GO:0008239

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Name dipeptidyl-peptidase activity
Categary Function
Go Slim No
Go Link GO:0008239
Unique Molecular Interactions 88
Total Molecular Interactions 104
Total Single Events 854
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for dipeptidyl-peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for dipeptidyl-peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
2 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
3 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
4 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
5 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
6 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
7 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
8 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
9 INT255324 Negative_regulation of Binding of Dpep1 and 2E 1 0.02 0 0.73
10 INT255325 Binding of Dpep1 and 2E 1 0.02 0 0.73
11 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
12 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
13 INT255326 Binding of Dpep1 and AIS 1 0.00 0 0.6
14 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42
15 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39
16 INT110350 Positive_regulation of Arigg3 Positive_regulation of Positive_regulation of Dpp4 1 0.01 0 0.33
17 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
18 INT255322 Binding of Dpep1 and Csnk2b 1 0.01 0 0.29
19 INT255316 Csnk2b Regulation of Binding of Dpep1 1 0.01 0 0.22
20 INT321980 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Ins1 1 0.16 0.81 0.22
21 INT312708 DPP8 Positive_regulation of DPP4 1 0.24 0.54 0.19
22 INT312706 DPP9 Positive_regulation of DPP4 1 0.26 0.54 0.19
23 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
24 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18
25 INT251453 Binding of Kcnc1 and Dpp10 1 0.20 0.18 0.18
26 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16
27 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
28 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 0.20 0.45 0.13
29 INT93745 Binding of Dpp4 and Hephl1 1 0.02 0.15 0.11
30 INT332637 Negative_regulation of Dpp4 Negative_regulation of Localization of Ins1 1 0.06 1.66 0.1
31 INT242204 DPP4 Positive_regulation of Gene_expression of GLP1R 1 0.03 0.66 0.1
32 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 0.02 0.71 0.1
33 INT194718 DPP4 Positive_regulation of MAPK1 1 0.02 0.29 0.09
34 INT220244 IL1B Regulation of Gene_expression of DPEP1 1 0.17 0 0.08
35 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
36 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
37 INT220247 IL1B Regulation of Protein_catabolism of DPEP1 1 0.10 0 0.08
38 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
39 INT36476 C2 Negative_regulation of Positive_regulation of DPP3 1 0.46 0 0.06
40 INT321465 Gip Regulation of DPP4 1 0.03 0.59 0.06
41 INT224922 Binding of FAP and TARM1 1 0.06 1.4 0.06
42 INT321466 Glp1r Regulation of DPP4 1 0.04 0.59 0.06
43 INT267923 Negative_regulation of Dpp4 Positive_regulation of Glp1r 1 0.00 0.23 0.05
44 INT321467 Binding of DPP4 and Glp1r 1 0.03 0.42 0.05
45 INT332631 Negative_regulation of Dpp4 Negative_regulation of Gcg 1 0.05 1 0.05
46 INT332628 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Gcg 1 0.05 1 0.05
47 INT251451 Binding of Dpp6 and Dpp10 1 0.21 0.06 0
48 INT311229 DPP4 Positive_regulation of Gene_expression of INS 1 0.32 0.57 0
49 INT321981 Dpp4 Regulation of Glp1r 1 0.07 1.06 0
50 INT255024 DPP4 Negative_regulation of Protein_catabolism of GLP1R 1 0.14 0.78 0
51 INT332634 Dpp4 Positive_regulation of Localization of Ins1 1 0.06 0.76 0
52 INT253212 Negative_regulation of Dpp4 Positive_regulation of Localization of INS 1 0.01 0.42 0
53 INT253213 Negative_regulation of Dpp4 Positive_regulation of Localization of GCG 1 0.05 0.4 0
54 INT321982 Dpp4 Regulation of Gene_expression of Glp1r 1 0.07 1.06 0
55 INT321976 Dpp4 Regulation of Gcg 1 0.13 1.06 0
56 INT255041 DPP4 Positive_regulation of GIP 1 0.49 0.32 0
57 INT255021 DPP4 Negative_regulation of Protein_catabolism of GIP 1 0.32 0.78 0
58 INT255043 DPP4 Positive_regulation of GLP1R 1 0.35 0.32 0
59 INT253214 Negative_regulation of Dpp4 Negative_regulation of Gene_expression of GCG 1 0.04 0.43 0
60 INT255023 Negative_regulation of DPP4 Positive_regulation of GIP 1 0.35 0.27 0
61 INT321977 Dpp4 Regulation of Negative_regulation of Gcg 1 0.13 1.06 0
62 INT348644 Binding of DPP4 and GLP1R 1 0.16 0.5 0
63 INT255042 Negative_regulation of DPP4 Positive_regulation of GLP1R 1 0.33 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for dipeptidyl-peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in dipeptidyl-peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
2 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
3 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
4 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
5 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
6 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
7 INT14625 Binding of Dpep1 2 0.02 0 3.36
8 INT201952 Binding of DPP4 11 0.37 8.81 2.91
9 INT81377 Gene_expression of Dpp4 8 0.71 5.15 2.51
10 INT61805 Positive_regulation of Dpp4 4 0.44 0.41 2.49
11 INT84465 Localization of DPP4 8 0.75 7.28 2.29
12 INT93744 Binding of Dpp4 4 0.48 0.91 1.61
13 INT116836 Binding of FAP 6 0.37 6.76 1.47
14 INT84463 Regulation of Gene_expression of DPP4 5 0.39 4.81 1.33
15 INT201955 Regulation of DPP4 18 0.45 11.91 1.18
16 INT35885 Positive_regulation of DPP3 4 0.50 0.1 1.18
17 INT35887 Protein_catabolism of DPP3 3 0.85 0 1.14
18 INT176609 Gene_expression of Dpep1 8 0.03 2.37 1.07
19 INT101614 Gene_expression of Dpp4 7 0.78 2.73 1.02
20 INT226478 Protein_catabolism of DPP4 11 0.85 5.52 0.95
21 INT220249 Gene_expression of DPEP1 1 0.40 0.99 0.95
22 INT255304 Regulation of Binding of Dpep1 1 0.02 0 0.95
23 INT46483 Localization of Dpep1 4 0.06 1.58 0.88
24 INT84462 Positive_regulation of Localization of DPP4 2 0.32 1.27 0.85
25 INT77019 Negative_regulation of DPP3 5 0.56 0.35 0.75
26 INT25960 Regulation of Dpp4 6 0.32 1.69 0.73
27 INT110349 Regulation of Binding of Dpp4 1 0.26 0 0.72
28 INT113893 Protein_catabolism of Dpp4 3 0.57 0.69 0.7
29 INT255306 Positive_regulation of Dpep1 1 0.02 0 0.61
30 INT35883 Positive_regulation of Protein_catabolism of DPP3 1 0.26 0 0.55
31 INT130039 Protein_catabolism of Dpp4 5 0.66 3.03 0.47
32 INT255308 Negative_regulation of Binding of Dpep1 1 0.02 0 0.46
33 INT227518 Positive_regulation of Gene_expression of Dpp4 1 0.34 0 0.44
34 INT251446 Gene_expression of Dpp10 1 0.36 0.31 0.44
35 INT220254 Positive_regulation of Gene_expression of DPEP1 1 0.22 0.56 0.44
36 INT61804 Negative_regulation of Positive_regulation of Dpp4 1 0.37 0.24 0.42
37 INT110347 Positive_regulation of Dpp4 2 0.55 0.07 0.33
38 INT110345 Positive_regulation of Positive_regulation of Dpp4 1 0.39 0 0.33
39 INT110306 Positive_regulation of Gene_expression of Dpp4 1 0.06 0.77 0.33
40 INT88374 Gene_expression of DPP3 3 0.75 1.2 0.32
41 INT280027 Negative_regulation of Localization of Dpp4 1 0.15 1.13 0.32
42 INT130035 Regulation of Dpp4 1 0.45 0.1 0.3
43 INT227514 Regulation of Dpep1 1 0.02 0.06 0.3
44 INT226476 Positive_regulation of Protein_catabolism of DPP4 2 0.45 1.64 0.28
45 INT280030 Localization of Dpp4 2 0.28 2.03 0.27
46 INT255073 Negative_regulation of DPP8 1 0.25 0.52 0.27
47 INT69801 Positive_regulation of DPEP1 3 0.49 0.89 0.23
48 INT317219 Regulation of Negative_regulation of Dpp4 1 0.21 0 0.22
49 INT201956 Regulation of Binding of DPP4 1 0.34 0.35 0.21
50 INT88924 Negative_regulation of FAP 2 0.41 1.77 0.2
51 INT312711 Phosphorylation of DPP4 1 0.59 0.42 0.19
52 INT312714 Positive_regulation of Phosphorylation of DPP4 1 0.44 0.42 0.19
53 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18
54 INT280033 Binding of Dpp4 2 0.14 1.94 0.17
55 INT220251 Regulation of DPEP1 1 0.12 0.33 0.15
56 INT311240 Negative_regulation of Gene_expression of DPP4 6 0.59 3.43 0.13
57 INT255072 Regulation of Negative_regulation of DPP4 2 0.44 1.22 0.13
58 INT220259 Protein_catabolism of DPEP1 1 0.34 0 0.11
59 INT312716 Regulation of DPP8 1 0.31 0.78 0.1
60 INT116835 Regulation of FAP 1 0.03 0 0.1
61 INT311232 Negative_regulation of Protein_catabolism of DPP4 2 0.33 1.18 0.09
62 INT69802 Binding of DPEP1 1 0.02 0 0.09
63 INT220263 Negative_regulation of DPEP1 1 0.22 0.28 0.09
64 INT280029 Negative_regulation of Negative_regulation of Dpp4 1 0.15 0.94 0.08
65 INT332610 Positive_regulation of Negative_regulation of Dpp4 1 0.19 1.42 0.08
66 INT312720 Gene_expression of DPP8 1 0.34 0.47 0.08
67 INT251447 Transcription of Dpp10 1 0.28 0 0.08
68 INT270815 Localization of DPEP1 1 0.06 0.08 0.07
69 INT155540 Negative_regulation of Protein_catabolism of Dpp4 1 0.03 1 0.07
70 INT270819 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
71 INT332623 Positive_regulation of Protein_catabolism of Dpp4 1 0.19 1.02 0.05
72 INT312377 Transcription of DPP4 1 0.72 3.38 0.05
73 INT255032 Negative_regulation of Localization of DPP4 1 0.30 0.24 0.04
74 INT255034 Positive_regulation of Negative_regulation of DPP4 2 0.37 0.83 0.03
75 INT220258 Negative_regulation of Gene_expression of DPEP1 1 0.22 0 0.03
76 INT251443 Binding of Dpp10 1 0.19 0.18 0.03
77 INT268374 Gene_expression of FAP 2 0.37 6.6 0
78 INT193336 Negative_regulation of Positive_regulation of FAP 1 0.29 1.23 0
79 INT268370 Phosphorylation of FAP 1 0.24 1.11 0
80 INT131634 Negative_regulation of Gene_expression of Dpp4 1 0.04 0.07 0
81 INT300618 Negative_regulation of Gene_expression of FAP 1 0.21 2.05 0
82 INT339942 Negative_regulation of Negative_regulation of DPP4 1 0.33 0.27 0
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