GO:0008502

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Name melatonin receptor activity
Categary Function
Go Slim No
Go Link GO:0008502
Unique Molecular Interactions 42
Total Molecular Interactions 53
Total Single Events 317
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for melatonin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for melatonin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
2 INT136420 Binding of DeltaFosB and Rorb 1 0.03 0.66 0.97
3 INT239533 Binding of MTNR1A and NCOR2 1 0.01 0.53 0.87
4 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
5 INT200300 Binding of Nenf and Rorb 1 0.00 0 0.64
6 INT211993 Binding of Ppara and Rorb 1 0.00 1.13 0.54
7 INT189151 MTNR1B Positive_regulation of Gene_expression of IL6 1 0.01 0.35 0.47
8 INT309135 Edc4 Regulation of Positive_regulation of Rorb 1 0.00 0.54 0.47
9 INT73660 Rorb Regulation of Gene_expression of Pdyn 1 0.04 0.49 0.44
10 INT189154 MTNR1B Positive_regulation of Gene_expression of IFNG 1 0.01 0.06 0.43
11 INT200303 Oprm1 Negative_regulation of Rorb 1 0.00 0.1 0.39
12 INT200301 Sp3 Regulation of Rorb 1 0.00 0.07 0.38
13 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
14 INT300610 Rorb Regulation of Dnm2 1 0.01 0.27 0.37
15 INT189148 MTNR1B Positive_regulation of POMC 1 0.00 0.34 0.29
16 INT189145 MTNR1B Positive_regulation of Gene_expression of IL2 1 0.02 0.3 0.26
17 INT189142 MTNR1B Positive_regulation of Gene_expression of IL12A 1 0.01 0.29 0.24
18 INT189146 MTNR1B Positive_regulation of Gene_expression of TNF 1 0.01 0.06 0.22
19 INT189156 MTNR1B Positive_regulation of Gene_expression of ROS1 1 0.01 0.06 0.22
20 INT189157 MTNR1B Positive_regulation of Gene_expression of IL1B 1 0.00 0.06 0.22
21 INT85687 Binding of SGCG and GPR50 1 0.40 0 0.2
22 INT320256 Binding of Atf4 and Rorb 1 0.06 0.36 0.17
23 INT320262 Binding of Atf3 and Rorb 1 0.06 0.36 0.17
24 INT309125 Trib3 Positive_regulation of Rorb 1 0.00 0.16 0.16
25 INT200305 Rorb Positive_regulation of Gene_expression of Oprm1 1 0.00 0 0.13
26 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
27 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
28 INT290565 Binding of Rare1 and Rorb 1 0.00 0.32 0.12
29 INT290563 Binding of Rxrg and Rorb 1 0.00 0.2 0.12
30 INT189144 MTNR1B Positive_regulation of Gene_expression of CD4 1 0.01 0.35 0.11
31 INT171164 Agt Regulation of Positive_regulation of Rorb 1 0.02 0.64 0.1
32 INT189152 MTNR1B Negative_regulation of Localization of IL8 1 0.00 0.15 0.07
33 INT300309 Akt1 Regulation of Rorb 1 0.05 3.28 0.06
34 INT303062 Rorb Regulation of Creb1 1 0.00 1.06 0.06
35 INT309131 Edc4 Positive_regulation of Phosphorylation of Rorb 1 0.00 0 0.04
36 INT309146 Dlat Positive_regulation of Phosphorylation of Rorb 1 0.00 0 0.04
37 INT303054 Rorb Positive_regulation of Gene_expression of Syt1 1 0.01 0 0.03
38 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
39 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
40 INT303056 Rorb Regulation of Bad 1 0.00 0.52 0.03
41 INT196074 Mtnr1a Positive_regulation of Tmtr 1 0.00 0 0
42 INT189147 Binding of CALM1 and MTNR1B 1 0.00 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for melatonin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in melatonin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24
2 INT116617 Phosphorylation of Rorb 15 0.07 3.43 6.12
3 INT58489 Gene_expression of Rorb 51 0.41 4.7 5.39
4 INT186421 Positive_regulation of Phosphorylation of Rorb 9 0.06 1.26 4.65
5 INT101959 Regulation of Rorb 10 0.14 5.18 3.17
6 INT122656 Gene_expression of MTNR1A 21 0.75 6.37 2.46
7 INT124938 Gene_expression of MTNR1B 15 0.15 3.63 1.72
8 INT58488 Positive_regulation of Gene_expression of Rorb 7 0.19 1.98 1.63
9 INT110906 Binding of Rorb 14 0.48 2.88 1.62
10 INT200369 Negative_regulation of Rorb 6 0.07 3.76 1.62
11 INT189169 Positive_regulation of MTNR1B 10 0.16 3.71 1.61
12 INT145318 Transcription of Rorb 8 0.37 0.77 1.61
13 INT66764 Negative_regulation of Positive_regulation of Rorb 2 0.12 0.95 1.23
14 INT65980 Regulation of Gene_expression of Rorb 5 0.14 1.07 1.11
15 INT101340 Localization of MTNR1A 3 0.55 2.07 1.04
16 INT116618 Negative_regulation of Phosphorylation of Rorb 1 0.00 0.18 0.92
17 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9
18 INT310061 Negative_regulation of Negative_regulation of Rorb 1 0.01 1.03 0.84
19 INT122657 Positive_regulation of MTNR1A 9 0.49 4.14 0.76
20 INT43489 Gene_expression of Mtnr1a 5 0.20 0.97 0.73
21 INT85710 Binding of GPR50 3 0.35 0.37 0.7
22 INT110907 Negative_regulation of Binding of Rorb 3 0.59 0.85 0.68
23 INT239549 Gene_expression of GPR50 3 0.44 0.06 0.5
24 INT53736 Positive_regulation of Mtnr1a 2 0.06 0 0.43
25 INT124937 Binding of MTNR1B 2 0.07 0.83 0.38
26 INT171140 Positive_regulation of Positive_regulation of Rorb 3 0.04 0.63 0.36
27 INT200370 Negative_regulation of Gene_expression of Rorb 2 0.02 0.13 0.35
28 INT239542 Negative_regulation of GPR50 1 0.43 0.07 0.26
29 INT295943 Negative_regulation of MTNR1A 4 0.21 2.66 0.24
30 INT189172 Regulation of MTNR1B 3 0.06 0.43 0.24
31 INT189166 Positive_regulation of Gene_expression of MTNR1B 1 0.02 0.14 0.21
32 INT189167 Positive_regulation of Positive_regulation of MTNR1B 1 0.02 0.1 0.2
33 INT189175 Localization of MTNR1B 4 0.12 2 0.16
34 INT186423 Regulation of Positive_regulation of Rorb 1 0.02 0 0.14
35 INT189174 Positive_regulation of Localization of MTNR1B 2 0.09 0.76 0.13
36 INT122655 Positive_regulation of Gene_expression of MTNR1A 1 0.06 0 0.12
37 INT296126 Negative_regulation of Gene_expression of MTNR1A 2 0.21 0.77 0.11
38 INT196064 Binding of Mtnr1a 1 0.03 0.06 0.09
39 INT122405 Localization of Mtnr1a 2 0.05 0.9 0.08
40 INT189170 Regulation of Gene_expression of MTNR1B 1 0.02 0.4 0.08
41 INT269274 Regulation of MTNR1A 3 0.60 1.47 0.05
42 INT189173 Negative_regulation of MTNR1B 2 0.06 0.3 0
43 INT189168 Negative_regulation of Gene_expression of MTNR1B 1 0.02 0.15 0
44 INT196061 Regulation of Mtnr1a 1 0.04 0 0
45 INT313020 Positive_regulation of Regulation of Rorb 1 0.01 0.92 0
46 INT316180 Regulation of Localization of MTNR1B 1 0.04 0.07 0
47 INT316178 Negative_regulation of Localization of MTNR1B 1 0.09 0.31 0
48 INT196062 Negative_regulation of Mtnr1a 1 0.03 0 0
49 INT296119 Negative_regulation of Transcription of MTNR1A 1 0.07 0.44 0
50 INT296124 Transcription of MTNR1A 1 0.11 0.44 0
51 INT196066 Positive_regulation of Localization of Mtnr1a 1 0.04 0 0
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