GO:0008299

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Name isoprenoid biosynthetic process
Categary Process
Go Slim No
Go Link GO:0008299
Unique Molecular Interactions 77
Total Molecular Interactions 89
Total Single Events 756
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for isoprenoid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for isoprenoid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18593 Binding of Sst and Fdft1 2 0.11 0.08 2.12
2 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
3 INT348380 Binding of Fdps and Lpar5 1 0.07 1.45 1.25
4 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
5 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
6 INT52435 Positive_regulation of Binding of Sst and Fdft1 1 0.09 0.08 0.98
7 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 0.08 0 0.96
8 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
9 INT348396 Binding of LPAR5 and Fdps 1 0.07 0.81 0.69
10 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
11 INT348381 Fdps Positive_regulation of Lpar5 1 0.07 0.75 0.64
12 INT348399 Fdps Positive_regulation of LPAR5 1 0.08 0.75 0.64
13 INT190003 Binding of MVD and Slc6a3 1 0.13 0.19 0.37
14 INT110274 Binding of Fdps and Plin2 1 0.00 0.22 0.18
15 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
16 INT152628 Mvk Negative_regulation of Cysltr1 1 0.46 0 0.13
17 INT270723 Negative_regulation of HMGCR Positive_regulation of LDLR 1 0.02 0.52 0.12
18 INT176020 IL8 Negative_regulation of Phosphorylation of HMGCR 1 0.00 0.1 0.11
19 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
20 INT206075 Negative_regulation of FDPS Negative_regulation of Binding of GGPS1 1 0.01 0 0.09
21 INT206078 Binding of FDPS and GGPS1 1 0.00 0 0.09
22 INT205589 Binding of PPT2 and COQ2 1 0.04 1.02 0.07
23 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
24 INT102505 VEGFA Negative_regulation of Fdft1 1 0.00 0.56 0.06
25 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06
26 INT270134 BPs Negative_regulation of FDPS 1 0.01 0.36 0.05
27 INT239320 Eef1a2 Negative_regulation of Hmgcr 1 0.06 0.89 0.04
28 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
29 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
30 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03
31 INT248493 Pdss1 Positive_regulation of Gene_expression of Smn1 1 0.16 0.4 0.03
32 INT301243 Mir29a Positive_regulation of Mvd 1 0.03 1.66 0
33 INT268095 Binding of IFNW1 and PDSS1 1 0.00 0.35 0
34 INT248497 Positive_regulation of Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0
35 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0
36 INT248494 Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0
37 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
38 INT206085 FDPS Positive_regulation of AGFG1 1 0.00 0.4 0
39 INT233323 GAD1 Regulation of HMGCR 1 0.09 0.2 0
40 INT248501 Binding of Upf1 and Pdss1 1 0.01 0.21 0
41 INT316355 Binding of CR1 and Hmgcr 1 0.01 0.59 0
42 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0
43 INT205863 Binding of FDPS and HTLVR 1 0.00 0.07 0
44 INT268096 Binding of CYP4F3 and PDSS1 1 0.00 0.35 0
45 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0
46 INT283009 Binding of Bcl2 and Pdss2 1 0.03 0.56 0
47 INT206060 FDPS Positive_regulation of AKT1 1 0.00 0.4 0
48 INT301242 Mvd Positive_regulation of Gene_expression of Mir29a 1 0.04 0.1 0
49 INT248491 Binding of Smn1 and Pdss1 1 0.12 0.21 0
50 INT248495 Pdss1 Positive_regulation of Smn1 1 0.13 0.25 0
51 INT268098 Binding of FAS and PDSS1 1 0.03 0.34 0
52 INT283004 Binding of Becn1 and Pdss2 1 0.00 0.57 0
53 INT320702 Binding of PMVK and C1QL3 1 0.01 0.06 0
54 INT326064 APOA1 Positive_regulation of HMGCR 1 0.16 0.19 0
55 INT339709 HMGCR Positive_regulation of Gene_expression of SREBF2 1 0.05 0.54 0
56 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
57 INT206181 FDPS Positive_regulation of ras 1 0.00 0.4 0
58 INT205875 Binding of FDPS and G4 1 0.02 0.13 0
59 INT246533 Fdft1 Positive_regulation of Gene_expression of Gstp2 1 0.01 1.57 0
60 INT262156 Nr1i2 Negative_regulation of Gene_expression of Hmgcs2 1 0.22 0.22 0
61 INT282287 Binding of Cpox and Hmgcr 1 0.01 0.99 0
62 INT248498 Smn1 Positive_regulation of Pdss1 1 0.16 0.09 0
63 INT329221 Prkag1 Negative_regulation of Hmgcr 1 0.06 0.48 0
64 INT326066 APOA1 Positive_regulation of Positive_regulation of HMGCR 1 0.17 0.19 0
65 INT295499 Lcat Regulation of Transcription of Hmgcr 1 0.04 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for isoprenoid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in isoprenoid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT879 Localization of Fdft1 16 0.59 1.11 12.59
2 INT92493 Gene_expression of Fdps 19 0.75 11.28 10.08
3 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
4 INT14029 Regulation of Fdft1 9 0.19 0.68 7.4
5 INT7695 Positive_regulation of Fdft1 13 0.30 1.51 6.51
6 INT2552 Binding of Fdft1 6 0.15 0.48 5.88
7 INT7696 Negative_regulation of Fdft1 9 0.21 2.8 5.64
8 INT37139 Negative_regulation of Fdps 9 0.38 4.33 4.46
9 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
10 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
11 INT18591 Positive_regulation of Localization of Fdft1 4 0.12 0.73 3.48
12 INT26641 Gene_expression of Fdft1 4 0.20 1.61 3.15
13 INT111820 Positive_regulation of Fdps 10 0.42 10.63 3.01
14 INT151947 Positive_regulation of MVD 3 0.67 1.53 2.97
15 INT179867 Localization of Fdps 7 0.63 3.62 2.86
16 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94
17 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91
18 INT64503 Negative_regulation of PDSS1 3 0.38 1.39 1.47
19 INT40720 Negative_regulation of Localization of Fdft1 2 0.36 0 1.36
20 INT85378 Binding of Pdss1 6 0.28 3.81 1.35
21 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
22 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
23 INT14028 Transcription of Fdft1 2 0.34 0.07 1.21
24 INT877 Regulation of Localization of Fdft1 2 0.19 0 1.18
25 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
26 INT153129 Positive_regulation of Pdss1 25 0.21 5.83 1.1
27 INT15346 Negative_regulation of Regulation of Fdft1 1 0.13 0.21 1.08
28 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
29 INT116512 Gene_expression of MVD 4 0.75 1.61 1.06
30 INT25071 Binding of PDSS1 5 0.32 2.42 0.97
31 INT37950 Regulation of PDSS1 3 0.44 1.24 0.91
32 INT81904 Positive_regulation of FDPS 5 0.67 2.83 0.85
33 INT62247 Positive_regulation of Transcription of Fdft1 1 0.08 0 0.82
34 INT62233 Regulation of Regulation of Fdft1 1 0.10 0 0.73
35 INT85379 Gene_expression of Pdss1 19 0.55 3.42 0.72
36 INT190002 Regulation of MVD 1 0.13 0.87 0.66
37 INT37252 Binding of Fdps 4 0.20 3.57 0.63
38 INT90213 Negative_regulation of Mvk 3 0.05 6.28 0.59
39 INT288644 Binding of Pdss2 2 0.25 1.37 0.55
40 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52
41 INT348392 Positive_regulation of Phosphorylation of Fdps 1 0.16 0.59 0.47
42 INT348389 Phosphorylation of Fdps 1 0.26 0.59 0.47
43 INT191583 Positive_regulation of Gene_expression of Fdps 2 0.15 1.55 0.44
44 INT348395 Negative_regulation of Gene_expression of Fdps 1 0.16 0.49 0.42
45 INT80543 Negative_regulation of Pdss1 4 0.42 0.95 0.36
46 INT168166 Positive_regulation of Mvk 3 0.37 0 0.35
47 INT191601 Negative_regulation of Fdft1 2 0.04 2.13 0.33
48 INT273132 Regulation of FDPS 1 0.31 1.28 0.33
49 INT142695 Gene_expression of HMGCR 17 0.65 3.75 0.32
50 INT54557 Positive_regulation of Positive_regulation of Fdft1 1 0.13 0 0.32
51 INT92249 Gene_expression of FDPS 7 0.46 4.97 0.31
52 INT232236 Negative_regulation of Gene_expression of Hmgcr 3 0.35 1.36 0.31
53 INT81908 Binding of FDPS 3 0.36 1.27 0.31
54 INT54558 Positive_regulation of Gene_expression of Fdft1 1 0.18 0 0.31
55 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29
56 INT322907 Positive_regulation of Gene_expression of Hmgcr 4 0.03 1.45 0.28
57 INT37951 Positive_regulation of PDSS1 8 0.41 2.5 0.27
58 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23
59 INT182749 Binding of Hmgcr 3 0.32 0.55 0.22
60 INT176036 Phosphorylation of HMGCR 1 0.05 0.19 0.22
61 INT171829 Localization of PDSS1 1 0.65 0.18 0.18
62 INT122383 Negative_regulation of Negative_regulation of Fdft1 1 0.02 0.44 0.17
63 INT191584 Protein_catabolism of Fdps 1 0.12 1.92 0.16
64 INT227749 Negative_regulation of Binding of Pdss1 1 0.04 0.95 0.16
65 INT190001 Negative_regulation of Positive_regulation of MVD 1 0.12 0.23 0.16
66 INT101388 Regulation of Fdps 4 0.38 0.97 0.15
67 INT87196 Regulation of Hmgcr 3 0.45 0.7 0.14
68 INT176038 Binding of HMGCR 1 0.03 0.72 0.14
69 INT26642 Negative_regulation of Gene_expression of Fdft1 1 0.02 0.35 0.14
70 INT191658 Negative_regulation of GGPS1 3 0.09 0.06 0.13
71 INT315005 Binding of Hmgcs2 1 0.11 0.73 0.11
72 INT246532 Positive_regulation of Fdft1 1 0.01 3.85 0.11
73 INT191645 Regulation of Fdft1 1 0.01 0.29 0.11
74 INT142342 Regulation of Negative_regulation of Hmgcr 1 0.20 0.48 0.1
75 INT151948 Positive_regulation of Gene_expression of MVD 2 0.49 1.35 0.09
76 INT206157 Binding of GGPS1 1 0.04 0 0.09
77 INT320705 Gene_expression of PMVK 1 0.50 0.8 0.09
78 INT191660 Positive_regulation of GGPS1 2 0.05 0.15 0.08
79 INT228554 Negative_regulation of Negative_regulation of Hmgcr 1 0.24 0.44 0.08
80 INT197011 Regulation of Gene_expression of HMGCR 1 0.32 0.09 0.08
81 INT81905 Protein_catabolism of FDPS 1 0.64 0.78 0.07
82 INT81907 Positive_regulation of Binding of FDPS 1 0.49 0.8 0.07
83 INT248484 Positive_regulation of Gene_expression of Pdss1 1 0.15 0.31 0.07
84 INT153688 Negative_regulation of Negative_regulation of Hmgcr 1 0.42 1.21 0.06
85 INT153690 Localization of Hmgcr 1 0.74 1.21 0.06
86 INT153689 Negative_regulation of Localization of Hmgcr 1 0.42 1.21 0.06
87 INT246531 Gene_expression of Fdft1 1 0.01 3.08 0.05
88 INT71164 Gene_expression of PDSS1 7 0.59 4.78 0.04
89 INT176037 Transcription of HMGCR 2 0.37 0.07 0.04
90 INT282271 Positive_regulation of Regulation of Hmgcr 1 0.12 1.44 0.04
91 INT71163 Negative_regulation of Gene_expression of PDSS1 1 0.37 0.57 0.04
92 INT318720 Regulation of Binding of Pdss1 1 0.02 0.74 0.04
93 INT295501 Negative_regulation of Gene_expression of Hmgcr 1 0.26 0.21 0.04
94 INT176040 Negative_regulation of Transcription of HMGCR 1 0.04 0.07 0.04
95 INT311758 Regulation of Gene_expression of Hmgcr 1 0.08 0 0.04
96 INT176033 Positive_regulation of HMGCR 8 0.33 2.56 0.03
97 INT200791 Binding of Mvd 1 0.13 1.5 0.03
98 INT243183 Regulation of Negative_regulation of HMGCR 1 0.15 0.06 0.03
99 INT320708 Binding of PMVK 1 0.36 0.58 0.03
100 INT200788 Positive_regulation of Mvd 2 0.17 1.55 0
101 INT197015 Positive_regulation of Gene_expression of HMGCR 2 0.29 0.76 0
102 INT176185 Transcription of Hmgcr 2 0.31 0.56 0
103 INT205590 Positive_regulation of COQ2 1 0.49 0.49 0
104 INT191657 Positive_regulation of Gene_expression of GGPS1 1 0.04 0.29 0
105 INT248466 Regulation of Localization of Pdss1 1 0.14 0.57 0
106 INT205591 Positive_regulation of Positive_regulation of COQ2 1 0.49 0.24 0
107 INT248476 Localization of Pdss1 1 0.23 0.85 0
108 INT197013 Localization of HMGCR 1 0.36 0 0
109 INT262066 Positive_regulation of Transcription of Hmgcs2 1 0.23 0.12 0
110 INT262058 Gene_expression of Hmgcs2 1 0.28 0.21 0
111 INT191653 Negative_regulation of Gene_expression of GGPS1 1 0.03 0.3 0
112 INT37952 Regulation of Positive_regulation of PDSS1 1 0.09 0.08 0
113 INT116511 Negative_regulation of Gene_expression of MVD 1 0.57 0.2 0
114 INT262110 Negative_regulation of Hmgcs2 1 0.20 0.09 0
115 INT176904 Negative_regulation of Transcription of PDSS1 1 0.02 0.37 0
116 INT248487 Negative_regulation of Gene_expression of Pdss1 1 0.13 0.14 0
117 INT205593 Binding of COQ2 1 0.37 0 0
118 INT343817 Transcription of Fdps 1 0.32 0 0
119 INT320704 Regulation of PMVK 1 0.33 0.05 0
120 INT176897 Transcription of PDSS1 1 0.03 0.36 0
121 INT247129 Positive_regulation of Protein_catabolism of Hmgcr 1 0.06 0.38 0
122 INT191656 Negative_regulation of Gene_expression of FDPS 1 0.03 0.65 0
123 INT301210 Gene_expression of Mvd 1 0.19 1.48 0
124 INT262101 Transcription of Hmgcs2 1 0.32 0.21 0
125 INT176209 Negative_regulation of Transcription of Hmgcr 1 0.25 0.3 0
126 INT151949 Positive_regulation of Positive_regulation of MVD 1 0.49 0.16 0
127 INT173493 Regulation of Gene_expression of Hmgcr 1 0.33 0 0
128 INT247134 Protein_catabolism of Hmgcr 1 0.14 0.38 0
129 INT343816 Regulation of Gene_expression of Fdps 1 0.21 0.43 0
130 INT191661 Gene_expression of GGPS1 1 0.05 0.73 0
131 INT273131 Regulation of Gene_expression of FDPS 1 0.31 0.64 0
132 INT248467 Regulation of Pdss1 1 0.08 0.16 0
133 INT203686 Negative_regulation of Positive_regulation of Hmgcr 1 0.02 0.4 0
134 INT301206 Negative_regulation of Gene_expression of Mvd 1 0.12 0.1 0
135 INT258070 Positive_regulation of Regulation of HMGCR 1 0.10 0.44 0
136 INT295506 Transcription of Hmgcr 1 0.43 0.19 0
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