GO:0009595

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Name detection of biotic stimulus
Categary Process
Go Slim No
Go Link GO:0009595
Unique Molecular Interactions 41
Total Molecular Interactions 49
Total Single Events 317
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for detection of biotic stimulus. They are ordered first by their pain relevance and then by number of times they were reported for detection of biotic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
2 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
3 INT36743 NLRP3 Regulation of Mbp 1 0.01 0 0.43
4 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
5 INT191499 CMA1 Positive_regulation of NLRP3 1 0.02 0.42 0.3
6 INT191502 Binding of CMA1 and NLRP3 1 0.01 0.42 0.3
7 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
8 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
9 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28
10 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
11 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27
12 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
13 INT191504 CPN2 Positive_regulation of NLRP3 1 0.00 0.37 0.27
14 INT219193 Nlrp3 Positive_regulation of Positive_regulation of NLRP3 1 0.24 1.03 0.26
15 INT191498 Binding of CTSG and NLRP3 1 0.07 0.37 0.25
16 INT191496 CTSG Positive_regulation of NLRP3 1 0.09 0.37 0.25
17 INT191536 Klk1c2 Positive_regulation of NLRP3 1 0.02 0.36 0.24
18 INT191537 Binding of Klk1c2 and NLRP3 1 0.02 0.36 0.24
19 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
20 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
21 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
22 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
23 INT23165 Binding of NLRP3 and BDNF-AS 1 0.01 0.83 0.16
24 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
25 INT23164 Negative_regulation of Binding of NLRP3 and BDNF-AS 1 0.01 0.83 0.16
26 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
27 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
28 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
29 INT34431 NLRP3 Positive_regulation of Localization of POMC 1 0.41 0.31 0.14
30 INT219152 NLRP3 Positive_regulation of Positive_regulation of CASP1 1 0.02 0.83 0.1
31 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
32 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
33 INT188007 NLRP3 Regulation of Binding of TP53BP1 1 0.28 0.62 0.08
34 INT188006 NLRP3 Regulation of Gene_expression of TP53BP1 1 0.28 0.36 0.04
35 INT188005 NLRP3 Regulation of TP53BP1 1 0.34 0.3 0.04
36 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04
37 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
38 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03
39 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
40 INT270831 Positive_regulation of Panx1 Positive_regulation of NLRP3 1 0.18 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for detection of biotic stimulus. They are ordered first by their pain relevance and then by number of times they were reported in detection of biotic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
2 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47
3 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57
4 INT103910 Binding of NOD2 19 0.47 12.24 2.93
5 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
6 INT10612 Localization of NLRP3 13 0.78 8.91 2.27
7 INT24453 Binding of NLRP3 18 0.48 13.7 1.93
8 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
9 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
10 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53
11 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
12 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
13 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15
14 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
15 INT36742 Regulation of NLRP3 2 0.16 0 0.63
16 INT244153 Positive_regulation of Gene_expression of NOD1 1 0.46 1.36 0.63
17 INT244161 Positive_regulation of NOD1 4 0.64 1.83 0.62
18 INT15981 Positive_regulation of Positive_regulation of NLRP3 2 0.44 1.02 0.62
19 INT162791 Regulation of NOD1 2 0.13 0.58 0.55
20 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
21 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
22 INT244159 Transcription of NLRP3 3 0.64 5.61 0.39
23 INT171764 Localization of NOD2 2 0.74 0.86 0.37
24 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
25 INT244143 Positive_regulation of Positive_regulation of NOD1 1 0.46 0.68 0.31
26 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
27 INT244171 Negative_regulation of NOD1 3 0.47 0 0.28
28 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
29 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
30 INT346896 Binding of Nod2 1 0.21 0.72 0.26
31 INT219173 Negative_regulation of Gene_expression of NLRP3 1 0.19 1.02 0.26
32 INT219174 Negative_regulation of Positive_regulation of NLRP3 1 0.19 1.02 0.26
33 INT29590 Positive_regulation of Localization of NLRP3 3 0.49 0.51 0.23
34 INT318992 Localization of NOD1 1 0.11 1.1 0.23
35 INT346899 Regulation of Positive_regulation of Nod2 1 0.18 0.75 0.22
36 INT222271 Transcription of NOD1 2 0.66 0.32 0.21
37 INT191531 Regulation of Negative_regulation of NLRP3 1 0.08 0.32 0.19
38 INT222274 Regulation of Regulation of NOD2 1 0.27 0.45 0.13
39 INT204777 Negative_regulation of Localization of Nod2 1 0.28 0.61 0.09
40 INT204779 Localization of Nod2 1 0.48 0.6 0.08
41 INT204770 Regulation of Nod2 1 0.29 0.66 0.07
42 INT244164 Positive_regulation of Transcription of NLRP3 1 0.43 0.13 0.05
43 INT222267 Regulation of Transcription of NOD2 1 0.45 0 0.05
44 INT48471 Regulation of Positive_regulation of NLRP3 1 0.07 0.36 0.05
45 INT346893 Negative_regulation of Gene_expression of Nod2 1 0.28 0.13 0.04
46 INT244158 Regulation of Gene_expression of NOD1 1 0.56 0 0.03
47 INT284053 Positive_regulation of Positive_regulation of Nod2 1 0.25 0.08 0
48 INT343496 Negative_regulation of Gene_expression of NOD1 1 0.12 0 0
49 INT343493 Protein_catabolism of NOD1 1 0.25 0 0
50 INT222273 Positive_regulation of Regulation of NOD2 1 0.46 0.09 0
51 INT343495 Negative_regulation of Protein_catabolism of NOD1 1 0.12 0 0
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