GO:0008285

Name negative regulation of cell proliferation Categary Process Go Slim No Go Link GO:0008285

Unique Molecular Interactions 8694 Total Molecular Interactions 12109 Total Single Events 94353 Pain Genes Associated 412

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT221180	Binding of OPRM1 and Flna	1	0.09	0.22	12.65
2	INT206768	TP53 Positive_regulation of Ltp	2	0.01	5.83	10.21
3	INT77646	Binding of Ngf and Ntrk1	23	0.40	7.85	9.26
4	INT84921	Binding of NGF and NTRK1	13	0.50	6.39	6.1
5	INT338167	Binding of CDKN2A and MC1R	1	0.42	6.14	5.76
6	INT142177	Calca Positive_regulation of Gene_expression of Igf1	8	0.78	3.57	5.71
7	INT79759	Ngf Regulation of Il6	1	0.60	4.62	5.62
8	INT95068	Tlr4 Positive_regulation of IL1B	1	0.03	4.54	5.6
9	INT88279	Ngf Positive_regulation of Ntrk1	5	0.76	3.06	5.23
10	INT182124	Binding of IRF6 and TLR4	14	0.10	16.11	4.65
11	INT139706	Tnf Positive_regulation of Ltp	1	0.03	2.61	4.63
12	INT128296	Negative_regulation of IL1B Positive_regulation of Insr	1	0.10	1.36	4.52
13	INT128295	IL1B Positive_regulation of Insr	1	0.11	1.36	4.5
14	INT64718	IL1B Positive_regulation of Gene_expression of IL6	15	0.59	9.37	4.48
15	INT111758	Binding of Drd2 and Insrr	1	0.01	0.94	4.33
16	INT103724	Oprd1 Positive_regulation of Gtpbp4	3	0.30	0.91	4.18
17	INT182194	Binding of IL8 and CXCR2	10	0.56	7.14	4.16
18	INT200322	Binding of Rest and Sp3	1	0.39	2.93	3.98
19	INT82023	Binding of Ntrk1 and Ngf	5	0.53	3.48	3.92
20	INT61359	TNF Positive_regulation of NFKB1	11	0.63	6.66	3.89
21	INT134284	Binding of OPRM1 and PLD2	1	0.52	0	3.72
22	INT322411	Hist1h1t Positive_regulation of Positive_regulation of OPRM1	1	0.00	1.25	3.63
23	INT57985	Il1b Positive_regulation of Il6	5	0.59	1.66	3.53
24	INT87491	CALCA Positive_regulation of Gene_expression of IL8	1	0.72	0.92	3.52
25	INT17317	Binding of Jun and Fos	7	0.42	1.03	3.5
26	INT180984	IRF6 Positive_regulation of Localization of IL8	7	0.11	2.13	3.47
27	INT195931	Binding of OPRM1 and Trpv1	1	0.07	0.87	3.43
28	INT215943	Binding of Mmp14 and Timp2	1	0.21	1.59	3.33
29	INT146412	Tnf Positive_regulation of Gene_expression of Trpv1	2	0.66	5.22	3.22
30	INT91271	Mtr Regulation of Gene_expression of Il6	1	0.20	0	3.17
31	INT64719	IL1B Positive_regulation of IL6	7	0.41	6.84	3.14
32	INT208572	Binding of IL8 and CXCR1	6	0.33	5.2	3.08
33	INT118158	Binding of Prkca and Prkcz	1	0.07	1.14	2.98
34	INT150889	Il1a Regulation of Il10	1	0.22	3.49	2.95
35	INT150886	Il1a Regulation of Il1b	1	0.02	3.46	2.93
36	INT150888	Il1a Regulation of Il6	1	0.10	3.47	2.93
37	INT73821	CALCA Positive_regulation of Localization of IL8	1	0.25	2.37	2.91
38	INT111757	Positive_regulation of Binding of Drd2 and Insrr	1	0.02	0.64	2.89
39	INT221746	Ngf Positive_regulation of Ntrk1	1	0.02	0.92	2.88
40	INT130721	Binding of IL1B and IL1RN	6	0.05	5.29	2.85
41	INT86180	SFTPA1 Positive_regulation of Localization of IL6	2	0.06	2.01	2.85
42	INT222522	Il1a Positive_regulation of Gene_expression of Il6	2	0.06	1.79	2.79
43	INT190167	Binding of JUN and MMP12	1	0.26	0.82	2.76
44	INT154187	Il6 Positive_regulation of Gene_expression of Cd2	1	0.08	3.07	2.71
45	INT154188	Il6 Positive_regulation of Gene_expression of Atf3	1	0.76	3.07	2.71
46	INT318474	Positive_regulation of OPRM1 Positive_regulation of Localization of CA2	1	0.17	0.55	2.7
47	INT147107	TGFB1 Positive_regulation of Gene_expression of NGF	1	0.49	0.67	2.69
48	INT167769	Prkca Positive_regulation of Positive_regulation of Sigmar1	1	0.38	0.86	2.63
49	INT140024	Tnf Positive_regulation of Gene_expression of Il1b	2	0.49	2.75	2.61
50	INT121698	HRAS Negative_regulation of Gene_expression of MMP3	1	0.06	0.5	2.6
51	INT152501	Binding of Tnf and Tnfrsf1a	4	0.31	3	2.58
52	INT67905	Binding of Spn and Fosl1	1	0.24	2.1	2.54
53	INT151826	Tnf Positive_regulation of TNF	1	0.04	3.38	2.51
54	INT294909	Pax3 Positive_regulation of Gene_expression of Il6	1	0.09	5.43	2.51
55	INT107322	Positive_regulation of TRPV1 Positive_regulation of Localization of IL8	3	0.13	1.64	2.5
56	INT117532	SETBP1 Positive_regulation of Gene_expression of TNF	1	0.54	0.85	2.44
57	INT122163	Binding of TNF and TNFRSF1B	6	0.44	6.06	2.41
58	INT136129	Calca Positive_regulation of ATP8A2	1	0.38	0.89	2.4
59	INT115367	Binding of IL6 and IL6R	12	0.07	8.16	2.36
60	INT61733	Tlr4 Positive_regulation of Gene_expression of Tnf	3	0.26	1.99	2.36
61	INT88730	Binding of OPRM1 and Mop3	1	0.00	0	2.34
62	INT322410	Hist1h1t Positive_regulation of Phosphorylation of OPRM1	1	0.00	0.08	2.31
63	INT54489	Binding of Jun and Rabep2	4	0.16	1.48	2.3
64	INT139705	Negative_regulation of Tnf Positive_regulation of Ltp	1	0.03	1.19	2.3
65	INT124121	IL6 Positive_regulation of CCL2	1	0.26	1.84	2.25
66	INT126717	Binding of Il6 and Il6st	3	0.21	3.35	2.22
67	INT124120	IL6 Regulation of CCL2	1	0.15	1.8	2.22
68	INT155984	Il1a Negative_regulation of Gene_expression of Cyp3a11	1	0.24	0.92	2.2
69	INT279361	Binding of TNF and KLF1	4	0.00	3.72	2.19
70	INT94492	Il6 Positive_regulation of Gene_expression of Il1b	1	0.27	3.81	2.19
71	INT94491	Il1b Positive_regulation of Gene_expression of Tnf	1	0.25	3.81	2.19
72	INT94504	Il6 Positive_regulation of Gene_expression of Tnf	1	0.30	3.8	2.19
73	INT94494	Il1b Positive_regulation of Gene_expression of Il6	1	0.27	3.81	2.19
74	INT86179	TNF Positive_regulation of Localization of IL6	5	0.35	1.66	2.17
75	INT209924	IL1B Negative_regulation of PPARA	1	0.20	4.38	2.17
76	INT1315	Pomc Positive_regulation of Localization of Gnrhr	3	0.38	0.16	2.16
77	INT318473	Positive_regulation of OPRM1 Positive_regulation of CA2	1	0.17	0.46	2.13
78	INT77807	Edn1 Positive_regulation of Gene_expression of Ptgs2	1	0.33	0.53	2.1
79	INT148704	Binding of TNF and TNFRSF1A	5	0.44	3.3	2.09
80	INT196586	Negative_regulation of Mapk14 Negative_regulation of TNF	2	0.04	2.02	2.08
81	INT51198	Positive_regulation of Binding of OPRM1 and PDYN	2	0.18	0.3	2.08
82	INT51199	Binding of OPRM1 and PDYN	2	0.13	0.3	2.08
83	INT126400	ITIH4 Positive_regulation of Gene_expression of Il6	1	0.00	2.11	2.08
84	INT81295	Ifng Positive_regulation of Gene_expression of Nos2	4	0.39	0.87	2.05
85	INT121216	Prkca Regulation of Positive_regulation of Oprd1	1	0.02	0.32	2.02
86	INT70043	IL6 Regulation of IL10	3	0.18	3.59	2.01
87	INT88883	IRF6 Positive_regulation of Nfkb1	1	0.11	0.53	2.01
88	INT35502	Ghrh Positive_regulation of Localization of Gnrhr	7	0.57	0.18	2
89	INT140032	Tnf Positive_regulation of Gene_expression of Ifng	2	0.43	2.23	2
90	INT140030	Il1b Positive_regulation of Gene_expression of Ifng	2	0.48	2.23	2
91	INT140026	Il1b Positive_regulation of Gene_expression of Tnf	2	0.49	2.23	2
92	INT54488	Npepo Regulation of Gene_expression of Jun	1	0.30	0	1.98
93	INT164784	Il6 Positive_regulation of Gene_expression of Cx3cr1	1	0.47	2.37	1.98
94	INT87891	Agt Regulation of Cck	1	0.28	0	1.97
95	INT278937	LEP Positive_regulation of Gene_expression of IL6	1	0.32	3.42	1.97
96	INT217042	IRF6 Positive_regulation of TNF	4	0.27	3.03	1.95
97	INT129212	RYBP Positive_regulation of Tnf	2	0.03	1.9	1.95
98	INT97208	Binding of Gabrg1 and Gabbr1	2	0.07	0.31	1.94
99	INT156509	Il6 Regulation of Positive_regulation of Grin1	1	0.28	1.93	1.93
100	INT102130	Il6 Positive_regulation of Gene_expression of Crp	4	0.05	7.39	1.91
101	INT83418	Binding of OPRL1 and Ntrk1	1	0.02	0	1.91
102	INT279359	Binding of ADA and TNF	1	0.20	2.61	1.91
103	INT113572	Binding of DMRT1 and OPRM1	1	0.01	0	1.9
104	INT51051	IL1B Positive_regulation of Localization of IL6	7	0.57	3.79	1.87
105	INT183781	Binding of IL6 and INS	6	0.22	8.97	1.87
106	INT201940	Binding of IL8 and CXCL10	2	0.28	2.46	1.86
107	INT81920	Binding of IL1B and NFKB1	1	0.04	1.54	1.85
108	INT81914	Binding of HSF1 and NFKB1	1	0.05	1.54	1.85
109	INT50993	Il1b Positive_regulation of Fos	2	0.40	0.43	1.84
110	INT199287	TNF Positive_regulation of Transcription of Oprm1	2	0.02	1.86	1.8
111	INT121218	Arrb2 Regulation of Negative_regulation of Prkca	1	0.17	0.23	1.8
112	INT224432	TNF Positive_regulation of Gene_expression of VEGFA	1	0.13	5.83	1.8
113	INT66504	Binding of Agt and Agtr1a	8	0.39	3.78	1.78
114	INT167319	Binding of OPRM1 and PCSK2	1	0.22	0.63	1.77
115	INT23392	Gal Regulation of Trpv1	1	0.05	0.33	1.77
116	INT167320	Binding of CPE and OPRM1	1	0.14	0.63	1.77
117	INT302646	ARSA Positive_regulation of TGFB1	1	0.10	0.52	1.76
118	INT167321	Binding of ENG and OPRM1	1	0.27	0.63	1.76
119	INT139640	Jun Regulation of Gene_expression of Npy	1	0.21	1.98	1.75
120	INT167765	Prkca Positive_regulation of Sigmar1	1	0.41	0.63	1.74
121	INT157524	Binding of GRM5 and OPRM1	1	0.36	0	1.74
122	INT57249	GNRH1 Regulation of Regulation of CGA	1	0.20	0	1.74
123	INT37840	Binding of Cyp27b1 and Oprd1	1	0.01	0	1.73
124	INT346217	Braf Positive_regulation of Phosphorylation of Map2k1	1	0.22	3.23	1.72
125	INT129717	TGFB1 Positive_regulation of Gene_expression of TNFRSF10D	3	0.38	4.29	1.71
126	INT137207	Tnf Positive_regulation of Nfkb1	3	0.23	2.69	1.71
127	INT200335	Binding of Oprm1 and Rest	1	0.40	0.07	1.7
128	INT167427	Mapk8 Regulation of Regulation of Tnf	1	0.26	2.83	1.7
129	INT89379	TNF Positive_regulation of Gene_expression of IL6	5	0.50	4.37	1.69
130	INT10202	Agt Positive_regulation of Avp	3	0.70	0	1.69
131	INT213071	IL6 Positive_regulation of Gene_expression of CRP	4	0.52	6.58	1.68
132	INT108385	Binding of Crygs and Ntrk1	1	0.01	0	1.67
133	INT139433	Binding of Prkaca and Prkca	1	0.37	0.13	1.67
134	INT101926	Binding of Dio1 and Drd2	4	0.28	0.39	1.66
135	INT145826	Calca Positive_regulation of Gene_expression of Igf1	3	0.75	3.05	1.66
136	INT108066	Binding of NTRK1 and Ngf	3	0.33	2.56	1.66
137	INT100274	IL1RN Negative_regulation of IL1B	5	0.53	1.79	1.65
138	INT278223	Binding of NOS3 and ACSM3	1	0.41	6.32	1.65
139	INT83093	IL1B Positive_regulation of BDKRB1	1	0.51	0.44	1.65
140	INT103725	Negative_regulation of Oprd1 Positive_regulation of Gtpbp4	1	0.17	0.38	1.65
141	INT191618	Binding of App and Nf1	1	0.35	3.77	1.65
142	INT134742	Binding of OPRM1 and SV2A	1	0.33	0.18	1.64
143	INT103726	Regulation of Oprd1 Positive_regulation of Gtpbp4	1	0.10	0.38	1.64
144	INT147108	TGFB1 Positive_regulation of Gene_expression of FN1	4	0.47	1.01	1.63
145	INT61134	IL10 Negative_regulation of Gene_expression of IL1B	3	0.46	2.13	1.63
146	INT135516	PRKCA Negative_regulation of Phosphorylation of OPRM1	1	0.12	0	1.62
147	INT247281	GLC1N Negative_regulation of HRAS	1	0.02	1.98	1.62
148	INT79778	Tlr4 Positive_regulation of Localization of TNF	4	0.08	4.21	1.61
149	INT167202	TNF Regulation of Gene_expression of Ngf	1	0.10	1.47	1.6
150	INT209853	TNF Regulation of Gene_expression of CD36	1	0.61	3.41	1.59
151	INT195930	OPRM1 Regulation of Prkaca	1	0.01	0	1.59
152	INT266767	SFTPA1 Positive_regulation of Gene_expression of TNF	1	0.01	1.69	1.59
153	INT141907	F2r Regulation of Plat	1	0.46	0	1.59
154	INT105112	Plat Positive_regulation of JUN	1	0.01	1.55	1.58
155	INT168609	Binding of Itgb1 and Mmp9	1	0.02	0.41	1.58
156	INT158774	Mapk14 Regulation of Il6	1	0.11	0.08	1.57
157	INT221182	Negative_regulation of Binding of OPRM1 and Flna	1	0.07	0	1.57
158	INT76651	Cpe Positive_regulation of Gene_expression of Il6	1	0.08	0	1.56
159	INT116093	OPRM1 Positive_regulation of Positive_regulation of NFKB1	1	0.36	0.08	1.56
160	INT315284	PRKG1 Positive_regulation of Nos1	1	0.33	0.85	1.56
161	INT74937	IL1B Positive_regulation of CPOX	5	0.18	1.13	1.55
162	INT182097	Binding of Il6 and Il1	4	0.07	4.67	1.55
163	INT198653	TNF Positive_regulation of MIF	1	0.15	3.81	1.55
164	INT113337	EPO Positive_regulation of JAK2	1	0.76	2.8	1.55
165	INT252633	Binding of TNF and Tnfrsf1b	4	0.05	3.66	1.54
166	INT151849	IL10 Negative_regulation of Gene_expression of IL8	4	0.14	3.26	1.54
167	INT91456	IL1B Positive_regulation of Gene_expression of CPOX	6	0.17	3.36	1.53
168	INT41101	Mdk Negative_regulation of SST	1	0.02	0	1.53
169	INT167201	Gtf3a Regulation of TNF	1	0.01	1.39	1.52
170	INT158775	Regulation of Tnf Regulation of Ephb1	1	0.18	0.09	1.52
171	INT135276	Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6	1	0.02	0.52	1.52
172	INT158777	Tnf Regulation of Ephb1	1	0.18	0.09	1.51
173	INT76656	POMC Positive_regulation of Gene_expression of Il6	1	0.03	0	1.51
174	INT260897	CRH Positive_regulation of Localization of IL8	1	0.24	0.09	1.51
175	INT79021	Regulation of Binding of Jun and Fos	2	0.50	0.66	1.5
176	INT10276	Il1b Regulation of Gene_expression of Penk	1	0.61	0.85	1.5
177	INT140029	Ifng Positive_regulation of Gene_expression of Tnf	1	0.43	1.69	1.5
178	INT140028	Ifng Positive_regulation of Gene_expression of Il1b	1	0.48	1.69	1.5
179	INT324926	Ptpro Positive_regulation of Bdkrb2	1	0.01	2.25	1.5
180	INT126718	Binding of Il6 and Il6r	3	0.09	2.33	1.49
181	INT64628	Binding of Oxt and Gal	2	0.29	0.29	1.49
182	INT293009	IRF6 Positive_regulation of Positive_regulation of CA2	1	0.04	0.66	1.49
183	INT293013	IL8 Positive_regulation of Positive_regulation of CA2	1	0.12	0.66	1.49
184	INT92057	Ifng Positive_regulation of Gene_expression of Ik	1	0.03	0.45	1.49
185	INT14375	Gal Positive_regulation of Localization of Prl	1	0.77	0	1.48
186	INT155497	Oprk1 Negative_regulation of Tenc1	1	0.08	0.34	1.48
187	INT136844	Binding of Prkca and Nrgn	1	0.33	0	1.47
188	INT156008	Bcl2 Regulation of Localization of Aifm1	1	0.17	1.92	1.47
189	INT30042	Binding of YY1 and Gnrhr	1	0.18	0	1.47
190	INT161870	OPRM1 Positive_regulation of Prkcg	1	0.01	0.12	1.47
191	INT150885	Il6 Regulation of Il10	1	0.22	1.74	1.47
192	INT165450	Gal Regulation of Ceacam3	1	0.41	0.06	1.47
193	INT150887	Il1b Regulation of Il10	1	0.04	1.74	1.47
194	INT158776	Il1b Regulation of Ephb1	1	0.15	0.09	1.46
195	INT141676	OPRM1 Positive_regulation of Ltp	1	0.04	0	1.46
196	INT285569	TNF Negative_regulation of Gene_expression of Il6	1	0.03	2.83	1.46
197	INT141675	OPRM1 Positive_regulation of Negative_regulation of Ltp	1	0.04	0	1.46
198	INT72755	Tap1 Negative_regulation of TNF	1	0.43	2.45	1.46
199	INT12691	SST Negative_regulation of Localization of POMC	3	0.24	1.24	1.45
200	INT1314	Pomc Regulation of Localization of Gnrhr	2	0.16	0.14	1.45

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82
2	INT9238	Gene_expression of IL6	1575	0.78	1135.66	424.22
3	INT5235	Negative_regulation of TNF	924	0.59	772.91	331.98
4	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81
5	INT34869	Negative_regulation of PTGS2	778	0.59	366.76	319.85
6	INT11624	Gene_expression of OPRM1	445	0.78	72.36	294.36
7	INT9158	Gene_expression of Tnf	722	0.78	522.01	277.68
8	INT6852	Localization of TNF	883	0.81	705.95	270.84
9	INT10832	Gene_expression of IL8	1050	0.78	698.72	270
10	INT9659	Gene_expression of Il6	991	0.78	715.11	265.57
11	INT5972	Gene_expression of IL1B	948	0.78	510.91	263.97
12	INT16868	Gene_expression of Il6	807	0.78	499.48	256.57
13	INT6481	Binding of TNF	624	0.48	510.2	214.82
14	INT767	Localization of Gnrhr	565	0.80	106.68	214.57
15	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210
16	INT11313	Positive_regulation of Il6	526	0.70	331.27	201.59
17	INT6488	Gene_expression of Tnf	484	0.78	339.61	191.58
18	INT10194	Positive_regulation of IL6	702	0.70	600.62	183.38
19	INT4768	Positive_regulation of OPRM1	212	0.70	31.09	164.28
20	INT13353	Positive_regulation of Tnf	332	0.70	248.75	148.1
21	INT9660	Regulation of TNF	363	0.62	312.94	139.99
22	INT4658	Binding of OPRM1	188	0.48	25.96	136.24
23	INT64161	Positive_regulation of Prkca	213	0.70	85.06	129.91
24	INT8243	Positive_regulation of Il6	451	0.70	358.24	119.28
25	INT9235	Negative_regulation of Gene_expression of TNF	346	0.59	252.98	118.61
26	INT50674	Gene_expression of PTGS2	459	0.78	253.33	118.51
27	INT7395	Localization of GNRH1	399	0.81	62.88	117.68
28	INT12339	Localization of IL8	437	0.81	251.87	117.39
29	INT11051	Positive_regulation of Gene_expression of IL6	415	0.69	319.21	109.3
30	INT12082	Localization of IL6	365	0.81	241.78	105.78
31	INT10272	Gene_expression of Il1b	194	0.78	121.02	103.03
32	INT10838	Positive_regulation of IL8	381	0.70	295.51	101.62
33	INT397	Localization of SST	232	0.81	58.05	101.19
34	INT11381	Positive_regulation of IL1B	330	0.70	209.31	100.9
35	INT74058	Gene_expression of Nos1	260	0.78	80.04	95.71
36	INT1639	Negative_regulation of OPRM1	107	0.59	13.86	90.37
37	INT64158	Negative_regulation of Prkca	121	0.59	29.8	88.66
38	INT10166	Localization of Tnf	237	0.81	153.95	88.64
39	INT8650	Gene_expression of Gal	152	0.78	61.97	81.72
40	INT1309	Positive_regulation of Localization of Gnrhr	152	0.69	24.25	81.56
41	INT7528	Regulation of OPRM1	100	0.62	20.63	80.57
42	INT148	Positive_regulation of Gnrhr	182	0.70	47.44	79.64
43	INT15769	Gene_expression of Il1b	146	0.78	114.51	75.35
44	INT10274	Positive_regulation of Il1b	123	0.70	79.76	73.56
45	INT9236	Regulation of Gene_expression of TNF	204	0.62	162.66	72.99
46	INT11380	Negative_regulation of IL1B	215	0.59	125.62	72.35
47	INT10359	Gene_expression of Ifng	159	0.78	79.6	72.14
48	INT5969	Gene_expression of Il1a	221	0.75	96.31	71.38
49	INT58400	Negative_regulation of Tnf	182	0.59	129.97	71
50	INT49995	Positive_regulation of Gene_expression of Tnf	187	0.70	125.07	70.54
51	INT10837	Positive_regulation of Gene_expression of IL8	294	0.70	190.08	70.34
52	INT6849	Localization of IL1B	229	0.81	112.56	69.63
53	INT7534	Gene_expression of Ifng	193	0.78	111.02	68.6
54	INT9484	Gene_expression of Jun	175	0.78	34.89	68.54
55	INT6489	Positive_regulation of Gene_expression of Tnf	140	0.70	92.31	67.85
56	INT19511	Localization of Il6	212	0.81	118.17	67.67
57	INT6486	Positive_regulation of Tnf	168	0.70	123.47	66.05
58	INT8347	Gene_expression of SST	181	0.78	104.59	65.45
59	INT15613	Negative_regulation of Ptgs2	160	0.59	71.08	65.08
60	INT11937	Localization of Il6	228	0.81	139.83	64.39
61	INT9657	Positive_regulation of Gene_expression of Il6	237	0.70	180.45	63.6
62	INT10706	Regulation of Il6	150	0.62	93.23	62.34
63	INT50971	Gene_expression of Ntrk1	180	0.75	73.52	62.28
64	INT17401	Gene_expression of IGF1	475	0.78	232.18	62.07
65	INT39153	Positive_regulation of PTGS2	182	0.70	96.16	60.6
66	INT14740	Gene_expression of TGFB1	272	0.78	168.48	60.18
67	INT770	Regulation of Localization of Gnrhr	127	0.61	17.91	58.23
68	INT48901	Negative_regulation of IL6	186	0.57	136.33	57.87
69	INT64159	Gene_expression of Prkca	90	0.78	34.65	55.97
70	INT52692	Gene_expression of Ptgs2	160	0.78	85.06	55.73
71	INT19	Regulation of Gnrhr	131	0.62	36.4	55.66
72	INT52800	Negative_regulation of Gene_expression of Tnf	142	0.59	92.27	55.47
73	INT82650	Gene_expression of Bcl2	312	0.78	211.71	55.03
74	INT49993	Positive_regulation of Gene_expression of Il6	149	0.70	88.07	53.78
75	INT9234	Negative_regulation of Gene_expression of IL6	171	0.59	101.61	53.15
76	INT52611	Negative_regulation of Ptgs2	142	0.59	66.31	52.71
77	INT69484	Positive_regulation of Gene_expression of OPRM1	75	0.70	12.86	52.27
78	INT22112	Positive_regulation of Localization of TNF	164	0.70	115.66	52.18
79	INT5118	Regulation of SST	97	0.62	34.35	51.74
80	INT83199	Gene_expression of Nos3	193	0.78	100.72	51.57
81	INT49028	Positive_regulation of Nos1	102	0.70	34.73	51.05
82	INT6473	Positive_regulation of Gene_expression of IL1B	204	0.70	117.23	50.86
83	INT53083	Gene_expression of Ptgs2	153	0.78	90.04	50.39
84	INT9210	Regulation of IL6	166	0.62	125.61	49.95
85	INT6796	Positive_regulation of Jun	165	0.70	37.18	49.64
86	INT51163	Gene_expression of Gal	119	0.78	67.48	49.23
87	INT66029	Negative_regulation of Tnf	100	0.59	84.28	48.16
88	INT55670	Negative_regulation of Gene_expression of Tnf	83	0.59	57.16	46.33
89	INT1564	Localization of OPRM1	41	0.80	8.03	44.67
90	INT5307	Regulation of Tnf	87	0.62	78.71	43.4
91	INT50957	Negative_regulation of Il6	134	0.59	79.08	42.67
92	INT13354	Transcription of TNF	108	0.72	85.81	42.32
93	INT5130	Regulation of GNRH1	139	0.62	31.95	42.08
94	INT9298	Positive_regulation of Gtpbp4	64	0.69	12.29	41.97
95	INT9233	Negative_regulation of Gene_expression of IL1B	114	0.59	56.99	41.82
96	INT65245	Gene_expression of Nos3	121	0.78	98.14	41.56
97	INT11939	Negative_regulation of Il6	138	0.59	87.46	41.24
98	INT57442	Phosphorylation of Prkca	98	0.70	31.58	41.04
99	INT48075	Positive_regulation of Il1b	71	0.67	48.63	40.48
100	INT5973	Regulation of IL1B	109	0.62	66.6	39.88
101	INT16455	Gene_expression of Drd2	116	0.78	22.71	38.47
102	INT55135	Positive_regulation of Gene_expression of PTGS2	137	0.70	80.32	38.46
103	INT11854	Gene_expression of Il1rl1	57	0.77	30.19	38.25
104	INT43507	Gene_expression of Gabbr1	79	0.78	28.53	38.22
105	INT77307	Gene_expression of Bcl2	399	0.77	319.77	38
106	INT385	Gene_expression of Agt	182	0.78	63.62	37.91
107	INT5039	Positive_regulation of Gal	67	0.68	27.97	37.36
108	INT48222	Positive_regulation of Localization of IL8	123	0.59	78.04	37.2
109	INT64558	Negative_regulation of Nos1	88	0.58	26.76	36.78
110	INT9239	Regulation of Gene_expression of IL6	106	0.61	75.24	36.53
111	INT390	Positive_regulation of Agt	170	0.70	61.47	36.08
112	INT77407	Regulation of Gene_expression of OPRM1	51	0.62	12.58	35.75
113	INT13501	Binding of Drd2	65	0.48	23.76	35.6
114	INT1361	Negative_regulation of Gnrhr	118	0.58	57.77	35.54
115	INT53577	Negative_regulation of Localization of TNF	110	0.59	59.28	35.23
116	INT6484	Binding of IL1B	122	0.47	75.84	35.07
117	INT326	Gene_expression of Gnrhr	105	0.76	35.87	34.93
118	INT692	Negative_regulation of SST	72	0.59	28.68	34.52
119	INT67613	Positive_regulation of PPARG	94	0.70	69.15	34.38
120	INT14559	Gene_expression of Igf1	254	0.78	112	34.17
121	INT666	Gene_expression of Jun	124	0.78	54.61	33.67
122	INT40160	Positive_regulation of Adora1	74	0.70	26.36	33.03
123	INT5868	Positive_regulation of GNRH1	122	0.69	20.96	32.8
124	INT691	Binding of SST	67	0.48	24.66	32.67
125	INT9658	Negative_regulation of Gene_expression of Il6	110	0.59	66.29	32.58
126	INT8915	Gene_expression of Igf1	199	0.78	78.58	32.51
127	INT6683	Gene_expression of Drd2	64	0.78	11.31	32.28
128	INT73982	Gene_expression of Hmox1	141	0.78	119.43	32.17
129	INT9655	Regulation of Il6	98	0.62	70.92	31.95
130	INT1159	Negative_regulation of Agt	133	0.59	40.14	31.67
131	INT35406	Localization of Tnf	94	0.81	64.63	31.65
132	INT9347	Localization of Il1b	58	0.81	26.13	31.53
133	INT11087	Positive_regulation of Drd2	54	0.69	12.4	31.43
134	INT47764	Binding of Jun	106	0.48	22.62	31.39
135	INT7396	Regulation of Localization of GNRH1	81	0.62	6.57	31.31
136	INT86780	Positive_regulation of Hmox1	145	0.70	117.09	31.18
137	INT56290	Negative_regulation of Gene_expression of Il6	79	0.59	47.98	31.07
138	INT64164	Regulation of Prkca	34	0.62	10.44	30.99
139	INT1158	Regulation of Agt	106	0.61	29.4	30.29
140	INT69483	Transcription of OPRM1	45	0.72	7.31	30.22
141	INT77652	Negative_regulation of Gene_expression of IL8	99	0.59	67.57	30.21
142	INT52690	Positive_regulation of Ptgs2	65	0.68	39.51	30.02
143	INT7397	Negative_regulation of Localization of GNRH1	86	0.59	15.45	29.78
144	INT6660	Positive_regulation of Jun	148	0.69	67.58	29.73
145	INT50230	Positive_regulation of Localization of IL6	105	0.70	69.21	29.52
146	INT7412	Positive_regulation of SST	71	0.70	24.44	29.48
147	INT86437	Binding of IL6	154	0.48	121.22	29.3
148	INT49431	Phosphorylation of OPRM1	31	0.82	2.2	29.09
149	INT4868	Gene_expression of GAL	75	0.78	22.23	29.02
150	INT28361	Gene_expression of TP53	443	0.78	384.86	28.8
151	INT57692	Positive_regulation of Gene_expression of Il1b	50	0.67	43.54	28.29
152	INT22045	Gene_expression of IRF6	158	0.75	58.07	27.81
153	INT48202	Gene_expression of Tgfb1	146	0.78	89.93	27.76
154	INT5135	Negative_regulation of GNRH1	106	0.58	36.63	27.71
155	INT64499	Positive_regulation of IRF6	123	0.49	52.73	27.51
156	INT5604	Positive_regulation of Drd2	47	0.67	10.75	27.41
157	INT17331	Positive_regulation of JUN	132	0.69	60.4	27.03
158	INT52801	Regulation of Gene_expression of Tnf	55	0.62	48.74	26.59
159	INT5966	Localization of Il1a	50	0.78	22.91	26.54
160	INT3559	Negative_regulation of Localization of Gnrhr	73	0.58	18.89	26.41
161	INT9682	Positive_regulation of IGF1	238	0.70	120.03	26.36
162	INT10273	Positive_regulation of Gene_expression of Il1b	47	0.68	31.15	26.21
163	INT50490	Regulation of PTGS2	80	0.48	39.51	25.85
164	INT5948	Regulation of Il1b	44	0.60	22.8	25.4
165	INT74688	Regulation of Nos1	55	0.62	22.16	25.3
166	INT7394	Positive_regulation of Localization of GNRH1	67	0.69	7.22	25.29
167	INT67610	Positive_regulation of Pparg	53	0.70	31.91	25.2
168	INT56224	Negative_regulation of Gene_expression of Ifng	40	0.58	23.34	25.08
169	INT5199	Gene_expression of Fosl1	44	0.78	8.66	24.8
170	INT43486	Positive_regulation of Ifng	52	0.69	32.71	24.77
171	INT12484	Binding of Drd2	45	0.48	15.17	24.72
172	INT10836	Negative_regulation of IL8	95	0.59	52.59	24.71
173	INT100423	Gene_expression of Bax	141	0.75	98.43	24.48
174	INT10349	Negative_regulation of Il1b	48	0.58	25.53	24.24
175	INT10835	Regulation of IL8	79	0.49	53.04	24.14
176	INT8518	Localization of Ifng	53	0.81	36.68	24.13
177	INT14556	Positive_regulation of Igf1	105	0.69	52.21	24.04
178	INT5131	Gene_expression of GNRH1	109	0.78	28.79	23.94
179	INT63419	Gene_expression of PTGES	109	0.77	40.83	23.67
180	INT51029	Negative_regulation of Il1b	34	0.57	29.34	23.62
181	INT11746	Positive_regulation of Il1a	65	0.63	42.94	23.54
182	INT50970	Positive_regulation of Ntrk1	51	0.57	29.38	22.83
183	INT3330	Gene_expression of AGT	149	0.76	98.65	22.73
184	INT48081	Localization of Il1b	46	0.80	21.59	22.4
185	INT66753	Negative_regulation of Positive_regulation of Tnf	45	0.59	35.28	22.33
186	INT7715	Regulation of Drd2	35	0.62	10.79	22.3
187	INT48312	Gene_expression of NTRK1	72	0.78	38.21	22.24
188	INT14731	Positive_regulation of TGFB1	78	0.67	52.57	22.23
189	INT14733	Positive_regulation of Gene_expression of TGFB1	71	0.69	49.89	22.2
190	INT8483	Positive_regulation of Positive_regulation of TNF	73	0.67	60.35	22.03
191	INT3299	Positive_regulation of AGT	126	0.68	79.45	21.91
192	INT693	Negative_regulation of Localization of SST	46	0.59	8.57	21.75
193	INT73625	Gene_expression of PPARG	108	0.78	104.85	21.42
194	INT74059	Positive_regulation of Gene_expression of Nos1	55	0.70	11.5	21.39
195	INT52693	Positive_regulation of Gene_expression of Ptgs2	57	0.70	25.51	21.18
196	INT5040	Regulation of Gal	42	0.60	12.72	21.18
197	INT117527	Binding of Prkca	25	0.48	6.43	21.05
198	INT97798	Localization of IRF6	86	0.73	33.27	20.94
199	INT52106	Negative_regulation of Localization of IL8	57	0.52	22.81	20.8
200	INT28216	Gene_expression of HRAS	173	0.75	93.97	20.78