GO:0008633

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Name activation of pro-apoptotic gene products
Categary Process
Go Slim No
Go Link GO:0008633
Unique Molecular Interactions 734
Total Molecular Interactions 951
Total Single Events 7111
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of pro-apoptotic gene products. They are ordered first by their pain relevance and then by number of times they were reported for activation of pro-apoptotic gene products. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
2 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
3 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
4 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
5 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
6 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
7 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
8 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
9 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
10 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
11 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
12 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
13 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
14 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
15 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
16 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
17 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
18 INT146462 TNFSF10 Positive_regulation of Gene_expression of TNFRSF10D 1 0.27 1.45 0.71
19 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
20 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
21 INT106600 ZNF398 Negative_regulation of Protein_catabolism of IFI27 1 0.03 0.21 0.7
22 INT45497 PDYN Positive_regulation of TNFRSF10B 1 0.52 0 0.7
23 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
24 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
25 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
26 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
27 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
28 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
29 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
30 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56
31 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
32 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
33 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
34 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
35 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53
36 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
37 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
38 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
39 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5
40 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
41 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
42 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
43 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
44 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
45 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48
46 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
47 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
48 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
49 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
50 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
51 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
52 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
53 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
54 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
55 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
56 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
57 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
58 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
59 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
60 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
61 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
62 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
63 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
64 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
65 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
66 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
67 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
68 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
69 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
70 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
71 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38
72 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
73 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
74 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
75 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
76 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
77 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
78 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
79 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
80 INT176373 IL18 Regulation of FASLG 1 0.41 0.4 0.35
81 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
82 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
83 INT228446 PMAIP1 Regulation of Transcription of Mtpn 1 0.00 0 0.34
84 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
85 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
86 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
87 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
88 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
89 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
90 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
91 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
92 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
93 INT29984 Bad Positive_regulation of Localization of Prl 1 0.15 0 0.3
94 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
95 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
96 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
97 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
98 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
99 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
100 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
101 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
102 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
103 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
104 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
105 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
106 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
107 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
108 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
109 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27
110 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
111 INT32157 Binding of TNFRSF10B and Oprd1 1 0.01 0 0.27
112 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
113 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
114 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
115 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
116 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
117 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
118 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25
119 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25
120 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
121 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
122 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
123 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
124 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
125 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
126 INT120376 Bad Positive_regulation of Gene_expression of Oxtr 1 0.08 0 0.22
127 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
128 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
129 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
130 INT343849 Binding of FAS and TLR4 1 0.04 0.32 0.21
131 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
132 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
133 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21
134 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
135 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
136 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
137 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
138 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
139 INT339336 Binding of NKX3-1 and TAC4 1 0.03 0.08 0.18
140 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
141 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
142 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
143 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
144 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
145 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
146 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
147 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
148 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
149 INT229245 Positive_regulation of Binding of FAS and Tnf 1 0.25 0.92 0.17
150 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
151 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
152 INT229246 Binding of FAS and Tnf 1 0.19 0.91 0.17
153 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
154 INT175328 FASLG Positive_regulation of FAS 1 0.01 0.9 0.17
155 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
156 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
157 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
158 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
159 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
160 INT171871 Binding of FAS and Sumo1 1 0.02 1.43 0.16
161 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
162 INT329168 MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.56 0.15
163 INT329172 Phosphorylation of MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.62 0.15
164 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
165 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
166 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
167 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
168 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
169 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
170 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
171 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
172 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14
173 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
174 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
175 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
176 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
177 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
178 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
179 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
180 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13
181 INT243319 Binding of ATP6V0A1 and BBC3 1 0.07 0.59 0.13
182 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
183 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
184 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
185 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
186 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
187 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
188 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12
189 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
190 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
191 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
192 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
193 INT48211 Binding of SELL and DEDD2 1 0.03 0.18 0.12
194 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
195 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
196 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
197 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
198 INT176130 AKT1 Regulation of Gene_expression of COX18 1 0.13 0.82 0.11
199 INT299015 Binding of FAS and Il18 1 0.38 0.83 0.11
200 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of pro-apoptotic gene products. They are ordered first by their pain relevance and then by number of times they were reported in activation of pro-apoptotic gene products. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
3 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
4 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
5 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
6 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
7 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
8 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
9 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
10 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
11 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
12 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
13 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
14 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44
15 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
16 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
17 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
18 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
19 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
20 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83
21 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
22 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
23 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
24 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
25 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
26 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
27 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
28 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51
29 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
30 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
31 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
32 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
33 INT32155 Gene_expression of TNFRSF10B 36 0.67 30.32 5.74
34 INT80033 Binding of FAS 37 0.48 41.19 5.67
35 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
36 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
37 INT150528 Positive_regulation of Gene_expression of TNFSF10 26 0.67 30.71 5.43
38 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
39 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
40 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
41 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
42 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56
43 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
44 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
45 INT103345 Positive_regulation of Gene_expression of BAK1 10 0.57 6.4 4.19
46 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
47 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
48 INT33229 Gene_expression of Bad 9 0.70 6.95 4.15
49 INT84686 Regulation of BAX 26 0.49 28.54 4.13
50 INT51654 Regulation of Bad 21 0.40 12.18 4.06
51 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
52 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
53 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
54 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93
55 INT94408 Positive_regulation of Gene_expression of IFI27 28 0.65 12.89 3.53
56 INT124579 Localization of BAX 35 0.78 30.31 3.43
57 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
58 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
59 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
60 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
61 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
62 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99
63 INT36886 Transcription of Myc 6 0.69 3.16 2.86
64 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
65 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78
66 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73
67 INT22739 Positive_regulation of DYNLL1 5 0.67 1.69 2.67
68 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
69 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
70 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
71 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
72 INT32153 Positive_regulation of Gene_expression of TNFRSF10B 14 0.49 10.81 2.61
73 INT158827 Positive_regulation of FADD 7 0.43 2.6 2.54
74 INT29983 Localization of Bad 5 0.28 4.44 2.52
75 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
76 INT95136 Binding of FASLG 6 0.33 8.01 2.41
77 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34
78 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
79 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
80 INT118791 Binding of AKT1 32 0.48 15.51 2.25
81 INT86999 Regulation of DYNLL1 5 0.44 2.85 2.18
82 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
83 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
84 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
85 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
86 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
87 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07
88 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07
89 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06
90 INT98132 Regulation of FAS 16 0.42 20.57 2.06
91 INT102176 Transcription of FAS 3 0.60 3.22 2.05
92 INT105332 Regulation of Gene_expression of IFI27 14 0.45 8.39 2.02
93 INT106607 Protein_catabolism of IFI27 6 0.93 1.76 2.01
94 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98
95 INT107905 Gene_expression of BCL2L11 9 0.75 7.58 1.92
96 INT125869 Regulation of Gene_expression of TNFSF10 5 0.38 8.77 1.9
97 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86
98 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
99 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
100 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
101 INT130775 Regulation of FASLG 4 0.30 5.8 1.82
102 INT125865 Regulation of TNFSF10 12 0.44 15.75 1.81
103 INT43143 Binding of Bad 8 0.21 5.12 1.81
104 INT97750 Positive_regulation of Positive_regulation of FAS 4 0.49 4.9 1.8
105 INT104929 Binding of TNFRSF10B 10 0.46 6.66 1.76
106 INT130771 Transcription of TNFSF10 3 0.51 3.4 1.74
107 INT113908 Negative_regulation of TNFRSF10B 5 0.57 4.35 1.71
108 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
109 INT93427 Negative_regulation of Bad 4 0.02 2.5 1.63
110 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
111 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56
112 INT103967 Negative_regulation of Gene_expression of BAK1 8 0.42 7.02 1.54
113 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54
114 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
115 INT162463 Localization of BID 6 0.73 7.47 1.5
116 INT62800 Regulation of BAK1 7 0.41 10.12 1.47
117 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
118 INT18495 Regulation of Bad 6 0.19 4.79 1.45
119 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41
120 INT159186 Positive_regulation of Gene_expression of DYNLL1 1 0.49 1.25 1.4
121 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
122 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
123 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
124 INT116265 Binding of Myc 9 0.36 4.28 1.36
125 INT130773 Regulation of Gene_expression of FAS 5 0.37 6.87 1.32
126 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
127 INT154081 Negative_regulation of Localization of Bad 2 0.16 2.06 1.31
128 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31
129 INT130926 Negative_regulation of TNFSF10 9 0.36 10.18 1.3
130 INT142017 Positive_regulation of Positive_regulation of BAK1 2 0.52 1.74 1.3
131 INT106605 Regulation of Protein_catabolism of IFI27 1 0.42 0.46 1.29
132 INT43127 Positive_regulation of Positive_regulation of TNFRSF10B 3 0.49 3.25 1.26
133 INT135551 Positive_regulation of Gene_expression of FASLG 2 0.67 6.71 1.26
134 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
135 INT107904 Positive_regulation of Gene_expression of BCL2L11 3 0.53 2.22 1.24
136 INT115108 Negative_regulation of Gene_expression of FAS 9 0.57 9.16 1.23
137 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
138 INT130774 Transcription of FASLG 5 0.67 2.02 1.22
139 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
140 INT303667 Regulation of BCL2L11 3 0.16 1.03 1.21
141 INT135556 Localization of AKT1 38 0.69 12.78 1.17
142 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
143 INT121861 Regulation of BID 4 0.31 2.73 1.15
144 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
145 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
146 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
147 INT124317 Regulation of Gene_expression of FASLG 2 0.23 1.54 1.1
148 INT160010 Positive_regulation of Transcription of IFI27 1 0.28 0.98 1.1
149 INT70021 Localization of BCL2 23 0.74 21.6 1.09
150 INT160007 Transcription of IFI27 1 0.38 0.97 1.09
151 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
152 INT108340 Negative_regulation of Phosphorylation of BAD 11 0.49 8.29 1.02
153 INT161369 Protein_catabolism of FAS 1 0.86 1.23 1
154 INT75251 Negative_regulation of Positive_regulation of DYNLL1 1 0.41 0.18 0.99
155 INT59600 Regulation of TNFRSF10B 4 0.39 3.63 0.98
156 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96
157 INT98134 Binding of BAX 17 0.39 11.45 0.93
158 INT17894 Regulation of Myc 10 0.60 5.65 0.93
159 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
160 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
161 INT159668 Positive_regulation of Bad 8 0.45 6.32 0.89
162 INT158825 Phosphorylation of FADD 1 0.81 1.63 0.89
163 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
164 INT130772 Positive_regulation of Transcription of FAS 1 0.24 0.67 0.87
165 INT130776 Positive_regulation of Transcription of TNFSF10 1 0.17 0.68 0.87
166 INT130770 Positive_regulation of Transcription of FASLG 1 0.22 0.68 0.87
167 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
168 INT108341 Positive_regulation of BAD 8 0.42 8.75 0.85
169 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
170 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
171 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
172 INT133767 Transcription of Bad 2 0.57 1.72 0.84
173 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
174 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
175 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
176 INT202683 Localization of FAS 6 0.73 5.86 0.8
177 INT82896 Transcription of BAX 3 0.67 4.61 0.8
178 INT70019 Binding of BCL2 25 0.47 17.55 0.79
179 INT164616 Positive_regulation of Negative_regulation of TNFRSF10B 1 0.09 0.75 0.79
180 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
181 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
182 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
183 INT275180 Positive_regulation of Phosphorylation of Bad 4 0.40 3.79 0.77
184 INT237971 Regulation of Gene_expression of TNFRSF10B 3 0.23 3.52 0.76
185 INT106621 Negative_regulation of Protein_catabolism of IFI27 3 0.40 0.49 0.76
186 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
187 INT201628 Positive_regulation of Gene_expression of Bad 12 0.68 13.86 0.72
188 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
189 INT25663 Localization of PMAIP1 3 0.38 2.47 0.71
190 INT155089 Negative_regulation of FADD 2 0.42 1.31 0.71
191 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69
192 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
193 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
194 INT142696 Positive_regulation of BBC3 3 0.67 1.7 0.67
195 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
196 INT106613 Regulation of IFI27 6 0.57 3.12 0.66
197 INT153802 Positive_regulation of Localization of BAD 1 0.30 0.64 0.66
198 INT25664 Negative_regulation of Localization of PMAIP1 1 0.09 0.09 0.66
199 INT153799 Localization of BAD 1 0.45 0.63 0.66
200 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
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