GO:0008219

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Name cell death
Categary Process
Go Slim Yes
Go Link GO:0008219
Unique Molecular Interactions 1533
Total Molecular Interactions 2070
Total Single Events 17690
Pain Genes Associated 119

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell death. They are ordered first by their pain relevance and then by number of times they were reported for cell death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
2 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
3 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
4 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
5 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
6 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
7 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
8 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
9 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
10 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
11 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
12 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
13 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
14 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
15 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
16 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
17 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
18 INT23755 Mptp1 Regulation of PDYN 1 0.01 2.27 1.98
19 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
20 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
21 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
22 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
23 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
24 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
25 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
26 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 0.03 0 1.63
27 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
28 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
29 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
30 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
31 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
32 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
33 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5
34 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
35 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
36 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
37 INT41591 Binding of PDYN and FAIM3 1 0.00 0 1.41
38 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
39 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
40 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
41 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
42 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
43 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
44 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
45 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
46 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
47 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
48 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
49 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
50 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
51 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
52 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
53 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
54 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
55 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
56 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
57 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15
58 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
59 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 0.02 0.82 1.13
60 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1
61 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
62 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
63 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07
64 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
65 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
66 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
67 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
68 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
69 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99
70 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
71 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
72 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
73 INT20888 POMC Positive_regulation of Localization of PDYN 1 0.40 0 0.92
74 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
75 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
76 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
77 INT346266 MTX1 Regulation of IL17A 1 0.08 1.33 0.89
78 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
79 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
80 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
81 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
82 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88
83 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
84 INT42765 Binding of PDYN and Oprl1 1 0.00 0 0.87
85 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
86 INT323698 Gene_expression of MIR146A Regulation of FAF1 1 0.16 1.82 0.86
87 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
88 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
89 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
90 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
91 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
92 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
93 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
94 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
95 INT18663 PDYN Negative_regulation of Binding of Gnrhr 1 0.01 0 0.83
96 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
97 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
98 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
99 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
100 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
101 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
102 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
103 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76
104 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
105 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
106 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
107 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
108 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
109 INT137699 AR Regulation of PDYN 1 0.46 0.93 0.75
110 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
111 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
112 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74
113 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
114 INT133939 Binding of OPRL1 and PDYN 1 0.00 0 0.73
115 INT133934 Binding of OPRD1 and PDYN 1 0.02 0 0.73
116 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
117 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
118 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
119 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
120 INT187171 Binding of Tnfrsf1b and Gtf3a 1 0.03 2.15 0.72
121 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
122 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
123 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71
124 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
125 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
126 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
127 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
128 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
129 INT45497 PDYN Positive_regulation of TNFRSF10B 1 0.52 0 0.7
130 INT133944 Binding of PDYN and TP53INP2 1 0.00 0 0.69
131 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
132 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
133 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
134 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
135 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
136 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
137 INT240065 KCNIP3 Regulation of Transcription of PDYN 1 0.42 0.88 0.67
138 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
139 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67
140 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66
141 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
142 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
143 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
144 INT70833 Binding of PDYN and Pnoc 1 0.53 0 0.65
145 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
146 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
147 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
148 INT70161 Casp1 Regulation of Oprd1 1 0.03 0 0.65
149 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
150 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
151 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
152 INT48303 MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
153 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
154 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
155 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
156 INT77529 PDYN Positive_regulation of Odc1 1 0.02 0 0.63
157 INT36511 Binding of Htr2a and Eef1a1 1 0.22 0 0.62
158 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
159 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
160 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
161 INT36512 Binding of Htr2a and Man2a2 1 0.19 0 0.62
162 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
163 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
164 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
165 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
166 INT109256 PDYN Positive_regulation of Binding of CRYGS 1 0.00 0.1 0.61
167 INT77120 Pomc Regulation of HYAL1 1 0.01 0 0.61
168 INT34840 Binding of KNG1 and PDYN 1 0.01 0 0.61
169 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
170 INT47461 PDYN Regulation of POMC 1 0.01 0 0.6
171 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
172 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
173 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
174 INT240069 KCNIP3 Regulation of Gene_expression of PDYN 1 0.25 0.75 0.59
175 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
176 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
177 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58
178 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
179 INT72416 Binding of PDYN and El2 1 0.45 0 0.58
180 INT62035 PDYN Regulation of Gene_expression of IGHE 1 0.33 0 0.57
181 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
182 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
183 INT27871 Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
184 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
185 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
186 INT133913 Faf1 Negative_regulation of Regulation of TRPV1 1 0.18 0.16 0.56
187 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
188 INT306935 Tnfsf12 Positive_regulation of Gene_expression of Cxcl10 1 0.03 3.55 0.55
189 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
190 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
191 INT133914 Binding of TRPV1 and Faf1 1 0.20 0.17 0.55
192 INT221783 Nlrp1a Negative_regulation of Camk4 1 0.08 1.39 0.55
193 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
194 INT350150 Binding of LPP and ATXN2 1 0.35 1.82 0.54
195 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
196 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
197 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
198 INT353978 Lmx1b Regulation of Gene_expression of Pet1 1 0.31 0.21 0.53
199 INT77098 Nlrp1a Negative_regulation of Positive_regulation of Ppig 1 0.47 0.68 0.53
200 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell death. They are ordered first by their pain relevance and then by number of times they were reported in cell death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65
2 INT442 Localization of PDYN 99 0.81 11.87 72.75
3 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04
4 INT1430 Regulation of PDYN 88 0.60 16.99 60.32
5 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
6 INT1510 Binding of PDYN 94 0.48 4.68 56.44
7 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
8 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14
9 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
10 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33
11 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
12 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
13 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
14 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
15 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
16 INT8531 Transcription of PDYN 56 0.72 19.51 30.99
17 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
18 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
19 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
20 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
21 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
22 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23
23 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
24 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
25 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
26 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
27 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
28 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
29 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
30 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
31 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
32 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47
33 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
34 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
35 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
36 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
37 INT9663 Protein_catabolism of PDYN 43 0.99 0.67 16.15
38 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37
39 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23
40 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82
41 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
42 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
43 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
44 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
45 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
46 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
47 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
48 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
49 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
50 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
51 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
52 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
53 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41
54 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
55 INT29745 Binding of APP 47 0.48 26.49 12.4
56 INT12232 Regulation of Gene_expression of PDYN 21 0.60 9.91 12.18
57 INT28770 Negative_regulation of Gene_expression of PDYN 16 0.57 4.95 12.06
58 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
59 INT29964 Positive_regulation of Positive_regulation of PDYN 9 0.67 1.56 11.31
60 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
61 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
62 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03
63 INT95341 Gene_expression of NDOR1 17 0.75 4.27 10.98
64 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
65 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
66 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
67 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69
68 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
69 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38
70 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06
71 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
72 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
73 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
74 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
75 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
76 INT41569 Regulation of APP 32 0.62 17.15 9.4
77 INT35707 Gene_expression of Nlrp1a 20 0.75 9.61 9.32
78 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22
79 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
80 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
81 INT35366 Binding of AR 87 0.47 30.52 8.9
82 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
83 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
84 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
85 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
86 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
87 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
88 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
89 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
90 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
91 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
92 INT27785 Regulation of HTR2A 11 0.44 8 8.18
93 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
94 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
95 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72
96 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
97 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
98 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
99 INT114394 Negative_regulation of Positive_regulation of Nlrp1a 4 0.42 1.09 7.37
100 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31
101 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
102 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
103 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15
104 INT8532 Regulation of Transcription of PDYN 10 0.44 4.97 6.95
105 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
106 INT195442 Gene_expression of FIG4 23 0.65 5.13 6.92
107 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
108 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
109 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
110 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61
111 INT18460 Positive_regulation of Transcription of PDYN 11 0.67 2.14 6.61
112 INT77789 Positive_regulation of Tnfrsf1b 12 0.65 13.77 6.58
113 INT206603 Localization of Nlrp1a 9 0.16 1.37 6.57
114 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
115 INT38807 Negative_regulation of PLA2G6 29 0.59 10.1 6.42
116 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
117 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
118 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
119 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
120 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
121 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
122 INT48308 Binding of PLP1 7 0.48 9.59 6.09
123 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
124 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
125 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
126 INT163540 Gene_expression of HYAL1 27 0.68 12.11 5.95
127 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
128 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
129 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
130 INT107619 Gene_expression of PTGER3 42 0.75 15 5.61
131 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
132 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
133 INT51337 Binding of Clu 3 0.12 0.05 5.45
134 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
135 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25
136 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
137 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
138 INT173584 Localization of IL17A 14 0.74 10.83 5.19
139 INT123422 Gene_expression of Lmx1b 18 0.78 6.93 5.17
140 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
141 INT171033 Localization of SMPD1 15 0.16 11.92 5.16
142 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15
143 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
144 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
145 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
146 INT48307 Positive_regulation of PLP1 5 0.66 8.42 5.09
147 INT171019 Gene_expression of SMPD1 26 0.27 12.08 5.08
148 INT89546 Phosphorylation of NEFH 10 0.76 3.49 5.08
149 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
150 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
151 INT99091 Regulation of AR 70 0.45 31.68 5.05
152 INT91475 Binding of NDOR1 3 0.27 0.61 4.97
153 INT17234 Positive_regulation of Negative_regulation of PDYN 4 0.45 0.66 4.89
154 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
155 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87
156 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84
157 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
158 INT113373 Positive_regulation of Gene_expression of Tnfrsf1b 15 0.65 8.64 4.79
159 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73
160 INT5205 Localization of AR 43 0.80 12.87 4.63
161 INT84727 Negative_regulation of Gene_expression of AR 38 0.58 12.46 4.63
162 INT9390 Negative_regulation of Negative_regulation of PDYN 5 0.42 1.31 4.54
163 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
164 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
165 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
166 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
167 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
168 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
169 INT58003 Localization of APP 32 0.80 13.75 4.2
170 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
171 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
172 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
173 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4
174 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
175 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
176 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
177 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
178 INT116349 Positive_regulation of Gene_expression of NDOR1 3 0.47 2.56 3.86
179 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
180 INT103579 Negative_regulation of Positive_regulation of PDYN 2 0.42 1.34 3.77
181 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
182 INT60667 Transcription of HTR2A 5 0.67 0.44 3.71
183 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69
184 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64
185 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
186 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
187 INT18662 Negative_regulation of Binding of PDYN 5 0.57 0.34 3.58
188 INT88197 Binding of ZAK 9 0.46 6.23 3.54
189 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53
190 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
191 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
192 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
193 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
194 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
195 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
196 INT207449 Negative_regulation of OLR1 23 0.42 17.17 3.37
197 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
198 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
199 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
200 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
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