GO:0008408

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Name 3'-5' exonuclease activity
Categary Function
Go Slim No
Go Link GO:0008408
Unique Molecular Interactions 35
Total Molecular Interactions 41
Total Single Events 202
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 3'-5' exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for 3'-5' exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
2 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
3 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
4 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
5 INT344238 MCRS1 Regulation of TREX1 1 0.08 1.02 0.34
6 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
7 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
8 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
9 INT299495 EXOSC10 Regulation of IL6 1 0.01 0.59 0.17
10 INT299496 EXOSC10 Regulation of CSRP1 1 0.00 0.59 0.17
11 INT114967 ERI1 Negative_regulation of CPOX 1 0.00 0.25 0.14
12 INT89763 Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1 1 0.10 0.87 0.14
13 INT204993 Eri1 Positive_regulation of Gene_expression of Pink1 1 0.22 0.61 0.08
14 INT299491 Binding of IL6 and EXOSC10 1 0.01 0.44 0.08
15 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
16 INT204998 Hmmr Positive_regulation of Eri1 1 0.00 0.58 0.06
17 INT172349 Eri1 Regulation of Gene_expression of Agrp 1 0.03 0.28 0.05
18 INT172348 Eri1 Negative_regulation of Gene_expression of Agrp 1 0.07 0.28 0.05
19 INT191923 Binding of EXOSC10 and Tlr4 1 0.21 0.48 0.04
20 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
21 INT191899 Binding of EXOSC10 and PNN 1 0.00 0.96 0.03
22 INT315263 Eri1 Regulation of Rela 1 0.00 0.49 0
23 INT315271 Eri1 Regulation of Nfe2l2 1 0.00 0.48 0
24 INT172347 Eri1 Negative_regulation of Hras1 1 0.00 0.76 0
25 INT315265 Eri1 Negative_regulation of Keap1 1 0.01 0.26 0
26 INT315260 Eri1 Regulation of Keap1 1 0.00 0.48 0
27 INT191900 Binding of EXOSC10 and COPD 1 0.01 0.53 0
28 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0
29 INT185353 Eri1 Negative_regulation of Transcription of Egfr 1 0.01 0.5 0
30 INT172345 Eri1 Negative_regulation of Gene_expression of Hras1 1 0.00 0.76 0
31 INT172344 Eri1 Negative_regulation of Positive_regulation of Hras1 1 0.00 0.76 0
32 INT185357 Eri1 Negative_regulation of Gene_expression of Egfr 1 0.01 0.57 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 3'-5' exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in 3'-5' exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT131808 Localization of Apex1 2 0.16 13.46 4.61
2 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
3 INT167477 Regulation of TREX1 1 0.24 1.04 1.12
4 INT332756 Localization of TREX1 1 0.01 0 0.81
5 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
6 INT191905 Binding of EXOSC10 19 0.04 11.24 0.57
7 INT191904 Positive_regulation of EXOSC10 11 0.06 5.43 0.57
8 INT138404 Regulation of Negative_regulation of TREX1 1 0.18 0.18 0.46
9 INT138405 Negative_regulation of TREX1 1 0.37 0.18 0.46
10 INT169943 Gene_expression of Eri1 22 0.35 10.45 0.41
11 INT182073 Binding of APEX1 4 0.12 1.72 0.32
12 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
13 INT344883 Binding of TREX1 1 0.25 0.09 0.21
14 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
15 INT89772 Positive_regulation of APEX1 4 0.21 2.29 0.19
16 INT190110 Positive_regulation of Eri1 2 0.27 3.47 0.15
17 INT182078 Gene_expression of APEX1 3 0.59 4.77 0.12
18 INT204967 Negative_regulation of Eri1 2 0.17 1.41 0.12
19 INT200071 Gene_expression of ERI1 2 0.65 0.41 0.12
20 INT200070 Negative_regulation of ERI1 1 0.11 0.24 0.12
21 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
22 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
23 INT169935 Positive_regulation of Gene_expression of Eri1 3 0.19 2.46 0.09
24 INT191908 Negative_regulation of Positive_regulation of EXOSC10 1 0.01 0.25 0.09
25 INT172342 Regulation of Eri1 2 0.03 0.3 0.08
26 INT200069 Regulation of ERI1 1 0.05 0.15 0.08
27 INT191906 Positive_regulation of Positive_regulation of EXOSC10 2 0.04 0.66 0.07
28 INT182080 Localization of APEX1 2 0.57 2.3 0.05
29 INT214043 Positive_regulation of Localization of APEX1 1 0.38 0.64 0.05
30 INT190102 Protein_catabolism of Eri1 3 0.25 1.69 0.04
31 INT182079 Negative_regulation of APEX1 5 0.18 1.75 0
32 INT210093 Gene_expression of EXOSC10 5 0.65 2.31 0
33 INT217417 Binding of ERI1 2 0.36 0.99 0
34 INT256198 Positive_regulation of Gene_expression of EXOSC10 1 0.49 0.56 0
35 INT204991 Positive_regulation of Positive_regulation of Eri1 1 0.19 0.96 0
36 INT191907 Positive_regulation of Binding of EXOSC10 1 0.01 0.36 0
37 INT210091 Regulation of EXOSC10 1 0.04 0.54 0
38 INT210094 Negative_regulation of EXOSC10 1 0.03 0.15 0
39 INT182075 Negative_regulation of Positive_regulation of APEX1 1 0.13 0.63 0
40 INT283730 Binding of Eri1 1 0.01 0.26 0
41 INT182072 Regulation of APEX1 1 0.08 0.76 0
42 INT219055 Regulation of Gene_expression of Eri1 1 0.00 0.1 0
43 INT214034 Positive_regulation of Gene_expression of APEX1 1 0.53 0.85 0
44 INT310100 Transcription of APEX1 1 0.09 0 0
45 INT204984 Transcription of Eri1 1 0.21 0.78 0
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