GO:0008333

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Name endosome to lysosome transport
Categary Process
Go Slim No
Go Link GO:0008333
Unique Molecular Interactions 90
Total Molecular Interactions 134
Total Single Events 665
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endosome to lysosome transport. They are ordered first by their pain relevance and then by number of times they were reported for endosome to lysosome transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
2 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
3 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
4 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
5 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
6 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
7 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
8 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
9 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
10 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
11 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
12 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27
13 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
14 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24
15 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
16 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22
17 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
18 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
19 INT190637 Negative_regulation of Binding of Rab7 and Rnf115 1 0.25 0.68 0.17
20 INT86892 Glp2r Regulation of Gene_expression of Cdx2 1 0.38 0 0.17
21 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
22 INT190630 Binding of Rab7 and Rnf115 1 0.22 0.68 0.17
23 INT260059 AKTIP Positive_regulation of TRPA1 1 0.02 0 0.15
24 INT276813 NR3C1 Regulation of Gene_expression of Hgs 1 0.03 1.09 0.13
25 INT182493 HGS Positive_regulation of OLR1 1 0.00 2.51 0.13
26 INT351144 Binding of Ighg2b and Ighg2a 1 0.00 0.78 0.12
27 INT210363 Binding of ALB and M6PR 1 0.00 1.19 0.1
28 INT226750 Hgs Positive_regulation of Tsg101 1 0.04 0.25 0.1
29 INT226708 Oprd1 Positive_regulation of Tsg101 1 0.00 0.3 0.1
30 INT226725 Gpbar1 Positive_regulation of Tsg101 1 0.03 0.3 0.1
31 INT226737 Hgs Positive_regulation of Vps28 1 0.03 0.25 0.1
32 INT226733 Vps4a Positive_regulation of Tsg101 1 0.00 0.25 0.1
33 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
34 INT276814 IL18 Positive_regulation of Gene_expression of Hgs 1 0.05 0.09 0.09
35 INT276815 IL7 Positive_regulation of Gene_expression of Hgs 1 0.03 0.09 0.09
36 INT226760 Gpbar1 Positive_regulation of Hgs 1 0.00 0.26 0.09
37 INT208299 Binding of Hook3 and IGIP 1 0.03 0.37 0.08
38 INT276816 IL8 Positive_regulation of Gene_expression of Hgs 1 0.03 0.13 0.08
39 INT182491 OLR1 Positive_regulation of HGS 1 0.00 1.22 0.07
40 INT305737 Binding of Sort1 and Gga2 1 0.19 0.11 0.06
41 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05
42 INT288369 Binding of Laptm5 and Mgrn1 1 0.05 0 0.04
43 INT205411 SORT1 Negative_regulation of TNFRSF9 1 0.10 0.23 0.03
44 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03
45 INT298872 RAB7A Regulation of Protein_catabolism of GFM1 1 0.47 0.22 0.03
46 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
47 INT298873 RAB7A Regulation of Protein_catabolism of NTRK1 1 0.12 0.25 0.03
48 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0
49 INT298854 Binding of LAMP2 and RAB7A 1 0.16 0.56 0
50 INT307054 RHCE Regulation of AKTIP 1 0.00 0.6 0
51 INT164217 Binding of Cdx1 and Cdx2 1 0.36 0 0
52 INT226751 Tsg101 Negative_regulation of Vps28 1 0.07 0.14 0
53 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0
54 INT226739 Tsg101 Regulation of Negative_regulation of Cxcr4 1 0.13 0.69 0
55 INT298875 Binding of RAB7A and VPS13C 1 0.21 0.49 0
56 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0
57 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0
58 INT298848 Binding of SPG21 and RILP 1 0.10 0.21 0
59 INT226736 Tsg101 Regulation of Negative_regulation of Sdf2l1 1 0.02 0.39 0
60 INT293231 AKTIP Regulation of DPH1 1 0.01 0 0
61 INT321125 Binding of RHOB and IgG 1 0.01 0.31 0
62 INT298853 Binding of AGFG1 and RILP 1 0.02 0.21 0
63 INT298866 Binding of AGFG1 and RAB7A 1 0.04 0.21 0
64 INT180124 Rhob Positive_regulation of Rock1 1 0.14 0 0
65 INT226717 Gene_expression of Tsg101 Negative_regulation of Vps28 1 0.09 0.14 0
66 INT280477 Binding of Bdnf and Sort1 1 0.03 0.08 0
67 INT298846 Binding of MCC and RILP 1 0.01 0.36 0
68 INT226711 Binding of Ambp and Tsg101 1 0.01 0.33 0
69 INT298850 Binding of RAB7A and MTG1 1 0.01 0.24 0
70 INT298877 Positive_regulation of Binding of RAB7A and VPS13C 1 0.22 0.49 0
71 INT298851 Binding of IK and RAB7A 1 0.02 0.57 0
72 INT164218 Regulation of Binding of Cdx1 and Cdx2 1 0.27 0 0
73 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0
74 INT298869 Binding of RAB7A and RILP 1 0.25 1.07 0
75 INT298857 Binding of RILP and MTG1 1 0.01 0.35 0
76 INT329005 Binding of TSG101 and LITAF 1 0.04 1.41 0
77 INT226719 Negative_regulation of Tsg101 Negative_regulation of Negative_regulation of Egfr 1 0.05 0.41 0
78 INT298865 Positive_regulation of Binding of RILP and MTG1 1 0.01 0.35 0
79 INT298847 Binding of VAPA and RILP 1 0.05 0.54 0
80 INT226713 Tsg101 Regulation of Protein_catabolism of Cd4 1 0.07 0.54 0
81 INT329007 Binding of MPZ and TSG101 1 0.01 0.71 0
82 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0
83 INT298861 Binding of APOB and RAB7A 1 0.00 0.32 0
84 INT298870 Binding of PDB1 and RAB7A 1 0.51 0.21 0
85 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endosome to lysosome transport. They are ordered first by their pain relevance and then by number of times they were reported in endosome to lysosome transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
2 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
3 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
4 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
5 INT148901 Binding of Sort1 2 0.39 3.65 4.32
6 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
7 INT148899 Regulation of Sort1 2 0.50 2.72 3.46
8 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
9 INT66881 Positive_regulation of Sort1 2 0.57 0.99 2.16
10 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
11 INT226667 Gene_expression of Hgs 4 0.75 7.33 2.06
12 INT66882 Gene_expression of Sort1 3 0.73 0.64 1.97
13 INT240058 Gene_expression of RHOB 2 0.55 4.29 1.84
14 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
15 INT240059 Binding of RHOB 7 0.48 3.96 1.59
16 INT226651 Positive_regulation of Gene_expression of Hgs 3 0.67 4.92 1.48
17 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31
18 INT305718 Localization of Sort1 1 0.73 0.83 1.3
19 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21
20 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17
21 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
22 INT305721 Binding of Sort1 1 0.47 0.92 1.1
23 INT86889 Gene_expression of Cdx2 8 0.60 4.23 1.02
24 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
25 INT148900 Localization of Sort1 1 0.44 0.5 1.01
26 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96
27 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
28 INT276509 Positive_regulation of Positive_regulation of Sort1 1 0.41 0.22 0.76
29 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72
30 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
31 INT226670 Positive_regulation of Hgs 3 0.67 2.07 0.61
32 INT136927 Gene_expression of HGS 18 0.70 14.42 0.6
33 INT288354 Gene_expression of Mgrn1 1 0.60 0 0.58
34 INT143958 Negative_regulation of Gene_expression of Cdx2 1 0.13 0.1 0.58
35 INT184345 Gene_expression of Tsg101 10 0.58 3.56 0.57
36 INT201259 Negative_regulation of RAB7A 2 0.41 2.45 0.54
37 INT288355 Localization of Mgrn1 1 0.67 0 0.52
38 INT66883 Positive_regulation of Gene_expression of Sort1 1 0.49 0.14 0.42
39 INT66880 Transcription of Sort1 1 0.52 0.14 0.4
40 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
41 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
42 INT39350 Positive_regulation of Ighg2a 2 0.35 2.39 0.37
43 INT276788 Negative_regulation of Hgs 1 0.57 0.71 0.36
44 INT207899 Binding of Hgs 2 0.47 1.96 0.35
45 INT305724 Positive_regulation of Gene_expression of Sort1 1 0.49 0.12 0.31
46 INT190032 Negative_regulation of Cdx2 2 0.38 0.74 0.3
47 INT288356 Positive_regulation of Mgrn1 1 0.45 0.07 0.29
48 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
49 INT227102 Gene_expression of Mtm1 2 0.77 9.58 0.26
50 INT205445 Gene_expression of SORT1 1 0.71 0.73 0.26
51 INT190010 Transcription of Cdx2 1 0.53 0.69 0.26
52 INT184995 Binding of HGS 4 0.26 3.1 0.25
53 INT164210 Gene_expression of Cdx2 3 0.56 2.22 0.25
54 INT298929 Negative_regulation of Gene_expression of RAB7A 1 0.35 0.3 0.25
55 INT136929 Transcription of HGS 1 0.48 3.75 0.23
56 INT264556 Negative_regulation of Gene_expression of Hgs 2 0.41 0.58 0.19
57 INT288359 Binding of Mgrn1 1 0.33 0.07 0.18
58 INT276791 Negative_regulation of Binding of Hgs 1 0.42 0.29 0.17
59 INT226689 Binding of Tsg101 3 0.16 1.1 0.16
60 INT317803 Negative_regulation of Ighg2a 1 0.02 0.71 0.15
61 INT317802 Regulation of Ighg2a 1 0.01 0.49 0.14
62 INT317804 Regulation of Gene_expression of Ighg2a 1 0.01 0.5 0.14
63 INT237340 Positive_regulation of Mtm1 1 0.60 1.52 0.14
64 INT298884 Binding of RAB7A 1 0.45 9.82 0.14
65 INT307059 Localization of AKTIP 1 0.01 0.48 0.14
66 INT184977 Negative_regulation of HGS 3 0.28 1.38 0.13
67 INT317801 Gene_expression of Ighg2a 1 0.03 0.49 0.13
68 INT207901 Regulation of Hgs 3 0.26 1.17 0.12
69 INT305727 Regulation of Gene_expression of Sort1 1 0.24 0.13 0.11
70 INT210401 Binding of M6PR 2 0.01 1.23 0.1
71 INT73439 Regulation of SORT1 1 0.01 0.44 0.1
72 INT276787 Localization of Hgs 1 0.78 1.1 0.1
73 INT95798 Binding of SORT1 3 0.33 0.43 0.09
74 INT226625 Positive_regulation of Tsg101 1 0.21 0.75 0.09
75 INT121918 Binding of Rab7 1 0.34 0.64 0.09
76 INT307060 Negative_regulation of AKTIP 6 0.01 2.79 0.08
77 INT208271 Binding of Hook3 1 0.03 0.36 0.08
78 INT237346 Localization of Mtm1 1 0.80 0.71 0.08
79 INT326522 Positive_regulation of Gene_expression of HGS 1 0.07 2.62 0.08
80 INT276785 Positive_regulation of Positive_regulation of Hgs 1 0.49 0.29 0.08
81 INT326523 Negative_regulation of Gene_expression of HGS 1 0.06 2.64 0.08
82 INT237345 Positive_regulation of Gene_expression of Mtm1 1 0.69 3.03 0.08
83 INT237341 Binding of Mtm1 1 0.48 1.16 0.07
84 INT210255 Positive_regulation of Negative_regulation of Cdx2 1 0.33 0 0.07
85 INT86888 Regulation of Gene_expression of Cdx2 1 0.48 0 0.07
86 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
87 INT298891 Positive_regulation of Positive_regulation of RAB7A 1 0.47 2.65 0.07
88 INT290044 Regulation of Tsg101 1 0.26 2.46 0.07
89 INT180103 Positive_regulation of Rhob 1 0.18 0.06 0.06
90 INT290043 Localization of Tsg101 1 0.68 0.76 0.06
91 INT209148 Transcription of ADRB2 1 0.53 0 0.06
92 INT346713 Positive_regulation of AKTIP 1 0.01 0.31 0.05
93 INT276793 Regulation of Localization of Hgs 1 0.26 0.21 0.05
94 INT148811 Localization of RHOB 1 0.59 0.58 0.05
95 INT237348 Negative_regulation of Gene_expression of Mtm1 1 0.42 0.23 0.05
96 INT185008 Localization of HGS 2 0.52 0.43 0.04
97 INT205448 Positive_regulation of Gene_expression of SORT1 1 0.64 0.16 0.04
98 INT205427 Negative_regulation of Gene_expression of SORT1 1 0.54 0.16 0.04
99 INT276789 Regulation of Regulation of Hgs 1 0.26 0.21 0.04
100 INT185015 Positive_regulation of HGS 8 0.40 4.65 0.03
101 INT276792 Transcription of Hgs 1 0.69 0.11 0.03
102 INT307057 Regulation of AKTIP 1 0.00 0.72 0.03
103 INT226697 Negative_regulation of Tsg101 6 0.25 1.91 0
104 INT298918 Binding of RILP 2 0.17 0.55 0
105 INT298924 Regulation of Gene_expression of RAB7A 1 0.42 0.54 0
106 INT298892 Regulation of Localization of RAB7A 1 0.58 0.54 0
107 INT307061 Gene_expression of AKTIP 1 0.01 0.21 0
108 INT237339 Positive_regulation of Binding of Mtm1 1 0.50 0.26 0
109 INT298914 Regulation of Binding of RAB7A 1 0.58 1.2 0
110 INT298913 Regulation of Positive_regulation of RAB7A 1 0.42 1.12 0
111 INT276786 Regulation of Positive_regulation of Hgs 1 0.44 0 0
112 INT226681 Positive_regulation of Gene_expression of Tsg101 1 0.30 1.01 0
113 INT298896 Positive_regulation of Localization of RAB7A 1 0.47 0.55 0
114 INT321120 Positive_regulation of RHOB 1 0.13 0.3 0
115 INT298895 Positive_regulation of RILP 1 0.33 0.42 0
116 INT165482 Gene_expression of Rab7 1 0.09 0.06 0
117 INT321122 Negative_regulation of RHOB 1 0.11 0.37 0
118 INT226652 Negative_regulation of Gene_expression of Tsg101 1 0.16 0 0
119 INT227111 Transcription of Mtm1 1 0.63 0 0
120 INT164203 Binding of Cdx2 1 0.33 0 0
121 INT237343 Regulation of Mtm1 1 0.27 0.37 0
122 INT352684 Regulation of Binding of RILP 1 0.01 0.22 0
123 INT200396 Negative_regulation of Binding of HGS 1 0.29 0.84 0
124 INT164202 Regulation of Cdx2 1 0.25 0 0
125 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
126 INT226693 Protein_catabolism of Tsg101 1 0.28 0.3 0
127 INT298906 Negative_regulation of Binding of RAB7A 1 0.40 0.99 0
128 INT329011 Protein_catabolism of RAB7A 1 0.07 1.06 0
129 INT298894 Localization of RAB7A 1 0.76 3.41 0
130 INT298893 Positive_regulation of Gene_expression of RAB7A 1 0.65 2.86 0
131 INT184982 Regulation of HGS 1 0.18 1.25 0
132 INT298888 Positive_regulation of Regulation of RAB7A 1 0.44 0.54 0
133 INT164215 Positive_regulation of Gene_expression of Cdx2 1 0.43 0 0
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