GO:0008545

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Name JUN kinase kinase activity
Categary Function
Go Slim No
Go Link GO:0008545
Unique Molecular Interactions 20
Total Molecular Interactions 22
Total Single Events 152
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JUN kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for JUN kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
2 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
3 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 0.01 0.29 0.32
4 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
5 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
6 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
7 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
8 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
9 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
10 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
11 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
12 INT178440 Map2k4 Positive_regulation of Mapk14 1 0.04 0.13 0
13 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
14 INT178445 Map2k4 Positive_regulation of Mapk8 1 0.11 0.13 0
15 INT178432 Map2k7 Positive_regulation of Mapk8 1 0.11 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for JUN kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in JUN kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
2 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
3 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
4 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
5 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
6 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
7 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
8 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
9 INT128925 Negative_regulation of Map2k7 2 0.10 0.66 0.68
10 INT179405 Positive_regulation of Map2k7 1 0.16 1.32 0.55
11 INT151125 Negative_regulation of Localization of Map2k7 1 0.08 0.61 0.51
12 INT128924 Regulation of Map2k7 3 0.08 0.87 0.5
13 INT151121 Localization of Map2k7 1 0.14 0.59 0.5
14 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
15 INT202347 Gene_expression of Map2k4 13 0.74 11.68 0.4
16 INT128918 Negative_regulation of Gene_expression of Map2k7 1 0.02 0.37 0.37
17 INT274074 Binding of Map2k4 1 0.08 1.98 0.36
18 INT202360 Positive_regulation of Map2k4 2 0.48 9.89 0.29
19 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
20 INT151131 Negative_regulation of Phosphorylation of Map2k7 1 0.10 0.31 0.19
21 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
22 INT302772 Regulation of Map2k7 1 0.02 0.33 0.11
23 INT188350 Localization of Map2k4 2 0.67 0.46 0.09
24 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
25 INT347978 Positive_regulation of Phosphorylation of Map2k7 1 0.27 1.08 0.08
26 INT281759 Negative_regulation of Map2k7 1 0.03 0.2 0.05
27 INT202363 Phosphorylation of Map2k4 11 0.79 2.94 0.04
28 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
29 INT274075 Positive_regulation of Gene_expression of Map2k4 1 0.16 4.28 0.04
30 INT347987 Phosphorylation of Map2k7 1 0.37 0.53 0.04
31 INT222018 Positive_regulation of Map2k7 1 0.02 0.77 0.03
32 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
33 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
34 INT202386 Transcription of Map2k4 1 0.69 0.15 0
35 INT202367 Positive_regulation of Phosphorylation of Map2k4 1 0.48 0.15 0
36 INT202342 Negative_regulation of Map2k4 1 0.36 0 0
37 INT202354 Negative_regulation of Transcription of Map2k4 1 0.36 0 0
38 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
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