_catabolism of SERPINA6 1 0.57 0.53 0.17
128 INT297577 Localization of APOA1 12 0.65 4.58 0.15
129 INT252219 Negative_regulation of Binding of Apoa1 1 0.16 0.95 0.15
130 INT179259 Negative_regulation of Localization of SERPINA6 1 0.08 0.5 0.13
131 INT268931 Positive_regulation of Regulation of Nr3c1 1 0.10 0.34 0.13
132 INT179253 Regulation of SERPINA6 1 0.06 0.57 0.12
133 INT190693 Negative_regulation of Regulation of APOA1 1 0.09 1.94 0.11
134 INT299416 Gene_expression of Star 1 0.53 1.72 0.1
135 INT75015 Gene_expression of Cyp11b1 1 0.01 0.08 0.08
136 INT75021 Negative_regulation of Gene_expression of Cyp11b1 1 0.01 0.08 0.08
137 INT280628 Regulation of Transcription of NR3C1 1 0.09 0 0.07
138 INT134850 Positive_regulation of Negative_regulation of Nr3c1 1 0.02 0 0.04
139 INT335114 Negative_regulation of Transcription of APOA1 1 0.16 0.46 0.04
140 INT255452 Negative_regulation of Gene_expression of APOA1 1 0.41 2.46 0.03
141 INT299403 Regulation of Star 5 0.39 0.78 0
142 INT254042 Regulation of Gene_expression of STAR 2 0.10 3.16 0
143 INT267959 Negative_regulation of Positive_regulation of APOA1 2 0.41 1.4 0
144 INT265946 Regulation of STAR 2 0.04 3.15 0
145 INT326078 Positive_regulation of Negative_regulation of APOA1 1 0.40 0.32 0
146 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
147 INT326072 Negative_regulation of Localization of APOA1 1 0.34 0.38 0
148 INT245628 Regulation of Localization of Nr3c1 1 0.15 0 0
149 INT255448 Positive_regulation of Binding of APOA1 1 0.48 2.88 0
150 INT186254 Transcription of STAR 1 0.02 0.2 0
151 INT255449 Positive_regulation of Positive_regulation of APOA1 1 0.48 1.44 0
152 INT320939 Transcription of Mecp2 1 0.69 0.2 0
153 INT328132 Regulation of Mecp2 1 0.40 1 0
154 INT326079 Regulation of Localization of APOA1 1 0.36 0.24 0
155 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
156 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
157 INT299423 Transcription of Star 1 0.54 0.06 0
158 INT213117 Negative_regulation of Positive_regulation of Apoa1 1 0.07 0.54 0
159 INT326068 Positive_regulation of Localization of APOA1 1 0.40 1.76 0
160 INT288894 Regulation of Localization of Apoa1 1 0.14 0.42 0
161 INT299405 Positive_regulation of Star 1 0.39 0.07 0
162 INT97919 Negative_regulation of Cyp11b1 1 0.33 0 0
163 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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