GO:0008543

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Name fibroblast growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0008543
Unique Molecular Interactions 1566
Total Molecular Interactions 1942
Total Single Events 12629
Pain Genes Associated 90

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
4 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
5 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
6 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
7 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
8 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
9 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
10 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
11 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
12 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
13 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
14 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
15 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
16 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
17 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
18 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
19 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
20 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
21 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
22 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
23 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
24 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
25 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
26 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
27 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
28 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
29 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
30 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
31 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
32 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
33 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
34 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
35 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
36 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
37 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
38 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
39 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
40 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
41 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
42 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
43 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
44 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
45 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
46 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
47 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
48 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
49 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
50 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
51 INT66333 Fgf2 Negative_regulation of Positive_regulation of Npy 1 0.20 0.17 0.85
52 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
53 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
54 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
55 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
56 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
57 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
58 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
59 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
60 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
61 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
62 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
63 INT21233 Ngf Regulation of Fgf1 1 0.46 0.09 0.79
64 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
65 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
66 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
67 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
68 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
69 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
70 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
71 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
72 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
73 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
74 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
75 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
76 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
77 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
78 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
79 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
80 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
81 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
82 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
83 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
84 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
85 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
86 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
87 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
88 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
89 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62
90 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
91 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
92 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
93 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
94 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61
95 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
96 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
97 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
98 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
99 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
100 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
101 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
102 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
103 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
104 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
105 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
106 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
107 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
108 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
109 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
110 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
111 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
112 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
113 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
114 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
115 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
116 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
117 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
118 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
119 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
120 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
121 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
122 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
123 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
124 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
125 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
126 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
127 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
128 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
129 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
130 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
131 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
132 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
133 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
134 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
135 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
136 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
137 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
138 INT66336 Fgf2 Regulation of Gene_expression of Npy 1 0.12 0.09 0.5
139 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
140 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
141 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
142 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
143 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
144 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
145 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
146 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
147 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
148 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
149 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
150 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
151 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
152 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
153 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
154 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
155 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
156 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
157 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
158 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
159 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
160 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
161 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
162 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
163 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
164 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
165 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
166 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
167 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
168 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
169 INT66335 Fgf1 Regulation of Fgf2 1 0.10 0.08 0.45
170 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
171 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
172 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
173 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
174 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
175 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
176 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
177 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
178 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
179 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
180 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
181 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
182 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
183 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42
184 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
185 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
186 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
187 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
188 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
189 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
190 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
191 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
192 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
193 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
194 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
195 INT205567 Regulation of Binding of Fgf1 and Chat 1 0.29 0.28 0.41
196 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
197 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
198 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
199 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
200 INT205566 Binding of Fgf1 and Chat 1 0.24 0.28 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
3 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
4 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
5 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
6 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
7 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
8 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
9 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
10 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
11 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
12 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
13 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
14 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
15 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
16 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
17 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
18 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
19 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
20 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
21 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
22 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
23 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
24 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
25 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
26 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
27 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
28 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
29 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
30 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
31 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
32 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
33 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
34 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
35 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
36 INT68133 Localization of Fgf2 36 0.81 15.37 9.14
37 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
38 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
39 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
40 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
41 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
42 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
43 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
44 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
45 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
46 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
47 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
48 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
49 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
50 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2
51 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
52 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
53 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
54 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
55 INT97018 Binding of CALM3 7 0.43 0.13 5.82
56 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
57 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
58 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
59 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
60 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
61 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
62 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
63 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
64 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
65 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
66 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
67 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
68 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
69 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
70 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
71 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
72 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
73 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
74 INT20981 Binding of HRAS 42 0.48 24.49 4.23
75 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
76 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
77 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
78 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
79 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
80 INT169475 Localization of HRAS 14 0.73 9.02 3.9
81 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
82 INT48143 Gene_expression of Fgf1 32 0.78 8.2 3.72
83 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
84 INT109391 Gene_expression of Fgfr1 7 0.56 1.78 3.67
85 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47
86 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43
87 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
88 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
89 INT168003 Localization of Fgf2 24 0.80 12.52 3.31
90 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
91 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
92 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24
93 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
94 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
95 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
96 INT101083 Binding of Fgf2 14 0.42 4.12 3.14
97 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
98 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
99 INT192676 Binding of PTEN 14 0.46 10.58 3.06
100 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
101 INT119218 Positive_regulation of Fgfr1 4 0.58 1.11 3.05
102 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
103 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
104 INT115317 Transcription of FGF2 14 0.62 12.79 3
105 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
106 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
107 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
108 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96
109 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94
110 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
111 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
112 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
113 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
114 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81
115 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
116 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
117 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
118 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
119 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
120 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
121 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
122 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
123 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
124 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
125 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
126 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6
127 INT142908 Localization of FGFR1 18 0.38 11.46 2.57
128 INT64688 Negative_regulation of Gene_expression of Fgf2 5 0.59 5.07 2.56
129 INT95944 Binding of Fgf12 11 0.28 8.98 2.53
130 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
131 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
132 INT24672 Localization of FGF2 27 0.71 14.59 2.48
133 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
134 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
135 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39
136 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
137 INT7410 Positive_regulation of Localization of FGFR3 9 0.45 1.97 2.36
138 INT65034 Regulation of Fgf1 7 0.61 2.42 2.34
139 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
140 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
141 INT143247 Positive_regulation of CAMK4 9 0.67 5.25 2.28
142 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
143 INT118791 Binding of AKT1 32 0.48 15.51 2.25
144 INT132893 Binding of CHUK 1 0.00 0.63 2.25
145 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23
146 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
147 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
148 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
149 INT97898 Regulation of FGF2 8 0.60 3.85 2.09
150 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08
151 INT151467 Localization of CASP9 9 0.73 7.62 2.04
152 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03
153 INT334975 Gene_expression of Fgf15 1 0.74 7.12 2.02
154 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
155 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
156 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
157 INT12965 Negative_regulation of RICTOR 3 0.37 0.32 2
158 INT99636 Negative_regulation of Localization of Fgf2 4 0.41 1.32 1.97
159 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
160 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
161 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
162 INT64687 Regulation of Gene_expression of Fgf2 7 0.62 2.29 1.89
163 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
164 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
165 INT102970 Localization of ADRBK1 4 0.66 0.45 1.85
166 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
167 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
168 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
169 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
170 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
171 INT101707 Gene_expression of FGF4 9 0.78 3.99 1.73
172 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
173 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
174 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
175 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7
176 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68
177 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
178 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
179 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
180 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
181 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
182 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
183 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
184 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
185 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
186 INT7333 Localization of CALM3 4 0.72 0.4 1.55
187 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
188 INT26579 Regulation of RICTOR 2 0.23 0.09 1.51
189 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
190 INT73816 Positive_regulation of Fgf1 5 0.70 2.31 1.49
191 INT122547 Positive_regulation of Positive_regulation of FGF2 3 0.44 3.1 1.49
192 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48
193 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46
194 INT53735 Regulation of FGFR3 4 0.26 0.76 1.45
195 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44
196 INT92685 Transcription of Ctgf 7 0.72 3.92 1.44
197 INT24671 Binding of FGF2 14 0.35 8.73 1.43
198 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41
199 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
200 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41
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