GO:0008236

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Name serine-type peptidase activity
Categary Function
Go Slim No
Go Link GO:0008236
Unique Molecular Interactions 461
Total Molecular Interactions 677
Total Single Events 4260
Pain Genes Associated 65

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for serine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for serine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
2 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
3 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
4 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
5 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
6 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
7 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
8 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
9 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
10 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
11 INT31391 Binding of PRCP and Abpa 1 0.03 0.16 1.42
12 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
13 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
14 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
15 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
16 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
17 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
18 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
19 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
20 INT314037 THL Negative_regulation of Localization of Plau 1 0.17 1.64 0.99
21 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96
22 INT118204 ST14 Regulation of YY1 1 0.04 0 0.93
23 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
24 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
25 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
26 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
27 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
28 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
29 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
30 INT46246 Tpsg1 Regulation of Ache 1 0.15 0.06 0.76
31 INT46247 Tpsg1 Regulation of Binding of Ache 1 0.15 0.06 0.76
32 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
33 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
34 INT182044 Binding of Proc and IgG 1 0.00 2.38 0.74
35 INT31389 Negative_regulation of Binding of PRCP and Abpa 1 0.02 0.09 0.72
36 INT31390 Positive_regulation of Binding of PRCP and Abpa 1 0.04 0.08 0.71
37 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
38 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
39 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69
40 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
41 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
42 INT32782 Binding of Vip and Elane 1 0.17 0 0.61
43 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61
44 INT31392 Binding of PRCP and Gpr37 1 0.01 0.1 0.6
45 INT207504 Binding of ap and Klkb1 1 0.13 0 0.58
46 INT313223 Binding of Cx3cr1 and Mcpt1 1 0.06 0.99 0.56
47 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
48 INT313224 Negative_regulation of Binding of Cx3cr1 and Mcpt1 1 0.07 0.99 0.56
49 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
50 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
51 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
52 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53
53 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5
54 INT297152 Binding of PRTN3 and SNRNP70 1 0.40 1.27 0.5
55 INT135378 Binding of Cfb and Oprk1 1 0.01 0.31 0.49
56 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
57 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47
58 INT70183 Binding of PRCP and NCOR2 1 0.04 0.08 0.46
59 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46
60 INT242401 Negative_regulation of Bdkrb1 Negative_regulation of Gene_expression of Mcpt1 1 0.16 1.45 0.46
61 INT353631 Oas1a Positive_regulation of Klkb1 1 0.00 0 0.44
62 INT87555 TPSAB1 Positive_regulation of IGHE 1 0.42 0.71 0.43
63 INT87556 TPSAB1 Positive_regulation of CD79A 1 0.40 0.7 0.42
64 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42
65 INT132730 Plat Positive_regulation of Il6 1 0.08 0.76 0.41
66 INT132729 Plat Positive_regulation of Il1b 1 0.09 0.76 0.41
67 INT346238 PREP Negative_regulation of IL1B 1 0.04 0.99 0.41
68 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
69 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
70 INT23664 Cd2 Negative_regulation of Fap 1 0.33 0 0.4
71 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39
72 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
73 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38
74 INT346227 Binding of PRTN3 and Vim 1 0.01 0.93 0.38
75 INT86075 ST14 Regulation of OPRD1 1 0.07 0 0.37
76 INT172023 Binding of FN1 and PRTN3 1 0.00 1.05 0.37
77 INT84521 Binding of F7 and TF 1 0.06 0.09 0.37
78 INT70185 PRCP Positive_regulation of Gene_expression of FOS 1 0.05 0.1 0.37
79 INT187837 Ass1 Regulation of Mcpt1 1 0.00 1.29 0.37
80 INT77494 PREP Positive_regulation of TRH 1 0.16 0 0.36
81 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
82 INT312750 Elane Positive_regulation of Positive_regulation of Ltp 1 0.01 0.38 0.34
83 INT155166 Binding of C2 and C3 1 0.40 0 0.34
84 INT98066 Binding of Plau and Plau 1 0.00 1.49 0.34
85 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34
86 INT110350 Positive_regulation of Arigg3 Positive_regulation of Positive_regulation of Dpp4 1 0.01 0 0.33
87 INT35690 Dpp6 Regulation of Jmjd1c 1 0.17 0 0.33
88 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33
89 INT93896 Plat Positive_regulation of Gtf3a 1 0.00 0.51 0.32
90 INT123398 TPSAB1 Positive_regulation of Gene_expression of PTAFR 1 0.14 0.51 0.32
91 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
92 INT338051 Ngf Positive_regulation of Localization of F2 1 0.11 0 0.32
93 INT124259 Negative_regulation of Plat Positive_regulation of Jun 4 0.11 1.74 0.31
94 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31
95 INT207502 Positive_regulation of Binding of ap and Klkb1 1 0.18 0 0.31
96 INT259132 KLK7 Positive_regulation of Binding of DSG2 1 0.51 0.91 0.31
97 INT259130 KLK7 Positive_regulation of Binding of DSG1 1 0.51 0.91 0.31
98 INT259133 KLK7 Positive_regulation of DSG2 1 0.51 0.91 0.31
99 INT62616 Regulation of Binding of PRLR and ST14 1 0.00 0 0.31
100 INT259131 KLK7 Positive_regulation of DSG1 1 0.51 0.91 0.31
101 INT62615 Binding of PRLR and ST14 1 0.00 0 0.31
102 INT207503 Binding of Klkb1 and Scn7a 1 0.02 0 0.3
103 INT191499 CMA1 Positive_regulation of NLRP3 1 0.02 0.42 0.3
104 INT191502 Binding of CMA1 and NLRP3 1 0.01 0.42 0.3
105 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3
106 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
107 INT207114 Binding of Plau and Plaur 1 0.19 0.7 0.29
108 INT70186 PRCP Positive_regulation of INSRR 1 0.01 0.09 0.29
109 INT247081 Binding of F5 and F7 1 0.00 0.87 0.28
110 INT327366 Binding of Fap and Ttr 1 0.33 2.9 0.28
111 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27
112 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27
113 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27
114 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
115 INT207505 Negative_regulation of Binding of ap and Klkb1 1 0.15 0 0.26
116 INT299745 Binding of Masp1 and IgG 1 0.03 0.69 0.26
117 INT76081 Plg Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.26
118 INT76082 Plg Regulation of Gene_expression of IL6 1 0.01 0.19 0.26
119 INT114818 Try4 Positive_regulation of Afg3l2 1 0.04 0.39 0.25
120 INT348755 Plat Regulation of Gene_expression of Cldn5 1 0.10 0.45 0.25
121 INT341541 Binding of C1R and C1QL1 1 0.09 0.21 0.25
122 INT341532 Binding of C1R and TRGC1 1 0.04 0.21 0.25
123 INT114820 TPSG1 Positive_regulation of Afg3l2 1 0.06 0.39 0.24
124 INT114819 Proc Positive_regulation of Afg3l2 1 0.07 0.39 0.24
125 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
126 INT191536 Klk1c2 Positive_regulation of NLRP3 1 0.02 0.36 0.24
127 INT191537 Binding of Klk1c2 and NLRP3 1 0.02 0.36 0.24
128 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
129 INT77046 Binding of Pcsk2 and Olfr714 1 0.09 0.07 0.23
130 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
131 INT346232 PREP Negative_regulation of Binding of IL1B 1 0.04 0.47 0.23
132 INT222184 SERPINB1 Regulation of PRTN3 1 0.00 1.04 0.23
133 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23
134 INT149791 Binding of Lrp8 and Reln 4 0.36 0.38 0.22
135 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22
136 INT70182 PRCP Positive_regulation of IER3 1 0.15 0.1 0.22
137 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
138 INT106991 TPSD1 Positive_regulation of NR1I2 1 0.07 0.39 0.22
139 INT321980 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Ins1 1 0.16 0.81 0.22
140 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
141 INT60909 TPP1 Positive_regulation of Gh1 1 0.00 0 0.22
142 INT124262 Negative_regulation of Plat Positive_regulation of Mapk1 1 0.13 0.41 0.21
143 INT213547 Proc Regulation of Bdnf 1 0.00 0.1 0.21
144 INT124263 Plat Positive_regulation of Gene_expression of Cpox 1 0.07 0.42 0.21
145 INT345186 Lpar2 Positive_regulation of Gene_expression of Plau 1 0.05 2.2 0.2
146 INT251450 Binding of Dpp6 and Kcnc1 1 0.37 0.18 0.2
147 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2
148 INT255259 Binding of Plg and Tsp1 1 0.05 0.84 0.2
149 INT27675 Plg Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.75 0.2
150 INT338043 F2 Positive_regulation of Localization of Prkca 1 0.04 0.1 0.2
151 INT244093 Binding of C2 and Arhgap4 3 0.23 0.38 0.19
152 INT312708 DPP8 Positive_regulation of DPP4 1 0.24 0.54 0.19
153 INT312706 DPP9 Positive_regulation of DPP4 1 0.26 0.54 0.19
154 INT297153 Binding of PRTN3 and NPSR1 1 0.39 0.85 0.19
155 INT55809 Binding of Ttr and Fap 1 0.12 2.56 0.19
156 INT314049 THL Negative_regulation of Gene_expression of Plau 1 0.20 2.91 0.19
157 INT338050 Ngf Positive_regulation of F2 1 0.11 0.25 0.18
158 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18
159 INT210029 PROC Negative_regulation of PRTN3 1 0.00 1.06 0.18
160 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18
161 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18
162 INT251453 Binding of Kcnc1 and Dpp10 1 0.20 0.18 0.18
163 INT338061 Nrtn Positive_regulation of F2 1 0.07 0.25 0.18
164 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18
165 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18
166 INT259934 Plat Positive_regulation of Gene_expression of Mmp9 2 0.33 1.05 0.17
167 INT247084 Binding of F7 and H1F0 1 0.00 0.38 0.17
168 INT259634 Elane Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17
169 INT266899 Binding of Prkca and Plat 1 0.02 0.57 0.17
170 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16
171 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16
172 INT258340 Binding of Ms4a1 and Cfb 1 0.04 0.32 0.16
173 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16
174 INT281319 Binding of F7 and tf 1 0.24 1 0.16
175 INT259135 Gene_expression of KLK7 Positive_regulation of DSG2 1 0.47 1.21 0.16
176 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
177 INT294207 Serpine1 Regulation of Gene_expression of Plat 1 0.50 0.92 0.16
178 INT199128 Ctsb Positive_regulation of Prss1 1 0.02 0.9 0.15
179 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
180 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
181 INT338056 Ctsg Positive_regulation of F2rl3 1 0.30 0 0.15
182 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
183 INT170817 CMA1 Positive_regulation of Gene_expression of AGT 1 0.19 1.41 0.14
184 INT300512 Binding of Plau and Vtn 1 0.06 2.28 0.13
185 INT218499 Cfb Negative_regulation of ap 1 0.00 0.74 0.13
186 INT92246 Binding of Hgfac and F13a1 1 0.00 0.65 0.13
187 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 0.20 0.45 0.13
188 INT75739 Ltf Negative_regulation of Il6 1 0.35 0.39 0.13
189 INT338055 F2 Positive_regulation of Par2 1 0.08 0.22 0.13
190 INT75738 Ltf Negative_regulation of Tnf 1 0.31 0.39 0.13
191 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13
192 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
193 INT207109 F2 Positive_regulation of Phosphorylation of Akt2 1 0.08 0.25 0.12
194 INT75737 Ltf Negative_regulation of Gene_expression of Il6 1 0.35 0.32 0.12
195 INT284215 Binding of C2 and Eclc 1 0.01 0.37 0.12
196 INT287035 Gopc Positive_regulation of Prtn3 1 0.02 0.48 0.12
197 INT294208 Gene_expression of Serpine1 Negative_regulation of Plat 1 0.47 0.94 0.12
198 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11
199 INT321863 Timp1 Negative_regulation of Gene_expression of Mcpt1 1 0.25 0.79 0.11
200 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11

Single Events

The table below shows the top 100 pain related interactions that have been reported for serine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in serine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15
2 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57
3 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4
4 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
5 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74
6 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85
7 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06
8 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52
9 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11
10 INT27937 Gene_expression of Klkb1 35 0.55 1.86 10.08
11 INT64054 Positive_regulation of Tmprss11d 19 0.67 9.33 9.99
12 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91
13 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
14 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31
15 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65
16 INT112967 Regulation of Mcpt1 15 0.54 13.03 8.58
17 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49
18 INT31125 Binding of Dpp6 10 0.36 0.22 8.26
19 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
20 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74
21 INT124488 Positive_regulation of Gene_expression of Plat 14 0.70 5.46 6.52
22 INT16997 Binding of PRTN3 34 0.48 33.44 6.45
23 INT116420 Localization of Elane 16 0.14 7.8 6
24 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94
25 INT124825 Transcription of Plat 8 0.70 3.15 5.68
26 INT22839 Gene_expression of F2 31 0.74 15.53 5.56
27 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38
28 INT107247 Regulation of Plat 10 0.44 7.21 5.14
29 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08
30 INT51983 Negative_regulation of Prtn3 23 0.34 12.54 5
31 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83
32 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74
33 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73
34 INT110768 Transcription of Mcpt1 12 0.52 7.66 4.71
35 INT140350 Binding of C2 17 0.36 3.97 4.69
36 INT44066 Gene_expression of Ltf 20 0.77 15.09 4.57
37 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55
38 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
39 INT67279 Localization of PRTN3 11 0.50 14.18 4.3
40 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
41 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
42 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07
43 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05
44 INT32791 Gene_expression of Dpp6 5 0.76 2.51 4.04
45 INT57525 Negative_regulation of Ltf 9 0.50 4.2 4.03
46 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
47 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53
48 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
49 INT63506 Localization of F2 21 0.77 7.53 3.41
50 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
51 INT181001 Regulation of PRTN3 5 0.18 6.07 3.39
52 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37
53 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3
54 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28
55 INT16390 Regulation of Plg 13 0.48 6.72 3.2
56 INT129208 Regulation of Gene_expression of Mcpt1 8 0.29 5.94 3.13
57 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
58 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01
59 INT115857 Gene_expression of PRSS3 10 0.72 4.13 2.96
60 INT201952 Binding of DPP4 11 0.37 8.81 2.91
61 INT58527 Gene_expression of Prtn3 20 0.71 15.99 2.9
62 INT146029 Positive_regulation of Positive_regulation of Tmprss11d 2 0.67 2.12 2.88
63 INT124489 Regulation of Gene_expression of Plat 5 0.45 0.48 2.87
64 INT115464 Gene_expression of Plau 41 0.72 30.21 2.79
65 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77
66 INT157048 Regulation of Localization of Mcpt1 3 0.18 0.31 2.73
67 INT113149 Gene_expression of Tmprss11d 15 0.75 8.51 2.72
68 INT73029 Negative_regulation of Klkb1 7 0.35 0 2.72
69 INT245286 Localization of Plau 6 0.66 9.56 2.58
70 INT60423 Positive_regulation of TPSG1 11 0.57 11.02 2.55
71 INT81377 Gene_expression of Dpp4 8 0.71 5.15 2.51
72 INT8512 Gene_expression of PREP 17 0.65 7.98 2.5
73 INT61805 Positive_regulation of Dpp4 4 0.44 0.41 2.49
74 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48
75 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44
76 INT28698 Positive_regulation of F7 13 0.64 9.5 2.38
77 INT124826 Positive_regulation of Transcription of Plat 3 0.68 0.33 2.38
78 INT64053 Negative_regulation of Positive_regulation of Tmprss11d 3 0.57 1.34 2.38
79 INT184378 Binding of Cfb 54 0.20 12.49 2.36
80 INT100488 Negative_regulation of Positive_regulation of Mcpt1 4 0.10 2.85 2.33
81 INT61340 Regulation of Prep 7 0.50 6.13 2.31
82 INT84465 Localization of DPP4 8 0.75 7.28 2.29
83 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2
84 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
85 INT23667 Gene_expression of Hgfac 10 0.03 6.74 2.19
86 INT211979 Positive_regulation of Localization of Mcpt1 5 0.09 2.68 2.16
87 INT9840 Positive_regulation of F7 17 0.57 17.83 2.08
88 INT172559 Localization of Proc 16 0.02 21.49 2.08
89 INT23748 Localization of Ltf 15 0.79 5.43 2.07
90 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
91 INT152074 Gene_expression of KLK7 2 0.71 29.66 2.01
92 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99
93 INT30531 Gene_expression of C2 15 0.66 5.5 1.99
94 INT28830 Localization of Klkb1 9 0.61 0.6 1.96
95 INT17326 Binding of Plg 14 0.43 11.72 1.94
96 INT6064 Positive_regulation of PRCP 4 0.40 0.26 1.92
97 INT32130 Gene_expression of TPSG1 12 0.51 6.59 1.88
98 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86
99 INT83358 Positive_regulation of Elane 8 0.21 8.14 1.83
100 INT273335 Negative_regulation of Localization of Mcpt1 5 0.32 2.66 1.83
101 INT265064 Binding of Reln 1 0.02 2.7 1.83
102 INT64738 Regulation of Dpp6 1 0.01 0 1.79
103 INT31388 Regulation of PRCP 3 0.45 0.55 1.76
104 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75
105 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75
106 INT27936 Positive_regulation of Gene_expression of Klkb1 5 0.41 1.28 1.75
107 INT115858 Positive_regulation of PRSS3 5 0.50 2.06 1.72
108 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
109 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
110 INT125820 Localization of TPSD1 13 0.70 2.19 1.7
111 INT28735 Localization of Reln 2 0.12 1.49 1.7
112 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69
113 INT30138 Binding of TPP1 1 0.16 0.74 1.69
114 INT122852 Gene_expression of Prss1 7 0.76 13.51 1.64
115 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
116 INT93744 Binding of Dpp4 4 0.48 0.91 1.61
117 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54
118 INT124824 Negative_regulation of Transcription of Plat 1 0.43 0.48 1.54
119 INT46389 Positive_regulation of Cfb 20 0.23 8.29 1.49
120 INT115463 Positive_regulation of Plau 13 0.47 8.47 1.49
121 INT22836 Regulation of F2 9 0.59 2.3 1.49
122 INT116836 Binding of FAP 6 0.37 6.76 1.47
123 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46
124 INT14477 Positive_regulation of TPSAB1 10 0.69 5.88 1.46
125 INT66792 Binding of TPSAB1 7 0.16 4.93 1.45
126 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41
127 INT181872 Regulation of Localization of PRTN3 1 0.09 1.98 1.41
128 INT153515 Localization of Plat 10 0.77 4.21 1.4
129 INT25621 Localization of Cfb 8 0.20 2.23 1.4
130 INT16388 Protein_catabolism of Plg 6 0.79 3.46 1.4
131 INT159312 Regulation of Reln 4 0.43 1.79 1.4
132 INT115861 Transcription of PRSS3 2 0.67 1.45 1.4
133 INT125980 Binding of CFD 8 0.42 10.96 1.39
134 INT227424 Binding of Prep 6 0.35 2.61 1.39
135 INT125733 Positive_regulation of Positive_regulation of Mcpt1 6 0.44 3.79 1.38
136 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
137 INT17325 Negative_regulation of Protein_catabolism of Plg 1 0.32 0 1.37
138 INT150728 Positive_regulation of Gene_expression of PRSS3 1 0.09 1.19 1.36
139 INT66943 Negative_regulation of Negative_regulation of Prtn3 2 0.34 1.18 1.35
140 INT145231 Gene_expression of Try4 1 0.03 1.76 1.35
141 INT84463 Regulation of Gene_expression of DPP4 5 0.39 4.81 1.33
142 INT41381 Positive_regulation of Gene_expression of Plg 8 0.44 3.29 1.3
143 INT30091 Binding of PRCP 4 0.27 0.48 1.29
144 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
145 INT53666 Regulation of Furin 4 0.37 0.3 1.24
146 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
147 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
148 INT153514 Positive_regulation of Localization of Plat 2 0.62 0.55 1.23
149 INT135410 Negative_regulation of Transcription of Mcpt1 2 0.19 1.45 1.22
150 INT27155 Binding of F12 8 0.36 1.61 1.21
151 INT164205 Binding of Proc 12 0.36 12.31 1.19
152 INT201955 Regulation of DPP4 18 0.45 11.91 1.18
153 INT96034 Negative_regulation of Proc 11 0.33 10.21 1.18
154 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15
155 INT78686 Protein_catabolism of PRSS3 2 0.88 1.5 1.15
156 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14
157 INT199315 Binding of Plat 8 0.34 7.02 1.14
158 INT123643 Gene_expression of Reln 19 0.75 1.85 1.13
159 INT207850 Positive_regulation of Regulation of Mcpt1 2 0.20 1.65 1.1
160 INT72286 Positive_regulation of Binding of Dpp6 1 0.06 0 1.1
161 INT185502 Binding of PREP 6 0.37 4.04 1.09
162 INT182533 Positive_regulation of Prtn3 6 0.37 5.99 1.06
163 INT165275 Regulation of Cfb 5 0.06 0.83 1.06
164 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05
165 INT324529 Negative_regulation of Binding of PREP 1 0.37 2.48 1.05
166 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03
167 INT101614 Gene_expression of Dpp4 7 0.78 2.73 1.02
168 INT198406 Localization of C2 5 0.65 1.42 1.01
169 INT14479 Negative_regulation of TPSAB1 6 0.58 4.83 0.99
170 INT66484 Negative_regulation of Binding of Dpp6 1 0.01 0 0.96
171 INT226478 Protein_catabolism of DPP4 11 0.85 5.52 0.95
172 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95
173 INT140720 Negative_regulation of Reln 5 0.57 2.43 0.95
174 INT314024 Negative_regulation of Localization of Plau 1 0.18 1.27 0.94
175 INT105697 Negative_regulation of KLK4 7 0.43 2.78 0.93
176 INT74777 Positive_regulation of Gene_expression of TPSAB1 4 0.50 3.7 0.92
177 INT45105 Gene_expression of ST14 2 0.58 0.43 0.92
178 INT207500 Binding of Klkb1 2 0.31 0 0.87
179 INT203132 Negative_regulation of Gene_expression of Elane 1 0.20 1.5 0.86
180 INT168444 Positive_regulation of Positive_regulation of C2 2 0.43 0.93 0.85
181 INT84462 Positive_regulation of Localization of DPP4 2 0.32 1.27 0.85
182 INT196322 Binding of F2 18 0.15 7.74 0.83
183 INT126030 Regulation of CFD 4 0.21 3.92 0.83
184 INT284711 Localization of CMA1 3 0.78 2.1 0.82
185 INT44757 Gene_expression of PRCP 3 0.53 1.39 0.82
186 INT116419 Negative_regulation of Localization of Elane 2 0.01 0.58 0.82
187 INT53669 Regulation of Transcription of Furin 1 0.16 0.15 0.82
188 INT312812 Positive_regulation of Localization of CMA1 1 0.05 1.02 0.82
189 INT259143 Positive_regulation of Gene_expression of KLK7 1 0.64 11.94 0.82
190 INT53670 Transcription of Furin 3 0.50 0.39 0.81
191 INT8513 Regulation of PREP 8 0.26 3.17 0.8
192 INT81762 Negative_regulation of PREP 6 0.42 1.88 0.8
193 INT240781 Negative_regulation of HGFAC 3 0.01 3.93 0.8
194 INT30926 Regulation of Gene_expression of Plg 11 0.45 2.14 0.78
195 INT248227 Protein_catabolism of CFD 4 0.46 2.48 0.77
196 INT91561 Regulation of Pcsk2 2 0.52 0.15 0.76
197 INT25960 Regulation of Dpp4 6 0.32 1.69 0.73
198 INT44001 Negative_regulation of Positive_regulation of F12 5 0.59 2.53 0.73
199 INT181637 Gene_expression of CMA1 10 0.66 4.16 0.72
200 INT110349 Regulation of Binding of Dpp4 1 0.26 0 0.72
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