GO:0009266

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Name response to temperature stimulus
Categary Process
Go Slim No
Go Link GO:0009266
Unique Molecular Interactions 81
Total Molecular Interactions 98
Total Single Events 1832
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to temperature stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to temperature stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
2 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93
3 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
4 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
5 INT134384 Trpa1 Negative_regulation of Gene_expression of Trpm8 1 0.47 1.21 1.02
6 INT80718 Trpv3 Negative_regulation of Chn1 1 0.01 0.7 0.92
7 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
8 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
9 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
10 INT102086 TRNAI1 Negative_regulation of Positive_regulation of P2rx3 1 0.00 0.47 0.74
11 INT129557 Binding of Trpv2 and Trpv1 1 0.41 0.18 0.74
12 INT281241 Positive_regulation of P2RX7 Negative_regulation of Gene_expression of P2rx3 1 0.03 0.79 0.71
13 INT144124 Binding of P2rx6 and Trpv2 1 0.09 0 0.7
14 INT192131 Ngf Regulation of Gene_expression of P2rx3 1 0.18 0.3 0.66
15 INT128599 Binding of P2rx3 and Ppip5k1 1 0.05 0.41 0.64
16 INT145637 Calca Positive_regulation of P2rx3 1 0.33 0.7 0.64
17 INT128598 Ppip5k1 Negative_regulation of P2rx3 1 0.05 0.49 0.62
18 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
19 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
20 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
21 INT216919 Ngf Positive_regulation of Gene_expression of P2rx3 1 0.18 0.69 0.53
22 INT145636 Ngf Regulation of P2rx3 1 0.39 0.4 0.49
23 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47
24 INT330543 Prkcg Regulation of Regulation of Trpm8 1 0.11 0.28 0.47
25 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
26 INT183139 Negative_regulation of Dctn6 Positive_regulation of Trpm8 1 0.01 0 0.43
27 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
28 INT215171 Ptger2 Regulation of P2rx3 1 0.23 0.45 0.41
29 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4
30 INT78627 Gdnf Negative_regulation of Negative_regulation of P2rx3 1 0.00 0.42 0.38
31 INT221917 RPS3AP18 Negative_regulation of Positive_regulation of Trpv3 1 0.01 0.25 0.38
32 INT192132 Ngf Positive_regulation of P2rx3 1 0.18 0.59 0.38
33 INT230584 Positive_regulation of Trpv1 Positive_regulation of Trpm8 1 0.28 0.16 0.37
34 INT263072 Kncn Regulation of Transcription of Trpm8 1 0.08 0.99 0.36
35 INT230585 Trpv1 Positive_regulation of Trpm8 1 0.28 0.15 0.36
36 INT114809 Selp Positive_regulation of Gene_expression of F3 1 0.00 0.88 0.34
37 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33
38 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33
39 INT277011 CRP Positive_regulation of Gene_expression of F3 1 0.06 1.03 0.32
40 INT348382 Binding of Trpv3 and Lpar5 1 0.06 0.32 0.3
41 INT348401 Binding of LPAR5 and Trpv3 1 0.07 0.32 0.3
42 INT191503 CD40LG Regulation of Gene_expression of F3 1 0.01 0.99 0.27
43 INT282647 IL6 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
44 INT282648 IL8 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
45 INT215170 Prkg2 Positive_regulation of P2rx3 1 0.02 0.11 0.25
46 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23
47 INT242595 Trpm8 Negative_regulation of Trpv1 1 0.24 0 0.23
48 INT343433 Binding of Trpv2 and Trpv1 1 0.36 0.06 0.23
49 INT330546 Positive_regulation of Trpm8 Positive_regulation of Positive_regulation of Ca2 1 0.13 0.67 0.22
50 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
51 INT332324 Negative_regulation of Myoz1 Positive_regulation of Phosphorylation of P2rx3 1 0.05 0.26 0.21
52 INT9572 Binding of Nts and Trpv3 1 0.02 0.07 0.21
53 INT343436 Binding of Trpv2 and Gpx6 1 0.01 0.13 0.2
54 INT343434 Regulation of Binding of Trpv2 and Gpx6 1 0.01 0.13 0.2
55 INT192133 Ngf Regulation of P2rx3 1 0.11 0.42 0.19
56 INT142224 Urb1 Negative_regulation of Trpm8 1 0.03 0.1 0.17
57 INT142223 Trpa1 Negative_regulation of Trpm8 1 0.20 0.1 0.17
58 INT147385 Binding of TRPV1 and TRPV2 1 0.37 0 0.15
59 INT147386 Regulation of Binding of TRPV1 and TRPV2 1 0.45 0 0.15
60 INT191001 F3 Positive_regulation of F2 1 0.00 0.62 0.14
61 INT309742 CALM3 Regulation of TRPV3 1 0.04 0 0.13
62 INT296238 Trpm8 Regulation of Trpa1 1 0.30 0.21 0.12
63 INT296234 Trpm8 Regulation of Pla2g6 1 0.18 0.21 0.12
64 INT276497 F3 Positive_regulation of F7 1 0.02 1.64 0.1
65 INT8675 Positive_regulation of Binding of F2 and F3 2 0.17 0.43 0.09
66 INT8671 Binding of F2 and F3 2 0.13 0.42 0.09
67 INT215175 Binding of P2rx3 and Ptger2 1 0.21 0.27 0.09
68 INT139581 Binding of Atrn and Negative_regulation of Trpm8 1 0.01 0 0.09
69 INT8674 Positive_regulation of Binding of F3 and ANGPTL5 1 0.06 0.48 0.09
70 INT8678 Binding of F3 and ANGPTL5 1 0.04 0.48 0.09
71 INT330542 Prkaca Regulation of Regulation of Trpm8 1 0.03 0.1 0.05
72 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
73 INT296236 Anxa1 Positive_regulation of Trpm8 1 0.04 0.09 0.05
74 INT296232 Anxa1 Regulation of Trpm8 1 0.03 0.54 0.04
75 INT215691 Binding of P2ry2 and P2rx3 1 0.08 0.46 0.03
76 INT355636 OLR1 Positive_regulation of Positive_regulation of F3 1 0.01 0.57 0
77 INT281097 Binding of P2rx3 and P2rx2 1 0.06 0 0
78 INT304461 Gopc Regulation of Gene_expression of P2rx3 1 0.09 0.07 0
79 INT130413 TNFSF14 Positive_regulation of F3 1 0.11 0 0
80 INT355640 OLR1 Positive_regulation of Gene_expression of F3 1 0.01 0.57 0
81 INT230416 F3 Regulation of MSLN 1 0.06 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to temperature stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to temperature stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
2 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85
3 INT81251 Gene_expression of Trpv2 78 0.78 28.27 41.76
4 INT117632 Gene_expression of Trpm8 99 0.78 29.41 30.9
5 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46
6 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05
7 INT78233 Positive_regulation of P2rx3 36 0.56 21.49 17.25
8 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13
9 INT69652 Regulation of P2rx3 26 0.61 17.17 15.4
10 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
11 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34
12 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17
13 INT81249 Positive_regulation of Trpv2 21 0.70 8.13 12.36
14 INT96406 Regulation of Trpv2 14 0.62 7.45 12.04
15 INT143767 Negative_regulation of Trpm8 26 0.58 12.34 10.83
16 INT78579 Negative_regulation of P2rx3 23 0.59 10.13 10.78
17 INT80717 Gene_expression of Trpv3 20 0.72 10.05 9.96
18 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28
19 INT119098 Positive_regulation of TRPV3 20 0.68 10.12 9.01
20 INT78578 Localization of P2rx3 21 0.78 9.55 8.86
21 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
22 INT134381 Regulation of Trpm8 25 0.54 8.31 8.25
23 INT102080 Positive_regulation of P2rx3 20 0.67 6.91 7.3
24 INT78232 Binding of P2rx3 25 0.41 6.26 6.78
25 INT139580 Negative_regulation of Trpm8 19 0.58 3.8 6.26
26 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
27 INT93165 Gene_expression of TRPV2 32 0.78 12.49 5.62
28 INT146347 Negative_regulation of Gene_expression of Trpm8 9 0.55 6.96 5.42
29 INT159442 Positive_regulation of Gene_expression of Trpm8 10 0.70 5.86 5.34
30 INT114627 Positive_regulation of Gene_expression of Trpv2 9 0.70 6.41 5.18
31 INT159443 Regulation of Gene_expression of Trpm8 9 0.57 6.63 5.12
32 INT105216 Positive_regulation of Trpv2 9 0.61 4.12 4.93
33 INT91917 Negative_regulation of P2rx3 11 0.59 6.56 4.51
34 INT15851 Positive_regulation of Trpv3 11 0.60 4.6 4.35
35 INT81250 Transcription of Trpv2 7 0.64 1.54 4.27
36 INT181495 Regulation of TRPV3 3 0.25 6.57 4.22
37 INT115853 Transcription of Trpm8 15 0.68 7.72 4.1
38 INT102850 Gene_expression of Trpv3 12 0.56 2.06 4.01
39 INT124028 Localization of Trpv2 6 0.80 2.04 3.96
40 INT78493 Negative_regulation of F3 11 0.27 8.35 3.76
41 INT130239 Transcription of Trpm8 10 0.66 2.83 3.74
42 INT100188 Positive_regulation of Gene_expression of P2rx3 8 0.49 5.96 3.26
43 INT167029 Regulation of Gene_expression of P2rx3 5 0.30 3.12 3.06
44 INT9569 Negative_regulation of Trpv3 6 0.40 0.84 3.03
45 INT134378 Binding of Trpm8 8 0.48 1.74 2.95
46 INT103049 Regulation of P2rx3 9 0.60 6 2.92
47 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85
48 INT91918 Localization of P2rx3 10 0.72 3.16 2.82
49 INT137967 Positive_regulation of Gene_expression of Trpm8 11 0.70 3.29 2.66
50 INT134377 Regulation of Gene_expression of Trpm8 7 0.59 3.18 2.66
51 INT145635 Phosphorylation of P2rx3 2 0.75 2.74 2.52
52 INT96803 Negative_regulation of Gene_expression of P2rx3 6 0.51 3.65 2.49
53 INT215496 Phosphorylation of P2rx3 10 0.44 1.88 2.41
54 INT117633 Localization of Trpm8 5 0.79 1.23 2.41
55 INT230576 Positive_regulation of Trpv3 8 0.46 0.83 2.35
56 INT99865 Binding of Trpv2 4 0.48 1.13 2.25
57 INT134380 Negative_regulation of Gene_expression of Trpm8 3 0.43 1.78 2.24
58 INT46088 Localization of F3 15 0.37 13.7 2.23
59 INT92542 Negative_regulation of Trpv2 8 0.59 1.54 2.15
60 INT149755 Transcription of P2rx3 13 0.60 8.28 2.11
61 INT126910 Positive_regulation of Gene_expression of P2rx3 3 0.62 1.81 2.08
62 INT9106 Positive_regulation of F3 8 0.22 4.92 1.85
63 INT124639 Localization of Trpv3 4 0.49 0.69 1.74
64 INT261815 Regulation of Gene_expression of Trpv2 2 0.32 0.97 1.65
65 INT160481 Negative_regulation of TRPV3 6 0.59 3.78 1.64
66 INT103550 Binding of TRPV3 3 0.44 1.41 1.61
67 INT107895 Positive_regulation of Gene_expression of Trpv2 4 0.46 0.98 1.6
68 INT119994 Negative_regulation of Trpv2 5 0.58 3.04 1.58
69 INT149512 Positive_regulation of Gene_expression of Trpv3 2 0.49 2.48 1.57
70 INT152720 Localization of Trpv2 6 0.69 2.71 1.54
71 INT199144 Regulation of Trpv3 2 0.30 0.79 1.48
72 INT130241 Positive_regulation of Positive_regulation of Trpm8 5 0.69 0.15 1.45
73 INT195134 Binding of Trpm8 5 0.37 0.82 1.26
74 INT115854 Transcription of Trpv2 4 0.53 0.89 1.18
75 INT215493 Positive_regulation of Phosphorylation of P2rx3 2 0.33 1.27 1.14
76 INT88820 Positive_regulation of Gene_expression of F3 8 0.67 5.48 1.08
77 INT44002 Negative_regulation of Gene_expression of F3 5 0.20 1.64 0.98
78 INT152491 Regulation of Transcription of P2rx3 2 0.27 0.87 0.91
79 INT159898 Localization of Trpm8 4 0.74 1.33 0.9
80 INT307250 Negative_regulation of Gene_expression of P2rx3 3 0.40 0.71 0.87
81 INT116366 Binding of P2rx3 2 0.36 0.54 0.87
82 INT263064 Regulation of Transcription of Trpm8 2 0.43 2.33 0.8
83 INT122072 Regulation of Binding of P2rx3 1 0.24 0.58 0.76
84 INT188159 Positive_regulation of Positive_regulation of P2rx3 1 0.20 0.74 0.75
85 INT102082 Negative_regulation of Positive_regulation of P2rx3 1 0.41 0.47 0.74
86 INT230575 Negative_regulation of Gene_expression of Trpv3 2 0.28 0.57 0.73
87 INT119993 Regulation of Trpv2 2 0.22 0.07 0.72
88 INT148469 Negative_regulation of Transcription of Trpv2 1 0.39 0.29 0.69
89 INT46087 Regulation of F3 4 0.45 3.49 0.68
90 INT148470 Negative_regulation of Transcription of Trpm8 1 0.38 0.28 0.68
91 INT330549 Regulation of Regulation of Trpm8 1 0.24 0.52 0.68
92 INT131639 Positive_regulation of Binding of P2rx3 3 0.47 1.22 0.66
93 INT142953 Positive_regulation of Gene_expression of TRPV2 2 0.70 5.56 0.64
94 INT102081 Positive_regulation of Positive_regulation of P2rx3 1 0.49 0.31 0.64
95 INT125189 Transcription of Trpv3 3 0.53 1.08 0.63
96 INT145634 Negative_regulation of Phosphorylation of P2rx3 2 0.54 0.52 0.61
97 INT67346 Regulation of Gene_expression of F3 2 0.13 1.42 0.6
98 INT149754 Positive_regulation of Transcription of P2rx3 5 0.44 3 0.59
99 INT149513 Negative_regulation of Gene_expression of Trpv3 2 0.53 0.79 0.59
100 INT143768 Negative_regulation of Positive_regulation of Trpm8 3 0.43 0.57 0.57
101 INT167926 Transcription of P2rx3 2 0.50 1.48 0.56
102 INT230581 Positive_regulation of Regulation of Trpv3 1 0.31 0 0.55
103 INT161770 Regulation of Gene_expression of Trpv2 1 0.07 0.84 0.55
104 INT230579 Positive_regulation of Localization of Trpv2 1 0.32 0 0.55
105 INT230573 Positive_regulation of Localization of Trpv3 1 0.33 0 0.55
106 INT82930 Localization of F3 3 0.26 2.07 0.54
107 INT174271 Binding of F3 6 0.15 6.85 0.53
108 INT230574 Binding of Trpv3 1 0.25 0 0.53
109 INT149753 Negative_regulation of Transcription of P2rx3 3 0.38 2.59 0.52
110 INT146625 Regulation of Trpv3 2 0.62 0.72 0.52
111 INT73485 Binding of F3 3 0.03 1.53 0.51
112 INT167925 Negative_regulation of Transcription of P2rx3 1 0.40 1.49 0.5
113 INT137968 Negative_regulation of Positive_regulation of Trpm8 5 0.43 0.9 0.49
114 INT126909 Negative_regulation of Localization of P2rx3 1 0.38 0.58 0.48
115 INT149511 Negative_regulation of Transcription of Trpv3 1 0.42 0.79 0.47
116 INT230577 Negative_regulation of Trpv3 1 0.28 0 0.46
117 INT139579 Positive_regulation of Negative_regulation of Trpm8 2 0.69 0.44 0.45
118 INT149514 Positive_regulation of Transcription of Trpv3 1 0.45 0.78 0.45
119 INT230572 Negative_regulation of Gene_expression of Trpv2 1 0.28 0.28 0.43
120 INT152719 Localization of Trpv3 2 0.73 0.24 0.42
121 INT118437 Transcription of TRPV3 3 0.60 0.88 0.4
122 INT166067 Negative_regulation of Localization of P2rx3 1 0.36 0.47 0.4
123 INT330548 Positive_regulation of Regulation of Trpm8 1 0.41 0.67 0.36
124 INT332313 Regulation of Phosphorylation of P2rx3 1 0.56 0.31 0.36
125 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31
126 INT215495 Negative_regulation of Phosphorylation of P2rx3 1 0.19 0 0.31
127 INT118439 Transcription of TRPV2 2 0.71 0.26 0.29
128 INT135079 Positive_regulation of Localization of Trpm8 1 0.49 0 0.29
129 INT343430 Negative_regulation of Gene_expression of Trpv2 1 0.39 0.73 0.29
130 INT252656 Positive_regulation of Binding of F3 1 0.07 1.89 0.29
131 INT137669 Positive_regulation of Positive_regulation of Trpm8 2 0.50 0.32 0.28
132 INT210686 Regulation of F3 2 0.12 0.91 0.27
133 INT261822 Positive_regulation of Localization of Trpv2 1 0.42 0.41 0.27
134 INT169838 Regulation of Negative_regulation of Trpv2 1 0.22 0.16 0.27
135 INT103546 Positive_regulation of Gene_expression of TRPV3 1 0.35 0.19 0.26
136 INT157905 Binding of TRPV2 1 0.31 0.91 0.25
137 INT332310 Positive_regulation of Phosphorylation of P2rx3 1 0.46 0.26 0.24
138 INT287261 Negative_regulation of Binding of Trpm8 2 0.42 0.23 0.22
139 INT160480 Positive_regulation of Negative_regulation of TRPV3 1 0.47 0.09 0.22
140 INT118444 Positive_regulation of Transcription of TRPV2 1 0.44 0.26 0.21
141 INT118443 Positive_regulation of Transcription of TRPV3 1 0.44 0.26 0.21
142 INT196113 Binding of Trpv2 2 0.33 0.58 0.2
143 INT138506 Negative_regulation of F3 2 0.04 1.23 0.2
144 INT136279 Positive_regulation of TRPV2 1 0.50 0 0.2
145 INT136892 Positive_regulation of Positive_regulation of TRPV3 1 0.49 0.09 0.18
146 INT96802 Negative_regulation of Negative_regulation of P2rx3 1 0.59 0.07 0.17
147 INT287260 Regulation of Negative_regulation of Trpm8 1 0.61 0 0.17
148 INT35073 Transcription of F3 1 0.03 0.34 0.17
149 INT54099 Protein_catabolism of Trpm8 1 0.54 0.17 0.17
150 INT283040 Positive_regulation of Transcription of Trpm8 1 0.47 0.87 0.16
151 INT242196 Positive_regulation of Localization of F3 3 0.09 1.71 0.15
152 INT334875 Negative_regulation of Transcription of Trpv2 1 0.23 0.25 0.13
153 INT169839 Positive_regulation of Negative_regulation of Trpv2 1 0.38 0.09 0.12
154 INT215500 Regulation of Phosphorylation of P2rx3 1 0.20 0 0.11
155 INT296221 Regulation of Localization of Trpm8 1 0.45 0.3 0.11
156 INT230580 Negative_regulation of Positive_regulation of Trpv2 1 0.28 0 0.1
157 INT282363 Negative_regulation of Positive_regulation of Trpv3 1 0.40 0.21 0.1
158 INT327443 Regulation of Gene_expression of F3 1 0.03 0.67 0.08
159 INT146626 Positive_regulation of Regulation of Trpv3 1 0.47 0.23 0.07
160 INT93164 Localization of TRPV2 2 0.74 0.07 0.05
161 INT281105 Positive_regulation of Regulation of P2rx3 1 0.26 0.07 0.04
162 INT296225 Regulation of Positive_regulation of Trpm8 1 0.27 0.27 0.03
163 INT160479 Positive_regulation of Localization of TRPV3 1 0.50 0 0
164 INT160478 Localization of TRPV3 1 0.75 0 0
165 INT167580 Regulation of Transcription of Trpm8 1 0.25 0.26 0
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