GO:0008234

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Name cysteine-type peptidase activity
Categary Function
Go Slim No
Go Link GO:0008234
Unique Molecular Interactions 403
Total Molecular Interactions 486
Total Single Events 6799
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cysteine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for cysteine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
2 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
3 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
4 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
5 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
6 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
7 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
8 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
9 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
10 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
11 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
12 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
13 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
14 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
15 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
16 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
17 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
18 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
19 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
20 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
21 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
22 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
23 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
24 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
25 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
26 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
27 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
28 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
29 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
30 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
31 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
32 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
33 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
34 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
35 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
36 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
37 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96
38 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96
39 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
40 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
41 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
42 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
43 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
44 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
45 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
46 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
47 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
48 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
49 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
50 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
51 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
52 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
53 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
54 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
55 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
56 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
57 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
58 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
59 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
60 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
61 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
62 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
63 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
64 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
65 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
66 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58
67 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
68 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
69 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
70 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
71 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
72 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
73 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
74 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
75 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
76 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
77 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
78 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
79 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43
80 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41
81 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
82 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
83 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
84 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41
85 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
86 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
87 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
88 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
89 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
90 INT122502 TNF Positive_regulation of Localization of CAPN2 1 0.24 0.18 0.38
91 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
92 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
93 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36
94 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
95 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
96 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
97 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
98 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
99 INT50107 Ei24 Positive_regulation of Localization of CTSB 3 0.00 0.6 0.29
100 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
101 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28
102 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27
103 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
104 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27
105 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
106 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
107 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
108 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
109 INT159991 Ctsk Positive_regulation of POMC 1 0.01 0.35 0.25
110 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
111 INT296449 Binding of Gria1 and Tinagl1 1 0.08 0.25 0.23
112 INT69042 Negative_regulation of Casp1 Negative_regulation of Positive_regulation of IL1B 1 0.21 0.17 0.22
113 INT69041 Casp1 Negative_regulation of Gene_expression of IL1B 1 0.21 0.17 0.22
114 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
115 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
116 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
117 INT69040 Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
118 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
119 INT69039 Negative_regulation of Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
120 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22
121 INT247112 Binding of MPZ and SENP8 1 0.00 2.47 0.21
122 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
123 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
124 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
125 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
126 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
127 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
128 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
129 INT349538 Smcp Positive_regulation of Positive_regulation of Casp9 1 0.04 0.68 0.18
130 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
131 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
132 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
133 INT69038 Casp1 Regulation of Gene_expression of IFNA1 1 0.07 0.16 0.18
134 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18
135 INT96417 CYC1 Positive_regulation of Casp9 1 0.02 0.96 0.17
136 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
137 INT10291 Trh Regulation of CTSC 1 0.01 0 0.16
138 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
139 INT199128 Ctsb Positive_regulation of Prss1 1 0.02 0.9 0.15
140 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15
141 INT199129 Ctsb Positive_regulation of PRSS1 1 0.01 0.9 0.15
142 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
143 INT181997 TNFRSF11B Negative_regulation of CTSK 1 0.05 0.58 0.14
144 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
145 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
146 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
147 INT301283 Nfatc1 Regulation of Ctsk 1 0.06 0.19 0.13
148 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
149 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
150 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
151 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
152 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
153 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
154 INT321578 Binding of Plaur and Positive_regulation of Ctsb 1 0.15 0.92 0.12
155 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
156 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
157 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
158 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
159 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
160 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
161 INT205709 CAMP Positive_regulation of Positive_regulation of Casp1 1 0.00 0.27 0.11
162 INT171645 Negative_regulation of CTSB Positive_regulation of PRSS1 1 0.44 0.36 0.1
163 INT171644 CTSB Positive_regulation of PRSS1 1 0.52 0.36 0.1
164 INT171648 Binding of CTSB and PRSS1 1 0.27 0.42 0.1
165 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
166 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
167 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
168 INT258143 Binding of Hcrt and Atxn3 1 0.15 1.93 0.08
169 INT278376 Negative_regulation of Casp1 Negative_regulation of Hps5 1 0.05 0.05 0.08
170 INT240484 Ctsk Positive_regulation of Protein_catabolism of Col7a1 1 0.12 0.42 0.07
171 INT264300 CTSK Positive_regulation of CYP27A1 1 0.03 0.69 0.07
172 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
173 INT313807 Binding of TYRP1 and YOD1 1 0.00 0.49 0.06
174 INT313804 Binding of VARS and YOD1 1 0.00 0.49 0.06
175 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
176 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
177 INT62030 Bche Regulation of Localization of CTSB 1 0.09 0.15 0.06
178 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
179 INT313806 Binding of TYR and YOD1 1 0.01 0.49 0.06
180 INT320402 Binding of Usp14 and Psmb10 1 0.00 0 0.05
181 INT65410 Penk Positive_regulation of Uchl1 1 0.05 0.19 0.05
182 INT65415 Penk Positive_regulation of Binding of Uchl1 1 0.05 0.19 0.05
183 INT65413 Tac1 Positive_regulation of Uchl1 1 0.02 0.19 0.05
184 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
185 INT242411 Mch Positive_regulation of Casp3 1 0.09 0.15 0.04
186 INT331350 Mir483 Negative_regulation of BC051665 1 0.00 0 0.04
187 INT353665 Binding of CXCL10 and SENP8 1 0.02 0.34 0.04
188 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
189 INT320439 Binding of Uchl5 and Psmb10 1 0.00 0 0.04
190 INT242413 Regulation of Mch Positive_regulation of Casp3 1 0.05 0.16 0.04
191 INT353670 Binding of DCPS and SENP8 1 0.00 0.34 0.04
192 INT110967 REG1A Positive_regulation of Gene_expression of CTSB 1 0.01 0 0.04
193 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04
194 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
195 INT251565 Binding of Casp8 and Fadd 1 0.04 1.18 0.04
196 INT251570 Binding of Casp8 and Faf1 1 0.01 1.18 0.04
197 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
198 INT172897 Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3 1 0.04 1.19 0.03
199 INT172910 Lox Positive_regulation of Positive_regulation of Casp3 1 0.03 1.19 0.03
200 INT220445 Bcl2 Negative_regulation of Positive_regulation of Casp9 1 0.01 1.37 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for cysteine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in cysteine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
9 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
10 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
11 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
12 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
13 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
14 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
15 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
16 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
17 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
18 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
19 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
20 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
21 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
22 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
23 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
24 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
25 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
26 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
27 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
28 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
29 INT98178 Localization of Casp3 32 0.65 21.01 7.77
30 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
31 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
32 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42
33 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28
34 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
35 INT57232 Binding of Casp3 22 0.36 9.42 6.2
36 INT181017 Gene_expression of Ctss 6 0.65 9.82 6.19
37 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
38 INT50105 Localization of CTSB 29 0.78 10.98 5.21
39 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
40 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
41 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
42 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
43 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
44 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
45 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
46 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04
47 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
48 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
49 INT110980 Gene_expression of CTSB 17 0.45 8.02 2.69
50 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
51 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58
52 INT73028 Positive_regulation of Transcription of Ctsb 1 0.55 1.53 2.54
53 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53
54 INT141183 Gene_expression of Casp9 9 0.75 11.96 2.46
55 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
56 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44
57 INT37427 Positive_regulation of Gene_expression of Ctsb 2 0.37 1.02 2.33
58 INT31118 Localization of Casp3 17 0.73 11.55 2.3
59 INT7173 Regulation of Positive_regulation of Ctsb 1 0.49 0 2.29
60 INT159989 Positive_regulation of Ctsk 17 0.69 10.51 2.25
61 INT129280 Gene_expression of Casp9 9 0.68 5.48 2.25
62 INT224620 Positive_regulation of Gene_expression of Ctsk 13 0.68 8.35 2.21
63 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
64 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
65 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
66 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
67 INT146660 Negative_regulation of Ctsk 9 0.43 6.01 2.07
68 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04
69 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91
70 INT153775 Positive_regulation of CTSK 9 0.52 5.44 1.9
71 INT47302 Regulation of Gene_expression of Ctsl 2 0.53 0.54 1.77
72 INT122503 Localization of CAPN2 1 0.35 1.43 1.76
73 INT121964 Positive_regulation of Positive_regulation of Casp9 8 0.32 5.52 1.73
74 INT50106 Positive_regulation of Localization of CTSB 9 0.33 3.15 1.69
75 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69
76 INT73027 Transcription of Ctsb 1 0.56 1.01 1.68
77 INT88916 Negative_regulation of Casp9 5 0.33 3.01 1.67
78 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
79 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
80 INT88920 Negative_regulation of Positive_regulation of Casp9 7 0.59 5.27 1.57
81 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
82 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
83 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
84 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
85 INT42335 Binding of CTSB 11 0.34 5.98 1.37
86 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
87 INT69034 Regulation of Casp1 3 0.27 3.56 1.36
88 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
89 INT181055 Positive_regulation of Ctss 5 0.67 2.84 1.35
90 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32
91 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
92 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
93 INT96073 Localization of Casp1 11 0.78 4.91 1.29
94 INT244415 Regulation of Ctss 1 0.26 1.57 1.17
95 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15
96 INT141184 Negative_regulation of Casp9 5 0.42 5.48 1.15
97 INT141190 Negative_regulation of Transcription of Casp9 1 0.57 1.42 1.15
98 INT141178 Transcription of Casp9 1 0.69 1.42 1.14
99 INT47305 Positive_regulation of Gene_expression of Ctsl 5 0.59 2.06 1.12
100 INT20317 Localization of Ctsb 3 0.81 0.68 1.12
101 INT59136 Negative_regulation of Positive_regulation of CTSB 3 0.41 2.02 1.11
102 INT182005 Positive_regulation of Gene_expression of CTSK 7 0.52 4.01 1.08
103 INT267750 Binding of Casp1 4 0.35 1.53 1.02
104 INT141187 Positive_regulation of Gene_expression of Casp9 3 0.49 4.2 1
105 INT209423 Negative_regulation of Gene_expression of Ctsk 4 0.41 2.4 0.96
106 INT6534 Negative_regulation of Ctsl1 3 0.54 0.11 0.94
107 INT31117 Binding of Casp3 14 0.23 5.27 0.93
108 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
109 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
110 INT96074 Negative_regulation of Gene_expression of Casp1 4 0.57 2.77 0.87
111 INT7175 Negative_regulation of Positive_regulation of Ctsb 1 0.34 0 0.86
112 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
113 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
114 INT123124 Positive_regulation of Gene_expression of Uchl1 1 0.49 0.54 0.84
115 INT123125 Positive_regulation of Positive_regulation of Uchl1 1 0.49 0.54 0.84
116 INT101146 Positive_regulation of Transcription of Uchl1 1 0.13 1.22 0.84
117 INT101145 Transcription of Uchl1 1 0.18 1.17 0.82
118 INT159728 Localization of Uchl1 2 0.73 0.54 0.8
119 INT120046 Negative_regulation of Localization of Ctsl 2 0.40 0.31 0.8
120 INT205685 Regulation of Positive_regulation of Casp1 3 0.11 1.62 0.78
121 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
122 INT181040 Positive_regulation of Gene_expression of Ctss 2 0.45 1.51 0.75
123 INT137503 Positive_regulation of Positive_regulation of Casp9 6 0.67 4.66 0.74
124 INT159988 Localization of Ctsk 5 0.70 2.9 0.74
125 INT182049 Protein_catabolism of Casp1 3 0.20 1.64 0.73
126 INT79243 Negative_regulation of Localization of CTSB 2 0.57 1.35 0.73
127 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
128 INT244413 Regulation of Transcription of Ctss 1 0.26 0.89 0.71
129 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7
130 INT156875 Positive_regulation of Gene_expression of Casp8 2 0.49 2.49 0.7
131 INT20318 Regulation of Ctsb 1 0.54 0.19 0.69
132 INT244416 Transcription of Ctss 1 0.52 0.88 0.68
133 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
134 INT285006 Positive_regulation of Casp7 4 0.25 4.11 0.66
135 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
136 INT189960 Gene_expression of SENP8 9 0.54 17.54 0.64
137 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
138 INT126164 Positive_regulation of Ctsb 15 0.49 3.34 0.63
139 INT59137 Protein_catabolism of CTSB 5 0.96 3.92 0.62
140 INT153773 Regulation of Gene_expression of CTSK 2 0.34 1.36 0.62
141 INT243712 Positive_regulation of Gene_expression of Uchl1 4 0.21 2.68 0.61
142 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
143 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
144 INT28687 Gene_expression of Ctsl1 4 0.61 0.48 0.57
145 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
146 INT67297 Negative_regulation of CTSC 3 0.42 0.5 0.54
147 INT51843 Localization of Ctsl1 3 0.62 0.54 0.54
148 INT69142 Positive_regulation of Atxn3 3 0.50 1.52 0.53
149 INT90078 Negative_regulation of Positive_regulation of Casp1 2 0.42 1.38 0.53
150 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
151 INT126367 Positive_regulation of Gene_expression of CTSB 3 0.04 1.57 0.52
152 INT160148 Positive_regulation of Ctsl 2 0.43 0.74 0.52
153 INT193736 Regulation of Positive_regulation of CTSB 1 0.04 1.13 0.52
154 INT273195 Localization of Ctss 2 0.19 1.65 0.51
155 INT129281 Positive_regulation of Gene_expression of Casp9 1 0.31 0.84 0.48
156 INT36603 Positive_regulation of CTSH 1 0.01 0 0.46
157 INT293504 Regulation of Gene_expression of Uchl1 1 0.03 0.31 0.46
158 INT6533 Binding of Ctsl1 2 0.34 0 0.45
159 INT129144 Regulation of Localization of Casp3 1 0.26 0.84 0.44
160 INT259608 Protein_catabolism of Ctss 1 0.11 1.22 0.44
161 INT133316 Localization of CTSK 5 0.52 2.43 0.43
162 INT153436 Positive_regulation of Localization of Casp3 3 0.49 2.12 0.43
163 INT271483 Regulation of Regulation of Uchl1 1 0.01 0.58 0.41
164 INT197157 Gene_expression of CAPN7 19 0.51 11.33 0.4
165 INT155293 Positive_regulation of Protein_catabolism of Casp3 3 0.45 1.7 0.4
166 INT277727 Negative_regulation of Casp7 2 0.21 2.42 0.4
167 INT117939 Transcription of Casp1 1 0.27 0.89 0.4
168 INT202908 Binding of Uchl1 1 0.08 0.27 0.4
169 INT348083 Positive_regulation of Ctsl1 1 0.08 0.21 0.4
170 INT117938 Negative_regulation of Transcription of Casp1 1 0.22 0.89 0.4
171 INT142872 Regulation of Casp8 6 0.29 3.11 0.39
172 INT181179 Binding of CYLD 4 0.43 7.06 0.39
173 INT240482 Regulation of Ctsk 1 0.45 1.77 0.39
174 INT229855 Gene_expression of Casp7 3 0.28 2.3 0.38
175 INT165472 Localization of CTSC 2 0.68 0.38 0.38
176 INT122508 Positive_regulation of Localization of CAPN2 1 0.23 0.18 0.38
177 INT224637 Protein_catabolism of Ctsl 1 0.12 0.76 0.37
178 INT122509 Regulation of Localization of CAPN2 1 0.12 0.28 0.37
179 INT159990 Negative_regulation of Negative_regulation of Ctsk 1 0.13 0.41 0.37
180 INT122505 Regulation of CAPN2 1 0.20 0.28 0.37
181 INT316037 Positive_regulation of Localization of Ctss 1 0.12 1.07 0.37
182 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36
183 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
184 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35
185 INT165916 Negative_regulation of Localization of Casp3 2 0.41 2.41 0.34
186 INT122507 Negative_regulation of Localization of CAPN2 1 0.21 0.4 0.34
187 INT137502 Regulation of Positive_regulation of Casp9 1 0.32 0.52 0.32
188 INT168388 Negative_regulation of Positive_regulation of Casp9 1 0.20 1.43 0.3
189 INT6536 Negative_regulation of Binding of Ctsl1 1 0.39 0 0.3
190 INT153774 Regulation of CTSK 2 0.28 0.1 0.29
191 INT122506 Gene_expression of CAPN2 1 0.26 0.19 0.29
192 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
193 INT298971 Positive_regulation of Localization of Casp1 2 0.06 0.97 0.28
194 INT126366 Regulation of Binding of CTSB 1 0.01 0.31 0.28
195 INT176260 Binding of CASP8 5 0.36 2.73 0.27
196 INT123126 Protein_catabolism of Uchl1 1 0.64 0.2 0.27
197 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
198 INT75299 Binding of Atxn3 8 0.43 5.3 0.26
199 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26
200 INT285009 Negative_regulation of Gene_expression of Casp7 1 0.16 1 0.26
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