GO:0008637

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Name apoptotic mitochondrial changes
Categary Process
Go Slim No
Go Link GO:0008637
Unique Molecular Interactions 717
Total Molecular Interactions 1004
Total Single Events 7148
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apoptotic mitochondrial changes. They are ordered first by their pain relevance and then by number of times they were reported for apoptotic mitochondrial changes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
8 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
9 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
10 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
11 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
12 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
13 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
14 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
15 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
16 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
17 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
18 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
19 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
20 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
21 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
22 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
23 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
24 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
25 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
26 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
27 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
28 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
29 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
30 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
31 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
32 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
33 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
34 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
35 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
36 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
37 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
38 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
39 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
40 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
41 INT16048 MAX Positive_regulation of SLC25A4 1 0.50 0 0.71
42 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
43 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
44 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
45 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
46 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
47 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
48 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
49 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
50 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
51 INT112701 Bid Regulation of RFFL 1 0.00 0.52 0.62
52 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
53 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
54 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
55 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
56 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
57 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
58 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
59 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
60 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
61 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
62 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
63 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
64 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
65 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
66 INT151558 ERLEC1 Regulation of Atp2a1 1 0.00 0.64 0.53
67 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
68 INT151557 NARG2 Regulation of Atp2a1 1 0.01 0.64 0.53
69 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
70 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
71 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
72 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
73 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
74 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
75 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
76 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
77 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
78 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
79 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
80 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
81 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
82 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
83 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
84 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
85 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
86 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
87 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
88 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
89 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
90 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
91 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
92 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
93 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
94 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
95 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
96 INT324802 Binding of Cd24a and Siglecg 1 0.03 1.34 0.4
97 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
98 INT62110 SLC25A4 Negative_regulation of Regulation of Gh 1 0.06 0 0.39
99 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
100 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
101 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
102 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
103 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
104 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
105 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
106 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
107 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
108 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
109 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
110 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
111 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
112 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
113 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
114 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
115 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
116 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
117 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
118 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
119 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
120 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
121 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
122 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
123 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
124 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
125 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
126 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
127 INT107189 Atp2a2 Negative_regulation of Atp2a1 1 0.27 0 0.26
128 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
129 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
130 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
131 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
132 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
133 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
134 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
135 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
136 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
137 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
138 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
139 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
140 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
141 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
142 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
143 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
144 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
145 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
146 INT324824 Positive_regulation of Binding of Cd24a and Siglecg 1 0.03 0.68 0.2
147 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
148 INT64964 Binding of Alb and Cd24 1 0.02 0.2 0.2
149 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
150 INT324822 Binding of Cd24a and Hsp90aa1 1 0.10 0.71 0.19
151 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
152 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19
153 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
154 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
155 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
156 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
157 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
158 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
159 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
160 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
161 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
162 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
163 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
164 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
165 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
166 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
167 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
168 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
169 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
170 INT218930 Akt1 Positive_regulation of Xiap 1 0.06 0.64 0.16
171 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
172 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15
173 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
174 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
175 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
176 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
177 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
178 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15
179 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
180 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15
181 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
182 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
183 INT213005 Hdl1 Positive_regulation of Akt1 3 0.19 3.81 0.14
184 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14
185 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
186 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
187 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
188 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
189 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
190 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
191 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
192 INT355226 VEGFA Positive_regulation of Akt1 1 0.04 0.27 0.14
193 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
194 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
195 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
196 INT252336 Il2 Positive_regulation of Akt1 1 0.01 0 0.13
197 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
198 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13
199 INT182478 Binding of Akt1 and Cx3cr1 1 0.11 0.12 0.13
200 INT320765 Dsg2 Positive_regulation of Akt1 1 0.48 0.74 0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for apoptotic mitochondrial changes. They are ordered first by their pain relevance and then by number of times they were reported in apoptotic mitochondrial changes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
7 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
8 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
9 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
10 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
11 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
12 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
13 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
14 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
15 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
16 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
17 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
18 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
19 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
20 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
21 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
22 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
23 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
24 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
25 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
26 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
27 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
28 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
29 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
30 INT123787 Gene_expression of Bid 25 0.66 16 6.35
31 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
32 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
33 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
34 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
35 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
36 INT145929 Regulation of Bax 20 0.60 18.12 5.35
37 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32
38 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
39 INT134657 Localization of Akt1 37 0.68 11.58 4.62
40 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
41 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
42 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
43 INT75136 Binding of Akt1 27 0.27 8.81 4.15
44 INT84686 Regulation of BAX 26 0.49 28.54 4.13
45 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
46 INT123752 Regulation of Bax 19 0.60 16.45 4
47 INT112692 Localization of Bax 31 0.80 20.97 3.98
48 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95
49 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
50 INT136692 Localization of Akt1 12 0.78 2.14 3.65
51 INT137634 Localization of Aifm1 17 0.80 11.8 3.45
52 INT124579 Localization of BAX 35 0.78 30.31 3.43
53 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
54 INT111482 Gene_expression of Cd24a 23 0.72 13.74 3.37
55 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
56 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
57 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
58 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
59 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
60 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
61 INT156016 Binding of BCL2L1 10 0.36 7.42 2.64
62 INT108555 Positive_regulation of HK2 5 0.29 4.91 2.62
63 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
64 INT214355 Binding of Akt1 13 0.36 3.72 2.59
65 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
66 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
67 INT149975 Negative_regulation of Ppif 1 0.41 0.44 2.36
68 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
69 INT151574 Gene_expression of Aifm1 5 0.62 3.63 2.34
70 INT97748 Positive_regulation of BCL2L1 12 0.67 9.83 2.26
71 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25
72 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
73 INT102752 Positive_regulation of Gene_expression of BCL2L1 14 0.67 13.8 2.19
74 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
75 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
76 INT154970 Localization of Bax 15 0.74 11.12 2.11
77 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
78 INT112698 Gene_expression of Bid 8 0.64 6.52 1.97
79 INT98836 Transcription of Bax 6 0.69 5.04 1.96
80 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
81 INT134442 Transcription of Bax 14 0.67 7.6 1.9
82 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
83 INT134443 Binding of Bax 10 0.47 5.62 1.84
84 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78
85 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
86 INT156005 Positive_regulation of Gene_expression of Aifm1 1 0.36 1.56 1.75
87 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
88 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
89 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
90 INT97749 Regulation of BCL2L1 10 0.41 9.72 1.65
91 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
92 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52
93 INT162463 Localization of BID 6 0.73 7.47 1.5
94 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
95 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
96 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
97 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
98 INT141037 Positive_regulation of Aifm1 3 0.45 3.32 1.38
99 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
100 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
101 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
102 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
103 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
104 INT121861 Regulation of BID 4 0.31 2.73 1.15
105 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
106 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
107 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
108 INT141036 Negative_regulation of Aifm1 1 0.00 1.26 1.07
109 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
110 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
111 INT152809 Negative_regulation of Hk2 2 0.57 1.95 0.98
112 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
113 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
114 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
115 INT98134 Binding of BAX 17 0.39 11.45 0.93
116 INT156015 Negative_regulation of Protein_catabolism of BCL2L1 1 0.42 1.23 0.93
117 INT156014 Protein_catabolism of BCL2L1 1 0.64 1.23 0.93
118 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
119 INT156017 Positive_regulation of Binding of BCL2L1 1 0.49 1.21 0.91
120 INT214709 Gene_expression of Hk2 5 0.76 9.11 0.86
121 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
122 INT142025 Localization of Bid 13 0.69 8.24 0.84
123 INT80671 Gene_expression of HK2 6 0.70 3.23 0.84
124 INT80665 Negative_regulation of Gene_expression of HK2 4 0.39 2.41 0.84
125 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
126 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
127 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
128 INT82896 Transcription of BAX 3 0.67 4.61 0.8
129 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
130 INT340843 Binding of Cd24a 1 0.02 0.24 0.8
131 INT55560 Binding of SLC25A4 8 0.36 1.94 0.79
132 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
133 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
134 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
135 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
136 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
137 INT112419 Negative_regulation of Positive_regulation of HK2 1 0.00 0.41 0.69
138 INT146711 Positive_regulation of Hk2 2 0.18 1.27 0.68
139 INT123784 Positive_regulation of Gene_expression of Bid 4 0.40 2.41 0.66
140 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
141 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
142 INT172204 Gene_expression of SLC25A4 8 0.70 4.11 0.62
143 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
144 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
145 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
146 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
147 INT133765 Regulation of Gene_expression of Bid 1 0.29 0.45 0.58
148 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57
149 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
150 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
151 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
152 INT340842 Regulation of Gene_expression of Cd24a 1 0.42 0.08 0.53
153 INT176242 Binding of Bax 10 0.42 10.18 0.52
154 INT107187 Gene_expression of Atp2a1 1 0.43 0 0.52
155 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
156 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
157 INT64961 Binding of Cd24 4 0.15 0.64 0.5
158 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
159 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
160 INT326696 Regulation of Cd24a 2 0.44 0 0.48
161 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
162 INT148985 Positive_regulation of Positive_regulation of BID 1 0.53 0.84 0.48
163 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
164 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
165 INT204293 Protein_catabolism of Bid 9 0.65 6.07 0.45
166 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
167 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
168 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
169 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
170 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
171 INT45887 Positive_regulation of SLC25A4 2 0.45 0.9 0.4
172 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
173 INT137640 Negative_regulation of Localization of Aifm1 2 0.58 0.39 0.39
174 INT121860 Negative_regulation of BID 2 0.29 1.92 0.38
175 INT121862 Negative_regulation of Negative_regulation of BID 1 0.29 0.54 0.38
176 INT229233 Positive_regulation of Phosphorylation of BAX 1 0.21 1.94 0.38
177 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
178 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
179 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
180 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34
181 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
182 INT123783 Transcription of Bid 2 0.08 0.68 0.34
183 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
184 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
185 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
186 INT116196 Protein_catabolism of Bid 7 0.66 6.24 0.32
187 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
188 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
189 INT164827 Negative_regulation of Atp2a1 1 0.43 0.15 0.32
190 INT62108 Positive_regulation of Localization of SLC25A4 1 0.49 0 0.31
191 INT109530 Negative_regulation of Positive_regulation of BAX 3 0.42 3.01 0.3
192 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
193 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
194 INT82900 Positive_regulation of Transcription of BAX 2 0.49 1.86 0.29
195 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
196 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
197 INT239955 Gene_expression of Atp2a1 7 0.29 0.78 0.26
198 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
199 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
200 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
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