GO:0008269

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Name JAK pathway signal transduction adaptor activity
Categary Function
Go Slim No
Go Link GO:0008269
Unique Molecular Interactions 16
Total Molecular Interactions 17
Total Single Events 141
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JAK pathway signal transduction adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported for JAK pathway signal transduction adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
2 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
3 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
4 INT118919 Binding of FRTS and Sh2b2 1 0.24 0 0.39
5 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27
6 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27
7 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2
8 INT266101 Binding of HPS1 and SH2B2 1 0.17 0.67 0.16
9 INT266107 Binding of MET and SH2B2 1 0.02 0.67 0.15
10 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14
11 INT207112 Sh2b2 Positive_regulation of Phosphorylation of Akt2 1 0.68 0.24 0.12
12 INT207115 Sh2b2 Positive_regulation of Akt2 1 0.49 0.24 0.12
13 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
14 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
15 INT266105 SH2B2 Positive_regulation of Gene_expression of HPS1 1 0.24 0.62 0.03
16 INT175246 Binding of F13A1 and SH2B2 1 0.00 2.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for JAK pathway signal transduction adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported in JAK pathway signal transduction adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78
2 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39
3 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8
4 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26
5 INT175262 Binding of SH2B2 18 0.36 22.85 3.18
6 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99
7 INT182893 Gene_expression of Sh2b2 8 0.65 1.74 2.65
8 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12
9 INT126760 Positive_regulation of Negative_regulation of SH2B2 1 0.05 1.01 1.6
10 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46
11 INT284739 Positive_regulation of Gene_expression of Sh2b2 2 0.26 0.83 0.71
12 INT182036 Gene_expression of Sh2b2 2 0.13 1.74 0.67
13 INT3501 Localization of Sh2b2 6 0.73 0.88 0.62
14 INT259035 Localization of SH2B2 3 0.43 1.77 0.42
15 INT197880 Binding of Sh2b2 2 0.19 0 0.38
16 INT243808 Positive_regulation of Transcription of Sh2b2 1 0.29 0.86 0.33
17 INT243807 Transcription of Sh2b2 1 0.39 0.85 0.33
18 INT313251 Negative_regulation of Positive_regulation of Sh2b2 1 0.12 0 0.29
19 INT266126 Regulation of SH2B2 1 0.30 0.84 0.27
20 INT284738 Positive_regulation of Localization of Sh2b2 1 0.09 0.6 0.26
21 INT175260 Negative_regulation of Gene_expression of SH2B2 2 0.25 4.41 0.21
22 INT306281 Gene_expression of SOCS2 1 0.01 0.52 0.14
23 INT259038 Negative_regulation of Positive_regulation of SH2B2 1 0.25 1.83 0.09
24 INT259040 Phosphorylation of SH2B2 1 0.47 0.85 0.03
25 INT259029 Regulation of Phosphorylation of SH2B2 1 0.26 0.85 0.03
26 INT268145 Negative_regulation of Sh2b2 1 0.41 0.07 0
27 INT268165 Binding of Sh2b2 1 0.36 0.13 0
28 INT117327 Negative_regulation of Negative_regulation of Sh2b2 1 0.25 0.13 0
29 INT117326 Positive_regulation of Negative_regulation of Sh2b2 1 0.27 0.16 0
30 INT230978 Positive_regulation of SOCS2 1 0.23 0.08 0
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