GO:0008340

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Name determination of adult lifespan
Categary Process
Go Slim No
Go Link GO:0008340
Unique Molecular Interactions 284
Total Molecular Interactions 362
Total Single Events 2628
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for determination of adult lifespan. They are ordered first by their pain relevance and then by number of times they were reported for determination of adult lifespan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT250085 Coq7 Positive_regulation of Ltp 1 0.00 0.52 1
3 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
4 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
5 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
6 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
7 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
8 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
9 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
10 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
11 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
12 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
13 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
14 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
15 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
16 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3
17 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
18 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
19 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
20 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
21 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
22 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
23 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
24 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
25 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
26 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
27 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
28 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
29 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
30 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
31 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
32 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
33 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
34 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
35 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
36 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
37 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
38 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
39 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
40 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
41 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21
42 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
43 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
44 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
45 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
46 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
47 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
48 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
49 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
50 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
51 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
52 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
53 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
54 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
55 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
56 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13
57 INT243319 Binding of ATP6V0A1 and BBC3 1 0.07 0.59 0.13
58 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
59 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
60 INT317162 Binding of Bdnf and Htt 1 0.51 0.2 0.12
61 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
62 INT319315 Binding of Ap2a2 and Htt 1 0.28 0.64 0.11
63 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
64 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
65 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
66 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
67 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
68 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
69 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
70 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
71 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
72 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
73 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
74 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
75 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
76 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
77 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
78 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
79 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
80 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
81 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
82 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
83 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
84 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
85 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
86 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
87 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
88 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
89 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
90 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
91 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
92 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
93 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
94 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
95 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
96 INT133992 Pou2f1 Regulation of Pou1f1 1 0.02 0 0.04
97 INT133981 Pdx1 Regulation of Pou1f1 1 0.05 0 0.04
98 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
99 INT133994 Pou1f1 Regulation of Gene_expression of Npff 1 0.15 0 0.04
100 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
101 INT133982 Pou1f1 Regulation of Pdx1 1 0.05 0 0.04
102 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
103 INT133985 Kcnip3 Regulation of Pou1f1 1 0.02 0 0.04
104 INT133993 Meis1 Regulation of Pou1f1 1 0.02 0 0.04
105 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
106 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
107 INT133979 Pou1f1 Regulation of Kcnip3 1 0.02 0 0.04
108 INT133999 Pou1f1 Regulation of Pou2f1 1 0.02 0 0.04
109 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
110 INT306527 Binding of Htt and Aifm1 1 0.20 0.82 0.04
111 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
112 INT133986 Pou1f1 Regulation of Meis1 1 0.02 0 0.04
113 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
114 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
115 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
116 INT317161 Htt Regulation of Transcription of Bdnf 1 0.48 0.41 0.03
117 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
118 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
119 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
120 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
121 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
122 INT322876 Binding of PDCD10 and Inpp5d 1 0.03 0.46 0.03
123 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
124 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
125 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
126 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
127 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
128 INT200311 Htt Positive_regulation of Rest 1 0.05 0.75 0.03
129 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
130 INT295126 Proc Regulation of Transcription of Pou1f1 1 0.00 0.3 0.03
131 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
132 INT342733 Gene_expression of Lrrk2 Positive_regulation of Apaf1 1 0.10 0.74 0.03
133 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
134 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
135 INT222536 Ghrl Positive_regulation of Transcription of Pou1f1 1 0.03 0.13 0
136 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
137 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
138 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
139 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
140 INT304020 AR Regulation of TP53 1 0.24 1.11 0
141 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
142 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
143 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
144 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
145 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
146 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
147 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
148 INT333690 Hr Negative_regulation of Transcription of Trp53 1 0.23 0.51 0
149 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0
150 INT334322 Binding of RB1 and TP53 1 0.34 2 0
151 INT342007 Mta1 Regulation of Trp53 1 0.15 0.15 0
152 INT121179 Binding of Htt and Rest 1 0.07 0.45 0
153 INT179095 Myc Positive_regulation of Gene_expression of Trp53 1 0.43 0.83 0
154 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
155 INT333689 Hr Positive_regulation of Protein_catabolism of Trp53 1 0.25 1.71 0
156 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
157 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
158 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
159 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
160 INT241256 TP53 Regulation of OPCML 1 0.12 1.31 0
161 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0
162 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
163 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0
164 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0
165 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
166 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
167 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
168 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 0.18 0.44 0
169 INT284232 Binding of TP53 and HNRNPUL1 1 0.26 0.88 0
170 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
171 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
172 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
173 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0
174 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0
175 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
176 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
177 INT268513 MIR34A Regulation of Gene_expression of TP53 1 0.00 0.9 0
178 INT172604 Binding of EP300 and TP53 1 0.00 0 0
179 INT193118 Trp53 Regulation of Gene_expression of Birc5 1 0.19 0.86 0
180 INT225564 Ncoa6 Regulation of Trp53 1 0.04 0.93 0
181 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
182 INT121177 Binding of Bdnf and Htt 1 0.23 0.44 0
183 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
184 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0
185 INT337639 TP53 Regulation of Gene_expression of MIR34A 1 0.08 1.19 0
186 INT350983 TP53 Regulation of VEGFA 1 0.03 0.61 0
187 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0
188 INT337680 Binding of TP53 and Scrib 1 0.03 1.6 0
189 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
190 INT222574 Crem Positive_regulation of Pou1f1 1 0.00 0.57 0
191 INT187575 TP53 Regulation of Gene_expression of Birc5 1 0.05 1.1 0
192 INT217781 Binding of MITF and TP53 1 0.00 1.2 0
193 INT267258 Binding of TP53 and BCL11B 1 0.09 0.42 0
194 INT121180 Htt Negative_regulation of Bdnf 1 0.43 0.47 0
195 INT305540 Binding of Trp53 and Tpt1 1 0.07 0.9 0
196 INT333697 Binding of Hr and Trp53 1 0.19 0.56 0
197 INT113343 Phosphorylation of TP53 Positive_regulation of Gene_expression of BAX 1 0.11 0.14 0
198 INT179090 Positive_regulation of Myc Regulation of Gene_expression of Trp53 1 0.23 0.69 0
199 INT301466 Smyd2 Negative_regulation of Binding of Trp53 1 0.20 0.3 0
200 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for determination of adult lifespan. They are ordered first by their pain relevance and then by number of times they were reported in determination of adult lifespan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
6 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
7 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
8 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
9 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
10 INT60585 Regulation of TP53 59 0.59 54.55 5.21
11 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
12 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
13 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
14 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
15 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
16 INT8103 Binding of TP53 46 0.44 40.2 2.96
17 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
18 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
19 INT55952 Transcription of TP53 16 0.61 12.14 2.36
20 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
21 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
22 INT65855 Localization of TP53 18 0.76 17.08 1.89
23 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
24 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
25 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
26 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
27 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
28 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
29 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
30 INT172953 Binding of Trp53 33 0.37 20.76 1.41
31 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
32 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
33 INT145221 Binding of Tp53 10 0.37 8.59 1.37
34 INT174156 Localization of Trp53 16 0.72 13.52 1.18
35 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
36 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
37 INT108997 Localization of Htt 28 0.77 3.76 1.07
38 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
39 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96
40 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
41 INT250509 Gene_expression of Pou1f1 65 0.76 11.8 0.84
42 INT154886 Gene_expression of Htt 18 0.76 15.51 0.82
43 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
44 INT188286 Gene_expression of Pou1f1 3 0.19 0.64 0.79
45 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
46 INT92142 Binding of MSH2 5 0.46 5.64 0.75
47 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
48 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
49 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
50 INT142696 Positive_regulation of BBC3 3 0.67 1.7 0.67
51 INT61506 Localization of Ghrhr 1 0.51 0 0.61
52 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6
53 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
54 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
55 INT133974 Binding of Pou1f1 3 0.37 0.52 0.59
56 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57
57 INT215340 Localization of Htt 10 0.61 5.12 0.55
58 INT287204 Protein_catabolism of Htt 6 0.99 2.8 0.53
59 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
60 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
61 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5
62 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
63 INT156734 Gene_expression of BBC3 3 0.58 2.41 0.46
64 INT216457 Negative_regulation of Pou1f1 16 0.57 2.69 0.44
65 INT243418 Binding of Htt 14 0.30 5.94 0.44
66 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44
67 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
68 INT132864 Binding of Htt 15 0.46 2.34 0.38
69 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
70 INT287207 Regulation of Protein_catabolism of Htt 3 0.45 1.73 0.35
71 INT330616 Positive_regulation of Gene_expression of Inpp5d 2 0.49 0.89 0.34
72 INT330615 Gene_expression of Inpp5d 2 0.66 0.78 0.31
73 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
74 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
75 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28
76 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
77 INT250514 Regulation of Gene_expression of Pou1f1 2 0.60 0.85 0.26
78 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
79 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
80 INT228124 Positive_regulation of Bbc3 3 0.49 2.29 0.24
81 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
82 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
83 INT287205 Regulation of Htt 5 0.45 3.56 0.22
84 INT330612 Positive_regulation of Localization of Inpp5d 1 0.02 0.35 0.22
85 INT330610 Localization of Inpp5d 1 0.02 0.3 0.22
86 INT282970 Gene_expression of Bbc3 2 0.02 2.83 0.2
87 INT347641 Regulation of Positive_regulation of Inpp5d 1 0.27 0.33 0.19
88 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
89 INT347643 Positive_regulation of Inpp5d 1 0.46 0.33 0.18
90 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
91 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
92 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
93 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
94 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
95 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
96 INT282973 Binding of Bbc3 2 0.01 2.87 0.13
97 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
98 INT182623 Localization of MSH2 3 0.77 5.49 0.12
99 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
100 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
101 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
102 INT111139 Localization of Tp53 4 0.45 2.4 0.09
103 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
104 INT340388 Negative_regulation of Gene_expression of Bbc3 1 0.01 0.73 0.08
105 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07
106 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
107 INT261890 Positive_regulation of Gene_expression of Htt 1 0.43 0.85 0.06
108 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
109 INT265479 Positive_regulation of Localization of BBC3 1 0.49 1.18 0.05
110 INT265489 Localization of BBC3 1 0.73 1.17 0.05
111 INT317175 Positive_regulation of Localization of Htt 1 0.48 0 0.05
112 INT306521 Transcription of Htt 1 0.69 4.13 0.05
113 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
114 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
115 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
116 INT331204 Negative_regulation of Binding of Htt 1 0.04 0.64 0.04
117 INT342721 Localization of Lrrk2 1 0.39 0.67 0.04
118 INT261891 Negative_regulation of Gene_expression of Htt 1 0.37 1.12 0.04
119 INT342722 Gene_expression of Lrrk2 2 0.41 1.81 0.03
120 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
121 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
122 INT200203 Regulation of Pou1f1 2 0.60 1.37 0.03
123 INT295100 Positive_regulation of Gene_expression of Pou1f1 1 0.49 1.09 0.03
124 INT342711 Positive_regulation of Gene_expression of Lrrk2 1 0.36 0.73 0.03
125 INT295095 Positive_regulation of Pou1f1 1 0.68 2.04 0.03
126 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
127 INT239151 Transcription of Pou1f1 4 0.70 2.96 0
128 INT154887 Transcription of Htt 3 0.66 0 0
129 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
130 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
131 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
132 INT190020 Gene_expression of Msh2 2 0.69 0.69 0
133 INT261886 Regulation of Htt 2 0.43 2.06 0
134 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
135 INT212518 Localization of MSH6 2 0.10 2.66 0
136 INT313014 Positive_regulation of Binding of Htt 2 0.13 0.91 0
137 INT190035 Binding of Msh6 2 0.28 2.72 0
138 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
139 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
140 INT341938 Positive_regulation of Negative_regulation of Htt 1 0.07 0.65 0
141 INT254883 Negative_regulation of Positive_regulation of Htt 1 0.05 1.14 0
142 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
143 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
144 INT206928 Transcription of MSH2 1 0.52 0.4 0
145 INT295088 Negative_regulation of Transcription of Pou1f1 1 0.57 0 0
146 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
147 INT317177 Negative_regulation of Transcription of Htt 1 0.41 0 0
148 INT295089 Negative_regulation of Positive_regulation of Pou1f1 1 0.42 0.09 0
149 INT262891 Positive_regulation of Ghrhr 1 0.15 0.33 0
150 INT350662 Regulation of Inpp5d 1 0.06 0.16 0
151 INT333671 Regulation of Transcription of Trp53 1 0.24 0.83 0
152 INT190015 Binding of Msh2 1 0.27 1.41 0
153 INT305347 Negative_regulation of Gene_expression of Msh6 1 0.25 2.22 0
154 INT222583 Transcription of Pou1f1 1 0.10 0.13 0
155 INT211715 Negative_regulation of Gene_expression of MSH6 1 0.06 1.09 0
156 INT254679 Negative_regulation of Positive_regulation of Bbc3 1 0.00 0.72 0
157 INT179076 Negative_regulation of Protein_catabolism of Trp53 1 0.32 0.43 0
158 INT107984 Positive_regulation of Gene_expression of MSH2 1 0.11 0 0
159 INT179957 Positive_regulation of Binding of Tp53 1 0.08 0.48 0
160 INT182624 Positive_regulation of Positive_regulation of MSH2 1 0.45 1.24 0
161 INT295101 Positive_regulation of Transcription of Pou1f1 1 0.49 0.24 0
162 INT333663 Positive_regulation of Protein_catabolism of Trp53 1 0.45 0.84 0
163 INT295096 Localization of Pou1f1 1 0.79 1.48 0
164 INT333662 Negative_regulation of Transcription of Trp53 1 0.53 1.15 0
165 INT309469 Negative_regulation of Localization of Htt 1 0.34 0.13 0
166 INT304071 Binding of MSH6 1 0.28 1.11 0
167 INT223765 Negative_regulation of Positive_regulation of Tp53 1 0.07 1.69 0
168 INT295109 Negative_regulation of Gene_expression of Pou1f1 1 0.42 0.32 0
169 INT222581 Positive_regulation of Gene_expression of Pou1f1 1 0.07 0.57 0
170 INT282980 Negative_regulation of Binding of Bbc3 1 0.01 0.7 0
171 INT295102 Positive_regulation of Localization of Pou1f1 1 0.49 0.97 0
172 INT317170 Regulation of Binding of Htt 1 0.43 0 0
173 INT305295 Regulation of Binding of TP53 1 0.39 1.09 0
174 INT305349 Gene_expression of Msh6 1 0.46 2.21 0
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