GO:0008328

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Name ionotropic glutamate receptor complex
Categary Component
Go Slim No
Go Link GO:0008328
Unique Molecular Interactions 88
Total Molecular Interactions 103
Total Single Events 1446
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor complex. They are ordered first by their pain relevance and then by number of times they were reported for ionotropic glutamate receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
2 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
3 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
4 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
5 INT127545 Gria1 Positive_regulation of Gene_expression of Gnptab 1 0.00 0.7 0.83
6 INT214876 Ap3d1 Negative_regulation of Gria1 1 0.00 0.4 0.78
7 INT311525 Binding of Gria1 and Ltp 1 0.00 0.1 0.73
8 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
9 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
10 INT51433 Gria1 Positive_regulation of Eif3g 1 0.03 0 0.7
11 INT162224 Grin1 Positive_regulation of Gene_expression of Gria1 1 0.27 0.07 0.66
12 INT162223 Grin1 Positive_regulation of Localization of Gria2 1 0.23 0.07 0.66
13 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
14 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
15 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
16 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
17 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
18 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
19 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
20 INT134530 Grin1 Regulation of Gria1 1 0.12 0 0.56
21 INT312751 Phosphorylation of Gria1 Positive_regulation of GRIA1 1 0.18 0.22 0.55
22 INT259184 Binding of Gria2 and Gria1 2 0.26 0.28 0.54
23 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54
24 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54
25 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
26 INT349130 Phosphorylation of Gria1 Positive_regulation of Shisa9 1 0.00 0.49 0.52
27 INT259180 Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
28 INT259181 Phosphorylation of Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
29 INT259183 Gria1 Positive_regulation of Phosphorylation of Gria2 1 0.30 0.39 0.49
30 INT71318 Grik4 Positive_regulation of Localization of Npy 1 0.05 0 0.47
31 INT273110 Bdnf Regulation of Positive_regulation of Gria1 1 0.43 0 0.47
32 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
33 INT86069 Positive_regulation of Gria1 Positive_regulation of Gene_expression of Fos 1 0.11 0.3 0.42
34 INT127543 Gria1 Positive_regulation of Gene_expression of Cryge 1 0.00 0.35 0.42
35 INT74713 Binding of Gria1 and Olr1868 1 0.00 0 0.42
36 INT127546 Gria1 Positive_regulation of Gene_expression of Kcnab3 1 0.02 0.35 0.42
37 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4
38 INT78558 Pomgnt1 Negative_regulation of Shisa9 1 0.00 0 0.35
39 INT103482 RARB Positive_regulation of Gene_expression of Gria1 1 0.00 0 0.27
40 INT103483 BDNF Positive_regulation of Gene_expression of Gria1 1 0.03 0 0.26
41 INT51432 Gria1 Positive_regulation of Trib3 1 0.04 0 0.25
42 INT197235 Binding of Grik1 and Kars 1 0.32 0.1 0.25
43 INT197232 Binding of Grik5 and Kars 1 0.17 0.1 0.25
44 INT273109 Bdnf Positive_regulation of Gene_expression of Gria1 1 0.66 0.07 0.24
45 INT102283 Binding of Grin2d and Nr2c2 1 0.03 0.08 0.24
46 INT287763 Binding of Gria2 and Ap3m1 1 0.02 0.33 0.21
47 INT311527 Binding of Grin2a and Gria1 1 0.01 0 0.21
48 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
49 INT287764 Binding of Gria2 and Nsf 1 0.34 0.33 0.18
50 INT346748 Binding of Shisa9 and Grip2 1 0.00 0 0.17
51 INT273097 Binding of Bdnf and Gria1 1 0.39 0.17 0.16
52 INT311526 Gria1 Regulation of Gene_expression of Grin2a 1 0.01 0.32 0.15
53 INT260497 VEGFA Positive_regulation of Gria2 1 0.03 1.08 0.12
54 INT273108 Gria1 Regulation of Positive_regulation of Gria2 1 0.04 0.09 0.1
55 INT273104 Mtor Negative_regulation of Gene_expression of Gria1 1 0.46 0.15 0.08
56 INT273115 Bdnf Negative_regulation of Gene_expression of Gria1 1 0.47 0.15 0.08
57 INT265256 Binding of Gria2 and Cdh2 2 0.02 0.17 0.07
58 INT218829 Ppp1cc Regulation of Phosphorylation of Gria1 1 0.20 0.63 0.07
59 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
60 INT346754 Binding of Dlg4 and Gria2 1 0.02 0 0.06
61 INT218830 Camk2a Regulation of Phosphorylation of Gria1 1 0.36 0.63 0.06
62 INT272600 Binding of Dlg4 and Grik5 1 0.20 0 0.03
63 INT273102 Bdnf Regulation of Gria1 1 0.30 0.08 0.03
64 INT273095 Rbm14 Regulation of Gria1 1 0.00 0.07 0.03
65 INT272601 Binding of Dlg4 and Grik2 1 0.22 0 0.03
66 INT273105 Mtor Regulation of Gria1 1 0.29 0.07 0.03
67 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0
68 INT265258 Positive_regulation of gr Regulation of Gria2 1 0.01 0 0
69 INT346746 Binding of Cacng2 and Gria2 1 0.21 0.18 0
70 INT160810 Gria2 Regulation of Shisa9 1 0.00 0 0
71 INT346747 Binding of Dlg4 and Shisa9 1 0.01 0 0
72 INT346764 Binding of RBM10 and Gria2 1 0.01 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor complex. They are ordered first by their pain relevance and then by number of times they were reported in ionotropic glutamate receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
2 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
3 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
4 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
5 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
6 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
7 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13
8 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
9 INT197210 Positive_regulation of Grik1 24 0.69 3.15 16.24
10 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
11 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85
12 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
13 INT49538 Binding of Gria1 22 0.47 2.66 13.35
14 INT259165 Phosphorylation of Gria2 4 0.65 11.65 11.07
15 INT57069 Regulation of Gria2 28 0.44 10.11 11.06
16 INT8072 Localization of Gria1 17 0.75 2.62 10.04
17 INT259169 Positive_regulation of Phosphorylation of Gria2 3 0.40 9.98 9.34
18 INT78766 Negative_regulation of Gria2 20 0.52 6.27 8.12
19 INT114509 Transcription of Gria2 10 0.58 0.75 7.27
20 INT57023 Negative_regulation of Gene_expression of Gria1 20 0.58 6.92 7.17
21 INT197216 Localization of Grik1 9 0.80 0.39 6.78
22 INT120298 Negative_regulation of Phosphorylation of Gria1 6 0.57 8.99 6.68
23 INT94927 Transcription of Gria1 12 0.69 3.14 5.94
24 INT57068 Regulation of Gene_expression of Gria2 12 0.36 3.76 5.44
25 INT259167 Negative_regulation of Phosphorylation of Gria2 2 0.34 5.24 5.13
26 INT85946 Localization of Gria2 10 0.61 1.23 5.09
27 INT26042 Binding of Gria2 20 0.40 4.88 5.04
28 INT114511 Positive_regulation of Gene_expression of Gria2 14 0.41 3.9 4.71
29 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67
30 INT197230 Regulation of Positive_regulation of Grik1 4 0.45 0 4.42
31 INT92902 Negative_regulation of Positive_regulation of Gria1 6 0.57 1.06 4.1
32 INT131969 Regulation of Grik1 6 0.61 0.57 3.69
33 INT197207 Negative_regulation of Grik1 5 0.43 1.91 3.5
34 INT102276 Gene_expression of Grin2d 10 0.71 4.74 3.37
35 INT84564 Regulation of Positive_regulation of Gria1 2 0.33 1.86 3.3
36 INT51427 Positive_regulation of Positive_regulation of Gria1 11 0.45 1.33 3.28
37 INT132243 Gene_expression of Grik4 5 0.58 1.86 2.98
38 INT131973 Positive_regulation of Transcription of Gria1 3 0.49 0.35 2.62
39 INT114513 Negative_regulation of Gene_expression of Gria2 8 0.48 0.89 2.61
40 INT153733 Negative_regulation of Transcription of Gria2 1 0.47 0 2.39
41 INT349126 Phosphorylation of Shisa9 1 0.01 3.37 2.31
42 INT259164 Positive_regulation of Binding of Gria2 4 0.40 2 1.91
43 INT197209 Positive_regulation of Positive_regulation of Grik1 4 0.50 0.36 1.74
44 INT124667 Negative_regulation of Grik2 4 0.41 2.06 1.7
45 INT114508 Positive_regulation of Negative_regulation of Gria2 2 0.36 0.98 1.64
46 INT71316 Localization of Grik4 3 0.15 0.11 1.55
47 INT131968 Transcription of Grik1 3 0.51 1.44 1.51
48 INT312743 Regulation of Phosphorylation of Gria1 2 0.51 2.01 1.5
49 INT124669 Gene_expression of Grik2 6 0.75 1.66 1.47
50 INT168537 Negative_regulation of Gene_expression of Grik1 3 0.57 0.11 1.44
51 INT65179 Regulation of Regulation of Gria1 2 0.07 0.37 1.39
52 INT281211 Positive_regulation of Shisa9 7 0.01 2.19 1.3
53 INT197224 Negative_regulation of Localization of Grik1 2 0.37 0 1.29
54 INT162222 Positive_regulation of Positive_regulation of Gria2 3 0.38 0.64 1.19
55 INT125676 Positive_regulation of Phosphorylation of Grik1 1 0.01 0 1.17
56 INT131970 Regulation of Grik2 3 0.26 0.65 1.15
57 INT102280 Regulation of Grin2d 2 0.25 0.05 1.08
58 INT102277 Binding of Grin2d 3 0.30 0.8 0.92
59 INT168534 Gene_expression of Grik5 3 0.38 0.64 0.9
60 INT201276 Negative_regulation of Positive_regulation of Grik1 1 0.34 0.3 0.89
61 INT131967 Transcription of Grik2 2 0.67 0.73 0.82
62 INT133464 Phosphorylation of Grin2d 1 0.50 0.95 0.76
63 INT131966 Regulation of Regulation of Grik2 1 0.26 0.45 0.75
64 INT197222 Regulation of Localization of Grik1 1 0.39 0 0.72
65 INT197206 Regulation of Gene_expression of Grik1 2 0.39 0.13 0.71
66 INT21196 Positive_regulation of Grik4 2 0.11 0 0.7
67 INT222615 Positive_regulation of Localization of Grik4 1 0.08 0 0.65
68 INT222646 Transcription of Grik4 1 0.12 0 0.64
69 INT162221 Positive_regulation of Localization of Gria2 2 0.38 0.09 0.61
70 INT349122 Regulation of Phosphorylation of Gria2 1 0.28 0.57 0.61
71 INT56135 Negative_regulation of Grik4 2 0.36 0.69 0.59
72 INT125675 Phosphorylation of Grik1 1 0.01 0 0.59
73 INT125677 Negative_regulation of Phosphorylation of Grik1 1 0.01 0 0.59
74 INT259166 Protein_catabolism of Gria2 2 0.70 0.47 0.58
75 INT200893 Negative_regulation of Transcription of Gria1 2 0.08 0.6 0.58
76 INT259171 Protein_catabolism of Gria1 1 0.76 0.48 0.58
77 INT230982 Positive_regulation of Transcription of Gria2 1 0.28 0.65 0.51
78 INT349125 Regulation of Phosphorylation of Shisa9 1 0.00 2.07 0.46
79 INT349121 Negative_regulation of Binding of Gria2 1 0.22 0.59 0.43
80 INT114512 Positive_regulation of Regulation of Gria2 1 0.33 0 0.41
81 INT105732 Negative_regulation of Grin2d 1 0.25 0.09 0.41
82 INT351452 Negative_regulation of Positive_regulation of Gria2 1 0.26 0.64 0.39
83 INT144582 Gene_expression of Shisa9 3 0.22 0.22 0.36
84 INT168536 Localization of Grik5 1 0.07 0.09 0.34
85 INT197217 Binding of Grik1 1 0.37 0.09 0.34
86 INT168539 Regulation of Gene_expression of Grik5 1 0.02 0.09 0.34
87 INT46059 Binding of Grik4 1 0.05 0 0.25
88 INT102282 Positive_regulation of Gene_expression of Grin2d 1 0.46 0.09 0.25
89 INT316938 Negative_regulation of Regulation of Gria1 1 0.32 0.23 0.24
90 INT260481 Positive_regulation of Grin2d 1 0.63 1.37 0.23
91 INT197208 Positive_regulation of Localization of Grik1 1 0.50 0.1 0.22
92 INT200897 Negative_regulation of Localization of Gria1 1 0.07 0 0.22
93 INT160805 Regulation of Shisa9 2 0.05 0 0.17
94 INT346726 Binding of Shisa9 1 0.14 0 0.17
95 INT260483 Localization of Grin2d 1 0.30 0.11 0.13
96 INT281209 Negative_regulation of Shisa9 1 0.01 0 0.09
97 INT281210 Negative_regulation of Negative_regulation of Shisa9 1 0.01 0 0.09
98 INT160809 Negative_regulation of Negative_regulation of Gria2 1 0.03 0 0.08
99 INT265255 Positive_regulation of Protein_catabolism of Gria2 1 0.27 0 0
100 INT124941 Negative_regulation of Gene_expression of Grik2 1 0.41 0 0
101 INT282476 Binding of Grik2 1 0.31 0.61 0
102 INT346731 Localization of Shisa9 1 0.21 0 0
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