GO:0009396

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Name folic acid-containing compound biosynthetic process
Categary Process
Go Slim No
Go Link GO:0009396
Unique Molecular Interactions 77
Total Molecular Interactions 87
Total Single Events 726
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for folic acid-containing compound biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for folic acid-containing compound biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
2 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
3 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
4 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
5 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
6 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
7 INT68161 Mthfs Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.12
8 INT68155 Pla2g1b Positive_regulation of Positive_regulation of Mthfs 1 0.03 0.64 1.12
9 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
10 INT25110 RYBP Negative_regulation of MTHFS 1 0.02 0 0.92
11 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
12 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
13 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
14 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs 1 0.00 0 0.58
15 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
16 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
17 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
18 INT338940 Fpgs Positive_regulation of Mtx1 1 0.32 0.32 0.47
19 INT177782 PDCD2 Positive_regulation of MTHFD2 1 0.06 0.76 0.46
20 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
21 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
22 INT141848 Mthfs Negative_regulation of Cpox 1 0.01 0 0.34
23 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
24 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
25 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
26 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
27 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
28 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
29 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
30 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
31 INT143628 MTHFS Positive_regulation of Gene_expression of MRXS5 1 0.01 0.55 0.23
32 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
33 INT236405 Mthfs Regulation of Gene_expression of VEGFA 1 0.00 0.25 0.2
34 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
35 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
36 INT44977 Negative_regulation of Mthfs Negative_regulation of Gfra1 1 0.00 0.2 0.15
37 INT236404 Binding of VEGFA and Mthfs 1 0.00 0.3 0.14
38 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
39 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
40 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
41 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12
42 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
43 INT54131 Binding of Cbr1 and Mthfs 1 0.01 0.25 0.12
44 INT236401 Binding of Flt1 and Mthfs 1 0.01 0.28 0.11
45 INT236406 Mthfs Negative_regulation of Gene_expression of VEGFA 1 0.00 0.3 0.11
46 INT289405 Mthfd1 Positive_regulation of C3ar1 1 0.00 0.53 0.11
47 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1
48 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
49 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
50 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
51 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
52 INT311986 Csf2 Positive_regulation of Mthfd1 1 0.03 0.28 0.08
53 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
54 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
55 INT284565 Gopc Positive_regulation of Mthfd1 1 0.11 0.22 0.05
56 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
57 INT314967 Binding of Cd4 and Mthfd1 1 0.09 0.11 0.04
58 INT252346 Binding of Apcs and Mthfd1 1 0.02 0.13 0.03
59 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
60 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03
61 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
62 INT189108 Mthfd1 Positive_regulation of H2 1 0.00 0.17 0
63 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
64 INT189106 Mthfd1 Positive_regulation of Gene_expression of H2 1 0.00 0.17 0
65 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
66 INT143066 Mthfd1 Regulation of Gene_expression of Plau 1 0.00 0 0
67 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
68 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0
69 INT252337 Mthfd1 Positive_regulation of Gene_expression of Cd80 1 0.04 0.1 0
70 INT284556 Tspan7 Positive_regulation of Mthfd1 1 0.00 1.66 0
71 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
72 INT286884 Binding of Gopc and Mthfd1 1 0.02 0 0
73 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0
74 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
75 INT252333 Mthfd1 Positive_regulation of Gene_expression of Cd86 1 0.04 0.1 0
76 INT189114 Mtap1a Positive_regulation of Gene_expression of Mthfd1 1 0.01 0.3 0
77 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for folic acid-containing compound biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in folic acid-containing compound biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36
2 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11
3 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
4 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
5 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54
6 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
7 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
8 INT44805 Positive_regulation of Mthfs 9 0.49 2.32 4.48
9 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
10 INT17444 Gene_expression of MTHFS 14 0.66 5.17 3.85
11 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
12 INT25128 Gene_expression of Mthfs 9 0.25 2.38 2.75
13 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
14 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
15 INT5068 Binding of Mthfs 4 0.44 1.26 1.7
16 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67
17 INT25131 Localization of Mthfs 5 0.34 2.09 1.63
18 INT10032 Localization of MTHFS 4 0.17 3.11 1.37
19 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
20 INT35396 Binding of Mthfs 3 0.07 1.1 1.02
21 INT45917 Regulation of Negative_regulation of MTHFS 1 0.44 0 1.02
22 INT39330 Negative_regulation of Negative_regulation of Mthfs 2 0.26 0.82 0.96
23 INT34923 Positive_regulation of MTHFS 2 0.49 1.4 0.9
24 INT34863 Positive_regulation of Negative_regulation of MTHFS 1 0.49 1.02 0.86
25 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
26 INT5067 Negative_regulation of Binding of Mthfs 1 0.41 0.26 0.81
27 INT64221 Positive_regulation of Gene_expression of Mthfs 2 0.07 0.44 0.77
28 INT22378 Negative_regulation of Negative_regulation of MTHFS 3 0.57 0.18 0.74
29 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
30 INT113192 Positive_regulation of Positive_regulation of Mthfs 1 0.07 0.45 0.68
31 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
32 INT34861 Regulation of Localization of Mthfs 1 0.23 0.38 0.61
33 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
34 INT42082 Regulation of Mthfs 3 0.44 0.57 0.58
35 INT45854 Positive_regulation of Negative_regulation of Mthfs 2 0.45 0.83 0.53
36 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
37 INT177878 Positive_regulation of Gene_expression of MTHFD2 1 0.26 1.16 0.46
38 INT177882 Gene_expression of MTHFD2 1 0.40 1.16 0.46
39 INT45855 Regulation of Negative_regulation of Mthfs 2 0.44 0.23 0.44
40 INT97316 Positive_regulation of Gene_expression of Mthfs 1 0.04 0 0.43
41 INT97317 Gene_expression of Mthfs 1 0.06 0 0.42
42 INT44273 Binding of MTHFS 3 0.29 0.81 0.41
43 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
44 INT338937 Positive_regulation of Gene_expression of Fpgs 1 0.48 0.13 0.37
45 INT338933 Gene_expression of Fpgs 1 0.54 0.13 0.37
46 INT25129 Negative_regulation of Localization of Mthfs 2 0.16 0.5 0.35
47 INT25132 Negative_regulation of Gene_expression of Mthfs 2 0.08 0.39 0.33
48 INT105447 Positive_regulation of Gene_expression of MTHFS 2 0.32 0.78 0.31
49 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
50 INT44275 Negative_regulation of Positive_regulation of MTHFS 1 0.25 0.15 0.25
51 INT67859 Negative_regulation of Gene_expression of MTHFS 1 0.07 0.33 0.24
52 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
53 INT44276 Negative_regulation of Regulation of MTHFS 1 0.16 0.08 0.18
54 INT106988 Negative_regulation of Binding of Mthfs 1 0.04 0.25 0.17
55 INT289385 Negative_regulation of Localization of Mthfd1 1 0.03 0.6 0.12
56 INT113808 Positive_regulation of Mthfs 1 0.01 0.81 0.12
57 INT122581 Negative_regulation of Positive_regulation of Mthfs 1 0.02 0.07 0.1
58 INT77507 Regulation of Mthfs 1 0.03 0.71 0.05
59 INT96481 Regulation of Positive_regulation of Mthfd1 2 0.02 1.3 0.04
60 INT188589 Transcription of Mthfd1 1 0.35 0.07 0.03
61 INT177852 Negative_regulation of Gene_expression of MTHFD2 1 0.22 0.4 0
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