GO:0008630

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Name DNA damage response, signal transduction resulting in induction of apoptosis
Categary Process
Go Slim No
Go Link GO:0008630
Unique Molecular Interactions 245
Total Molecular Interactions 329
Total Single Events 2760
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction resulting in induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage response, signal transduction resulting in induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
3 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
4 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
5 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
6 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
7 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
8 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
9 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
10 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
11 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
12 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
13 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
14 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
15 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
16 INT350076 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 1.29 0.5
17 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
18 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
19 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
20 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
21 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
22 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
23 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
24 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
25 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
26 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
27 INT216881 Binding of Apoc4 and Hmox1 1 0.01 1.78 0.4
28 INT147473 Nfe2l2 Positive_regulation of Gene_expression of Hmox1 1 0.74 0.49 0.39
29 INT147472 co Positive_regulation of Gene_expression of Hmox1 1 0.01 0.57 0.36
30 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
31 INT129293 OPRM1 Positive_regulation of Phosphorylation of IKBKE 1 0.05 0.28 0.35
32 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
33 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
34 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
35 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
36 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
37 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
38 INT216880 Apoc4 Positive_regulation of Hmox1 1 0.03 1.06 0.25
39 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
40 INT350099 Gene_expression of Hmox1 Positive_regulation of Gene_expression of MRXS5 1 0.01 0.51 0.24
41 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
42 INT350065 Gene_expression of Hmox1 Negative_regulation of Gene_expression of Tlr4 1 0.18 0.35 0.22
43 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
44 INT103867 SFTPA1 Positive_regulation of Hmox1 1 0.00 0.35 0.22
45 INT64340 Zc3h15 Negative_regulation of Hmox1 1 0.12 0.47 0.22
46 INT350078 Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 0.35 0.22
47 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
48 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
49 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
50 INT350096 Hmox1 Negative_regulation of Gene_expression of MRXS5 1 0.01 0.32 0.2
51 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
52 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2
53 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
54 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
55 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
56 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19
57 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
58 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
59 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
60 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
61 INT81296 Positive_regulation of Pparg Regulation of Gene_expression of Hmox1 1 0.25 0.17 0.17
62 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
63 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
64 INT350072 Ptger2 Positive_regulation of Hmox1 1 0.02 0.2 0.15
65 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
66 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
67 INT216882 Tlr4 Positive_regulation of Hmox1 1 0.17 0.19 0.15
68 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
69 INT350069 Prkaca Positive_regulation of Hmox1 1 0.05 0.2 0.15
70 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14
71 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
72 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
73 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
74 INT295267 Binding of Hmox1 and Gtf3a 1 0.01 0.49 0.13
75 INT295261 Binding of Hmox1 and Nfe2l2 1 0.17 0.49 0.13
76 INT295264 Positive_regulation of Binding of Hmox1 and Nfe2l2 1 0.25 0.5 0.13
77 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13
78 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12
79 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12
80 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11
81 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11
82 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
83 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
84 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1
85 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
86 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
87 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
88 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
89 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
90 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
91 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08
92 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
93 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
94 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
95 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
96 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
97 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
98 INT244290 Il6 Positive_regulation of Hmox1 1 0.38 0.09 0.07
99 INT244291 Nos2 Positive_regulation of Positive_regulation of Hmox1 1 0.34 0.07 0.07
100 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
101 INT346456 TLR3 Positive_regulation of IKBKE 1 0.02 0.45 0.06
102 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06
103 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06
104 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
105 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
106 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05
107 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
108 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
109 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
110 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04
111 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
112 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04
113 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04
114 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
115 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
116 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
117 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
118 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
119 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03
120 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
121 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
122 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
123 INT262150 Binding of Rare1 and Sfn 1 0.01 0.33 0.03
124 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
125 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
126 INT350071 Hmox1 Regulation of Tlr4 1 0.22 0.33 0.03
127 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
128 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
129 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
130 INT319686 Positive_regulation of Sfn Positive_regulation of Nfe2l2 1 0.18 0 0
131 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0
132 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0
133 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
134 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
135 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0
136 INT189396 MBD4 Regulation of C11orf2 1 0.05 0.66 0
137 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
138 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0
139 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
140 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
141 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
142 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0
143 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
144 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
145 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
146 INT260071 Binding of FANCC and XPA 1 0.24 0.76 0
147 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0
148 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
149 INT300616 Binding of MLH1 and PMS2 1 0.36 0.53 0
150 INT260066 Binding of PHF2 and XPA 1 0.20 1.04 0
151 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
152 INT229818 Fos Positive_regulation of Hmox1 1 0.43 0.37 0
153 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0
154 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
155 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
156 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0
157 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
158 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
159 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
160 INT296956 NRIP1 Regulation of Gene_expression of CIDEA 1 0.44 0.76 0
161 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
162 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
163 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0
164 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
165 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
166 INT232595 Binding of BRCA1 and HEPACAM 1 0.02 0.89 0
167 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
168 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
169 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
170 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0
171 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
172 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0
173 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
174 INT296955 Binding of CIDEA and MLST8 1 0.02 0.97 0
175 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0
176 INT319659 Sfn Positive_regulation of Nfe2l2 1 0.18 0 0
177 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0
178 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0
179 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
180 INT260398 Dclk2 Regulation of Gene_expression of Hmox1 1 0.01 1.02 0
181 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
182 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0
183 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
184 INT235651 TP73 Regulation of EPHA2 1 0.15 0.98 0
185 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0
186 INT296957 NRIP1 Regulation of Transcription of CIDEA 1 0.44 0.91 0
187 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
188 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0
189 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0
190 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
191 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
192 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
193 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0
194 INT285582 Binding of ABL1 and S100A8 1 0.02 0.2 0
195 INT212525 MSH6 Positive_regulation of Binding of C1qa 1 0.00 0.38 0
196 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
197 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
198 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
199 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
200 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction resulting in induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage response, signal transduction resulting in induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
2 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
3 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
4 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
5 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
6 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
7 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
8 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
9 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
10 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
11 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
12 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
13 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
14 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
15 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
16 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
17 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
18 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
19 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
20 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3
21 INT127904 Negative_regulation of Gene_expression of Hmox1 11 0.42 9.54 2.8
22 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
23 INT237655 Binding of Sfn 1 0.42 3.62 2.55
24 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46
25 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26
26 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
27 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77
28 INT97062 Binding of PML 10 0.41 11.63 1.65
29 INT80227 Regulation of Gene_expression of Hmox1 12 0.44 11.04 1.61
30 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55
31 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
32 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
33 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49
34 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
35 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
36 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46
37 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
38 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
39 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
40 INT91320 Localization of Hmox1 8 0.81 4.06 1.28
41 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
42 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
43 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
44 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14
45 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
46 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12
47 INT199187 Localization of Hmox1 2 0.78 3.36 1.11
48 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
49 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
50 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
51 INT92139 Binding of MLH1 12 0.42 15.62 1
52 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
53 INT201454 Positive_regulation of Positive_regulation of Hmox1 6 0.35 5.2 0.94
54 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
55 INT148461 Positive_regulation of Transcription of Hmox1 6 0.33 1.83 0.93
56 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
57 INT82568 Protein_catabolism of Hmox1 5 0.86 1.03 0.79
58 INT262726 Localization of PML 6 0.57 7.13 0.72
59 INT28118 Binding of Atm 13 0.38 12.24 0.68
60 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63
61 INT287003 Negative_regulation of Positive_regulation of Hmox1 2 0.34 3.1 0.63
62 INT129296 Phosphorylation of IKBKE 1 0.35 0.54 0.63
63 INT48212 Binding of ATM 5 0.47 3.89 0.57
64 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
65 INT160778 Transcription of ATM 1 0.40 1.03 0.57
66 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
67 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
68 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53
69 INT154151 Positive_regulation of TP73 5 0.67 5.71 0.52
70 INT237651 Negative_regulation of Sfn 3 0.51 1.7 0.49
71 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
72 INT135612 Regulation of IKBKE 1 0.21 1.24 0.48
73 INT270030 Negative_regulation of Positive_regulation of Hmox1 3 0.30 2.49 0.47
74 INT135614 Positive_regulation of IKBKE 1 0.23 1.26 0.47
75 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
76 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
77 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
78 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
79 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39
80 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
81 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
82 INT157157 Negative_regulation of Localization of HMOX1 1 0.37 0.74 0.37
83 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
84 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
85 INT73854 Transcription of ABL1 4 0.52 2.26 0.34
86 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
87 INT281659 Regulation of Transcription of HMOX1 2 0.27 2.12 0.33
88 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
89 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
90 INT216879 Binding of Hmox1 4 0.36 2.82 0.31
91 INT135772 Regulation of Positive_regulation of HMOX1 3 0.39 1.52 0.29
92 INT328227 Positive_regulation of Localization of Hmox1 1 0.45 0.67 0.28
93 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
94 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
95 INT91231 Binding of Hmox1 4 0.36 0.29 0.27
96 INT237652 Positive_regulation of Sfn 3 0.49 1.17 0.27
97 INT167438 Localization of ATM 3 0.55 1.61 0.27
98 INT158755 Localization of XPA 1 0.39 2.73 0.26
99 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
100 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
101 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
102 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
103 INT154150 Regulation of TP73 3 0.15 2.81 0.24
104 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
105 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23
106 INT201453 Protein_catabolism of Hmox1 3 0.95 4.25 0.23
107 INT350048 Negative_regulation of Regulation of Hmox1 1 0.30 0.37 0.23
108 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
109 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2
110 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19
111 INT239412 Binding of ABL1 8 0.28 5.39 0.18
112 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
113 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
114 INT89690 Binding of Brca2 2 0.37 1.8 0.18
115 INT89689 Binding of Brca1 2 0.37 2.55 0.18
116 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
117 INT227876 Transcription of ERCC6 1 0.68 1.87 0.17
118 INT115829 Regulation of Transcription of Hmox1 1 0.35 1.03 0.17
119 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16
120 INT163461 Regulation of ABL1 8 0.32 5.98 0.14
121 INT182408 Localization of ERCC6 4 0.72 2.31 0.14
122 INT154148 Negative_regulation of Gene_expression of TP73 3 0.21 1.89 0.14
123 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
124 INT201467 Protein_catabolism of HMOX1 2 0.77 0.83 0.13
125 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
126 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
127 INT182621 Localization of MLH1 9 0.64 9.31 0.12
128 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12
129 INT147244 Regulation of MLH1 3 0.08 2.64 0.12
130 INT167440 Regulation of ATM 2 0.20 0.68 0.12
131 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11
132 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
133 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
134 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
135 INT208914 Regulation of Brca1 1 0.10 0.79 0.11
136 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
137 INT146072 Binding of TP73 2 0.12 0.58 0.1
138 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
139 INT151702 Binding of ERCC6 6 0.37 1.47 0.09
140 INT282824 Regulation of PML 3 0.44 2.66 0.09
141 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
142 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
143 INT227880 Positive_regulation of Transcription of ERCC6 1 0.50 0.52 0.09
144 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08
145 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08
146 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07
147 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
148 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
149 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
150 INT115824 Positive_regulation of Transcription of Hmox1 3 0.45 0.43 0.06
151 INT139362 Negative_regulation of CHEK2 2 0.35 1.66 0.06
152 INT139364 Negative_regulation of Negative_regulation of CHEK2 1 0.26 1.67 0.06
153 INT163462 Negative_regulation of Regulation of ABL1 1 0.11 1.17 0.06
154 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05
155 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
156 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
157 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
158 INT296966 Positive_regulation of CIDEA 1 0.40 2.61 0.05
159 INT293311 Positive_regulation of Positive_regulation of HMOX1 3 0.69 1.99 0.04
160 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04
161 INT350052 Positive_regulation of Negative_regulation of Hmox1 1 0.35 0.34 0.04
162 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
163 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
164 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03
165 INT207803 Regulation of Atm 3 0.41 1.15 0.03
166 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
167 INT190022 Positive_regulation of Mlh1 2 0.38 3.16 0.03
168 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
169 INT187589 Positive_regulation of Gene_expression of Brca1 2 0.55 1.93 0.03
170 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
171 INT344009 Negative_regulation of Localization of BRCA1 1 0.30 0.18 0.03
172 INT141562 Negative_regulation of ERCC6 11 0.50 3.04 0
173 INT141563 Regulation of ERCC6 6 0.59 2.54 0
174 INT256134 Localization of Sirt1 5 0.50 2.99 0
175 INT207807 Localization of Atm 4 0.74 0.21 0
176 INT154149 Positive_regulation of Gene_expression of TP73 3 0.18 0.67 0
177 INT190039 Gene_expression of Mlh1 3 0.68 6.14 0
178 INT259116 Transcription of BRCA1 3 0.44 3.77 0
179 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
180 INT190038 Binding of Mlh1 2 0.28 3.11 0
181 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0
182 INT212518 Localization of MSH6 2 0.10 2.66 0
183 INT190035 Binding of Msh6 2 0.28 2.72 0
184 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
185 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0
186 INT252642 Transcription of Atm 1 0.53 0.18 0
187 INT227856 Regulation of Transcription of ERCC6 1 0.45 0 0
188 INT189352 Negative_regulation of Gene_expression of ERCC6 1 0.36 0 0
189 INT211582 Transcription of Mlh1 1 0.41 0.34 0
190 INT319641 Negative_regulation of Positive_regulation of Sfn 1 0.18 0 0
191 INT189345 Negative_regulation of Localization of ERCC6 1 0.41 0.06 0
192 INT187580 Positive_regulation of Brca1 1 0.10 1.17 0
193 INT154146 Regulation of Gene_expression of TP73 1 0.16 0.26 0
194 INT314708 Gene_expression of Brca2 1 0.41 1.75 0
195 INT268375 Positive_regulation of Positive_regulation of MLH1 1 0.12 0.76 0
196 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0
197 INT119064 Regulation of Gene_expression of BRCA1 1 0.53 0.05 0
198 INT190012 Regulation of Mlh1 1 0.34 0.34 0
199 INT289569 Transcription of Sirt1 1 0.71 0.25 0
200 INT350510 Localization of ABL1 1 0.40 2.51 0
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