GO:0008237

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Name metallopeptidase activity
Categary Function
Go Slim No
Go Link GO:0008237
Unique Molecular Interactions 904
Total Molecular Interactions 1167
Total Single Events 11958
Pain Genes Associated 98

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for metallopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for metallopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
3 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
4 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
5 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
6 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
7 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
8 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
9 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
10 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
11 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
12 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
13 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
14 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
15 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
16 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
17 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
18 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
19 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
20 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
21 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
22 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
23 INT54484 Npepo Positive_regulation of Gene_expression of Fos 1 0.43 0 1.63
24 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
25 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
26 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
27 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
28 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
29 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
30 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
31 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
32 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
33 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
34 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
35 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
36 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
37 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
38 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
39 INT54490 Npepo Positive_regulation of Gene_expression of Pdyn 1 0.06 0 1.35
40 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3
41 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
42 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
43 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
44 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
45 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
46 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
47 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
48 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
49 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
50 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
51 INT34422 Cck Positive_regulation of Negative_regulation of Npepo 1 0.31 0 1.14
52 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
53 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
54 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
55 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
56 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
57 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
58 INT54486 Npepo Positive_regulation of Gene_expression of Rabep2 1 0.14 0 1.08
59 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
60 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
61 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
62 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
63 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
64 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
65 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99
66 INT195219 Binding of CPB2 and CSRP1 1 0.03 0.99 0.96
67 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
68 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
69 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
70 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91
71 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
72 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
73 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88
74 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
75 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
76 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
77 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
78 INT92423 EC3 Negative_regulation of Mme 1 0.02 0.28 0.86
79 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
80 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85
81 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84
82 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
83 INT124427 NPEPPS Positive_regulation of Protein_catabolism of COL7A1 1 0.00 0.56 0.84
84 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
85 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
86 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
87 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83
88 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
89 INT61130 LTA4H Positive_regulation of CPQ 1 0.28 0 0.83
90 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83
91 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
92 INT16438 Atp6v0d2 Regulation of Localization of Lnpep 1 0.01 0 0.81
93 INT16435 Ubqln1 Regulation of Localization of Lnpep 1 0.01 0 0.81
94 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
95 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
96 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
97 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
98 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
99 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
100 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
101 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
102 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
103 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
104 INT255324 Negative_regulation of Binding of Dpep1 and 2E 1 0.02 0 0.73
105 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
106 INT255325 Binding of Dpep1 and 2E 1 0.02 0 0.73
107 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
108 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
109 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
110 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
111 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
112 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
113 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
114 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
115 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
116 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
117 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
118 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 0.16 0.16 0.66
119 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
120 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
121 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
122 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
123 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
124 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
125 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
126 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
127 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
128 INT2700 Binding of App and Cpe 1 0.00 0 0.63
129 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62
130 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
131 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
132 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
133 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
134 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
135 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
136 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
137 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
138 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
139 INT255326 Binding of Dpep1 and AIS 1 0.00 0 0.6
140 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
141 INT223865 Enpep Positive_regulation of Ltp 1 0.02 0 0.59
142 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
143 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
144 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
145 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57
146 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
147 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
148 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
149 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
150 INT263756 Binding of Bmp1 and Neto1 1 0.30 0.11 0.54
151 INT19690 Enpep Regulation of Negative_regulation of Penk 1 0.28 0 0.54
152 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54
153 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54
154 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54
155 INT45425 Npepo Regulation of Prl 2 0.32 0.16 0.53
156 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53
157 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
158 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
159 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
160 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52
161 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
162 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
163 INT194916 Kitl Positive_regulation of Gene_expression of Mmp1a 1 0.00 0.85 0.52
164 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52
165 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
166 INT207466 LGALS3 Positive_regulation of Gene_expression of ADAMTS5 1 0.15 0.88 0.51
167 INT11296 Tmem27 Positive_regulation of Localization of LH 1 0.16 0 0.51
168 INT130469 Tubgcp2 Negative_regulation of Naalad2 1 0.05 0.44 0.5
169 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
170 INT150921 ZNF398 Negative_regulation of Gene_expression of Mmp2 1 0.00 0.46 0.5
171 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
172 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
173 INT195220 Binding of CPB2 and IL6 1 0.04 0.5 0.49
174 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
175 INT224675 S100a4 Positive_regulation of Mmp3 1 0.04 0.94 0.48
176 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
177 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
178 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
179 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
180 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
181 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
182 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
183 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
184 INT323905 Positive_regulation of CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
185 INT323904 CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
186 INT138152 IL6 Positive_regulation of Transcription of Mmp2 1 0.00 0.23 0.46
187 INT138154 IL1B Positive_regulation of Transcription of Mmp2 1 0.04 0.23 0.46
188 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
189 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
190 INT323903 CNDP1 Positive_regulation of IL10 1 0.00 0.9 0.46
191 INT171123 TNF Positive_regulation of Localization of Spg7 1 0.01 1.35 0.46
192 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
193 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
194 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
195 INT224674 S100a4 Positive_regulation of Gene_expression of Mmp9 1 0.03 0.85 0.45
196 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
197 INT224692 S100a4 Positive_regulation of Gene_expression of Mmp1a 1 0.02 0.85 0.45
198 INT314044 THL Negative_regulation of Transcription of Mmp9 1 0.20 0.81 0.45
199 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
200 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44

Single Events

The table below shows the top 100 pain related interactions that have been reported for metallopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in metallopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
3 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
4 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
5 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
6 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
7 INT5214 Localization of Cpe 49 0.73 13.3 44.36
8 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
9 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
10 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
11 INT223416 Gene_expression of Trhde 2 0.48 64.16 34.21
12 INT2699 Binding of Cpe 40 0.48 7.07 33.64
13 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
14 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
15 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
16 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
17 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7
18 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
19 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39
20 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03
21 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
22 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
23 INT16431 Localization of Lnpep 62 0.70 6.28 23.94
24 INT310853 Positive_regulation of Gene_expression of Trhde 1 0.43 42.95 22.75
25 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
26 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
27 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
28 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
29 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
30 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
31 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
32 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
33 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86
34 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25
35 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
36 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
37 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
38 INT17938 Binding of Cpe 28 0.48 11.17 13.62
39 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
40 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
41 INT13287 Gene_expression of Cpb2 27 0.56 7.84 11.95
42 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
43 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
44 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28
45 INT18334 Positive_regulation of Cpb2 24 0.69 2.98 11.22
46 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
47 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
48 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
49 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
50 INT119777 Negative_regulation of Naalad2 9 0.40 5.93 10.11
51 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
52 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
53 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47
54 INT18941 Regulation of Enpep 17 0.55 2.56 9.38
55 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
56 INT20664 Binding of ACE 60 0.48 35.27 9.16
57 INT20425 Localization of Cpe 23 0.81 5.18 9.14
58 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
59 INT13840 Negative_regulation of CPQ 19 0.57 1.25 8.36
60 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
61 INT27050 Positive_regulation of Trhde 2 0.43 14.07 8.23
62 INT4880 Regulation of MME 17 0.61 7.78 8.2
63 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
64 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
65 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03
66 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
67 INT25958 Regulation of Ace 26 0.59 11.88 7.87
68 INT10627 Positive_regulation of Lnpep 24 0.69 3.36 7.85
69 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
70 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51
71 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
72 INT524 Positive_regulation of Cpa1 12 0.39 4.74 7.38
73 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
74 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
75 INT50990 Regulation of Cpb2 12 0.37 2.71 7.07
76 INT42038 Localization of ACE 26 0.80 8.88 7.06
77 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03
78 INT168600 Binding of Mmp9 14 0.44 12.79 6.92
79 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
80 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63
81 INT231964 Binding of Cpn1 1 0.25 5.28 6.63
82 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
83 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
84 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33
85 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
86 INT24504 Localization of Anpep 19 0.80 3.44 6.23
87 INT16687 Regulation of Cndp2 6 0.44 0.23 6.11
88 INT141558 Positive_regulation of Naalad2 2 0.45 2.41 6.04
89 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
90 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
91 INT123551 Regulation of Mmp2 17 0.57 11.6 6
92 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96
93 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86
94 INT10624 Regulation of Lnpep 13 0.61 3.27 5.6
95 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55
96 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
97 INT3768 Negative_regulation of ANPEP 16 0.59 4.96 5.52
98 INT33291 Protein_catabolism of Enpep 15 0.85 0.51 5.41
99 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
100 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
101 INT34358 Binding of MME 13 0.37 7.25 5.14
102 INT71841 Negative_regulation of Thop1 7 0.48 0.41 5.08
103 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
104 INT16432 Positive_regulation of Localization of Lnpep 12 0.32 1.15 5.05
105 INT28145 Binding of PAPPA 26 0.48 7.4 4.96
106 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
107 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83
108 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8
109 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73
110 INT29502 Localization of Mmp2 18 0.79 3.49 4.64
111 INT19967 Gene_expression of C9orf3 18 0.75 26.51 4.6
112 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6
113 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52
114 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
115 INT19966 Positive_regulation of C9orf3 19 0.67 21.88 4.38
116 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
117 INT26477 Regulation of ACE 26 0.45 16.31 4.33
118 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
119 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29
120 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26
121 INT387 Regulation of Ace 18 0.45 5.24 4.24
122 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18
123 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
124 INT60067 Localization of NPEPPS 9 0.26 3.36 4.15
125 INT99059 Positive_regulation of Cpb1 16 0.45 3.12 4.09
126 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07
127 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06
128 INT93339 Gene_expression of Naalad2 4 0.10 1.73 4.03
129 INT11872 Protein_catabolism of Rnpep 6 0.87 0 4
130 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96
131 INT220047 Negative_regulation of Gene_expression of Mmp3 4 0.29 5.93 3.95
132 INT78737 Positive_regulation of Gene_expression of Cpb2 5 0.38 1.77 3.84
133 INT140186 Positive_regulation of Gene_expression of Mmp3 7 0.55 6.04 3.82
134 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79
135 INT60415 Regulation of NPEPPS 13 0.27 5.81 3.78
136 INT117614 Positive_regulation of PAPPA 18 0.67 11.9 3.76
137 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
138 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75
139 INT180922 Negative_regulation of Mmp8 4 0.43 8.35 3.72
140 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
141 INT39786 Transcription of Lnpep 3 0.69 0.52 3.61
142 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59
143 INT26773 Protein_catabolism of CPQ 8 0.86 0.17 3.49
144 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
145 INT6405 Gene_expression of Enpep 9 0.67 4.79 3.4
146 INT18617 Gene_expression of Npepo 13 0.58 4.78 3.39
147 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38
148 INT50380 Gene_expression of Cpm 7 0.73 4.43 3.38
149 INT21662 Gene_expression of Cpz 4 0.51 1.14 3.36
150 INT14625 Binding of Dpep1 2 0.02 0 3.36
151 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
152 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34
153 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
154 INT32340 Negative_regulation of Lnpep 14 0.49 2.63 3.26
155 INT179456 Negative_regulation of Mmp3 8 0.39 5.95 3.26
156 INT18477 Protein_catabolism of ANPEP 7 0.79 0.41 3.26
157 INT307634 Binding of BMP1 1 0.36 3.12 3.26
158 INT29333 Positive_regulation of Enpep 8 0.70 3.22 3.25
159 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
160 INT93343 Gene_expression of Cpb2 10 0.58 4.63 3.24
161 INT155039 Gene_expression of ADAMTS5 23 0.67 7.85 3.22
162 INT22492 Binding of Enpep 10 0.47 0.7 3.2
163 INT35910 Binding of Mme 8 0.37 4.79 3.16
164 INT45199 Protein_catabolism of Cndp2 7 0.86 0.31 3.15
165 INT215926 Regulation of Gene_expression of Mmp14 1 0.45 5.33 3.15
166 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
167 INT17673 Negative_regulation of Localization of Lnpep 8 0.09 2.63 3.12
168 INT101034 Protein_catabolism of NPEPPS 8 0.65 2.08 3.12
169 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11
170 INT106037 Gene_expression of PEPD 10 0.75 4.18 3.11
171 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02
172 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99
173 INT35548 Regulation of Mme 9 0.45 10.62 2.97
174 INT140401 Binding of PEPD 3 0.47 2.22 2.97
175 INT138016 Regulation of Naalad2 3 0.43 1.28 2.96
176 INT170324 Negative_regulation of Gene_expression of Mmp1a 8 0.13 6.28 2.94
177 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93
178 INT30228 Protein_catabolism of Anpep 3 0.42 0.82 2.87
179 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
180 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
181 INT310844 Localization of Trhde 1 0.47 4.78 2.82
182 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8
183 INT12903 Gene_expression of Lnpep 14 0.71 1.3 2.78
184 INT220858 Positive_regulation of Mmp1a 15 0.38 9.11 2.77
185 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76
186 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74
187 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
188 INT172797 Negative_regulation of Mmp1a 8 0.24 6.47 2.74
189 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74
190 INT56382 Negative_regulation of Cpa1 5 0.34 2.06 2.73
191 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72
192 INT194892 Regulation of Mmp1a 5 0.22 4.93 2.67
193 INT141559 Localization of Naalad2 2 0.55 1.14 2.65
194 INT68444 Gene_expression of CPE 9 0.76 4.6 2.59
195 INT12051 Negative_regulation of Rnpep 7 0.36 0.42 2.59
196 INT243033 Localization of Mmp8 8 0.65 5.59 2.52
197 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51
198 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47
199 INT9455 Negative_regulation of Rnpep 5 0.31 0.52 2.47
200 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
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