GO:0009650

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Name UV protection
Categary Process
Go Slim No
Go Link GO:0009650
Unique Molecular Interactions 150
Total Molecular Interactions 274
Total Single Events 2506
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for UV protection. They are ordered first by their pain relevance and then by number of times they were reported for UV protection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
4 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
5 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
6 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
7 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
8 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
9 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
10 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
11 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
12 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
13 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
14 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
15 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
16 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
17 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
18 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
19 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
20 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
21 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
22 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
23 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
24 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
25 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
26 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
27 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
28 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
29 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
30 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
31 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
32 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
33 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
34 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
35 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
36 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
37 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
38 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
39 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
40 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
41 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
42 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
43 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
44 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
45 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
46 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
47 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
48 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
49 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
50 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
51 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35
52 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
53 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
54 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
55 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
56 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
57 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
58 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
59 INT241911 Binding of Cat and Ros1 1 0.03 0.85 0.27
60 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
61 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
62 INT120583 Gsta4 Regulation of Cat 1 0.03 0 0.23
63 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
64 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
65 INT334379 Ros1 Regulation of Cat 1 0.04 0.08 0.21
66 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2
67 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19
68 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19
69 INT241177 Abl2 Regulation of Cat 1 0.14 0.3 0.15
70 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15
71 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
72 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
73 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
74 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
75 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
76 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12
77 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12
78 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12
79 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12
80 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
81 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12
82 INT211921 Gene_expression of Nek1 Positive_regulation of Cat 1 0.01 0.26 0.1
83 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
84 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1
85 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1
86 INT241913 AAVS1 Positive_regulation of Cat 1 0.04 0.46 0.1
87 INT23896 Positive_regulation of Rtcd1 Positive_regulation of Cat 1 0.25 0 0.08
88 INT166919 Binding of CAT and GSTK1 1 0.09 0.16 0.07
89 INT227353 Binding of Cat and Mpo 1 0.18 0.56 0.07
90 INT281879 Cat Negative_regulation of Fig4 1 0.01 0.96 0.06
91 INT229419 Atp6v0a2 Regulation of Cat 1 0.01 1.73 0.06
92 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
93 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
94 INT266901 Nfe2l2 Positive_regulation of Cat 1 0.10 0.19 0.04
95 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
96 INT227352 Binding of Cat and Ros1 1 0.04 1.06 0.04
97 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
98 INT292416 SOD1 Regulation of Cat 1 0.01 0.45 0.03
99 INT311144 CAT Positive_regulation of APRT 1 0.01 0 0.03
100 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
101 INT338838 Binding of Cat and Tnnc1 1 0.03 1.77 0
102 INT285403 Binding of CAT and MPO 1 0.30 0.9 0
103 INT121318 Tgfb1 Negative_regulation of Ercc1 1 0.06 0.08 0
104 INT181697 Positive_regulation of Ldha Negative_regulation of Cat 1 0.29 0.6 0
105 INT311145 CAT Positive_regulation of Protein_catabolism of APRT 1 0.01 0 0
106 INT149115 Cat Negative_regulation of Pax3 1 0.02 0.05 0
107 INT155123 Binding of Gpx1 and Cat 1 0.04 0.05 0
108 INT210548 SCARA3 Regulation of Tenc1 1 0.03 0 0
109 INT206959 Lipg Regulation of Cat 1 0.02 0.5 0
110 INT342252 Binding of Ercc1 and Tymp 1 0.29 1.24 0
111 INT285772 ERCC1 Positive_regulation of Binding of RAD51 1 0.05 0 0
112 INT338839 Negative_regulation of Binding of Cat and Tnnc1 1 0.04 1.78 0
113 INT121313 Tgfb1 Positive_regulation of Ercc1 1 0.07 0.08 0
114 INT121315 Negative_regulation of Egfr Negative_regulation of Ercc1 1 0.42 0.08 0
115 INT239182 Gene_expression of Gh Negative_regulation of Cat 1 0.17 0.33 0
116 INT155124 Positive_regulation of Binding of Gpx1 and Cat 1 0.05 0.05 0
117 INT181696 Ldha Negative_regulation of Cat 1 0.27 1.16 0
118 INT285771 ERCC1 Regulation of Binding of RAD51 1 0.05 0 0
119 INT341409 Ccl4 Regulation of Cat 1 0.25 0.07 0
120 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
121 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
122 INT89807 Binding of Cat and Penk 1 0.21 0 0
123 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
124 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
125 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
126 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
127 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
128 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for UV protection. They are ordered first by their pain relevance and then by number of times they were reported in UV protection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54
3 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
4 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
5 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
6 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
7 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
8 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
9 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
10 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
11 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
12 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
13 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
14 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
15 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
16 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
17 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
18 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
19 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
20 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
21 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
22 INT38366 Regulation of Cat 45 0.62 23.45 5.34
23 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2
24 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
25 INT12948 Positive_regulation of Gene_expression of Cat 17 0.67 6.46 3.12
26 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
27 INT79722 Regulation of Cat 14 0.62 5.88 2.86
28 INT61136 Localization of MC1R 8 0.75 2.8 2.85
29 INT113892 Binding of Cat 6 0.48 3.95 2.65
30 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
31 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37
32 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
33 INT123873 Positive_regulation of Negative_regulation of Cat 7 0.50 2.86 1.86
34 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
35 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
36 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
37 INT163666 Localization of Cat 8 0.80 5.84 1.57
38 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
39 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
40 INT121307 Gene_expression of Ercc1 4 0.73 12.69 1.37
41 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
42 INT91122 Localization of CAT 6 0.78 4.13 1.19
43 INT148228 Positive_regulation of Regulation of Cat 1 0.49 1.16 1.19
44 INT12952 Negative_regulation of Gene_expression of Cat 16 0.57 7.44 1.14
45 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
46 INT125356 Negative_regulation of Negative_regulation of Cat 4 0.42 2.66 1.06
47 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
48 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
49 INT12945 Negative_regulation of Positive_regulation of Cat 3 0.41 2.61 0.97
50 INT53682 Regulation of Gene_expression of CAT 2 0.60 0.36 0.96
51 INT55052 Binding of Cat 10 0.36 5.46 0.92
52 INT66314 Negative_regulation of Positive_regulation of CAT 4 0.42 0.8 0.91
53 INT142919 Regulation of Gene_expression of Cat 2 0.32 0.33 0.89
54 INT93747 Localization of Cat 9 0.56 4.25 0.88
55 INT130188 Positive_regulation of Negative_regulation of Cat 5 0.45 2.26 0.86
56 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
57 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
58 INT251735 Binding of FEN1 1 0.17 1.13 0.74
59 INT89801 Positive_regulation of Positive_regulation of Cat 2 0.49 0.21 0.71
60 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
61 INT107417 Regulation of CAT 8 0.60 2.4 0.61
62 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
63 INT266893 Negative_regulation of Gene_expression of Cat 4 0.58 3.76 0.55
64 INT130387 Binding of CAT 4 0.36 2.39 0.55
65 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
66 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
67 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
68 INT136205 Positive_regulation of Regulation of Cat 1 0.38 0.51 0.43
69 INT121310 Positive_regulation of Ercc1 2 0.45 1.78 0.42
70 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
71 INT219001 Gene_expression of ERCC1 12 0.54 3.77 0.38
72 INT84981 Negative_regulation of Gene_expression of CAT 3 0.41 0.35 0.35
73 INT163803 Regulation of Gene_expression of Cat 3 0.61 1.51 0.33
74 INT314342 Positive_regulation of Localization of Cat 2 0.04 1.05 0.31
75 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
76 INT144868 Transcription of Cat 3 0.62 1.23 0.29
77 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
78 INT211917 Positive_regulation of Positive_regulation of Cat 1 0.62 0.97 0.29
79 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
80 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
81 INT158564 Negative_regulation of Positive_regulation of Cat 2 0.37 1.27 0.27
82 INT58442 Transcription of Cat 3 0.67 0.28 0.22
83 INT121311 Positive_regulation of Gene_expression of Ercc1 3 0.62 1.23 0.21
84 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
85 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17
86 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
87 INT55051 Negative_regulation of Binding of Cat 2 0.35 0.61 0.16
88 INT355976 Negative_regulation of Transcription of Cat 1 0.51 0.31 0.15
89 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
90 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
91 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
92 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
93 INT181919 Protein_catabolism of CAT 1 0.15 0.54 0.12
94 INT210542 Regulation of SCARA3 3 0.10 3.72 0.09
95 INT266463 Positive_regulation of Positive_regulation of CAT 2 0.49 1.85 0.09
96 INT252568 Negative_regulation of Regulation of Gpx1 1 0.08 1.11 0.09
97 INT285813 Negative_regulation of ERCC1 13 0.30 2.03 0.08
98 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
99 INT210547 Gene_expression of SCARA3 8 0.18 2.15 0.06
100 INT219454 Regulation of Gene_expression of SCARA3 1 0.09 1.32 0.06
101 INT89803 Negative_regulation of Regulation of Cat 3 0.41 1.77 0.03
102 INT229426 Negative_regulation of Localization of Cat 3 0.32 1.06 0.03
103 INT351331 Regulation of Transcription of Cat 1 0.24 0.29 0.03
104 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
105 INT205043 Positive_regulation of SCARA3 5 0.30 2.94 0
106 INT89804 Regulation of Positive_regulation of Cat 2 0.26 1.2 0
107 INT205044 Negative_regulation of SCARA3 1 0.28 0.22 0
108 INT342249 Binding of Ercc1 1 0.33 2.69 0
109 INT165869 Negative_regulation of Negative_regulation of Cat 1 0.35 0.15 0
110 INT293145 Regulation of Negative_regulation of Cat 1 0.18 0.09 0
111 INT285815 Binding of ERCC1 1 0.26 0 0
112 INT210545 Positive_regulation of Localization of SCARA3 1 0.13 0.96 0
113 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0
114 INT219474 Binding of SCARA3 1 0.06 0.47 0
115 INT268724 Positive_regulation of Negative_regulation of Gpx1 1 0.04 0.13 0
116 INT285814 Positive_regulation of ERCC1 1 0.35 0.14 0
117 INT121309 Localization of Ercc1 1 0.29 0 0
118 INT210546 Localization of SCARA3 1 0.20 0.48 0
119 INT107418 Negative_regulation of Regulation of CAT 1 0.31 0 0
120 INT335614 Positive_regulation of Regulation of MC1R 1 0.23 0 0
121 INT210544 Positive_regulation of Gene_expression of SCARA3 1 0.13 0.31 0
122 INT149430 Localization of ERCC2 1 0.43 0.76 0
123 INT219496 Negative_regulation of FEN1 1 0.35 0.36 0
124 INT197348 Protein_catabolism of Cat 1 0.32 0.06 0
125 INT307191 Protein_catabolism of Cat 1 0.10 0.19 0
126 INT342250 Negative_regulation of Gene_expression of Ercc1 1 0.40 0.99 0
127 INT285819 Negative_regulation of Negative_regulation of ERCC1 1 0.30 0.18 0
128 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0
129 INT347402 Negative_regulation of Binding of Gpx1 1 0.05 0 0
130 INT351593 Positive_regulation of Binding of Gpx1 1 0.08 0 0
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