GO:0008286

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Name insulin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0008286
Unique Molecular Interactions 2360
Total Molecular Interactions 3157
Total Single Events 25490
Pain Genes Associated 104

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
5 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
6 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
7 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
8 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
9 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
10 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
11 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
12 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
13 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
14 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
15 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
16 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
17 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
18 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
19 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
20 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
21 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
22 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
23 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
24 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
25 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
26 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
27 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
28 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
29 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
30 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
31 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
32 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
33 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
34 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
35 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
36 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
37 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
38 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
39 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
40 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
41 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
42 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
43 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23
44 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
45 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
46 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
47 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
48 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
49 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
50 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
51 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
52 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
53 INT37153 Binding of Mpz and Ptpn2 1 0.12 0.68 1.08
54 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
55 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
56 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
57 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
58 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
59 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
60 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
61 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
62 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
63 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
64 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
65 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
66 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
67 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
68 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
69 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
70 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
71 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
72 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
73 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
74 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
75 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
76 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
77 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
78 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
79 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
80 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
81 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
82 INT54854 Sorbs1 Regulation of Ins1 1 0.34 0.23 0.9
83 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
84 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
85 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
86 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
87 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
88 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
89 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
90 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
91 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
92 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
93 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
94 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
95 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
96 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
97 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
98 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
99 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
100 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
101 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
102 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
103 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
104 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
105 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
106 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
107 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
108 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
109 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
110 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
111 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
112 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
113 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
114 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
115 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
116 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
117 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
118 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
119 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
120 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
121 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
122 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
123 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
124 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
125 INT180805 Bdnf Regulation of Sorbs1 1 0.01 0.14 0.67
126 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
127 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
128 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
129 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
130 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
131 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
132 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
133 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
134 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
135 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
136 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
137 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
138 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
139 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
140 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
141 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
142 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
143 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
144 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
145 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
146 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
147 INT326471 Binding of ATP6V0A1 and IGKV2D-29 1 0.00 0.09 0.62
148 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
149 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
150 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
151 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
152 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
153 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
154 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
155 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
156 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
157 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
158 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
159 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
160 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
161 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
162 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
163 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
164 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
165 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
166 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
167 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
168 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
169 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
170 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
171 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
172 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
173 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
174 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
175 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
176 INT84067 IGFBP1 Regulation of GH1 1 0.02 1.18 0.54
177 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
178 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
179 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
180 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
181 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
182 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
183 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
184 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
185 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
186 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
187 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
188 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
189 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
190 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
191 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
192 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
193 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
194 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
195 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
196 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
197 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
198 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
199 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
200 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
4 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
5 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
6 INT251 Regulation of INS 398 0.62 232.47 55.04
7 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
8 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
9 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
10 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
11 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
12 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
13 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
14 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
15 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
16 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
17 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
18 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
19 INT8691 Localization of Insr 85 0.80 9.27 30.32
20 INT5300 Regulation of Insr 54 0.60 11.33 29.26
21 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
22 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
23 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
24 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
25 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
26 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
27 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
28 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
29 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
30 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
31 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
32 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
33 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
34 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
35 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
36 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
37 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
38 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
39 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
40 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
41 INT14572 Binding of INS 205 0.48 175.43 13.38
42 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
43 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
44 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
45 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63
46 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
47 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
48 INT8533 Regulation of Sorbs1 9 0.27 3.01 11.98
49 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
50 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
51 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
52 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
53 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
54 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
55 INT8535 Localization of Sorbs1 9 0.80 2.71 9.07
56 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
57 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
58 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
59 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
60 INT72539 Gene_expression of Sorbs1 10 0.78 4.98 8.14
61 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
62 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
63 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
64 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
65 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
66 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48
67 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4
68 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
69 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
70 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
71 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
72 INT228659 Phosphorylation of Eif4ebp1 10 0.80 27.53 6.87
73 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
74 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
75 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
76 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
77 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
78 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
79 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
80 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
81 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
82 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78
83 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
84 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
85 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
86 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
87 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
88 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
89 INT216754 Binding of ATP6V0A1 5 0.11 0.71 4.98
90 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
91 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
92 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
93 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
94 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
95 INT134657 Localization of Akt1 37 0.68 11.58 4.62
96 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
97 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
98 INT72538 Negative_regulation of Sorbs1 7 0.59 4.49 4.61
99 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
100 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
101 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
102 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39
103 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
104 INT9334 Positive_regulation of Igfbp1 22 0.54 9.3 4.31
105 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
106 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
107 INT20981 Binding of HRAS 42 0.48 24.49 4.23
108 INT51084 Binding of Insr 13 0.30 4.25 4.23
109 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
110 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
111 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16
112 INT75136 Binding of Akt1 27 0.27 8.81 4.15
113 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
114 INT83035 Binding of INSR 16 0.47 9.29 4.11
115 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1
116 INT43903 Regulation of Ptpn2 21 0.41 15.51 4.08
117 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
118 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
119 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
120 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
121 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
122 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
123 INT169475 Localization of HRAS 14 0.73 9.02 3.9
124 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8
125 INT28389 Negative_regulation of Ptpra 5 0.37 0.4 3.69
126 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
127 INT136692 Localization of Akt1 12 0.78 2.14 3.65
128 INT8536 Binding of Sorbs1 2 0.14 1.24 3.64
129 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59
130 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
131 INT10116 Localization of INSR 11 0.57 5.43 3.48
132 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
133 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
134 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36
135 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
136 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
137 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
138 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
139 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26
140 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
141 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
142 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
143 INT175262 Binding of SH2B2 18 0.36 22.85 3.18
144 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
145 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
146 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
147 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
148 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
149 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
150 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
151 INT115317 Transcription of FGF2 14 0.62 12.79 3
152 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
153 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99
154 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
155 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
156 INT52878 Positive_regulation of ATP6V0A1 9 0.54 1.35 2.92
157 INT77226 Phosphorylation of Eif4ebp1 36 0.09 6.39 2.91
158 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
159 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
160 INT72384 Positive_regulation of Phosphorylation of Shc1 1 0.32 0.48 2.9
161 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
162 INT306949 Gene_expression of NAMPT 27 0.67 24.47 2.86
163 INT140378 Negative_regulation of Irs2 4 0.57 1.77 2.86
164 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
165 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
166 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
167 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
168 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
169 INT204524 Binding of TLR9 17 0.43 11.69 2.76
170 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
171 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
172 INT182893 Gene_expression of Sh2b2 8 0.65 1.74 2.65
173 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63
174 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
175 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6
176 INT299340 Negative_regulation of RPTOR 1 0.53 1.68 2.6
177 INT214355 Binding of Akt1 13 0.36 3.72 2.59
178 INT142908 Localization of FGFR1 18 0.38 11.46 2.57
179 INT122060 Positive_regulation of Positive_regulation of Sorbs1 2 0.34 0.06 2.57
180 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52
181 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
182 INT9330 Binding of Igfbp1 8 0.31 2.99 2.5
183 INT24672 Localization of FGF2 27 0.71 14.59 2.48
184 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48
185 INT14561 Gene_expression of Igfbp1 12 0.35 6.27 2.46
186 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45
187 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
188 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
189 INT9721 Gene_expression of Ptpra 3 0.26 5.97 2.38
190 INT7410 Positive_regulation of Localization of FGFR3 9 0.45 1.97 2.36
191 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
192 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
193 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
194 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
195 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
196 INT118791 Binding of AKT1 32 0.48 15.51 2.25
197 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23
198 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
199 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
200 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
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