GO:0008329

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Name pattern recognition receptor activity
Categary Function
Go Slim No
Go Link GO:0008329
Unique Molecular Interactions 118
Total Molecular Interactions 196
Total Single Events 1054
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pattern recognition receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for pattern recognition receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
2 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
3 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
4 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
5 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
6 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
7 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
8 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
9 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
10 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
11 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
12 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
13 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
14 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41
15 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41
16 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41
17 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
18 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
19 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36
20 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
21 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
22 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
23 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
24 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
25 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
26 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
27 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
28 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32
29 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31
30 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31
31 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31
32 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
33 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
34 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
35 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
36 INT230460 Binding of TLR2 and TLR6 2 0.07 1.9 0.25
37 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
38 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
39 INT175324 Hsp90b1 Positive_regulation of TLR2 1 0.00 0.65 0.23
40 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
41 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
42 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
43 INT163096 Tlr2 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.16 0.21
44 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
45 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
46 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
47 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
48 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19
49 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
50 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
51 INT316124 TLR2 Positive_regulation of Gene_expression of HLA-DRA 1 0.14 0.34 0.16
52 INT330388 Binding of PTPRC and TLR2 1 0.00 1.19 0.16
53 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
54 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
55 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
56 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
57 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
58 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
59 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
60 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
61 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
62 INT342520 HSP90B1 Positive_regulation of Gene_expression of TLR2 1 0.06 0.4 0.13
63 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
64 INT230463 Binding of MT1JP and TLR2 1 0.02 0.44 0.12
65 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
66 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11
67 INT242881 SPI1 Negative_regulation of Regulation of TLR2 1 0.04 1.13 0.11
68 INT294778 PAM Positive_regulation of Gene_expression of TLR2 1 0.01 0.41 0.11
69 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11
70 INT294772 PAM Positive_regulation of TLR2 1 0.00 0.17 0.1
71 INT294779 IRF6 Positive_regulation of TLR2 1 0.06 0.17 0.1
72 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
73 INT175325 Binding of TLR2 and Tlr6 1 0.00 0.39 0.09
74 INT175327 Binding of TLR2 and Tlr1 1 0.00 0.39 0.09
75 INT285424 Regulation of Binding of TLR1 and TLR2 1 0.25 0.09 0.09
76 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
77 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
78 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
79 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
80 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
81 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
82 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
83 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
84 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
85 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
86 INT185383 IL10 Regulation of TLR2 1 0.06 0.68 0.04
87 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
88 INT294680 Binding of TLR2 and Tlr4 1 0.09 0.58 0.04
89 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
90 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
91 INT185378 IL1B Regulation of TLR2 1 0.04 0.68 0.04
92 INT185374 CSF2 Regulation of TLR2 1 0.04 0.68 0.04
93 INT185388 Binding of PVRL1 and TLR2 1 0.15 0.75 0.04
94 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
95 INT185382 IFNG Regulation of TLR2 1 0.09 0.69 0.04
96 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
97 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
98 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
99 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
100 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
101 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
102 INT341506 TLR2 Positive_regulation of Negative_regulation of Pdcd1 1 0.01 0.54 0.03
103 INT313077 Cd180 Regulation of Tlr2 1 0.01 0.09 0
104 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
105 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0
106 INT344224 Tlr2 Regulation of Gene_expression of Tlr4 1 0.03 0 0
107 INT313076 Tlr2 Positive_regulation of Gene_expression of Il10 1 0.02 0.14 0
108 INT341486 Positive_regulation of TLR2 Positive_regulation of CD8A 1 0.11 0.3 0
109 INT283979 TLR2 Positive_regulation of Gene_expression of IL23A 1 0.09 0.96 0
110 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0
111 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
112 INT313080 ST2 Regulation of Tlr2 1 0.02 0.09 0
113 INT341507 Positive_regulation of TLR2 Negative_regulation of Gene_expression of Pdcd1 1 0.01 0.3 0
114 INT313079 SIGIRR Regulation of Tlr2 1 0.18 0.09 0
115 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0
116 INT341488 Binding of CD8A and TLR2 1 0.08 0.31 0
117 INT316536 Binding of Tlr2 and Il23a 1 0.11 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pattern recognition receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in pattern recognition receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
2 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
3 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
4 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
5 INT150540 Binding of TLR2 50 0.45 35.86 10.43
6 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
7 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
8 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
9 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
10 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
11 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
12 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
13 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
14 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
15 INT186799 Localization of TLR2 5 0.68 2.51 2.58
16 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
17 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
18 INT175307 Regulation of Gene_expression of TLR2 9 0.56 7.08 1.58
19 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
20 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
21 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23
22 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
23 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
24 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
25 INT188575 Positive_regulation of Transcription of TLR2 1 0.30 1.37 0.88
26 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
27 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
28 INT186801 Positive_regulation of Binding of TLR2 3 0.42 2.05 0.67
29 INT290394 Negative_regulation of Positive_regulation of TLR2 4 0.34 2.8 0.65
30 INT180531 Positive_regulation of Positive_regulation of TLR2 4 0.32 4.28 0.62
31 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
32 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
33 INT325457 Negative_regulation of Binding of TLR2 1 0.04 1.3 0.43
34 INT145457 Positive_regulation of Clec7a 2 0.04 0.17 0.34
35 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
36 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
37 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
38 INT145758 Regulation of Tlr2 3 0.43 0.94 0.23
39 INT145761 Negative_regulation of Tlr2 2 0.41 1.97 0.23
40 INT294788 Regulation of Positive_regulation of TLR2 2 0.36 1.41 0.21
41 INT339625 Binding of Clec7a 1 0.03 0.14 0.17
42 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
43 INT145759 Regulation of Gene_expression of Tlr2 3 0.43 0.98 0.14
44 INT301958 Positive_regulation of Regulation of Tlr2 1 0.21 0.32 0.13
45 INT329058 Positive_regulation of Transcription of Tlr2 1 0.48 0.62 0.11
46 INT329049 Transcription of Tlr2 1 0.68 0.62 0.11
47 INT294789 Negative_regulation of Transcription of TLR2 2 0.39 0.73 0.1
48 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
49 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
50 INT276937 Localization of Clec7a 1 0.14 0.23 0.07
51 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
52 INT145757 Negative_regulation of Gene_expression of Tlr2 2 0.41 0.68 0.03
53 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
54 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
55 INT129802 Gene_expression of Clec7a 5 0.13 0.51 0
56 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
57 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
58 INT276944 Regulation of Clec7a 1 0.05 0 0
59 INT129801 Positive_regulation of Gene_expression of Clec7a 1 0.04 0.38 0
60 INT341500 Regulation of Binding of TLR2 1 0.12 0.25 0
61 INT294786 Regulation of Localization of TLR2 1 0.41 0 0
62 INT294781 Negative_regulation of Negative_regulation of TLR2 1 0.39 0.08 0
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