GO:0008277

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Name regulation of G-protein coupled receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0008277
Unique Molecular Interactions 220
Total Molecular Interactions 323
Total Single Events 1559
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
2 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
3 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
4 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
5 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
6 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
7 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
8 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
9 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
10 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
11 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49
12 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
13 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
14 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
15 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
16 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
17 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
18 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
19 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
20 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
21 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
22 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
23 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
24 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
25 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
26 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
27 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
28 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
29 INT146096 Positive_regulation of Binding of Oprm1 and Rgs9 1 0.44 0 0.94
30 INT124160 Binding of Rgs9 and Mors1 1 0.23 0.28 0.9
31 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
32 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
33 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
34 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
35 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
36 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
37 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
38 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
39 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
40 INT142507 Binding of Calca and Ramp1 1 0.31 0.48 0.73
41 INT126303 Binding of Rgs7 and Pag1 1 0.15 0.41 0.72
42 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
43 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
44 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
45 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
46 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
47 INT124158 Binding of Oprm1 and Rgs7 1 0.30 0.18 0.62
48 INT124161 Binding of Rgs7 and Rgs11 1 0.29 0.18 0.62
49 INT117199 Rgs1 Regulation of Rgs19 1 0.02 0.16 0.56
50 INT59155 Binding of Adcyap1 and Vip 2 0.34 0.08 0.55
51 INT164973 Binding of RASA1 and Rgs7 1 0.00 0 0.54
52 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
53 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
54 INT97483 ADCYAP1 Positive_regulation of Localization of SST 1 0.04 0 0.5
55 INT106662 Adcyap1 Regulation of Penk 1 0.00 0 0.49
56 INT106664 Adcyap1 Regulation of Gene_expression of Vip 1 0.00 0 0.49
57 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
58 INT97482 ADCYAP1 Positive_regulation of Localization of VIP 1 0.50 0 0.49
59 INT106663 Adcyap1 Regulation of Vip 1 0.00 0 0.49
60 INT97484 Binding of ADCYAP1 and GRP 1 0.26 0 0.48
61 INT97487 ADCYAP1 Positive_regulation of Tac1 1 0.02 0 0.48
62 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
63 INT138424 Binding of RAMP1 and Calca 1 0.01 0.08 0.47
64 INT194405 DCLK3 Positive_regulation of Gene_expression of RAMP1 1 0.16 0.09 0.43
65 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
66 INT273045 Vip Regulation of Adcyap1 1 0.17 0.5 0.38
67 INT187230 Binding of Adcyap1 and Vipr1 1 0.11 0.92 0.38
68 INT187228 Binding of Adcyap1 and Vipr2 1 0.11 0.91 0.38
69 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
70 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
71 INT190751 Adcyap1 Positive_regulation of Vipr2 2 0.16 1.02 0.36
72 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
73 INT138423 Binding of RAMP3 and Calca 1 0.01 0 0.32
74 INT315387 Adcyap1 Positive_regulation of Phosphorylation of Gopc 1 0.03 0.44 0.32
75 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
76 INT119332 Binding of Ramp3 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
77 INT83569 Grk5 Regulation of Oprk1 1 0.02 0 0.29
78 INT194406 Binding of RAMP1 and RPL34P34 1 0.00 0 0.29
79 INT139125 Adcyap1 Regulation of Ier3 1 0.54 0.8 0.29
80 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
81 INT63654 VIP Positive_regulation of Adcyap1 1 0.27 0.15 0.27
82 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
83 INT233780 Binding of ADCYAP1 and SCT 1 0.16 0 0.27
84 INT190996 ADCYAP1 Positive_regulation of Per1 1 0.06 0.45 0.27
85 INT190997 ADCYAP1 Positive_regulation of Per2 1 0.07 0.45 0.27
86 INT74118 Adcyap1 Positive_regulation of Localization of Avp 1 0.33 0 0.26
87 INT106658 Adcyap1 Positive_regulation of Gene_expression of Npy 1 0.54 0.16 0.25
88 INT106660 Adcyap1 Positive_regulation of Gene_expression of Chga 1 0.54 0.16 0.25
89 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
90 INT148574 Rgs7bp Regulation of Gene_expression of Rgs9 1 0.26 0 0.24
91 INT71091 ADCYAP1 Positive_regulation of Localization of GHRH 1 0.26 0.26 0.24
92 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
93 INT71090 ADCYAP1 Positive_regulation of GHRH 1 0.12 0.26 0.24
94 INT190741 Adcyap1 Positive_regulation of Gria2 1 0.00 0 0.24
95 INT69073 Adcyap1 Regulation of Localization of Gnrh1 2 0.66 0 0.22
96 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
97 INT273046 Vip Negative_regulation of Gene_expression of Adcyap1 1 0.20 1.14 0.21
98 INT190745 Adcyap1 Regulation of Car2 1 0.08 0 0.21
99 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
100 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
101 INT80049 Adcyap1 Positive_regulation of Positive_regulation of Slc4a4 1 0.19 0 0.2
102 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19
103 INT106630 Binding of GRK5 and PRKCA 1 0.16 0.82 0.19
104 INT165750 Regulation of Binding of Rgs9 and Naip7 1 0.02 0.07 0.19
105 INT172246 TAS2R14 Positive_regulation of Gene_expression of RAMP1 1 0.01 0.07 0.18
106 INT165752 Binding of Rgs9 and Naip7 1 0.03 0.07 0.18
107 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
108 INT172251 CALCRL Positive_regulation of Gene_expression of RAMP1 1 0.04 0.07 0.17
109 INT315396 Adcyap1 Regulation of IFNA1 1 0.02 0.14 0.17
110 INT190749 Adcyap1 Positive_regulation of Vipr1 1 0.11 0 0.17
111 INT165751 Hspa8 Positive_regulation of Protein_catabolism of Rgs9 1 0.50 0.17 0.17
112 INT190744 Adcyap1 Positive_regulation of Car2 1 0.10 0.08 0.16
113 INT224092 Adrbk1 Regulation of Grk5 1 0.08 0 0.16
114 INT74030 Adcyap1 Positive_regulation of Transcription of Penk 1 0.56 0.24 0.15
115 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
116 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
117 INT190747 Adcyap1 Regulation of Positive_regulation of Prkaca 1 0.05 0 0.14
118 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
119 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
120 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
121 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
122 INT224127 Grk5 Positive_regulation of Phosphorylation of Adora3 1 0.06 0 0.13
123 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
124 INT315388 Binding of Adcyap1r1 and Adcyap1 1 0.02 0.5 0.12
125 INT190743 Adcyap1 Regulation of Gene_expression of Car2 1 0.10 0.06 0.12
126 INT224088 Binding of Grk5 and Grk4 1 0.07 0 0.12
127 INT72729 Adcyap1 Positive_regulation of Localization of Slc4a4 1 0.23 0 0.12
128 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
129 INT148572 Binding of Rgs7bp and Regulation of Gene_expression of Rgs9 1 0.11 0 0.12
130 INT148573 Binding of Rgs7bp and Positive_regulation of Rgs9 1 0.21 0 0.11
131 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
132 INT93478 Adcyap1 Regulation of Vip 1 0.31 0 0.1
133 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
134 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
135 INT315383 Adcyap1 Regulation of Stat1 1 0.10 0.07 0.09
136 INT236043 ADCYAP1 Positive_regulation of VIPR1 1 0.00 0 0.09
137 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
138 INT171400 Binding of Adcyap1 and Prkcg 1 0.01 0.24 0.08
139 INT115933 U Regulation of PLCB1 1 0.00 0.3 0.08
140 INT190742 Adcyap1 Regulation of Gria2 1 0.00 0 0.08
141 INT110952 Adcyap1 Regulation of Localization of LH 1 0.22 0 0.07
142 INT315399 Adcyap1 Positive_regulation of Binding of IFNA1 1 0.02 0 0.06
143 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06
144 INT190750 Adcyap1 Regulation of Positive_regulation of Adcyap1r1 1 0.11 0 0.06
145 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
146 INT206675 Adcyap1 Positive_regulation of Gene_expression of Per1 1 0.05 0 0.05
147 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
148 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05
149 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05
150 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04
151 INT190738 Adcyap1 Positive_regulation of Gene_expression of Gnb2l1 1 0.08 0 0.03
152 INT190748 Adcyap1 Regulation of Gene_expression of Gopc 1 0.05 0 0.03
153 INT166496 ADCYAP1 Positive_regulation of Positive_regulation of RTCA 1 0.02 0.09 0
154 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
155 INT166497 RTCA Positive_regulation of ADCYAP1 1 0.02 0.09 0
156 INT356237 Binding of CLTC and GPSM2 1 0.00 0 0
157 INT233267 Hoxa10 Regulation of Itgb3 1 0.15 0.14 0
158 INT191614 Adcyap1 Positive_regulation of Rtcd1 1 0.01 0.93 0
159 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
160 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
161 INT74023 Adcyap1 Regulation of Transcription of Penk 1 0.32 0.2 0
162 INT233270 Meis1 Regulation of Gene_expression of Itgb3 1 0.47 0 0
163 INT109249 Calcrl Regulation of Ramp1 1 0.28 0.22 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54077 Gene_expression of Adcyap1 62 0.78 23.17 16.75
2 INT58896 Localization of Adcyap1 35 0.81 4.57 14.77
3 INT48259 Positive_regulation of Adcyap1 33 0.67 10.94 14.39
4 INT65965 Gene_expression of Adcyap1 52 0.78 22.53 13.14
5 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
6 INT111264 Gene_expression of Rgs9 16 0.76 1.96 10.94
7 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9
8 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28
9 INT105839 Positive_regulation of Grk5 5 0.70 0.35 9.2
10 INT106199 Positive_regulation of Adcyap1 32 0.68 13.68 9.14
11 INT111258 Regulation of Rgs9 11 0.54 1.81 8.9
12 INT52116 Regulation of Adcyap1 20 0.53 6.1 8.14
13 INT65964 Regulation of Adcyap1 13 0.45 10.1 7.54
14 INT119439 Positive_regulation of Rgs7 1 0.67 2.07 7
15 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
16 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
17 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
18 INT43224 Negative_regulation of Adcyap1 17 0.54 3.69 6.19
19 INT120200 Binding of RAMP1 6 0.47 0.72 6.16
20 INT93776 Negative_regulation of Rgs9 5 0.44 0.35 5.67
21 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
22 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
23 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
24 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
25 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69
26 INT66048 Positive_regulation of Gene_expression of Adcyap1 5 0.49 8.21 4.52
27 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
28 INT106548 Localization of Adcyap1 14 0.80 5.05 4.33
29 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
30 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
31 INT138209 Positive_regulation of Localization of Adcyap1 2 0.41 2.07 4.08
32 INT124141 Positive_regulation of Gene_expression of Rgs9 5 0.68 0.82 3.91
33 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
34 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
35 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
36 INT115877 Negative_regulation of Adcyap1 14 0.59 5.31 3.74
37 INT59154 Binding of Adcyap1 12 0.48 4.16 3.71
38 INT58897 Regulation of Localization of Adcyap1 4 0.45 1.82 3.48
39 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
40 INT122438 Transcription of Grk5 1 0.72 0 3.46
41 INT83565 Gene_expression of Grk5 5 0.55 0.16 3.39
42 INT116538 Negative_regulation of GRK6 1 0.48 0.84 3.31
43 INT120823 Positive_regulation of Gene_expression of Adcyap1 10 0.68 6.71 3.22
44 INT122441 Regulation of Grk5 1 0.62 0 3.13
45 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
46 INT119443 Gene_expression of Rgs7 4 0.65 0.41 3.04
47 INT111259 Negative_regulation of Gene_expression of Rgs9 3 0.41 0.15 2.96
48 INT148934 Binding of Ramp1 4 0.36 0.94 2.89
49 INT142502 Gene_expression of Ramp1 5 0.67 2.23 2.72
50 INT105837 Regulation of Gene_expression of Grk5 1 0.44 0.16 2.68
51 INT112252 Regulation of Rgs7 3 0.38 0 2.62
52 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
53 INT112253 Positive_regulation of Regulation of Rgs9 2 0.41 0.29 2.51
54 INT119435 Negative_regulation of Positive_regulation of Rgs7 1 0.42 0.77 2.51
55 INT59119 Positive_regulation of ADCYAP1 9 0.69 4.68 2.48
56 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
57 INT126277 Regulation of Gene_expression of Rgs9 3 0.61 0.53 2.45
58 INT142788 Transcription of Rgs19 1 0.32 0.28 2.42
59 INT105838 Negative_regulation of Grk5 2 0.43 0.1 2.37
60 INT97485 Localization of ADCYAP1 4 0.78 0.24 2.35
61 INT119437 Binding of Rgs9 2 0.33 0.45 2.32
62 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
63 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
64 INT112255 Positive_regulation of Rgs9 2 0.54 0.35 2.26
65 INT124389 Gene_expression of GRK6 3 0.70 1.14 2.16
66 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
67 INT147453 Positive_regulation of Gene_expression of ADCYAP1 3 0.69 3.49 2.1
68 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
69 INT119450 Transcription of Rgs9 3 0.51 0.58 2.05
70 INT124145 Phosphorylation of Rgs9 2 0.72 0.29 2.05
71 INT147451 Regulation of Gene_expression of ADCYAP1 3 0.61 1.88 2.04
72 INT119449 Positive_regulation of Transcription of Rgs9 1 0.37 0.54 2.02
73 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
74 INT54076 Transcription of Adcyap1 4 0.67 1.65 1.98
75 INT119448 Transcription of Rgs7 1 0.69 0.46 1.98
76 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94
77 INT194414 Positive_regulation of Gene_expression of RAMP1 4 0.60 0.57 1.89
78 INT77300 Negative_regulation of Positive_regulation of Adcyap1 3 0.35 0 1.88
79 INT66047 Regulation of Gene_expression of Adcyap1 2 0.58 3.36 1.84
80 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
81 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69
82 INT142790 Gene_expression of Rgs19 1 0.30 0.18 1.67
83 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
84 INT181266 Gene_expression of GPSM2 18 0.32 0.54 1.64
85 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
86 INT142784 Regulation of Transcription of Rgs19 1 0.20 0.19 1.61
87 INT112247 Positive_regulation of Regulation of Rgs7 1 0.42 0 1.52
88 INT148933 Localization of Ramp1 1 0.77 0.75 1.48
89 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
90 INT109419 Regulation of Rgs7 1 0.23 0.07 1.44
91 INT109423 Regulation of Gene_expression of Rgs7 1 0.23 0.07 1.44
92 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
93 INT109421 Gene_expression of Rgs7 1 0.51 0.07 1.39
94 INT59153 Positive_regulation of Binding of Adcyap1 3 0.43 0.56 1.37
95 INT166595 Positive_regulation of Binding of RAMP1 2 0.45 0.18 1.36
96 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
97 INT142503 Positive_regulation of Gene_expression of Ramp1 1 0.43 0.83 1.26
98 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
99 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
100 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
101 INT116536 Binding of GRK6 1 0.31 0.3 1.19
102 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
103 INT161486 Regulation of Ramp1 2 0.61 1.64 1.16
104 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
105 INT106549 Binding of Adcyap1 3 0.35 1.83 1.08
106 INT194413 Positive_regulation of RAMP1 1 0.36 0.07 1.08
107 INT124149 Positive_regulation of Phosphorylation of Rgs9 1 0.44 0.29 1.05
108 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
109 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
110 INT126279 Gene_expression of Rgs14 1 0.67 0.34 0.98
111 INT223967 Regulation of Gene_expression of RAMP1 1 0.39 0.5 0.97
112 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
113 INT119436 Positive_regulation of Transcription of Rgs7 1 0.67 0.19 0.94
114 INT122439 Positive_regulation of Transcription of Grk5 1 0.70 0 0.94
115 INT119324 Positive_regulation of Gene_expression of Ramp1 3 0.53 0.94 0.89
116 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
117 INT211737 Localization of Rgs7 1 0.02 0 0.86
118 INT142791 Positive_regulation of Rgs19 1 0.21 0.1 0.86
119 INT142782 Positive_regulation of Transcription of Rgs19 1 0.21 0.1 0.86
120 INT142792 Positive_regulation of Gene_expression of Rgs19 1 0.22 0.1 0.86
121 INT142789 Regulation of Gene_expression of Rgs19 1 0.20 0.1 0.86
122 INT43221 Negative_regulation of Negative_regulation of Adcyap1 1 0.18 0 0.85
123 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
124 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
125 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
126 INT124147 Positive_regulation of Binding of Rgs9 1 0.44 0.23 0.79
127 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
128 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
129 INT124388 Positive_regulation of Gene_expression of GRK6 1 0.45 0.41 0.75
130 INT112373 Negative_regulation of Positive_regulation of GPSM2 1 0.38 1.87 0.73
131 INT210014 Regulation of Binding of Adcyap1 1 0.38 0.25 0.73
132 INT124143 Regulation of Regulation of Rgs9 1 0.24 0.25 0.72
133 INT210012 Regulation of Transcription of Adcyap1 1 0.44 0.48 0.7
134 INT210011 Negative_regulation of Gene_expression of Adcyap1 1 0.36 1.22 0.69
135 INT140242 Regulation of GRK6 1 0.25 0.31 0.67
136 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
137 INT119440 Binding of Rgs7 1 0.36 0 0.65
138 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
139 INT122440 Regulation of Transcription of Grk5 1 0.24 0 0.63
140 INT285478 Negative_regulation of Rgs14 1 0.27 1.25 0.6
141 INT346182 Positive_regulation of Gene_expression of RAMP2 1 0.14 1.51 0.58
142 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
143 INT137580 Negative_regulation of Gene_expression of Adcyap1 3 0.43 0.15 0.57
144 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
145 INT142504 Positive_regulation of Ramp1 1 0.46 0.66 0.55
146 INT93520 Negative_regulation of ADCYAP1 3 0.42 0.32 0.53
147 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
148 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
149 INT68358 Regulation of Positive_regulation of Adcyap1 1 0.44 0 0.5
150 INT119326 Positive_regulation of Ramp2 1 0.42 0.2 0.48
151 INT119327 Positive_regulation of Ramp3 1 0.45 0.19 0.48
152 INT119329 Positive_regulation of Ramp1 1 0.43 0.2 0.48
153 INT203480 Negative_regulation of Transcription of Adcyap1 1 0.41 0.81 0.47
154 INT97486 Positive_regulation of Localization of ADCYAP1 1 0.67 0 0.47
155 INT203479 Transcription of Adcyap1 1 0.67 0.81 0.47
156 INT224164 Binding of GPSM2 5 0.17 1.14 0.46
157 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
158 INT181268 Localization of GPSM2 3 0.35 2.49 0.44
159 INT115876 Regulation of Gene_expression of Adcyap1 1 0.38 0.47 0.44
160 INT346192 Negative_regulation of RAMP2 1 0.12 0.92 0.42
161 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
162 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
163 INT156120 Localization of Arrb1 1 0.00 0 0.38
164 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
165 INT71095 Regulation of ADCYAP1 1 0.45 0.48 0.38
166 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
167 INT289642 Negative_regulation of Gene_expression of GPSM2 1 0.13 0 0.36
168 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
169 INT74604 Negative_regulation of Gene_expression of PLCB1 1 0.41 0.25 0.35
170 INT209419 Regulation of GPSM2 5 0.21 3.03 0.33
171 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
172 INT286265 Negative_regulation of GPSM2 3 0.20 1.06 0.31
173 INT59816 Positive_regulation of Gene_expression of PLCB1 2 0.49 0.22 0.31
174 INT173349 Gene_expression of GRK5 1 0.23 0.65 0.31
175 INT148570 Protein_catabolism of Rgs9 1 0.98 0.17 0.3
176 INT83559 Positive_regulation of Gene_expression of Grk5 1 0.32 0 0.3
177 INT119323 Binding of Ramp3 1 0.33 0.12 0.29
178 INT235857 Binding of PLCB1 1 0.36 0.35 0.29
179 INT119325 Binding of Ramp2 1 0.33 0.12 0.29
180 INT148571 Localization of Rgs9 1 0.40 0 0.28
181 INT125780 Negative_regulation of Itgb3 2 0.39 0.66 0.25
182 INT190727 Negative_regulation of Positive_regulation of Adcyap1 1 0.27 0 0.25
183 INT69072 Positive_regulation of Negative_regulation of Adcyap1 1 0.50 0 0.25
184 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
185 INT222653 Gene_expression of Ramp3 1 0.17 0 0.24
186 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
187 INT157956 Regulation of Phosphorylation of PLCB1 1 0.00 0.22 0.22
188 INT225973 Binding of Itgb1 2 0.08 1.1 0.2
189 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19
190 INT91278 Positive_regulation of Itgb3 4 0.31 1.73 0.19
191 INT106632 Binding of GRK5 1 0.31 0.82 0.19
192 INT181270 Protein_catabolism of GPSM2 1 0.31 0.42 0.19
193 INT74602 Negative_regulation of Positive_regulation of PLCB1 1 0.41 0.25 0.19
194 INT222647 Positive_regulation of Gene_expression of Ramp3 1 0.15 0 0.18
195 INT233246 Localization of Itgb3 3 0.54 0.25 0.17
196 INT239859 Protein_catabolism of Itgb3 1 0.64 0.25 0.17
197 INT165748 Positive_regulation of Protein_catabolism of Rgs9 1 0.49 0.17 0.17
198 INT284590 Regulation of Localization of Adcyap1 1 0.07 0 0.17
199 INT190732 Regulation of Positive_regulation of Adcyap1 1 0.33 0 0.13
200 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
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