GO:0008528

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Name G-protein coupled peptide receptor activity
Categary Function
Go Slim No
Go Link GO:0008528
Unique Molecular Interactions 164
Total Molecular Interactions 295
Total Single Events 1570
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled peptide receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled peptide receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
4 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
5 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
6 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
7 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
8 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
9 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
10 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
11 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
12 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91
13 INT115655 Glp1r Positive_regulation of Ins1 1 0.42 0 0.84
14 INT84102 B3GAT1 Positive_regulation of Localization of Glp1r 1 0.09 0 0.83
15 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
16 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
17 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
18 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
19 INT18402 Glp1r Regulation of Localization of Sst 1 0.19 0 0.77
20 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
21 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
22 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
23 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
24 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
25 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
26 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
27 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
28 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
29 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
30 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
31 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
32 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
33 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
34 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
35 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
36 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
37 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
38 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
39 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
40 INT59742 Glp1r Positive_regulation of Gene_expression of Npy 1 0.27 0.32 0.41
41 INT59740 Glp1r Positive_regulation of Localization of Npy 1 0.25 0.33 0.41
42 INT59739 Glp1r Positive_regulation of Transcription of Npy 1 0.25 0.32 0.41
43 INT55427 Grpr Positive_regulation of Localization of Glp1r 1 0.02 0 0.38
44 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
45 INT55426 Sct Positive_regulation of Localization of Glp1r 1 0.49 0 0.33
46 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
47 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
48 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
49 INT55429 Binding of Gip and Glp1r 1 0.39 0 0.31
50 INT55425 Gip Positive_regulation of Localization of Glp1r 1 0.44 0 0.3
51 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
52 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
53 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
54 INT185531 Binding of GRPR and NMBR 1 0.03 0 0.28
55 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 0.02 0 0.26
56 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
57 INT89469 Fk Positive_regulation of Gene_expression of Lhcgr 1 0.01 0 0.24
58 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
59 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
60 INT89468 Fk Regulation of Gene_expression of Lhcgr 1 0.01 0 0.23
61 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22
62 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2
63 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19
64 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19
65 INT125770 GLP1R Negative_regulation of Localization of GCG 2 0.29 0.65 0.16
66 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16
67 INT59744 Glp1r Regulation of Localization of Ins1 1 0.07 0.14 0.16
68 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
69 INT155084 Kiss1 Positive_regulation of Kiss1r 1 0.66 0.13 0.15
70 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15
71 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
72 INT324560 Binding of Kiss1r and Kiss1 1 0.35 0 0.14
73 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
74 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
75 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12
76 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
77 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
78 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12
79 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12
80 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
81 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12
82 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12
83 INT240806 Binding of Glp1r and Arc 1 0.19 0.53 0.11
84 INT314625 Ex Positive_regulation of GLP1R 1 0.03 0.3 0.11
85 INT240805 Positive_regulation of Binding of Glp1r and Arc 1 0.24 0.53 0.11
86 INT321983 Glp1r Negative_regulation of Localization of Gcg 1 0.09 1.36 0.11
87 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1
88 INT242203 GLP1R Regulation of GCG 1 0.04 0.64 0.1
89 INT242204 DPP4 Positive_regulation of Gene_expression of GLP1R 1 0.03 0.66 0.1
90 INT113724 Glp1r Regulation of MIA3 2 0.00 1.22 0.08
91 INT332639 Glp1r Negative_regulation of Localization of Gcg 1 0.03 0.87 0.07
92 INT311225 GLP1R Positive_regulation of Gene_expression of INS 1 0.49 0.33 0.06
93 INT321466 Glp1r Regulation of DPP4 1 0.04 0.59 0.06
94 INT267923 Negative_regulation of Dpp4 Positive_regulation of Glp1r 1 0.00 0.23 0.05
95 INT321467 Binding of DPP4 and Glp1r 1 0.03 0.42 0.05
96 INT332638 Gip Regulation of Glp1r 1 0.02 0.47 0.05
97 INT332633 Glp1r Negative_regulation of Gcg 1 0.04 1.13 0.05
98 INT332635 Glp1r Regulation of Localization of Gcg 1 0.03 0.94 0.04
99 INT240809 Glp1r Positive_regulation of Localization of Ins1 1 0.15 0.16 0.04
100 INT332640 Glp1r Regulation of Localization of Ins1 1 0.04 0.52 0.04
101 INT314771 Glp1r Positive_regulation of Gene_expression of Ins1 2 0.04 1.23 0.03
102 INT348220 Glp1r Regulation of Slc2a1 1 0.12 0.66 0.03
103 INT348225 Glp1r Regulation of Localization of Slc2a4 1 0.36 0.66 0.03
104 INT348226 Glp1r Regulation of Localization of Slc2a1 1 0.26 1.03 0.03
105 INT348222 Binding of Ins1 and Glp1r 1 0.05 0.82 0.03
106 INT348223 Glp1r Regulation of Positive_regulation of Slc2a4 1 0.26 0.66 0.03
107 INT348224 Glp1r Regulation of Slc2a4 1 0.26 0.66 0.03
108 INT332629 Binding of Glp1r and Positive_regulation of Localization of Gcg 1 0.03 0.47 0
109 INT311223 GLP1R Regulation of Localization of GCG 1 0.16 0.74 0
110 INT125769 GLP1R Regulation of INS 1 0.44 0.7 0
111 INT314774 Binding of Gast and Glp1r 1 0.01 0.62 0
112 INT229813 Fos Positive_regulation of Glp1r 1 0.03 0 0
113 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
114 INT321981 Dpp4 Regulation of Glp1r 1 0.07 1.06 0
115 INT332636 Binding of Glp1r and Positive_regulation of Localization of Ins1 1 0.03 0.47 0
116 INT188836 Binding of LHCGR and C4b 1 0.39 0.76 0
117 INT314773 Glp1r Positive_regulation of Gene_expression of Pdx1 1 0.01 0.57 0
118 INT255024 DPP4 Negative_regulation of Protein_catabolism of GLP1R 1 0.14 0.78 0
119 INT97462 Binding of Glp1r and 2361ex4-5 1 0.08 0.07 0
120 INT313572 GLP1R Negative_regulation of GCG 1 0.29 0.54 0
121 INT145818 Glp1r Regulation of INS 1 0.00 0.08 0
122 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0
123 INT125768 Positive_regulation of GLP1R Regulation of INS 1 0.48 0.71 0
124 INT321982 Dpp4 Regulation of Gene_expression of Glp1r 1 0.07 1.06 0
125 INT255025 Positive_regulation of GLP1R Positive_regulation of Localization of INS 1 0.17 0.12 0
126 INT255043 DPP4 Positive_regulation of GLP1R 1 0.35 0.32 0
127 INT145819 Glp1r Positive_regulation of MIA3 1 0.00 0.08 0
128 INT145816 Glp1r Positive_regulation of INS 1 0.00 0.08 0
129 INT348644 Binding of DPP4 and GLP1R 1 0.16 0.5 0
130 INT255042 Negative_regulation of DPP4 Positive_regulation of GLP1R 1 0.33 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled peptide receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled peptide receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54
3 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
4 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
5 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
6 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
7 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
8 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
9 INT47944 Positive_regulation of Localization of Glp1r 23 0.70 0.16 6.79
10 INT47942 Positive_regulation of Glp1r 38 0.70 15.94 6.47
11 INT72110 Gene_expression of Glp1r 48 0.78 22.46 6.17
12 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
13 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
14 INT37379 Regulation of Localization of Glp1r 10 0.62 0.16 4.32
15 INT18399 Regulation of Glp1r 11 0.53 3.78 2.97
16 INT61136 Localization of MC1R 8 0.75 2.8 2.85
17 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
18 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
19 INT115654 Localization of Glp1r 11 0.75 3.79 2.34
20 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
21 INT72109 Negative_regulation of Localization of Glp1r 8 0.59 0.8 2.3
22 INT59737 Negative_regulation of Glp1r 15 0.43 6.94 2.01
23 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
24 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
25 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
26 INT77415 Localization of GLP1R 23 0.63 11.1 1.69
27 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
28 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57
29 INT242212 Gene_expression of GLP1R 29 0.65 11.36 1.52
30 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
31 INT264798 Binding of GLP1R 9 0.40 2.95 1.27
32 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
33 INT11099 Localization of NPR1 5 0.67 1.49 1.21
34 INT145960 Positive_regulation of GLP1R 19 0.58 7.25 1.19
35 INT240800 Positive_regulation of Gene_expression of Glp1r 1 0.44 2.01 1.01
36 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
37 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98
38 INT246720 Gene_expression of Glp1r 9 0.63 6.53 0.96
39 INT55422 Binding of Glp1r 7 0.48 3.35 0.9
40 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88
41 INT121472 Positive_regulation of Glp1r 10 0.65 7.85 0.84
42 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81
43 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
44 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
45 INT115653 Regulation of Glp1r 2 0.60 1.09 0.67
46 INT70530 Binding of NPR1 3 0.17 0.71 0.65
47 INT92935 Binding of GRPR 2 0.32 1.99 0.62
48 INT242210 Positive_regulation of Gene_expression of GLP1R 6 0.58 3.59 0.61
49 INT145957 Positive_regulation of Localization of GLP1R 5 0.43 2.12 0.61
50 INT47943 Positive_regulation of Positive_regulation of Glp1r 5 0.70 1.38 0.59
51 INT264800 Positive_regulation of Binding of GLP1R 1 0.07 0.17 0.59
52 INT155080 Gene_expression of Kiss1r 4 0.63 0.69 0.54
53 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
54 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
55 INT70532 Regulation of Regulation of NPR1 1 0.12 0.31 0.49
56 INT133228 Protein_catabolism of Glp1r 8 0.88 2.65 0.48
57 INT311230 Regulation of GLP1R 6 0.38 3.2 0.45
58 INT246675 Negative_regulation of Glp1r 5 0.55 6.01 0.41
59 INT89465 Positive_regulation of Gene_expression of Lhcgr 4 0.24 1.03 0.41
60 INT332612 Protein_catabolism of Glp1r 1 0.18 3.56 0.38
61 INT70531 Negative_regulation of Negative_regulation of NPR1 1 0.19 0.24 0.37
62 INT138356 Positive_regulation of Regulation of Glp1r 1 0.12 0.45 0.35
63 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33
64 INT240798 Regulation of Gene_expression of Glp1r 1 0.39 0.58 0.31
65 INT242207 Negative_regulation of Localization of GLP1R 3 0.36 2.82 0.3
66 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
67 INT185607 Localization of GRPR 1 0.37 0 0.29
68 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
69 INT242211 Negative_regulation of GLP1R 9 0.36 3.4 0.26
70 INT89466 Regulation of Gene_expression of Lhcgr 1 0.29 0 0.25
71 INT240801 Negative_regulation of Gene_expression of Glp1r 2 0.37 1.34 0.24
72 INT332622 Negative_regulation of Protein_catabolism of Glp1r 1 0.11 0.94 0.21
73 INT332620 Negative_regulation of Gene_expression of Glp1r 1 0.08 1.07 0.2
74 INT121474 Positive_regulation of Positive_regulation of Glp1r 3 0.65 1.66 0.17
75 INT155082 Negative_regulation of Kiss1r 1 0.48 0.19 0.17
76 INT59738 Negative_regulation of Negative_regulation of Glp1r 1 0.20 0.14 0.16
77 INT155077 Regulation of Gene_expression of Kiss1r 1 0.50 0.17 0.15
78 INT348211 Negative_regulation of Binding of Glp1r 1 0.37 0.83 0.15
79 INT255030 Protein_catabolism of GLP1R 5 0.84 2.39 0.14
80 INT332608 Positive_regulation of Gene_expression of Glp1r 1 0.09 1.87 0.14
81 INT133229 Positive_regulation of Protein_catabolism of Glp1r 1 0.44 0.25 0.14
82 INT106498 Positive_regulation of Lhcgr 2 0.08 0.41 0.12
83 INT200267 Transcription of Lhcgr 1 0.09 0 0.12
84 INT332613 Positive_regulation of Protein_catabolism of Glp1r 1 0.09 1.55 0.11
85 INT153274 Gene_expression of LHCGR 2 0.67 1.53 0.1
86 INT256404 Positive_regulation of Positive_regulation of GLP1R 2 0.58 1.31 0.1
87 INT311235 Positive_regulation of Protein_catabolism of GLP1R 1 0.42 0.68 0.09
88 INT121470 Regulation of Positive_regulation of Glp1r 2 0.22 0.54 0.07
89 INT113719 Negative_regulation of Positive_regulation of Glp1r 1 0.17 1.12 0.07
90 INT155539 Negative_regulation of Protein_catabolism of Glp1r 1 0.10 0.99 0.07
91 INT255075 Negative_regulation of Gene_expression of GLP1R 2 0.36 0.64 0.05
92 INT332617 Positive_regulation of Negative_regulation of Glp1r 1 0.13 0.96 0.05
93 INT311238 Negative_regulation of Positive_regulation of GLP1R 1 0.36 0.36 0.05
94 INT332615 Negative_regulation of Positive_regulation of Glp1r 1 0.08 0.96 0.05
95 INT209191 Positive_regulation of LHCGR 1 0.28 0.05 0.05
96 INT246721 Regulation of Negative_regulation of Glp1r 1 0.58 0.35 0.04
97 INT121473 Positive_regulation of Localization of Glp1r 3 0.41 0.28 0
98 INT348215 Regulation of Regulation of Glp1r 1 0.39 0.48 0
99 INT223183 Positive_regulation of Lhcgr 1 0.09 0.2 0
100 INT318007 Regulation of Lhcgr 1 0.40 0.63 0
101 INT209178 Regulation of Regulation of LHCGR 1 0.25 0 0
102 INT209186 Regulation of LHCGR 1 0.35 0 0
103 INT255074 Negative_regulation of Negative_regulation of GLP1R 1 0.27 0.22 0
104 INT335614 Positive_regulation of Regulation of MC1R 1 0.23 0 0
105 INT332604 Binding of Glp1r 1 0.07 0.4 0
106 INT209188 Negative_regulation of Positive_regulation of LHCGR 1 0.24 0 0
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