GO:0008635

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Name activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
Categary Process
Go Slim No
Go Link GO:0008635
Unique Molecular Interactions 547
Total Molecular Interactions 650
Total Single Events 6045
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c. They are ordered first by their pain relevance and then by number of times they were reported for activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
3 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
4 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
5 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
6 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
7 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
8 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
9 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
10 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
11 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
12 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
13 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
14 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
15 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
16 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
17 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
18 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
19 INT41174 Bak1 Regulation of Localization of Prl 1 0.02 0 0.46
20 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
21 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
22 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
23 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
24 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
25 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
26 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
27 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
28 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
29 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
30 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
31 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
32 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
33 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
34 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
35 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
36 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
37 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
38 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
39 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
40 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
41 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
42 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
43 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
44 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
45 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
46 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
47 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
48 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
49 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
50 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
51 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
52 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
53 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
54 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
55 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
56 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
57 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
58 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
59 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
60 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
61 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
62 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
63 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
64 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
65 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
66 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
67 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
68 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
69 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
70 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
71 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
72 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
73 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
74 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
75 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
76 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
77 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
78 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
79 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
80 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
81 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
82 INT130922 HMHA1 Positive_regulation of Protein_catabolism of CYCS 1 0.06 1.39 0.14
83 INT130917 HMHA1 Positive_regulation of CYCS 1 0.06 1.39 0.14
84 INT130921 HMHA1 Positive_regulation of CASP9 1 0.03 1.37 0.14
85 INT345146 Binding of Trip6 and Siva1 1 0.02 1.6 0.14
86 INT130919 HMHA1 Positive_regulation of Protein_catabolism of CASP9 1 0.03 1.37 0.14
87 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
88 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
89 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
90 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
91 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
92 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
93 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
94 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
95 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
96 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
97 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
98 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
99 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
100 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
101 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
102 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
103 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
104 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
105 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
106 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
107 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
108 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
109 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
110 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
111 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
112 INT302290 Birc5 Regulation of BAK1 1 0.21 1.22 0.07
113 INT204301 Positive_regulation of Hrk Positive_regulation of Positive_regulation of Bak1 1 0.00 1.17 0.07
114 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07
115 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
116 INT302289 Negative_regulation of Birc5 Regulation of BAK1 1 0.20 1.22 0.07
117 INT285025 Bnip3 Positive_regulation of Bak1 1 0.11 0.78 0.07
118 INT285032 Bnip3 Positive_regulation of Bax 1 0.28 0.77 0.07
119 INT113218 TNFRSF25 Positive_regulation of Localization of CYCS 1 0.18 0.74 0.07
120 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07
121 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07
122 INT118260 Binding of TNF and CYCS 1 0.40 2.01 0.07
123 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
124 INT150388 Binding of MEFV and SIVA1 1 0.31 0.92 0.07
125 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
126 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07
127 INT345173 Binding of Siva1 and Lpar2 1 0.05 0.75 0.06
128 INT302147 PTGER2 Positive_regulation of BAK1 1 0.06 2.08 0.06
129 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06
130 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
131 INT302175 BAX Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
132 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
133 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
134 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
135 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
136 INT302138 PTGER2 Positive_regulation of Gene_expression of BAK1 1 0.06 2.08 0.06
137 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
138 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
139 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
140 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
141 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
142 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
143 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
144 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
145 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
146 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
147 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
148 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
149 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
150 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
151 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
152 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
153 INT204298 Bid Positive_regulation of Binding of Bak1 1 0.05 0.57 0.04
154 INT265462 CSPG4 Negative_regulation of Positive_regulation of CASP9 1 0.07 1.2 0.04
155 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
156 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
157 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
158 INT265461 CSPG4 Negative_regulation of Gene_expression of CASP9 1 0.06 1.2 0.04
159 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
160 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
161 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
162 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03
163 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03
164 INT192165 Binding of BAK1 and BCL2L1 2 0.06 1.35 0.03
165 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
166 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03
167 INT192166 Negative_regulation of Binding of BAK1 and BCL2L1 1 0.05 1.06 0.03
168 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
169 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03
170 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
171 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
172 INT224682 Mcl1 Regulation of Bak1 1 0.01 1.09 0.03
173 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
174 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03
175 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
176 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
177 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
178 INT201770 Binding of CASP9 and Apaf1 1 0.04 0.89 0.03
179 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
180 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
181 INT327404 Binding of Xiap and Siva1 1 0.02 1.97 0.03
182 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
183 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
184 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
185 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
186 INT224689 Binding of Bak1 and Mcl1 1 0.01 1.09 0.03
187 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03
188 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
189 INT333249 Cxcl12 Positive_regulation of Positive_regulation of Bak1 1 0.30 0.32 0.03
190 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
191 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03
192 INT333262 Bcl2 Regulation of Bak1 1 0.04 0.31 0.03
193 INT342733 Gene_expression of Lrrk2 Positive_regulation of Apaf1 1 0.10 0.74 0.03
194 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03
195 INT283013 Binding of Bak1 and Bcl2 4 0.06 1.03 0
196 INT185852 Binding of BAK1 and BAX 3 0.29 2.5 0
197 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
198 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
199 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0
200 INT198011 Binding of BAX and MCL1 2 0.20 3.04 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c. They are ordered first by their pain relevance and then by number of times they were reported in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
2 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
3 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
4 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
5 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
6 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
7 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
8 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
9 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
10 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
11 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
12 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
13 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
14 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
15 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
16 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
17 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
18 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
19 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
20 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
21 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
22 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
23 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
24 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
25 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
26 INT145929 Regulation of Bax 20 0.60 18.12 5.35
27 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
28 INT60585 Regulation of TP53 59 0.59 54.55 5.21
29 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
30 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
31 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
32 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
33 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
34 INT103345 Positive_regulation of Gene_expression of BAK1 10 0.57 6.4 4.19
35 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
36 INT84686 Regulation of BAX 26 0.49 28.54 4.13
37 INT123752 Regulation of Bax 19 0.60 16.45 4
38 INT112692 Localization of Bax 31 0.80 20.97 3.98
39 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
40 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
41 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
42 INT95119 Localization of CYCS 23 0.78 14.86 3.49
43 INT124579 Localization of BAX 35 0.78 30.31 3.43
44 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
45 INT8103 Binding of TP53 46 0.44 40.2 2.96
46 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73
47 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
48 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
49 INT55952 Transcription of TP53 16 0.61 12.14 2.36
50 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
51 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
52 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
53 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
54 INT154970 Localization of Bax 15 0.74 11.12 2.11
55 INT151467 Localization of CASP9 9 0.73 7.62 2.04
56 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
57 INT98836 Transcription of Bax 6 0.69 5.04 1.96
58 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
59 INT134442 Transcription of Bax 14 0.67 7.6 1.9
60 INT65855 Localization of TP53 18 0.76 17.08 1.89
61 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
62 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
63 INT134443 Binding of Bax 10 0.47 5.62 1.84
64 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
65 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
66 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
67 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
68 INT103967 Negative_regulation of Gene_expression of BAK1 8 0.42 7.02 1.54
69 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
70 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
71 INT62800 Regulation of BAK1 7 0.41 10.12 1.47
72 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
73 INT105086 Positive_regulation of CYCS 9 0.49 5.82 1.45
74 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
75 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
76 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
77 INT172953 Binding of Trp53 33 0.37 20.76 1.41
78 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
79 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
80 INT145221 Binding of Tp53 10 0.37 8.59 1.37
81 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
82 INT142017 Positive_regulation of Positive_regulation of BAK1 2 0.52 1.74 1.3
83 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
84 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
85 INT111340 Positive_regulation of Localization of CYCS 7 0.67 4.83 1.19
86 INT174156 Localization of Trp53 16 0.72 13.52 1.18
87 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
88 INT141179 Negative_regulation of Apaf1 2 0.41 1.53 1.14
89 INT141181 Negative_regulation of Transcription of Apaf1 1 0.40 1.42 1.14
90 INT141182 Transcription of Apaf1 1 0.68 1.41 1.14
91 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
92 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
93 INT122485 Negative_regulation of CASP9 18 0.46 15.78 1.12
94 INT53028 Negative_regulation of CYCS 6 0.57 2.65 1.11
95 INT102845 Localization of CASP3 7 0.81 2.81 1.06
96 INT93094 Gene_expression of Bak1 13 0.52 13.94 1.02
97 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
98 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
99 INT98134 Binding of BAX 17 0.39 11.45 0.93
100 INT135542 Positive_regulation of Bak1 17 0.43 16.12 0.88
101 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
102 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
103 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
104 INT1523 Binding of CYCS 4 0.47 0.53 0.8
105 INT82896 Transcription of BAX 3 0.67 4.61 0.8
106 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
107 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
108 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
109 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
110 INT14040 Binding of Bak1 2 0.30 0.55 0.72
111 INT133484 Negative_regulation of Localization of CYCS 4 0.42 2.77 0.7
112 INT169216 Negative_regulation of Positive_regulation of CYCS 1 0.42 0.82 0.7
113 INT14041 Regulation of Binding of Bak1 1 0.23 0 0.68
114 INT53022 Gene_expression of CYCS 5 0.65 4.01 0.66
115 INT204290 Positive_regulation of Bak1 3 0.22 5.19 0.66
116 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
117 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
118 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
119 INT285007 Regulation of Bak1 1 0.20 3.46 0.56
120 INT176242 Binding of Bax 10 0.42 10.18 0.52
121 INT151466 Binding of CASP9 3 0.36 2.44 0.5
122 INT135541 Negative_regulation of Bak1 6 0.30 4.52 0.49
123 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
124 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
125 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
126 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
127 INT26187 Regulation of CYCS 2 0.60 0.87 0.44
128 INT132496 Regulation of Gene_expression of CASP3 6 0.20 4.59 0.42
129 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
130 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
131 INT150946 Negative_regulation of Positive_regulation of Bak1 2 0.29 3.02 0.4
132 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
133 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
134 INT229233 Positive_regulation of Phosphorylation of BAX 1 0.21 1.94 0.38
135 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
136 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
137 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
138 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
139 INT172216 Binding of Bak1 5 0.25 8.48 0.33
140 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
141 INT93093 Regulation of Gene_expression of Bak1 3 0.30 2.09 0.32
142 INT150396 Gene_expression of SIVA1 1 0.75 2.34 0.32
143 INT122950 Binding of BAK1 16 0.41 12.85 0.31
144 INT140379 Positive_regulation of Gene_expression of Bak1 4 0.27 2.27 0.31
145 INT286753 Negative_regulation of Positive_regulation of Apaf1 1 0.09 2.82 0.31
146 INT109530 Negative_regulation of Positive_regulation of BAX 3 0.42 3.01 0.3
147 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
148 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
149 INT82900 Positive_regulation of Transcription of BAX 2 0.49 1.86 0.29
150 INT229853 Gene_expression of Bak1 2 0.25 2.04 0.29
151 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
152 INT159320 Negative_regulation of Protein_catabolism of CASP3 1 0.21 0.59 0.27
153 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
154 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
155 INT150947 Positive_regulation of Positive_regulation of Bak1 1 0.05 0.6 0.25
156 INT172227 Regulation of Localization of BAX 3 0.26 4.79 0.24
157 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23
158 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
159 INT181665 Localization of Apaf1 2 0.49 1.67 0.23
160 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
161 INT292751 Negative_regulation of Localization of CASP9 1 0.41 2.11 0.22
162 INT187555 Transcription of BAK1 3 0.19 2.6 0.21
163 INT187556 Regulation of Transcription of BAK1 1 0.02 1.22 0.21
164 INT187553 Regulation of Transcription of BAX 1 0.37 1.21 0.21
165 INT282088 Localization of Bak1 6 0.54 3.78 0.19
166 INT300463 Regulation of Regulation of Bax 1 0.29 1.33 0.18
167 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17
168 INT198036 Negative_regulation of BAK1 5 0.27 5.98 0.17
169 INT242278 Localization of SIVA1 1 0.01 1.07 0.17
170 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
171 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
172 INT242277 Positive_regulation of SIVA1 1 0.01 1.08 0.17
173 INT178607 Binding of CASP3 5 0.19 1.06 0.16
174 INT165361 Positive_regulation of APAF1 4 0.39 4.8 0.16
175 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
176 INT175518 Positive_regulation of Apaf1 3 0.15 2.37 0.15
177 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
178 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
179 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
180 INT130925 Protein_catabolism of CYCS 1 0.86 1.37 0.14
181 INT1524 Positive_regulation of Binding of CYCS 1 0.67 0 0.14
182 INT320315 Protein_catabolism of BAK1 3 0.76 3.13 0.13
183 INT285005 Negative_regulation of Bak1 1 0.14 0.16 0.13
184 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
185 INT185872 Localization of BAK1 6 0.74 11.28 0.12
186 INT265485 Positive_regulation of Localization of BAK1 4 0.50 5.17 0.12
187 INT185907 Positive_regulation of Binding of BAK1 2 0.60 1.59 0.12
188 INT238490 Regulation of Regulation of BAK1 1 0.19 2.56 0.12
189 INT133486 Negative_regulation of Binding of BAX 1 0.15 0.62 0.12
190 INT330036 Binding of Apaf1 2 0.25 2.06 0.11
191 INT336888 Negative_regulation of Transcription of Bax 1 0.07 0.68 0.11
192 INT190821 Positive_regulation of Negative_regulation of CASP3 1 0.06 0.51 0.1
193 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
194 INT111139 Localization of Tp53 4 0.45 2.4 0.09
195 INT190553 Regulation of Siva1 2 0.16 1.05 0.09
196 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09
197 INT165362 Gene_expression of APAF1 5 0.50 4.37 0.08
198 INT327394 Binding of Siva1 2 0.04 2.62 0.08
199 INT165363 Positive_regulation of Positive_regulation of APAF1 1 0.28 1.12 0.08
200 INT327140 Regulation of Localization of BAK1 1 0.45 0.71 0.07
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