GO:0008629

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Name induction of apoptosis by intracellular signals
Categary Process
Go Slim No
Go Link GO:0008629
Unique Molecular Interactions 1162
Total Molecular Interactions 1453
Total Single Events 11993
Pain Genes Associated 41

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis by intracellular signals. They are ordered first by their pain relevance and then by number of times they were reported for induction of apoptosis by intracellular signals. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
3 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
4 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
5 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
6 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
7 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
8 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
9 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
10 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
11 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
12 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
13 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
14 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
15 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
16 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
17 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
18 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
19 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
20 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
21 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
22 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
23 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
24 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
25 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
26 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
27 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
28 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
29 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
30 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
31 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
32 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
33 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
34 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
35 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
36 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
37 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
38 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
39 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
40 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
41 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
42 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
43 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
44 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
45 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
46 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
47 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
48 INT73462 PTPLA Regulation of Gene_expression of SART1 1 0.00 0.79 0.82
49 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
50 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
51 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
52 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
53 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
54 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
55 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
56 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
57 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
58 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
59 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
60 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
61 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
62 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
63 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
64 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
65 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
66 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
67 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
68 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
69 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
70 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
71 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
72 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
73 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
74 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
75 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
76 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
77 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
78 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
79 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
80 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
81 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
82 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
83 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
84 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
85 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
86 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
87 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
88 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
89 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
90 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
91 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
92 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
93 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
94 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
95 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
96 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
97 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
98 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
99 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
100 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
101 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
102 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
103 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
104 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
105 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
106 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
107 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5
108 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
109 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
110 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
111 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
112 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
113 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
114 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
115 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
116 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
117 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
118 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
119 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
120 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
121 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
122 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
123 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
124 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
125 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
126 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
127 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
128 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
129 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
130 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
131 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
132 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
133 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
134 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
135 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
136 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
137 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
138 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
139 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
140 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
141 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
142 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
143 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
144 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
145 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
146 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
147 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
148 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
149 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
150 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
151 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
152 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 0.10 0.06 0.39
153 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
154 INT51341 Binding of Pomc and Clu 1 0.14 0 0.38
155 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
156 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
157 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37
158 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
159 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
160 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
161 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
162 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
163 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
164 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
165 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36
166 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
167 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
168 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
169 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
170 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
171 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
172 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
173 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
174 INT228446 PMAIP1 Regulation of Transcription of Mtpn 1 0.00 0 0.34
175 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
176 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
177 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
178 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
179 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32
180 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
181 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
182 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
183 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
184 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
185 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
186 INT303105 CAMK4 Positive_regulation of Hras1 1 0.04 0.16 0.31
187 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
188 INT307215 Negative_regulation of Prkca Negative_regulation of Ppara 1 0.09 0.21 0.3
189 INT29984 Bad Positive_regulation of Localization of Prl 1 0.15 0 0.3
190 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
191 INT296473 Prkca Regulation of Serac1 1 0.00 0.14 0.3
192 INT166789 HRAS Regulation of Positive_regulation of NFKB1 1 0.05 0.31 0.3
193 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
194 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
195 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
196 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
197 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
198 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
199 INT185144 Prkca Positive_regulation of Snrpd1 1 0.00 0.16 0.29
200 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis by intracellular signals. They are ordered first by their pain relevance and then by number of times they were reported in induction of apoptosis by intracellular signals. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
4 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
5 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
6 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
7 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
8 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
9 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
10 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
11 INT117527 Binding of Prkca 25 0.48 6.43 21.05
12 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
13 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
14 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
15 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
16 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
17 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
18 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
19 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
20 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
21 INT79458 Localization of Prkca 30 0.81 11.13 15.78
22 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
23 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
24 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
25 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
26 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
27 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
28 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
29 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
30 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
31 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
32 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
33 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
34 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
35 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
36 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
37 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
38 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
39 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
40 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
41 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
42 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
43 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
44 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
45 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
46 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
47 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
48 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
49 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
50 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
51 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
52 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
53 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
54 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
55 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
56 INT51337 Binding of Clu 3 0.12 0.05 5.45
57 INT145929 Regulation of Bax 20 0.60 18.12 5.35
58 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
59 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32
60 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
61 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
62 INT60585 Regulation of TP53 59 0.59 54.55 5.21
63 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
64 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
65 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
66 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
67 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
68 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
69 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
70 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
71 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
72 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
73 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
74 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
75 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
76 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
77 INT20981 Binding of HRAS 42 0.48 24.49 4.23
78 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
79 INT103345 Positive_regulation of Gene_expression of BAK1 10 0.57 6.4 4.19
80 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
81 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
82 INT33229 Gene_expression of Bad 9 0.70 6.95 4.15
83 INT84686 Regulation of BAX 26 0.49 28.54 4.13
84 INT51654 Regulation of Bad 21 0.40 12.18 4.06
85 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
86 INT123752 Regulation of Bax 19 0.60 16.45 4
87 INT112692 Localization of Bax 31 0.80 20.97 3.98
88 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
89 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95
90 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
91 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
92 INT169475 Localization of HRAS 14 0.73 9.02 3.9
93 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
94 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
95 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
96 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
97 INT95119 Localization of CYCS 23 0.78 14.86 3.49
98 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
99 INT124579 Localization of BAX 35 0.78 30.31 3.43
100 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
101 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
102 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34
103 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
104 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
105 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
106 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
107 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
108 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
109 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
110 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99
111 INT8103 Binding of TP53 46 0.44 40.2 2.96
112 INT36886 Transcription of Myc 6 0.69 3.16 2.86
113 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
114 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
115 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78
116 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73
117 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
118 INT22739 Positive_regulation of DYNLL1 5 0.67 1.69 2.67
119 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
120 INT156016 Binding of BCL2L1 10 0.36 7.42 2.64
121 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
122 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
123 INT29983 Localization of Bad 5 0.28 4.44 2.52
124 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
125 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
126 INT55952 Transcription of TP53 16 0.61 12.14 2.36
127 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
128 INT97748 Positive_regulation of BCL2L1 12 0.67 9.83 2.26
129 INT118791 Binding of AKT1 32 0.48 15.51 2.25
130 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25
131 INT102752 Positive_regulation of Gene_expression of BCL2L1 14 0.67 13.8 2.19
132 INT86999 Regulation of DYNLL1 5 0.44 2.85 2.18
133 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
134 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
135 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
136 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
137 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
138 INT154970 Localization of Bax 15 0.74 11.12 2.11
139 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07
140 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06
141 INT151467 Localization of CASP9 9 0.73 7.62 2.04
142 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
143 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98
144 INT98836 Transcription of Bax 6 0.69 5.04 1.96
145 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
146 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
147 INT107905 Gene_expression of BCL2L11 9 0.75 7.58 1.92
148 INT134442 Transcription of Bax 14 0.67 7.6 1.9
149 INT65855 Localization of TP53 18 0.76 17.08 1.89
150 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
151 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
152 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86
153 INT134443 Binding of Bax 10 0.47 5.62 1.84
154 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
155 INT43143 Binding of Bad 8 0.21 5.12 1.81
156 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
157 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
158 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
159 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
160 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
161 INT97749 Regulation of BCL2L1 10 0.41 9.72 1.65
162 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
163 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
164 INT93427 Negative_regulation of Bad 4 0.02 2.5 1.63
165 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
166 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56
167 INT103967 Negative_regulation of Gene_expression of BAK1 8 0.42 7.02 1.54
168 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
169 INT162463 Localization of BID 6 0.73 7.47 1.5
170 INT62800 Regulation of BAK1 7 0.41 10.12 1.47
171 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
172 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46
173 INT125871 Gene_expression of XIAP 5 0.65 11.46 1.46
174 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
175 INT105086 Positive_regulation of CYCS 9 0.49 5.82 1.45
176 INT18495 Regulation of Bad 6 0.19 4.79 1.45
177 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
178 INT206244 Binding of CD24 7 0.48 5.71 1.43
179 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
180 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
181 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41
182 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
183 INT159186 Positive_regulation of Gene_expression of DYNLL1 1 0.49 1.25 1.4
184 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37
185 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
186 INT116265 Binding of Myc 9 0.36 4.28 1.36
187 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
188 INT154081 Negative_regulation of Localization of Bad 2 0.16 2.06 1.31
189 INT54587 Positive_regulation of Hras1 12 0.27 5.54 1.3
190 INT35944 Regulation of Clu 4 0.20 0.15 1.3
191 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
192 INT142017 Positive_regulation of Positive_regulation of BAK1 2 0.52 1.74 1.3
193 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
194 INT191804 Transcription of CD24 10 0.72 12.43 1.25
195 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
196 INT107904 Positive_regulation of Gene_expression of BCL2L11 3 0.53 2.22 1.24
197 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
198 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
199 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
200 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
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