GO:0008437

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Name thyrotropin-releasing hormone activity
Categary Function
Go Slim No
Go Link GO:0008437
Unique Molecular Interactions 155
Total Molecular Interactions 264
Total Single Events 1793
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyrotropin-releasing hormone activity. They are ordered first by their pain relevance and then by number of times they were reported for thyrotropin-releasing hormone activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44
2 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39
3 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29
4 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
5 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
6 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
7 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
8 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
9 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
10 INT33988 TRH Regulation of Localization of IGKV1D-39 1 0.12 0.47 1.35
11 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09
12 INT7927 Penk Regulation of Trh 2 0.26 0.66 1.09
13 INT34900 Trh Positive_regulation of Localization of Prl 1 0.05 0 1.09
14 INT17414 TRH Positive_regulation of Prl 4 0.47 0 1.07
15 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05
16 INT25155 TRH Positive_regulation of PRL 2 0.50 0.4 1
17 INT32840 Regulation of Binding of Trh and Penk 1 0.26 0 0.91
18 INT17416 TRH Positive_regulation of Localization of Prl 1 0.47 0 0.85
19 INT7926 Regulation of Penk Regulation of Trh 1 0.26 0.66 0.8
20 INT52561 Trh Positive_regulation of Localization of Lhb 1 0.01 0.14 0.77
21 INT3570 Trh Regulation of Localization of Gnrhr 2 0.26 0.3 0.75
22 INT196799 Prkaca Positive_regulation of Phosphorylation of Trh 1 0.02 0 0.74
23 INT41919 Binding of Tacr1 and Trh 1 0.06 0 0.74
24 INT43717 Positive_regulation of Binding of Trh and Penk 1 0.56 0 0.72
25 INT40763 Trh Negative_regulation of Penk 1 0.19 0 0.65
26 INT107330 Binding of Adarb1 and Trh 1 0.01 0 0.65
27 INT40762 Trh Negative_regulation of Prss12 1 0.06 0 0.65
28 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
29 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62
30 INT40153 Gnrh1 Regulation of Trh 1 0.47 0 0.59
31 INT25156 TRH Regulation of PRL 2 0.27 0.81 0.56
32 INT10079 Cp Regulation of Trh 1 0.01 0.59 0.53
33 INT34368 TRH Positive_regulation of GHRH 1 0.23 0.4 0.53
34 INT49696 Trh Regulation of GH1 2 0.02 0.22 0.52
35 INT222524 Abat Negative_regulation of Localization of Trh 1 0.02 0.16 0.51
36 INT34980 Regulation of Trh Positive_regulation of Localization of Prl 1 0.50 0 0.49
37 INT17610 Binding of Ctse and Trh 1 0.27 0.89 0.49
38 INT30801 Penk Negative_regulation of Trh 1 0.09 0 0.49
39 INT61510 Binding of Trh and Gm14673 1 0.01 0 0.48
40 INT30802 Pomc Negative_regulation of Trh 1 0.11 0 0.48
41 INT17463 Trh Regulation of Localization of Prl 2 0.30 0.22 0.47
42 INT34982 Trh Regulation of Dbi 1 0.12 0 0.47
43 INT34984 Negative_regulation of Trh Regulation of Dbi 1 0.19 0 0.47
44 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
45 INT19906 Positive_regulation of Trh Regulation of Prl 2 0.04 0.47 0.43
46 INT32161 Negative_regulation of Trh Positive_regulation of Prl 1 0.48 0 0.42
47 INT34985 Gene_expression of Pomc Positive_regulation of Localization of Trh 1 0.09 0 0.42
48 INT17415 Negative_regulation of TRH Positive_regulation of Prl 1 0.44 0 0.42
49 INT34983 Gene_expression of Dbi Positive_regulation of Localization of Trh 1 0.22 0 0.42
50 INT44312 Binding of Trh and Pag1 1 0.05 0.36 0.41
51 INT196797 Trh Negative_regulation of Prkaca 1 0.01 0 0.41
52 INT35201 Trh Regulation of Tshb 1 0.01 0.28 0.39
53 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
54 INT196800 Trh Negative_regulation of Ppp1cc 1 0.01 0 0.39
55 INT196796 Ppp1r1b Negative_regulation of Phosphorylation of Trh 1 0.01 0 0.39
56 INT3634 Trh Regulation of Gh1 3 0.20 0.23 0.38
57 INT105770 SST Negative_regulation of Localization of TRH 1 0.17 0.54 0.38
58 INT45798 TRH Regulation of Lhb 1 0.36 0.09 0.38
59 INT3616 Trh Positive_regulation of Localization of Gh1 4 0.73 0.49 0.36
60 INT77494 PREP Positive_regulation of TRH 1 0.16 0 0.36
61 INT29118 Trh Regulation of Oprd1 1 0.24 0.79 0.31
62 INT196798 Trh Positive_regulation of Phosphorylation of Ppp1r1b 1 0.01 0 0.3
63 INT73053 Prl Positive_regulation of Trh 1 0.22 0 0.3
64 INT222529 Binding of Trh and Vip 1 0.07 0.09 0.29
65 INT3638 Trh Regulation of Localization of Gnrh1 1 0.17 0 0.29
66 INT40151 Nts Regulation of Trh 1 0.21 0 0.29
67 INT40152 Sst Regulation of Trh 1 0.22 0 0.29
68 INT41192 Trh Positive_regulation of Localization of POMC 1 0.04 0 0.29
69 INT25375 Trh Regulation of Gh 1 0.04 1.01 0.28
70 INT17351 Npy Regulation of Trh 1 0.46 0 0.28
71 INT3569 Trh Negative_regulation of Positive_regulation of Gh1 1 0.20 0 0.27
72 INT3574 Trh Negative_regulation of Localization of Gh1 1 0.15 0 0.27
73 INT44443 GNRH1 Positive_regulation of Localization of TRH 1 0.08 0.19 0.26
74 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
75 INT122232 Trh Positive_regulation of Positive_regulation of LH 1 0.18 0 0.24
76 INT122225 Trh Positive_regulation of Gh1 1 0.06 0 0.24
77 INT122222 Trh Positive_regulation of LH 1 0.18 0 0.24
78 INT25247 TRH Regulation of CGA 1 0.26 0 0.24
79 INT49682 Positive_regulation of Trh Positive_regulation of Prl 1 0.05 0.26 0.23
80 INT63703 Regulation of TRH Positive_regulation of Prl 1 0.07 0 0.23
81 INT20186 TRH Regulation of Gene_expression of Gh 1 0.22 0.54 0.22
82 INT19905 Trh Regulation of Gnrhr 1 0.00 0.25 0.22
83 INT33714 Positive_regulation of Binding of ITPR3 and Trh 1 0.00 0.46 0.21
84 INT53230 Trh Positive_regulation of Tshb 1 0.55 0.2 0.2
85 INT83585 Trh Positive_regulation of Mc1r 1 0.50 0.35 0.2
86 INT3635 Trh Regulation of Localization of Tshb 1 0.35 0.3 0.19
87 INT122236 Gnrh1 Positive_regulation of Trh 1 0.29 0 0.19
88 INT3619 Trh Positive_regulation of Localization of Gnrhr 2 0.48 0.2 0.18
89 INT342744 Ddc Regulation of Trh 1 0.02 0.37 0.18
90 INT60348 Trh Positive_regulation of Positive_regulation of Acot1 1 0.29 0.44 0.17
91 INT11791 TRH Regulation of Localization of PRL 1 0.18 0 0.17
92 INT10291 Trh Regulation of CTSC 1 0.01 0 0.16
93 INT32286 POMC Negative_regulation of Trh 1 0.01 0 0.15
94 INT74070 Trh Regulation of Lhb 1 0.02 0.27 0.15
95 INT32285 POMC Regulation of Trh 1 0.01 0 0.15
96 INT32287 POMC Regulation of Localization of Trh 1 0.03 0 0.15
97 INT44393 Vip Positive_regulation of Localization of Trh 1 0.51 0 0.14
98 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
99 INT34443 Negative_regulation of Binding of Trh and Ptprg 1 0.20 0.08 0.12
100 INT34445 Binding of Trh and Ptprg 1 0.23 0.08 0.12
101 INT83584 Binding of Mc1r and Trh 1 0.36 0.17 0.1
102 INT33323 Regulation of Trh Positive_regulation of Prl 1 0.30 0 0.1
103 INT3562 Trh Positive_regulation of Klkb1 1 0.10 0 0.1
104 INT34932 NA Positive_regulation of Localization of Trh 1 0.01 0 0.1
105 INT33712 Trh Positive_regulation of Localization of ITPR3 1 0.00 0.8 0.1
106 INT27051 Trhde Regulation of Negative_regulation of Trh 1 0.17 0 0.09
107 INT32288 POMC Regulation of Positive_regulation of Trh 1 0.03 0 0.09
108 INT222483 Trh Regulation of Gene_expression of Gh1 1 0.03 0 0.09
109 INT218733 Trh Positive_regulation of Gene_expression of Hdc 1 0.27 0 0.09
110 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
111 INT1387 Binding of Gnrh1 and Trh 1 0.29 0 0.08
112 INT33324 Regulation of Binding of Prl and Trh 1 0.50 0 0.08
113 INT33325 Binding of Prl and Trh 1 0.42 0 0.08
114 INT1389 Binding of LH and Trh 1 0.16 0 0.08
115 INT1386 Negative_regulation of Binding of and Trh 1 0.18 0 0.08
116 INT1391 Negative_regulation of Binding of Gnrh1 and Trh 1 0.34 0 0.08
117 INT83586 Binding of MC2R and Trh 1 0.02 0.19 0.07
118 INT34448 Trh Negative_regulation of Negative_regulation of Ptprg 1 0.23 0 0.07
119 INT83587 Binding of MC4R and Trh 1 0.01 0.19 0.07
120 INT83588 Binding of MC3R and Trh 1 0.28 0.19 0.07
121 INT34450 Pck1 Regulation of Binding of Trh 1 0.15 0 0.07
122 INT83589 Binding of CALCRL and Trh 1 0.01 0.18 0.07
123 INT53228 Negative_regulation of Trh Positive_regulation of Tshb 1 0.47 0.06 0.06
124 INT3620 Trh Positive_regulation of Positive_regulation of Gh1 1 0.49 0 0.06
125 INT17919 Trh Positive_regulation of Fos 1 0.40 0.14 0.06
126 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06
127 INT222487 Trh Negative_regulation of Nmb 1 0.05 0.26 0.05
128 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05
129 INT53229 Trh Regulation of Gene_expression of Tshb 1 0.49 0.05 0.05
130 INT217590 Binding of Trh and Trhr2 1 0.04 0 0.04
131 INT321294 Ins1 Positive_regulation of Trh 1 0.00 0.08 0.04
132 INT273117 Trh Positive_regulation of Rps6kb1 1 0.01 0.09 0.04
133 INT222562 Trh Regulation of Localization of LH 1 0.04 0 0.03
134 INT222468 Nmb Positive_regulation of Localization of Trh 1 0.05 0.28 0.03
135 INT222510 Nmb Positive_regulation of Trh 1 0.05 0.28 0.03
136 INT44230 Negative_regulation of Binding of PLOD1 and TRH 1 0.19 0.9 0
137 INT44228 TRH Regulation of PLOD1 1 0.12 0.9 0
138 INT39202 TRH Regulation of GH1 1 0.22 0 0
139 INT44227 Binding of PLOD1 and TRH 1 0.17 0.9 0
140 INT44233 Binding of FSHR and TRH 1 0.34 0.9 0
141 INT218731 Lep Positive_regulation of Gene_expression of Trh 1 0.19 0.07 0
142 INT222496 Trh Positive_regulation of Gene_expression of Prl 1 0.10 0 0
143 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0
144 INT44229 TRH Regulation of FSHR 1 0.11 0.9 0
145 INT39205 TRH Positive_regulation of GH1 1 0.44 0 0
146 INT44231 Negative_regulation of Binding of FSHR and TRH 1 0.39 0.91 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyrotropin-releasing hormone activity. They are ordered first by their pain relevance and then by number of times they were reported in thyrotropin-releasing hormone activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT339 Regulation of Trh 156 0.62 39.27 83.55
2 INT403 Localization of Trh 241 0.81 28.55 81.45
3 INT1376 Binding of Trh 121 0.48 20 69.86
4 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83
5 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5
6 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63
7 INT61665 Phosphorylation of Trh 53 0.79 2.26 23.9
8 INT1327 Regulation of Localization of Trh 45 0.62 6.05 22.09
9 INT14419 Negative_regulation of Localization of Trh 40 0.59 2.04 17.42
10 INT13209 Regulation of Binding of Trh 19 0.62 2.84 16.26
11 INT23825 Negative_regulation of Binding of Trh 17 0.59 1.62 11.24
12 INT987 Localization of TRH 37 0.78 10.53 11.1
13 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03
14 INT8963 Gene_expression of Trh 25 0.68 7.5 10.97
15 INT8966 Regulation of Trh 12 0.62 2.73 10.79
16 INT3637 Positive_regulation of Localization of Trh 33 0.70 2.13 10.55
17 INT143964 Positive_regulation of Phosphorylation of Trh 10 0.20 0.1 10.54
18 INT892 Regulation of TRH 23 0.60 8.46 8.54
19 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17
20 INT9932 Positive_regulation of Positive_regulation of Trh 13 0.50 1.8 7.63
21 INT7923 Transcription of Trh 14 0.72 4.44 6.32
22 INT34440 Negative_regulation of Positive_regulation of Trh 12 0.59 0 5.7
23 INT31648 Binding of Trh 11 0.48 2.09 5.48
24 INT10078 Positive_regulation of Gene_expression of Trh 17 0.50 4.23 5.19
25 INT8965 Positive_regulation of Trh 11 0.57 5.28 4.46
26 INT8964 Regulation of Gene_expression of Trh 1 0.22 1.78 4.4
27 INT5015 Regulation of Gene_expression of Trh 9 0.62 6.47 4.25
28 INT949 Negative_regulation of TRH 12 0.43 3.06 3.4
29 INT34814 Negative_regulation of Trh 5 0.43 0.36 2.8
30 INT2324 Positive_regulation of Regulation of Trh 7 0.50 2.22 2.65
31 INT27267 Localization of Trh 11 0.80 1.76 2.47
32 INT59531 Positive_regulation of Transcription of Trh 6 0.69 1.31 2.42
33 INT988 Positive_regulation of Negative_regulation of Trh 3 0.50 0 2.39
34 INT25159 Regulation of Positive_regulation of TRH 4 0.44 0.35 2.28
35 INT16285 Regulation of Negative_regulation of Trh 3 0.62 0.9 2.22
36 INT14536 Positive_regulation of Gene_expression of Trh 4 0.50 0.54 1.9
37 INT133703 Negative_regulation of Phosphorylation of Trh 4 0.19 0.85 1.88
38 INT25332 Positive_regulation of Binding of Trh 3 0.50 0.08 1.84
39 INT16284 Negative_regulation of Negative_regulation of Trh 5 0.43 0.39 1.75
40 INT30683 Binding of TRH 4 0.36 0.96 1.55
41 INT23764 Regulation of Localization of TRH 4 0.45 0.75 1.4
42 INT948 Negative_regulation of Regulation of TRH 3 0.42 0.74 1.28
43 INT19999 Regulation of Positive_regulation of Trh 5 0.44 0.15 1.26
44 INT11242 Transcription of TRH 1 0.14 0 1.24
45 INT31647 Negative_regulation of Gene_expression of Trh 5 0.43 1.07 1.22
46 INT17918 Regulation of Regulation of Trh 4 0.45 1.37 1.11
47 INT13808 Negative_regulation of Regulation of Trh 3 0.43 0.18 1
48 INT43998 Regulation of Gene_expression of TRH 1 0.44 0.32 0.83
49 INT89109 Regulation of Transcription of Trh 2 0.45 1.98 0.74
50 INT42320 Positive_regulation of Regulation of Trh 1 0.50 0.15 0.74
51 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67
52 INT59532 Negative_regulation of Transcription of Trh 2 0.18 0.4 0.59
53 INT196794 Regulation of Phosphorylation of Trh 1 0.04 0 0.51
54 INT25158 Regulation of Regulation of TRH 1 0.42 0 0.42
55 INT77495 Protein_catabolism of TRH 1 0.65 0 0.35
56 INT44364 Protein_catabolism of Trh 1 0.66 0.34 0.34
57 INT27047 Protein_catabolism of Trh 5 0.91 0.06 0.26
58 INT43253 Positive_regulation of Localization of Trh 1 0.17 0.58 0.25
59 INT232448 Positive_regulation of Gene_expression of TRH 1 0.32 0.08 0.17
60 INT11792 Negative_regulation of Localization of TRH 1 0.28 0 0.16
61 INT39203 Positive_regulation of Negative_regulation of TRH 2 0.49 1.08 0.14
62 INT282833 Regulation of Binding of TRH 1 0.22 0.13 0.11
63 INT214094 Regulation of Localization of Trh 1 0.12 0.2 0.08
64 INT70640 Positive_regulation of Protein_catabolism of Trh 1 0.34 0.06 0.03
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