GO:0008589

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Name regulation of smoothened signaling pathway
Categary Process
Go Slim No
Go Link GO:0008589
Unique Molecular Interactions 106
Total Molecular Interactions 147
Total Single Events 455
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
2 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
3 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
4 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
5 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
6 INT324224 Binding of OTX2 and H9 1 0.11 0.17 0.33
7 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
8 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
9 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
10 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
11 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
12 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
13 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
14 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
15 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
16 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
17 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
18 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
19 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
20 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
21 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
22 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
23 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
24 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
25 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
26 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
27 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
28 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
29 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
30 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
31 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
32 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
33 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
34 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
35 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
36 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
37 INT104029 RPGRIP1L Negative_regulation of Gene_expression of LTB 1 0.16 0.06 0
38 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
39 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
40 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
41 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
42 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
43 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
44 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
45 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
46 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
47 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
48 INT205964 SMOX Positive_regulation of GLI1 1 0.20 0.66 0
49 INT212408 Binding of Zic1 and Odz2 1 0.00 0.15 0
50 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
51 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
52 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
53 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
54 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
55 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
56 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
57 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
58 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
59 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
60 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
61 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
62 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
63 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
64 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
65 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
66 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
67 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
68 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
69 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
70 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
71 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
72 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
73 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
74 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
75 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
76 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
77 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
2 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
3 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
4 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
5 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
6 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
7 INT142813 Localization of RPGRIP1L 1 0.59 0.99 1.01
8 INT119674 Localization of GLI2 6 0.52 2.84 0.99
9 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
10 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
11 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
12 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
13 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
14 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75
15 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
16 INT104840 Binding of GLI2 6 0.08 1.89 0.72
17 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
18 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
19 INT114955 Positive_regulation of Gene_expression of CREBBP 2 0.23 0.24 0.61
20 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
21 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
22 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
23 INT216363 Gene_expression of OTX2 4 0.54 0.32 0.55
24 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
25 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
26 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33
27 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
28 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
29 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
30 INT212388 Gene_expression of Zic1 2 0.40 0.3 0.25
31 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
32 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
33 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
34 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
35 INT152666 Negative_regulation of CREBBP 2 0.06 0.52 0.14
36 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
37 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
38 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
39 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
40 INT171528 Binding of CREBBP 3 0.07 0.47 0.08
41 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
42 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
43 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
44 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
45 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
46 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
47 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
48 INT205969 Regulation of GLI1 4 0.41 3.09 0.04
49 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
50 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
51 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
52 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
53 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
54 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
55 INT207729 Regulation of FGFR2 4 0.22 2.35 0
56 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
57 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
58 INT99716 Transcription of FGFR2 2 0.34 0.22 0
59 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
60 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
61 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
62 INT172620 Localization of CREBBP 2 0.09 0.06 0
63 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
64 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
65 INT205972 Regulation of Gene_expression of GLI1 1 0.41 1.17 0
66 INT268585 Negative_regulation of Gene_expression of GLI1 1 0.24 1.01 0
67 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
68 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
69 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
70 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
71 INT276802 Negative_regulation of Gene_expression of CREBBP 1 0.03 0 0
72 INT212407 Binding of Zic1 1 0.26 0.31 0
73 INT260089 Localization of PTCH1 1 0.70 0.37 0
74 INT282947 Negative_regulation of OTX2 1 0.35 0 0
75 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
76 INT324222 Binding of OTX2 1 0.20 0 0
77 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
78 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
79 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
80 INT207369 Transcription of GLI2 1 0.05 0.08 0
81 INT205967 Localization of GLI1 1 0.50 0.57 0
82 INT268570 Positive_regulation of Gene_expression of GLI1 1 0.19 0.97 0
83 INT268563 Transcription of GLI1 1 0.29 0.91 0
84 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
85 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
86 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
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