GO:0008432

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Name JUN kinase binding
Categary Function
Go Slim No
Go Link GO:0008432
Unique Molecular Interactions 88
Total Molecular Interactions 121
Total Single Events 983
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JUN kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for JUN kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
2 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
3 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
4 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
5 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
6 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
7 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
8 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
9 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
10 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
11 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
12 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
13 INT297689 Atn1 Regulation of Gene_expression of Il6 1 0.02 1.13 0.44
14 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
15 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
16 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
17 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
18 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
19 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
20 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
21 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
22 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
23 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
24 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
25 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
26 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
27 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
28 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
29 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
30 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
31 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
32 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
33 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
34 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
35 INT254643 Binding of Mapk8ip1 and Slc9a3r2 1 0.00 0.27 0.12
36 INT297695 Binding of Atn1 and Fut1 1 0.01 0.68 0.12
37 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
38 INT327405 Lox Positive_regulation of Ptk2 1 0.42 1.3 0.1
39 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
40 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
41 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
42 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
43 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
44 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07
45 INT329265 Binding of Ptk2 and Wnt2 1 0.05 1.04 0.07
46 INT333260 Gene_expression of Cxcl12 Negative_regulation of Gene_expression of Ptk2 1 0.21 1 0.07
47 INT333257 Gene_expression of Cxcl12 Negative_regulation of Ptk2 1 0.21 1 0.07
48 INT233278 Binding of LBX1 and Tgif1 1 0.00 0.25 0.06
49 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
50 INT143647 Negative_regulation of Mapk8ip1 Negative_regulation of Gene_expression of Fas 1 0.02 0.15 0.05
51 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
52 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
53 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
54 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
55 INT271526 Binding of ESB3 and Ptk2 1 0.01 0.97 0.03
56 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
57 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
58 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
59 INT351680 Fut1 Regulation of Ptk2 1 0.01 1.68 0
60 INT292464 Binding of PTK2 and MMRN1 1 0.03 0.26 0
61 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
62 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
63 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
64 INT292463 LAMB2 Positive_regulation of Phosphorylation of PTK2 1 0.01 0.7 0
65 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
66 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
67 INT269248 Lox Negative_regulation of Ptk2 1 0.24 1.02 0
68 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
69 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
70 INT233279 Binding of TLX1 and Tgif1 1 0.00 0.05 0
71 INT292452 Gene_expression of PTK2 Negative_regulation of Positive_regulation of AKT1 1 0.14 0.6 0
72 INT292453 PTK2 Regulation of Gene_expression of GEM 1 0.16 0.42 0
73 INT283863 Binding of MAPK1 and PTK2 1 0.12 0.97 0
74 INT295409 Ptk2 Positive_regulation of Phosphorylation of Oprk1 1 0.01 0 0
75 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0
76 INT292495 Mlph Regulation of Gene_expression of PTK2 1 0.03 0.21 0
77 INT292461 PTK2 Regulation of BCL2 1 0.02 0.76 0
78 INT292451 PTK2 Regulation of BAX 1 0.02 0.76 0
79 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
80 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
81 INT292448 Positive_regulation of PTK2 Positive_regulation of Phosphorylation of AKT1 1 0.15 0.28 0
82 INT295402 Ptk2 Positive_regulation of Localization of Oprk1 1 0.01 0 0
83 INT292457 PTK2 Regulation of BAD 1 0.03 0.76 0
84 INT351676 Fut1 Negative_regulation of Ptk2 1 0.01 4.39 0
85 INT292506 Mlph Regulation of PTK2 1 0.01 0.21 0
86 INT351677 Fut1 Negative_regulation of Gene_expression of Ptk2 1 0.01 3.64 0
87 INT292460 GEM Positive_regulation of Phosphorylation of PTK2 1 0.20 0.52 0
88 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for JUN kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in JUN kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
2 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
3 INT80681 Positive_regulation of Atn1 20 0.49 11.85 3.76
4 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
5 INT133085 Gene_expression of Mapk8ip1 7 0.66 6.13 2.98
6 INT95737 Positive_regulation of Phosphorylation of Mapk8ip1 2 0.06 3.27 2.74
7 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
8 INT133083 Positive_regulation of Gene_expression of Mapk8ip1 1 0.07 3.27 2.47
9 INT95736 Phosphorylation of Mapk8ip1 2 0.10 2.84 2.32
10 INT297674 Gene_expression of Atn1 11 0.29 6.69 2
11 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
12 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
13 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
14 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
15 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
16 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
17 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
18 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
19 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
20 INT143646 Negative_regulation of Mapk8ip1 5 0.03 5.46 1.28
21 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
22 INT87346 Binding of PTK2 6 0.37 4.03 1.18
23 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
24 INT297663 Localization of Atn1 1 0.25 1.84 0.93
25 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
26 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
27 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
28 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
29 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
30 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
31 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
32 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
33 INT80680 Negative_regulation of Atn1 3 0.42 1.5 0.64
34 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
35 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
36 INT297672 Positive_regulation of Localization of Atn1 1 0.17 0.94 0.55
37 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
38 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52
39 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
40 INT117772 Binding of Ptk2 1 0.37 0.17 0.46
41 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
42 INT167981 Negative_regulation of Negative_regulation of Mapk8ip1 1 0.01 0.91 0.45
43 INT179413 Positive_regulation of Mapk8ip1 1 0.01 0.97 0.4
44 INT271521 Phosphorylation of Ptk2 10 0.59 11.45 0.39
45 INT325423 Localization of Gstp1 1 0.06 0.85 0.37
46 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37
47 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
48 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33
49 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32
50 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
51 INT83594 Negative_regulation of Phosphorylation of Ptk2 5 0.42 1.62 0.29
52 INT297682 Binding of Atn1 4 0.16 1.58 0.28
53 INT95740 Negative_regulation of Phosphorylation of Mapk8ip1 1 0.01 0 0.27
54 INT271522 Negative_regulation of Phosphorylation of Ptk2 3 0.19 2.09 0.26
55 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
56 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
57 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
58 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
59 INT308522 Positive_regulation of Positive_regulation of Ptk2 2 0.22 2.37 0.21
60 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
61 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19
62 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
63 INT283561 Regulation of Gene_expression of Ptk2 5 0.42 1.1 0.17
64 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
65 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
66 INT83595 Negative_regulation of Gene_expression of Ptk2 1 0.23 1.62 0.14
67 INT131114 Positive_regulation of Gene_expression of Ptk2 1 0.49 0.27 0.14
68 INT327399 Negative_regulation of Positive_regulation of Ptk2 7 0.43 4.75 0.13
69 INT269240 Regulation of Ptk2 6 0.42 2.84 0.13
70 INT278171 Positive_regulation of Transcription of GSTP1 1 0.50 1.86 0.13
71 INT353269 Negative_regulation of Positive_regulation of Tgif1 1 0.11 0.5 0.13
72 INT283567 Regulation of Regulation of Ptk2 1 0.42 0.3 0.13
73 INT353275 Positive_regulation of Tgif1 1 0.13 0.5 0.13
74 INT223834 Localization of GSTP1 2 0.70 1.28 0.1
75 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09
76 INT120767 Negative_regulation of Gene_expression of GSTP1 3 0.42 1.15 0.09
77 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
78 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
79 INT271523 Positive_regulation of Gene_expression of Ptk2 6 0.65 8 0.08
80 INT297667 Protein_catabolism of Atn1 1 0.19 0.36 0.08
81 INT120771 Negative_regulation of Positive_regulation of GSTP1 1 0.30 0.39 0.08
82 INT147735 Regulation of Binding of PTK2 1 0.35 0.23 0.08
83 INT297685 Positive_regulation of Protein_catabolism of Atn1 1 0.13 0.36 0.08
84 INT120766 Regulation of Positive_regulation of GSTP1 1 0.32 0.39 0.08
85 INT280787 Gene_expression of Mapk8ip3 1 0.01 0.24 0.07
86 INT278173 Transcription of GSTP1 1 0.68 0.93 0.07
87 INT254642 Binding of Mapk8ip1 1 0.32 0.22 0.07
88 INT144400 Positive_regulation of Gene_expression of PTK2 33 0.70 21.24 0.06
89 INT333217 Regulation of Positive_regulation of Ptk2 1 0.12 0.36 0.05
90 INT329775 Regulation of Regulation of PTK2 1 0.11 0.49 0.05
91 INT238180 Binding of Ptk2 5 0.35 2.99 0.04
92 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
93 INT327396 Positive_regulation of Negative_regulation of Ptk2 1 0.37 0.95 0.04
94 INT285978 Negative_regulation of Gene_expression of Mapk8ip1 1 0.01 0.66 0.04
95 INT295374 Positive_regulation of Ptk2 1 0.34 0.06 0.04
96 INT353260 Gene_expression of Tgif1 1 0.21 0 0.03
97 INT353277 Positive_regulation of Gene_expression of Tgif1 1 0.18 0 0.03
98 INT353279 Phosphorylation of Tgif1 1 0.22 0.06 0.03
99 INT292474 Negative_regulation of Gene_expression of PTK2 8 0.41 5.17 0
100 INT283566 Localization of Ptk2 5 0.75 0.93 0
101 INT262779 Localization of PTK2 3 0.71 2.75 0
102 INT203874 Positive_regulation of Gene_expression of GSTP1 3 0.49 1.91 0
103 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
104 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
105 INT305470 Regulation of Gene_expression of GSTP1 1 0.06 0.59 0
106 INT286395 Negative_regulation of Transcription of Mapk8ip3 1 0.55 0 0
107 INT203877 Phosphorylation of GSTP1 1 0.79 0.22 0
108 INT292478 Negative_regulation of Negative_regulation of PTK2 1 0.41 0.97 0
109 INT283564 Positive_regulation of Localization of Ptk2 1 0.47 0 0
110 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
111 INT329769 Positive_regulation of Localization of PTK2 1 0.17 1.42 0
112 INT295392 Positive_regulation of Localization of Ptk2 1 0.37 0 0
113 INT321525 Transcription of Atn1 1 0.30 0 0
114 INT233252 Binding of Tgif1 1 0.01 0.74 0
115 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
116 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
117 INT199764 Positive_regulation of Gene_expression of Gstp1 1 0.55 2.21 0
118 INT233211 Regulation of Binding of Tgif1 1 0.00 0.36 0
119 INT286400 Transcription of Mapk8ip3 1 0.68 0 0
120 INT351669 Negative_regulation of Binding of Ptk2 1 0.40 0.73 0
121 INT203870 Negative_regulation of Binding of GSTP1 1 0.42 0.22 0
122 INT286397 Negative_regulation of Mapk8ip3 1 0.41 0.06 0
123 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
124 INT286391 Positive_regulation of Mapk8ip3 1 0.44 0.06 0
125 INT353276 Negative_regulation of Tgif1 1 0.11 0 0
126 INT295387 Localization of Ptk2 1 0.55 0 0
127 INT215423 Localization of MAP3K1 1 0.68 0.22 0
128 INT321520 Regulation of Atn1 1 0.20 0 0
129 INT206472 Transcription of Ptk2 1 0.52 0.46 0
130 INT238159 Regulation of Binding of Ptk2 1 0.03 0.06 0
131 INT292481 Negative_regulation of Localization of PTK2 1 0.41 0.07 0
132 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
133 INT215428 Binding of MAP3K1 1 0.44 0.05 0
134 INT329766 Positive_regulation of Positive_regulation of PTK2 1 0.11 0.51 0
135 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
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