GO:0008430

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Name selenium binding
Categary Function
Go Slim No
Go Link GO:0008430
Unique Molecular Interactions 102
Total Molecular Interactions 133
Total Single Events 1070
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for selenium binding. They are ordered first by their pain relevance and then by number of times they were reported for selenium binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
2 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
3 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
4 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
5 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
6 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
7 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
8 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98
9 INT144551 Binding of Lrp8 and Sepp1 1 0.55 1.73 0.93
10 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
11 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
12 INT49585 Binding of Glul and Selenbp2 1 0.20 0.19 0.76
13 INT210984 Cfp Positive_regulation of Positive_regulation of Dio1 1 0.07 0.81 0.75
14 INT210980 Cysltr1 Positive_regulation of Positive_regulation of Dio1 1 0.00 0.81 0.75
15 INT81631 Selenbp2 Negative_regulation of Fas 1 0.03 0.77 0.67
16 INT81630 Selenbp2 Negative_regulation of Positive_regulation of Fas 1 0.03 0.77 0.67
17 INT122475 Binding of Aap and Selenbp1 1 0.01 0.06 0.62
18 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
19 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
20 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
21 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
22 INT151338 Binding of Dio1 and P9Ehs1 1 0.09 0.16 0.52
23 INT122069 Gpx3 Negative_regulation of Trpv1 1 0.02 0.21 0.51
24 INT12677 Sepp1 Positive_regulation of Localization of Nkx1-1 1 0.06 0.1 0.46
25 INT12678 Sepp1 Regulation of Nkx1-1 1 0.03 0.1 0.45
26 INT12676 Sepp1 Positive_regulation of Nkx1-1 1 0.02 0.1 0.45
27 INT228850 Dio1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.06 0 0.44
28 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
29 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
30 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
31 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
32 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
33 INT50621 Positive_regulation of Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.37
34 INT263757 Binding of Gpx3 and Neto1 1 0.01 0 0.29
35 INT33977 DIO2 Regulation of PCDHB17 1 0.00 0.44 0.27
36 INT350835 Binding of SELS and Sels 1 0.16 1.24 0.26
37 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
38 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
39 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
40 INT50620 Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.22
41 INT127322 Gpx3 Regulation of Mapk1 1 0.00 0.27 0.21
42 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
43 INT172895 Binding of Cpox and Selenbp2 1 0.00 0.64 0.2
44 INT127321 Gpx3 Regulation of Mapk3 1 0.00 0.27 0.2
45 INT222025 Gpx3 Regulation of EPHB2 1 0.01 1.41 0.18
46 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
47 INT244855 Lbx1 Negative_regulation of Dio1 1 0.03 0.09 0.16
48 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
49 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
50 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
51 INT350820 INS Regulation of SELS 1 0.13 1.11 0.1
52 INT342232 Binding of POR and SEPP1 1 0.02 0.75 0.08
53 INT342231 Binding of SEPP1 and ARC 1 0.04 3.84 0.08
54 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
55 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
56 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
57 INT319786 Ccbp2 Positive_regulation of Negative_regulation of Dio1 1 0.09 0.94 0.05
58 INT350823 Binding of SAA1 and SELS 1 0.17 2.75 0.05
59 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
60 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
61 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
62 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
63 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
64 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
65 INT247765 Gpx3 Positive_regulation of Rarres2 1 0.01 0.86 0.03
66 INT257513 Regulation of Binding of Slc4a4 and H47 1 0.00 0.08 0.03
67 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
68 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
69 INT257512 Binding of Slc4a4 and H47 1 0.00 0.08 0.03
70 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
71 INT195638 Ccw Positive_regulation of Gene_expression of SEPP1 1 0.16 0 0.03
72 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
73 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
74 INT319787 Binding of Dio1 and Ccbp2 1 0.06 0.92 0.03
75 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
76 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
77 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
78 INT342229 SEPP1 Regulation of ARC 1 0.03 0.44 0
79 INT325900 Binding of Dio1 and Wbp5 1 0.00 0.25 0
80 INT350822 SELS Positive_regulation of Gene_expression of SAA1 1 0.21 0.87 0
81 INT155123 Binding of Gpx1 and Cat 1 0.04 0.05 0
82 INT215764 Dio1 Regulation of Ces1c 1 0.00 0.05 0
83 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
84 INT198918 Binding of Gpx3 and Lrp8 1 0.00 0.17 0
85 INT215246 Binding of Rab27a and Rph3a 1 0.07 0.26 0
86 INT155124 Positive_regulation of Binding of Gpx1 and Cat 1 0.05 0.05 0
87 INT250554 Binding of F5 and SELS 1 0.24 1.07 0
88 INT325901 Binding of Dio1 and F2 1 0.01 0.63 0
89 INT215241 Binding of Rab3a and Rph3a 1 0.00 0.26 0
90 INT263731 Positive_regulation of Binding of Gpx3 and Neto1 1 0.01 0 0
91 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
92 INT269770 Binding of DIO2 and NOVA2 1 0.07 0 0
93 INT350824 INS Positive_regulation of Gene_expression of SELS 1 0.22 0.85 0
94 INT235960 Binding of Aqp4 and H47 1 0.01 0.13 0
95 INT263868 Binding of Krt31 and H47 1 0.01 0.51 0
96 INT342234 Binding of SEPP1 and PKD1P4 1 0.00 2.55 0
97 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0
98 INT339120 Binding of ERBB2 and MIEN1 1 0.31 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for selenium binding. They are ordered first by their pain relevance and then by number of times they were reported in selenium binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
2 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91
3 INT6749 Binding of Dio1 25 0.38 4.41 13.07
4 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
5 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11
6 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
7 INT6748 Regulation of Dio1 15 0.45 2.63 11.18
8 INT31780 Binding of DIO2 17 0.36 10.07 10
9 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
10 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
11 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76
12 INT46168 Positive_regulation of Sepp1 12 0.50 8.02 7.47
13 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
14 INT36560 Binding of Selenbp2 6 0.19 1.42 6.07
15 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74
16 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
17 INT10162 Positive_regulation of Gpx3 10 0.40 3.37 3.68
18 INT64539 Gene_expression of Gpx3 14 0.58 9.42 3.64
19 INT30011 Negative_regulation of Sepp1 18 0.54 4.65 3.54
20 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
21 INT16864 Gene_expression of Selenbp2 4 0.76 0.52 3.34
22 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27
23 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
24 INT202577 Localization of DIO2 9 0.56 1.3 2.97
25 INT90981 Transcription of Dio1 2 0.42 1.44 2.85
26 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
27 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08
28 INT64648 Regulation of Selenbp2 4 0.23 1.63 2.05
29 INT167699 Positive_regulation of Positive_regulation of Dio1 2 0.26 1.12 2.04
30 INT27991 Positive_regulation of Gene_expression of Selenbp2 1 0.39 0.44 1.91
31 INT114746 Gene_expression of Sepp1 15 0.60 3.33 1.86
32 INT67710 Binding of Sepp1 3 0.41 1.77 1.83
33 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
34 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
35 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
36 INT35788 Phosphorylation of Gpx3 5 0.06 0.66 1.52
37 INT60206 Gene_expression of Selenbp1 2 0.42 0.16 1.46
38 INT143317 Regulation of Gene_expression of Dio1 4 0.26 2.9 1.4
39 INT197807 Negative_regulation of Sepp1 11 0.59 2.08 1.38
40 INT147345 Localization of Dio1 7 0.50 1.72 1.38
41 INT108249 Negative_regulation of Prdx2 3 0.32 1.85 1.36
42 INT143233 Positive_regulation of Binding of Dio1 1 0.21 0 1.36
43 INT103272 Positive_regulation of Gene_expression of Dio1 4 0.26 1.66 1.34
44 INT124996 Regulation of Gpx3 4 0.23 1.54 1.34
45 INT4603 Positive_regulation of SEPP1 5 0.49 2.13 1.33
46 INT34783 Positive_regulation of Selenbp2 2 0.17 0.35 1.19
47 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16
48 INT123542 Regulation of Sepp1 9 0.59 0.94 1.1
49 INT124201 Positive_regulation of Localization of Selenbp2 1 0.02 0 1.1
50 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
51 INT145063 Negative_regulation of Selenbp2 1 0.04 0.05 0.98
52 INT11189 Binding of Selenbp1 2 0.08 0.15 0.97
53 INT108243 Positive_regulation of Prdx2 3 0.34 0.85 0.95
54 INT60205 Transcription of Selenbp2 2 0.71 0.09 0.93
55 INT87759 Gene_expression of Sepp1 6 0.68 0.88 0.92
56 INT151336 Regulation of Binding of Dio1 2 0.30 0.2 0.9
57 INT60599 Regulation of SEPP1 6 0.33 1.5 0.89
58 INT76915 Localization of Gpx3 6 0.14 4.48 0.89
59 INT198870 Binding of Gpx3 5 0.01 2.47 0.81
60 INT63486 Negative_regulation of Positive_regulation of Dio1 1 0.19 0.33 0.79
61 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
62 INT198898 Protein_catabolism of Gpx3 6 0.02 2.49 0.71
63 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64
64 INT60207 Transcription of Selenbp1 1 0.33 0.08 0.62
65 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61
66 INT32400 Gene_expression of SEPP1 8 0.75 1.4 0.6
67 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
68 INT257949 Regulation of Gene_expression of DIO2 1 0.15 0.17 0.6
69 INT200875 Protein_catabolism of Dio1 1 0.03 0 0.57
70 INT123540 Regulation of Positive_regulation of Sepp1 1 0.45 0.12 0.51
71 INT257946 Regulation of Positive_regulation of DIO2 1 0.13 0.45 0.49
72 INT15047 Negative_regulation of SELS 1 0.35 0.34 0.49
73 INT39018 Protein_catabolism of DIO2 1 0.02 0 0.49
74 INT195097 Positive_regulation of Gene_expression of Gpx3 4 0.45 1.09 0.47
75 INT349611 Positive_regulation of Localization of DIO2 1 0.26 0 0.46
76 INT317984 Positive_regulation of Localization of Gpx3 1 0.01 1.42 0.46
77 INT197804 Positive_regulation of Sepp1 1 0.47 0.08 0.45
78 INT100254 Binding of SELS 6 0.36 4.54 0.4
79 INT40541 Negative_regulation of Positive_regulation of DIO2 2 0.41 0.86 0.4
80 INT319780 Negative_regulation of Gene_expression of Dio1 2 0.31 1.51 0.4
81 INT67711 Negative_regulation of Binding of Sepp1 1 0.50 0 0.39
82 INT347801 Regulation of Regulation of Dio1 1 0.15 0.55 0.39
83 INT228849 Negative_regulation of Binding of Dio1 1 0.06 0 0.36
84 INT26173 Regulation of SELS 3 0.52 3.4 0.32
85 INT350833 Positive_regulation of Gene_expression of SELS 1 0.61 6.07 0.32
86 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
87 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
88 INT197803 Positive_regulation of Negative_regulation of Sepp1 1 0.50 0 0.28
89 INT350825 Gene_expression of Sels 1 0.34 1.07 0.25
90 INT112457 Negative_regulation of Localization of Selenbp2 1 0.00 0 0.22
91 INT305975 Regulation of Gene_expression of SELS 2 0.60 3.19 0.21
92 INT197805 Localization of Sepp1 1 0.75 0.26 0.21
93 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
94 INT137312 Positive_regulation of Positive_regulation of Sepp1 1 0.40 0.74 0.19
95 INT350827 Localization of SELS 1 0.62 1.24 0.19
96 INT353278 Binding of Prdx2 1 0.21 0.05 0.18
97 INT353270 Regulation of Binding of Prdx2 1 0.25 0.05 0.18
98 INT305978 Protein_catabolism of SELS 1 0.86 0.88 0.17
99 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
100 INT98342 Localization of SEPP1 3 0.60 0.6 0.16
101 INT353274 Transcription of Prdx2 1 0.39 0.51 0.16
102 INT349614 Negative_regulation of Binding of DIO2 1 0.27 0.77 0.16
103 INT353264 Negative_regulation of Negative_regulation of Prdx2 1 0.24 0.45 0.15
104 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
105 INT78367 Positive_regulation of Negative_regulation of Dio1 1 0.50 0.46 0.14
106 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
107 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
108 INT191137 Binding of H47 4 0.19 1.22 0.13
109 INT141621 Negative_regulation of SEPP1 3 0.41 0.13 0.13
110 INT350834 Transcription of SELS 1 0.53 4.8 0.13
111 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
112 INT350832 Positive_regulation of Transcription of SELS 1 0.41 1 0.13
113 INT144549 Binding of Sepp1 1 0.36 0.31 0.13
114 INT169910 Positive_regulation of H47 1 0.17 1.52 0.12
115 INT141622 Transcription of SEPP1 1 0.52 0 0.12
116 INT250570 Negative_regulation of Gene_expression of SELS 2 0.43 2.85 0.1
117 INT335654 Negative_regulation of Gene_expression of DIO2 1 0.17 0.72 0.1
118 INT127659 Positive_regulation of Gene_expression of SEPP1 1 0.50 0.07 0.1
119 INT305626 Regulation of Gene_expression of Sepp1 1 0.04 0 0.1
120 INT169948 Gene_expression of H47 6 0.22 0.73 0.09
121 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09
122 INT252568 Negative_regulation of Regulation of Gpx1 1 0.08 1.11 0.09
123 INT191149 Positive_regulation of Binding of H47 1 0.07 0.55 0.05
124 INT191140 Negative_regulation of Binding of H47 1 0.06 0.56 0.05
125 INT197806 Regulation of Sepp1 2 0.45 0.37 0.04
126 INT228148 Localization of Sepp1 2 0.39 0.89 0.03
127 INT228149 Phosphorylation of Sepp1 1 0.26 0 0.03
128 INT169923 Negative_regulation of Positive_regulation of H47 1 0.12 0.72 0.03
129 INT279624 Negative_regulation of Gpx3 2 0.18 0.67 0
130 INT225419 Positive_regulation of Gene_expression of H47 1 0.08 0 0
131 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0
132 INT319778 Regulation of Localization of Dio1 1 0.24 0.29 0
133 INT342240 Positive_regulation of Binding of SEPP1 1 0.04 0.64 0
134 INT268724 Positive_regulation of Negative_regulation of Gpx1 1 0.04 0.13 0
135 INT350829 Regulation of Regulation of SELS 1 0.27 1.39 0
136 INT339178 Gene_expression of MIEN1 1 0.60 0.86 0
137 INT169932 Positive_regulation of Positive_regulation of H47 1 0.13 0.26 0
138 INT210664 Negative_regulation of Gene_expression of Gpx3 1 0.13 0.13 0
139 INT276140 Regulation of Negative_regulation of DIO2 1 0.34 0.07 0
140 INT320316 Positive_regulation of Localization of SEPP1 1 0.13 0 0
141 INT143737 Positive_regulation of SELS 1 0.67 0.06 0
142 INT342241 Binding of SEPP1 1 0.47 3.08 0
143 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0
144 INT319783 Positive_regulation of Localization of Dio1 1 0.26 0.24 0
145 INT339162 Positive_regulation of Gene_expression of MIEN1 1 0.39 0.45 0
146 INT347402 Negative_regulation of Binding of Gpx1 1 0.05 0 0
147 INT169950 Regulation of H47 1 0.07 0.1 0
148 INT351593 Positive_regulation of Binding of Gpx1 1 0.08 0 0
149 INT169924 Regulation of Gene_expression of H47 1 0.15 0.1 0
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